Developmental and environmental epigenetic programming of the endocrine pancreas: consequences for type 2 diabetes

CENP-A, a protein required for chromosome segregation in mitosis, declines with age in islet but not exocrine cells

(2016) Seung-Hee Lee et al.   Aging-US

Telomerase deficiency impairs glucose metabolism and insulin secretion

(2016) Doreen Kuhlow et al.   Aging-US

Maternal diet, aging and diabetes meet at a chromatin loop

(2016) Susan E. Ozanne et al.   Aging-US

Connecting Threads: Epigenetics and Metabolism

(2012) Sayako Katada et al.   CELL

Human β Cell Transcriptome Analysis Uncovers lncRNAs That Are Tissue-Specific, Dynamically Regulated, and Abnormally Expressed in Type 2 Diabetes

(2012) Ignasi Morán et al.   Cell Metabolism

DNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patients

(2012) Michael Volkmar et al.   EMBO JOURNAL

Periconceptional maternal micronutrient supplementation is associated with widespread gender related changes in the epigenome: a study of a unique resource in the Gambia

(2012) Batbayar Khulan et al.   HUMAN MOLECULAR GENETICS

Metaboloepigenetics: Interrelationships between energy metabolism and epigenetic control of gene expression

(2012) Dallas R. Donohoe et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Increased DNA Methylation and Decreased Expression ofPDX-1in Pancreatic Islets from Patients with Type 2 Diabetes

(2012) Beatrice T. Yang et al.   MOLECULAR ENDOCRINOLOGY

linking metabolism to epigenetics through O-GlcNAcylation

(2012) John A. Hanover et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Glucose activates free fatty acid receptor 1 gene transcription via phosphatidylinositol-3-kinase-dependent O-GlcNAcylation of pancreas-duodenum homeobox-1

(2012) M. Kebede et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chromatin-targeting small molecules cause class-specific transcriptional changes in pancreatic endocrine cells

(2012) S. Kubicek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-wide promoter DNA methylation dynamics of human hematopoietic progenitor cells during differentiation and aging

(2011) M. T. Bocker et al.   BLOOD

Mbd3/NURD Complex Regulates Expression of 5-Hydroxymethylcytosine Marked Genes in Embryonic Stem Cells

(2011) Ozlem Yildirim et al.   CELL

DNA Demethylation Dynamics

(2011) Nidhi Bhutani et al.   CELL

The Logic Linking Protein Acetylation and Metabolism

(2011) Leonard Guarente   Cell Metabolism

The Microbiome and Butyrate Regulate Energy Metabolism and Autophagy in the Mammalian Colon

(2011) Dallas R. Donohoe et al.   Cell Metabolism

Regulation of chromatin by histone modifications

(2011) Andrew J Bannister et al.   CELL RESEARCH

Epigenetic Memory and Preferential Lineage-Specific Differentiation in Induced Pluripotent Stem Cells Derived from Human Pancreatic Islet Beta Cells

(2011) Ori Bar-Nur et al.   Cell Stem Cell

Pancreatic β Cell Identity Is Maintained by DNA Methylation-Mediated Repression of Arx

(2011) Sangeeta Dhawan et al.   DEVELOPMENTAL CELL

Pancreas organogenesis: From bud to plexus to gland

(2011) Fong Cheng Pan et al.   DEVELOPMENTAL DYNAMICS

Specific Control of Pancreatic Endocrine β- and δ-Cell Mass by Class IIa Histone Deacetylases HDAC4, HDAC5, and HDAC9

(2011) Olivia Lenoir et al.   DIABETES

Child Health, Developmental Plasticity, and Epigenetic Programming

(2011) Z. Hochberg et al.   ENDOCRINE REVIEWS

Hypothesis: Environmental regulation of 5-hydroxymethylcytosine by oxidative stress

(2011) Nancy Chia et al.   Epigenetics

Context-specific  -to- -cell reprogramming by forced Pdx1 expression

(2011) Y.-P. Yang et al.   GENES & DEVELOPMENT

Nkx2.2 repressor complex regulates islet  -cell specification and prevents  -to- -cell reprogramming

(2011) J. B. Papizan et al.   GENES & DEVELOPMENT

Genome-wide survey reveals predisposing diabetes type 2-related DNA methylation variations in human peripheral blood

