Article
Endocrinology & Metabolism
Zaihan Zhu, Yanfen Zhang, Ruocen Bai, Ru Yang, Zhongyan Shan, Chunyan Ma, Jun Yang, Dandan Sun
Summary: This study found that miRNA polymorphisms involved in the insulin signaling pathways and the interaction effects of SNP-SNP, SNP-environmental factors were related to T2DM susceptibility in a Chinese population.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Dandan Sun, Zaihan Zhu, Yanfen Zhang, Ruocen Bai, Fang Zhu, Zhongyan Shan, Chunyan Ma, Jun Yang
Summary: This study investigated the relationships between five miRNA single nucleotide polymorphisms (SNP) and diastolic and systolic function of Type 2 diabetes mellitus (T2DM). The findings suggest that miR-133a-1-rs8089787 and let-7f-rs10877887 are associated with impaired cardiac diastolic function in T2DM, highlighting their potential as therapeutic targets for preventing diastolic dysfunction in T2DM.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2022)
Review
Endocrinology & Metabolism
Li-Mei Li, Bei-Ge Jiang, Liang-Liang Sun
Summary: Diabetes is a highly heterogeneous metabolic disease with different types and clinical manifestations. Distinguishing between types and defining subtypes is a major challenge in precise treatment. T2D is the main type of diabetes, and certain gene variants have been shown to increase the risk of T2D. HNF1 alpha gene mutations can cause different types of diabetes and exhibit high polymorphism.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Qiuyu Huang, Hanshen Chen, Fan Xu, Chao Liu, Yafeng Wang, Weifeng Tang, Liangwan Chen
Summary: The study revealed that the miR-146a rs2910164 C>G locus is a protective factor for T2DM, especially in the never drinking and BMI >= 24 kg/m(2) subgroups, while the rs11614913 T>C locus provides significant protection for smokers in T2DM susceptibility.
ENDOCRINE CONNECTIONS
(2021)
Article
Cell Biology
Yu-Xiang Yan, Huan-Bo Xiao, Jie Zhang, Shuo Wang, Jing Dong, Li-Juan Wu
Summary: This study found an association between miR-144 SNP rs9279 and increased risk of T2D, with carriers of the GG genotype showing significantly upregulated expression of miRNAs and cortisol. The SNP may contribute to the development of T2D by altering regulation of the stress response.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Review
Endocrinology & Metabolism
Hyun-Jin Kim, Kwang-il Kim
Summary: This review discusses the optimal blood pressure targets for patients with diabetes mellitus and summarizes the recommendations from different guidelines. A target blood pressure of <140/90 mm Hg is recommended, and <130/80 mm Hg for patients with diabetes mellitus who have high-risk clinical features.
DIABETES & METABOLISM JOURNAL
(2022)
Article
Multidisciplinary Sciences
Yan-Peng Li, Dilare Adi, Ying-Hong Wang, Yong-Tao Wang, Xiao-Lei Li, Zhen-Yan Fu, Fen Liu, Aibibanmu Aizezi, Jialin Abuzhalihan, Mintao Gai, Xiang Ma, Xiao-mei Li, Xiang Xie, YiTong Ma
Summary: This study investigated the effects of genetic variants of the Dab2 gene on the risk of type 2 diabetes mellitus (T2DM) in the Uygur and Han populations of Xinjiang, China. The results showed that the variations in the Dab2 gene loci rs2255280 and rs2855512 were associated with the incidence of T2DM in the Uygur population, but not in the Han population. These variations were independent predictors for T2DM in the Uygur population.
Article
Endocrinology & Metabolism
Zhongyu Li, Xiangmin Yuan, Xin Liu, Yuping Yang, Li Huang, Qiuhong Tan, Cuilin Li
Summary: This study investigated the association between SLC22A3 polymorphism and susceptibility to type 2 diabetes mellitus (T2DM) in the Chinese population. The results showed that SLC22A3 rs555754 and rs3123636 polymorphisms were significantly associated with susceptibility to T2DM, while rs3088442 was not. These findings are important for understanding the pathogenesis and prevention of T2DM.
