A Method for Gene-Based Pathway Analysis Using Genomewide Association Study Summary Statistics Reveals Nine New Type 1 Diabetes Associations

First integrin inhibitor since Tysabri nears approval for IBD

(2014) Cormac Sheridan   NATURE BIOTECHNOLOGY

Two novel pathway analysis methods based on a hierarchical model

(2013) Marina Evangelou et al.   BIOINFORMATICS

Properties of permutation-based gene tests and controlling type 1 error using a summary statistic based gene test

(2013) David M Swanson et al.   BMC GENETICS

Inactivation of BAD by IKK Inhibits TNFα-Induced Apoptosis Independently of NF-κB Activation

(2013) Jie Yan et al.   CELL

IL7RA haplotype-associated alterations in cellular immune function and gene expression patterns in multiple sclerosis

(2013) J Jäger et al.   GENES AND IMMUNITY

Systematic identification of trans eQTLs as putative drivers of known disease associations

(2013) Harm-Jan Westra et al.   NATURE GENETICS

Genetic insights into common pathways and complex relationships among immune-mediated diseases

(2013) Miles Parkes et al.   NATURE REVIEWS GENETICS

Integrated Enrichment Analysis of Variants and Pathways in Genome-Wide Association Studies Indicates Central Role for IL-2 Signaling Genes in Type 1 Diabetes, and Cytokine Signaling Genes in Crohn's Disease

(2013) Peter Carbonetto et al.   PLoS Genetics

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

(2012) Luke Jostins et al.   NATURE

An integrated map of genetic variation from 1,092 human genomes

(2012)   NATURE

Ensembl 2013

(2012) Paul Flicek et al.   NUCLEIC ACIDS RESEARCH

Comparison of Methods for Competitive Tests of Pathway Analysis

(2012) Marina Evangelou et al.   PLoS One

A Meta-Analysis and Genome-Wide Association Study of Platelet Count and Mean Platelet Volume in African Americans

(2012) Rehan Qayyum et al.   PLoS Genetics

An efficient hierarchical generalized linear mixed model for pathway analysis of genome-wide association studies

(2011) Lily Wang et al.   BIOINFORMATICS

Using the gene ontology to scan multilevel gene sets for associations in genome wide association studies

(2011) Daniel J. Schaid et al.   GENETIC EPIDEMIOLOGY

Long-range DNA looping and gene expression analyses identify DEXI as an autoimmune disease candidate gene

(2011) Lucy J. Davison et al.   HUMAN MOLECULAR GENETICS

Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease

(2011) Gosia Trynka et al.   NATURE GENETICS

Promise and pitfalls of the Immunochip

(2011) Adrian Cortes et al.   ARTHRITIS RESEARCH & THERAPY

A Versatile Gene-Based Test for Genome-wide Association Studies

(2010) Jimmy Z. Liu et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Control of α4β7 Integrin Expression and CD4 T Cell Homing by the β1 Integrin Subunit

(2010) Christopher C. DeNucci et al.   JOURNAL OF IMMUNOLOGY

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci

(2010) Andre Franke et al.   NATURE GENETICS

T1DBase: update 2011, organization and presentation of large-scale data sets for type 1 diabetes research

(2010) O. S. Burren et al.   NUCLEIC ACIDS RESEARCH

Reactome: a database of reactions, pathways and biological processes

(2010) D. Croft et al.   NUCLEIC ACIDS RESEARCH

Genetics and Beyond – The Transcriptome of Human Monocytes and Disease Susceptibility

(2010) Tanja Zeller et al.   PLoS One

Gene Ontology Analysis of GWA Study Data Sets Provides Insights into the Biology of Bipolar Disorder

(2009) Peter Holmans et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The SNP ratio test: pathway analysis of genome-wide association datasets

(2009) Colm O'Dushlaine et al.   BIOINFORMATICS

Gene and pathway-based second-wave analysis of genome-wide association studies

(2009) Gang Peng et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Pathway analysis by adaptive combination ofP-values

(2009) Kai Yu et al.   GENETIC EPIDEMIOLOGY

Using genome-wide pathway analysis to unravel the etiology of complex diseases

(2009) Clara C. Elbers et al.   GENETIC EPIDEMIOLOGY

Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes

(2009) Jeffrey C Barrett et al.   NATURE GENETICS

The NCBI BioSystems database

(2009) Lewis Y. Geer et al.   NUCLEIC ACIDS RESEARCH

Pathway Analysis of GWAS Provides New Insights into Genetic Susceptibility to 3 Inflammatory Diseases

(2009) Hariklia Eleftherohorinou et al.   PLoS One

Analysis of multiple SNPs in a candidate gene or region

(2008) Juliet Chapman et al.   GENETIC EPIDEMIOLOGY

PID: the Pathway Interaction Database

(2008) Carl F. Schaefer et al.   NUCLEIC ACIDS RESEARCH

Reactome knowledgebase of human biological pathways and processes

(2008) L. Matthews et al.   NUCLEIC ACIDS RESEARCH