(2011) Gidon Toperoff et al.   HUMAN MOLECULAR GENETICS

Modification of Histones by Sugar β-N-Acetylglucosamine (GlcNAc) Occurs on Multiple Residues, Including Histone H3 Serine 10, and Is Cell Cycle-regulated

(2011) Suisheng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pleiotropic and Age-dependent Effects of Decreased Protein Modification byO-LinkedN-Acetylglucosamine on Pancreatic β-Cell Function and Vascularization

(2011) Yudi Soesanto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential expression pattern of ZAC in developing mouse and human pancreas

(2011) Xiaoyu Du et al.   JOURNAL OF MOLECULAR HISTOLOGY

Pre- and Postnatal Methyl Deficiency in the Rat Differentially Alters Glucose Homeostasis

(2011) Greg C. Smith et al.   Journal of Nutrigenetics and Nutrigenomics

PDGF signalling controls age-dependent proliferation in pancreatic β-cells

(2011) Hainan Chen et al.   NATURE

5-hmC–mediated epigenetic dynamics during postnatal neurodevelopment and aging

(2011) Keith E Szulwach et al.   NATURE NEUROSCIENCE

Mapping of INS promoter interactions reveals its role in long-range regulation of SYT8 transcription

(2011) Zhixiong Xu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Alterations of NADPH Oxidase Activity in Rat Pancreatic Islets Induced by a High-Fat Diet

(2011) Maíra Mello Rezende Valle et al.   PANCREAS

Histone H4 lysine 16 hypoacetylation is associated with defective DNA repair and premature senescence in Zmpste24-deficient mice

(2011) V. Krishnan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Maternal diet and aging alter the epigenetic control of a promoter-enhancer interaction at the Hnf4a gene in rat pancreatic islets

(2011) I. Sandovici et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tet Proteins Can Convert 5-Methylcytosine to 5-Formylcytosine and 5-Carboxylcytosine

(2011) S. Ito et al.   SCIENCE

Chromatin "Prepattern" and Histone Modifiers in a Fate Choice for Liver and Pancreas

(2011) C.-R. Xu et al.   SCIENCE

Aging induces a distinct gene expression program in mouse islets

(2011) Matthew M. Rankin et al.   Islets

Tissue-specific dysregulation of DNA methylation in aging

(2010) Reid F. Thompson et al.   AGING CELL

The Redox Basis of Epigenetic Modifications: From Mechanisms to Functional Consequences

(2010) Anthony R. Cyr et al.   ANTIOXIDANTS & REDOX SIGNALING

Paternally Induced Transgenerational Environmental Reprogramming of Metabolic Gene Expression in Mammals

(2010) Benjamin R. Carone et al.   CELL

Histone Methyl Transferases and Demethylases; Can They Link Metabolism and Transcription?

(2010) Raffaele Teperino et al.   Cell Metabolism

Global Epigenomic Analysis of Primary Human Pancreatic Islets Provides Insights into Type 2 Diabetes Susceptibility Loci

(2010) Michael L. Stitzel et al.   Cell Metabolism

RNAi-dependent formation of heterochromatin and its diverse functions

(2010) Shiv IS Grewal   CURRENT OPINION IN GENETICS & DEVELOPMENT

Cellular Plasticity within the Pancreas— Lessons Learned from Development

(2010) Sapna Puri et al.   DEVELOPMENTAL CELL

Insulin promoter DNA methylation correlates negatively with insulin gene expression and positively with HbA1c levels in human pancreatic islets

(2010) B. T. Yang et al.   DIABETOLOGIA

Poor maternal nutrition leads to alterations in oxidative stress, antioxidant defense capacity, and markers of fibrosis in rat islets: potential underlying mechanisms for development of the diabetic phenotype in later life

(2010) Jane L. Tarry-Adkins et al.   FASEB JOURNAL

Epigenomics: maternal high-fat diet exposure in utero disrupts peripheral circadian gene expression in nonhuman primates

(2010) Melissa Suter et al.   FASEB JOURNAL

Genome-wide analysis of histone modifications in human pancreatic islets

(2010) R. Bhandare et al.   GENOME RESEARCH

Human aging-associated DNA hypermethylation occurs preferentially at bivalent chromatin domains