DIABETES METABOLIC SYNDROME AND OBESITY
(2023)
Article
Endocrinology & Metabolism
Sarah ElHajj Chehadeh, Noura S. Sayed, Hanin S. Abdelsamad, Wael Almahmeed, Ahsan H. Khandoker, Herbert F. Jelinek, Habiba S. Alsafar
Summary: This study investigated genetic variations and Single Nucleotide Polymorphisms (SNPs) associated with microvascular complications (DR, DNp, DPN) among T2DM patients of Arab origin. The findings revealed significant associations between certain SNPs and the complications, with stronger associations observed when multiple complications were present.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Genetics & Heredity
Ning Wang, Rui Tong, Jing Xu, Yanni Tian, Juan Pan, Jiaqi Cui, Huan Chen, Yanqi Peng, Sijia Fei, Shujun Yang, Lu Wang, Juanchuan Yao, Wei Cui
Summary: This study found a significant association between genetic variants in PDX1 and MC4R and T2DM risk in a Chinese Han population, with PDX1-rs9581943 showing a protective effect. Furthermore, genetic polymorphisms may be influenced by factors such as age, sex, BMI, smoking status, and drinking status.
BMC MEDICAL GENOMICS
(2021)
Article
Cardiac & Cardiovascular Systems
Salman M. Toor, Eman K. Aldous, Aijaz Parray, Naveed Akhtar, Yasser Al-Sarraj, Essam M. Abdelalim, Abdelilah Arredouani, Omar El-Agnaf, Paul J. Thornalley, Sajitha V. Pananchikkal, Ghulam Jeelani Pir, Raheem Ayadathil Thazhhe Kuni, Ashfaq Shuaib, Nehad M. Alajez, Omar M. E. Albagha
Summary: This study conducted comprehensive circulating miRNA profiling in ischemic stroke patients with and without type 2 diabetes mellitus, identifying 5 differentially regulated miRNAs between the two groups. The findings offer insights into potential pathways associated with stroke and diabetes comorbidity.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Endocrinology & Metabolism
Mark J. O'Connor, Philip Schroeder, Alicia Huerta-Chagoya, Paula Cortes-Sanchez, Silvia Bonas-Guarch, Marta Guindo-Martinez, Joanne B. Cole, Varinderpal Kaur, David Torrents, Kumar Veerapen, Niels Grarup, Mitja Kurki, Carsten F. Rundsten, Oluf Pedersen, Ivan Brandslund, Allan Linneberg, Torben Hansen, Aaron Leong, Jose C. Florez, Josep M. Mercader
Summary: GWAS using a recessive model identifies new loci associated with type 2 diabetes, including variants with larger effects.
Article
Medicine, General & Internal
Yan Li, Junbing He, Yi-ming Shao, Lanchun Chen, Ming Li, Donghui Tang, Zhizhou Shi, Qinghui Liao, Zhongqiu Guo, Juan Wang, Qiaoan Zheng, Yanni Zhao, Yuhua Chen
Summary: This study investigated the relationship between MCP-1 rs1024611 polymorphism and genetic susceptibility of type 2 diabetes mellitus (T2DM) with sepsis. The study found that the AG/GG genotypes and G allele of rs1024611 were significantly associated with an increased risk of T2DM with sepsis. Additionally, the frequency of the rs1024611 G allele was higher in the septic shock group compared to the general sepsis group. Furthermore, the GG genotype was associated with higher expression levels of MCP-1 and TNF-alpha.
Article
Endocrinology & Metabolism
Alexandra Fahrner, Nikoleta Alchus Laiferova, Barbara Ukropcova, Jozef Ukropec, Jan Krutzfeldt
Summary: Type 2 diabetes negatively affects muscle health. Paracrine signaling in the adult muscle stem cells niche is activated in T2D. The PDGF-miR-501 signaling pathway could be used to classify patients in clinical trials aiming to improve muscle health and glucose homeostasis in diabetes.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Medicine, General & Internal
Wenqian Lu, Cheng Hu
Summary: This review summarizes recent studies on biomolecules associated with GDM and postpartum diabetes, focusing on their predictive value in screening and diagnosis.