(2010) V. K. Rakyan et al.   GENOME RESEARCH

Locus co-occupancy, nucleosome positioning, and H3K4me1 regulate the functionality of FOXA2-, HNF4A-, and PDX1-bound loci in islets and liver

(2010) B. G. Hoffman et al.   GENOME RESEARCH

Tissue-specific disallowance of housekeeping genes: The other face of cell differentiation

(2010) L. Thorrez et al.   GENOME RESEARCH

Derepression of Polycomb targets during pancreatic organogenesis allows insulin-producing beta-cells to adopt a neural gene activity program

(2010) J. van Arensbergen et al.   GENOME RESEARCH

Experimental Intrauterine Growth Restriction Induces Alterations in DNA Methylation and Gene Expression in Pancreatic Islets of Rats

(2010) Reid F. Thompson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Resveratrol Potentiates Glucose-stimulated Insulin Secretion in INS-1E β-Cells and Human Islets through a SIRT1-dependent Mechanism

(2010) Laurène Vetterli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Conversion of adult pancreatic α-cells to β-cells after extreme β-cell loss

(2010) Fabrizio Thorel et al.   NATURE

Chronic high-fat diet in fathers programs β-cell dysfunction in female rat offspring

(2010) Sheau-Fang Ng et al.   NATURE

Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine

(2010) Chun-Xiao Song et al.   NATURE BIOTECHNOLOGY

A map of open chromatin in human pancreatic islets

(2010) Kyle J Gaulton et al.   NATURE GENETICS

Histone variants — ancient wrap artists of the epigenome

(2010) Paul B. Talbert et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Reduced histone biosynthesis and chromatin changes arising from a damage signal at telomeres

(2010) Roderick J O'Sullivan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Genomics, Type 2 Diabetes, and Obesity

(2010) Mark I. McCarthy   NEW ENGLAND JOURNAL OF MEDICINE

Developmental regulation and individual differences of neuronal H3K4me3 epigenomes in the prefrontal cortex

(2010) I. Cheung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Altered Histone Acetylation Is Associated with Age-Dependent Memory Impairment in Mice

(2010) S. Peleg et al.   SCIENCE

Heritable Individual-Specific and Allele-Specific Chromatin Signatures in Humans

(2010) R. McDaniell et al.   SCIENCE

Gene regulation by nucleosome positioning

(2010) Lu Bai et al.   TRENDS IN GENETICS

The emerging genetics of type 2 diabetes

(2010) Amélie Bonnefond et al.   TRENDS IN MOLECULAR MEDICINE

Aging and Chronic Sun Exposure Cause Distinct Epigenetic Changes in Human Skin

(2010) Elke Grönniger et al.   PLoS Genetics

The Role of Sirtuins in the Control of Metabolic Homeostasis

(2009) Jiujiu Yu et al.   Annals of the New York Academy of Sciences

The Ectopic Expression of Pax4 in the Mouse Pancreas Converts Progenitor Cells into α and Subsequently β Cells

(2009) Patrick Collombat et al.   CELL

Loss of Dnmt1 catalytic activity reveals multiple roles for DNA methylation during pancreas development and regeneration

(2009) Ryan M. Anderson et al.   DEVELOPMENTAL BIOLOGY

Global estimates of the prevalence of diabetes for 2010 and 2030

(2009) J.E. Shaw et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Diet-induced gene expression of isolated pancreatic islets from a polygenic mouse model of the metabolic syndrome

(2009) T. Dreja et al.   DIABETOLOGIA

Poor maternal nutrition followed by accelerated postnatal growth leads to telomere shortening and increased markers of cell senescence in rat islets

(2009) J. L. Tarry-Adkins et al.   FASEB JOURNAL

Nucleosome-binding affinity as a primary determinant of the nuclear mobility of the pioneer transcription factor FoxA

(2009) T. Sekiya et al.   GENES & DEVELOPMENT

Polycomb protein Ezh2 regulates pancreatic  -cell Ink4a/Arf expression and regeneration in diabetes mellitus

(2009) H. Chen et al.   GENES & DEVELOPMENT

An operational definition of epigenetics

(2009) S. L. Berger et al.   GENES & DEVELOPMENT

Folic Acid Supplementation during the Juvenile-Pubertal Period in Rats Modifies the Phenotype and Epigenotype Induced by Prenatal Nutrition

(2009) Graham C. Burdge et al.   JOURNAL OF NUTRITION

GlcNAcylation of a histone methyltransferase in retinoic-acid-induced granulopoiesis

(2009) Ryoji Fujiki et al.   NATURE

Parental origin of sequence variants associated with complex diseases

(2009) Augustine Kong et al.   NATURE

Dynamic DNA methylation programs persistent adverse effects of early-life stress

(2009) Chris Murgatroyd et al.   NATURE NEUROSCIENCE

In Brief

(2009)   NATURE REVIEWS NEUROSCIENCE

Epigenetic responses to environmental change and their evolutionary implications

(2009) B. M. Turner   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Early Low Protein Diet Aggravates Unbalance between Antioxidant Enzymes Leading to Islet Dysfunction

(2009) Nicolas Theys et al.   PLoS One

The human insulin gene is part of a large open chromatin domain specific for human islets

(2009) V. Mutskov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circadian Control of the NAD+ Salvage Pathway by CLOCK-SIRT1

(2009) Y. Nakahata et al.   SCIENCE

Essential Role of the Glycosyltransferase Sxc/Ogt in Polycomb Repression

(2009) Maria Cristina Gambetta et al.   SCIENCE

Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

(2009) M. Tahiliani et al.   SCIENCE

ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation

(2009) K. E. Wellen et al.   SCIENCE

Aging and Environmental Exposures Alter Tissue-Specific DNA Methylation Dependent upon CpG Island Context

(2009) Brock C. Christensen et al.   PLoS Genetics

A Metabolic Throttle Regulates the Epigenetic State of rDNA

(2008) Ingrid Grummt et al.   CELL

SIRT1 Redistribution on Chromatin Promotes Genomic Stability but Alters Gene Expression during Aging

(2008) Philipp Oberdoerffer et al.   CELL

The Emerging Genetic Architecture of Type 2 Diabetes

(2008) Alessandro Doria et al.   Cell Metabolism

Genetic determinants and molecular pathways in the pathogenesis of Type 2 diabetes

(2008) Wanzhu Jin et al.   CLINICAL SCIENCE

Developmental biology of the pancreas: A comprehensive review

(2008) George K. Gittes   DEVELOPMENTAL BIOLOGY

Methyltransferase Set7/9 Maintains Transcription and Euchromatin Structure at Islet-Enriched Genes

(2008) T. G. Deering et al.   DIABETES

Epigenetic regulation of PPARGC1A in human type 2 diabetic islets and effect on insulin secretion

(2008) C. Ling et al.   DIABETOLOGIA

Intra-individual Change Over Time in DNA Methylation With Familial Clustering

(2008) Hans T. Bjornsson   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Chop deletion reduces oxidative stress, improves β cell function, and promotes cell survival in multiple mouse models of diabetes

(2008) Benbo Song et al.   JOURNAL OF CLINICAL INVESTIGATION

Histone Deacetylase Inhibitors Modify Pancreatic Cell Fate Determination and Amplify Endocrine Progenitors

(2008) C. Haumaitre et al.   MOLECULAR AND CELLULAR BIOLOGY

Ezh1 and Ezh2 Maintain Repressive Chromatin through Different Mechanisms

(2008) Raphael Margueron et al.   MOLECULAR CELL

In vivo reprogramming of adult pancreatic exocrine cells to β-cells

(2008) Qiao Zhou et al.   NATURE

Genetic programming of liver and pancreas progenitors: lessons for stem-cell differentiation

(2008) Kenneth S. Zaret   NATURE REVIEWS GENETICS

DNA methylation landscapes: provocative insights from epigenomics

(2008) Miho M. Suzuki et al.   NATURE REVIEWS GENETICS

Effect of In Utero and Early-Life Conditions on Adult Health and Disease

(2008) Peter D. Gluckman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Generation and Regeneration of Cells of the Liver and Pancreas

(2008) K. S. Zaret et al.   SCIENCE

Targeted Deficiency of the Transcriptional Activator Hnf1α Alters Subnuclear Positioning of Its Genomic Targets

(2008) Reini F. Luco et al.   PLoS Genetics