CHINESE MEDICAL JOURNAL
(2022)
Article
Oncology
Han Yan, Lu Wen, Dan Tan, Pan Xie, Feng-mei Pang, Hong-hao Zhou, Wei Zhang, Zhao-qian Liu, Jie Tang, Xi Li, Xiao-ping Chen
Article
Oncology
Tao Zhu, Yuan-Feng Gao, Yi-Xin Chen, Zhi-Bin Wang, Ji-Ye Yin, Xiao-Yuan Mao, Xi Li, Wei Zhang, Hong-Hao Zhou, Zhao-Qian Liu
Article
Multidisciplinary Sciences
Yuan-Xiang Shi, Ji-Ye Yin, Yao Shen, Wei Zhang, Hong-Hao Zhou, Zhao-Qian Liu
SCIENTIFIC REPORTS
(2017)
Article
Multidisciplinary Sciences
Rong Liu, Ying Zeng, Cheng-Fang Zhou, Ying Wang, Xi Li, Zhao-Qian Liu, Xiao-Ping Chen, Wei Zhang, Hong-Hao Zhou
SCIENTIFIC REPORTS
(2017)
Article
Multidisciplinary Sciences
Chao Fang, Yi-Xin Chen, Na-Yiyuan Wu, Ji-Ye Yin, Xiang-Ping Li, Hsuan-Shun Huang, Wei Zhang, Hong-Hao Zhou, Zhao-Qian Liu
SCIENTIFIC REPORTS
(2017)
Article
Neurosciences
Tao Zhu, Pan Xie, Yuan-Feng Gao, Ma-Sha Huang, Xi Li, Wei Zhang, Hong-Hao Zhou, Zhao-Qian Liu
CNS NEUROSCIENCE & THERAPEUTICS
(2018)
Article
Oncology
Ma-Sha Huang, Fu-Qiang Yuan, Yang Gao, Jun-Yan Liu, Yi-Xin Chen, Chen-Jing Wang, Bai-Mei He, Hong-Hao Zhou, Zhao-Qian Liu
Review
Biochemistry & Molecular Biology
Juyan Zheng, Junluan Mo, Tao Zhu, Wei Zhuo, Yueneng Yi, Shuo Hu, Jiye Yin, Wei Zhang, Honghao Zhou, Zhaoqian Liu
Article
Neurosciences
Chao Luo, Xu Wang, Han-Xue Huang, Xiao-Yuan Mao, Hong-Hao Zhou, Zhao-Qian Liu
Summary: Metformin prevented olanzapine-induced metabolic dysfunction and regulated the gut microbiota in a dose-dependent manner. The study also showed changes in the gut-liver axis as a potential explanation for how metformin prevents metabolic dysfunction induced by olanzapine.
PSYCHOPHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
Teng-Zhi Long, Shao-Hua Shi, Shao Liu, Ai-Ping Lu, Zhao-Qian Liu, Min Li, Ting-Jun Hou, Dong-Sheng Cao
Summary: This study constructed a high-quality dataset and established a series of classification models using machine learning algorithms to predict hematotoxicity. The best model based on Attentive FP showed excellent performance on both the validation and test sets. Additionally, the study utilized SHAP and atom heatmap methods to identify important features and structural fragments related to hematotoxicity, and employed MMPA and representative substructure derivation technique to further investigate the transformation principles and distinctive structural features of hematotoxic chemicals.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2023)
Article
Oncology
Lei She, Xiaoyuan Mao, Lin Su, Zhaoqian Liu
Summary: By retrospectively analyzing the clinic data of GBM patients, this study identified GTR, unopened ventricles, and MGMT methylation as independent favorable prognostic factors for GBM patients' survival. The constructed score prediction model can provide prognostic reference for GBM.
Article
Pharmacology & Pharmacy
Chao Fang, Xiang-Ping Li, Wei-Jing Gong, Na-Yiyuan Wu, Jie Tang, Ji-Ye Yin, Xi Li, Wei Zhang, Hong-Hao Zhou, Zhao-Qian Liu
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
(2017)
Article
Biotechnology & Applied Microbiology
Rong Liu, Wei Zhang, Zhao-Qian Liu, Hong-Hao Zhou
Article
Oncology
Zhan Wang, Juan Chen, Mei-Zuo Zhong, Juan Huang, Yuan-Ping Hu, De-Yun Feng, Zhi-Jiao Zhou, Xiao Luo, Zhao-Qian Liu, Wu-Zhong Jiang, Wei-Bing Zhou
CANCER CHEMOTHERAPY AND PHARMACOLOGY
(2017)
Article
Chemistry, Multidisciplinary
Mou-ze Liu, Hai-yan He, Yue-li Zhang, Yong-fang Hu, Fa-zhong He, Jian-quan Luo, Zhi-ying Luo, Xiao-ping Chen, Zhao-qian Liu, Hong-hao Zhou, Ming-jie Shao, Ying-zi Ming, Hua-wen Xin, Wei Zhang
ACTA PHARMACOLOGICA SINICA
(2017)