Bringing genome-wide association findings into clinical use

Joint Effects of Common Genetic Variants on the Risk for Type 2 Diabetes in U.S. Men and Women of European Ancestry

(2013) Marilyn C. Cornelis   ANNALS OF INTERNAL MEDICINE

Implementing genomic medicine in the clinic: the future is here

(2013) Teri A. Manolio et al.   GENETICS IN MEDICINE

Clinical Immunologic Interventions for the Treatment of Type 1 Diabetes

(2013) L. Chatenoud et al.   Cold Spring Harbor Perspectives in Medicine

Inclusion of Gene-Gene and Gene-Environment Interactions Unlikely to Dramatically Improve Risk Prediction for Complex Diseases

(2012) Hugues Aschard et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Association Between Common Variants Near the Melanocortin 4 Receptor Gene and Severe Antipsychotic Drug–Induced Weight Gain

(2012) Anil K. Malhotra   ARCHIVES OF GENERAL PSYCHIATRY

Randomized Trial of Personal Genomics for Preventive Cardiology

(2012) Joshua W. Knowles et al.   Circulation-Cardiovascular Genetics

Therapeutic targeting of the complement system in age-related macular degeneration: a review

(2012) Robyn Troutbeck et al.   CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

A Genome-Wide Association Study Identifies Novel Loci for Paclitaxel-Induced Sensory Peripheral Neuropathy in CALGB 40101

(2012) R. M. Baldwin et al.   CLINICAL CANCER RESEARCH

The Clinical Pharmacogenomics Implementation Consortium: CPIC Guideline for SLCO1B1 and Simvastatin-Induced Myopathy

(2012) R A Wilke et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

What Will Diabetes Genomes Tell Us?

(2012) Karen L. Mohlke et al.   Current Diabetes Reports

Towards a Novel Molecular Classification of IBD

(2012) Severine Vermeire   DIGESTIVE DISEASES

Cumulative impact of common genetic variants and other risk factors on colorectal cancer risk in 42 103 individuals

(2012) Malcolm G Dunlop et al.   GUT

Genome-wide association study of aspirin-exacerbated respiratory disease in a Korean population

(2012) Byung Lae Park et al.   HUMAN GENETICS

A 2-Stage Genome-Wide Association Study to Identify Single Nucleotide Polymorphisms Associated With Development of Erectile Dysfunction Following Radiation Therapy for Prostate Cancer

(2012) Sarah L. Kerns et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Trends in Lipids and Lipoproteins in US Adults, 1988-2010

(2012) Margaret D. Carroll et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

An integrated encyclopedia of DNA elements in the human genome

(2012)   NATURE

Phenotypic Heterogeneity of Genomic Disorders and Rare Copy-Number Variants

(2012) Santhosh Girirajan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Evolution and Functional Impact of Rare Coding Variation from Deep Sequencing of Human Exomes

(2012) J. A. Tennessen et al.   SCIENCE

Genetics and the Individualized Prediction of Fracture

(2012) Tuan V. Nguyen et al.   Current Osteoporosis Reports

Making progress: preserving beta cells in type 1 diabetes

(2011) Mary Pat Gallagher et al.   Annals of the New York Academy of Sciences

Genomics Reaches the Clinic: From Basic Discoveries to Clinical Impact

(2011) Teri A. Manolio et al.   CELL

Genetic and genomic approaches to asthma

(2011) Youming Zhang et al.   CURRENT OPINION IN PULMONARY MEDICINE

A large multi-centre European study validates high-sensitivity C-reactive protein (hsCRP) as a clinical biomarker for the diagnosis of diabetes subtypes

(2011) G. Thanabalasingham et al.   DIABETOLOGIA

Inosine Triphosphate Protects Against Ribavirin-Induced Adenosine Triphosphate Loss by Adenylosuccinate Synthase Function

(2011) Yuki Hitomi et al.   GASTROENTEROLOGY

Rare versus common variants in pharmacogenetics: SLCO1B1 variation and methotrexate disposition

(2011) L. B. Ramsey et al.   GENOME RESEARCH

Type 2 diabetes and obesity: genomics and the clinic

(2011) Mary E. Travers et al.   HUMAN GENETICS

Current status of genome-wide association studies in cancer

(2011) Charles C. Chung et al.   HUMAN GENETICS

Genetic risk prediction in complex disease

(2011) Luke Jostins et al.   HUMAN MOLECULAR GENETICS

The genetics of asthma and allergic disease: a 21st century perspective

(2011) Carole Ober et al.   IMMUNOLOGICAL REVIEWS

Genomics for the world

(2011) Carlos D. Bustamante et al.   NATURE

Mapping and analysis of chromatin state dynamics in nine human cell types

(2011) Jason Ernst et al.   NATURE

Assessing and managing risk when sharing aggregate genetic variant data

(2011) David W. Craig et al.   NATURE REVIEWS GENETICS

Understanding type 1 diabetes through genetics: advances and prospects

(2011) Constantin Polychronakos et al.   NATURE REVIEWS GENETICS

A refined molecular taxonomy of breast cancer

(2011) M Guedj et al.   ONCOGENE

Organic Anion Transporting Polypeptide 1B1: a Genetically Polymorphic Transporter of Major Importance for Hepatic Drug Uptake

(2011) M. Niemi et al.   PHARMACOLOGICAL REVIEWS

Inflammatory disease protective R381Q IL23 receptor polymorphism results in decreased primary CD4+ and CD8+ human T-cell functional responses

(2011) R. Sarin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deflating the Genomic Bubble

(2011) J. P. Evans et al.   SCIENCE

Copy number variants in pharmacogenetic genes

(2011) Yijing He et al.   TRENDS IN MOLECULAR MEDICINE

Quantifying the Underestimation of Relative Risks from Genome-Wide Association Studies

(2011) Chris Spencer et al.   PLoS Genetics

A Genome-Wide Meta-Analysis of Six Type 1 Diabetes Cohorts Identifies Multiple Associated Loci

(2011) Jonathan P. Bradfield et al.   PLoS Genetics

Discriminatory accuracy and potential clinical utility of genomic profiling for breast cancer risk in BRCA-negative women

(2010) E. Comen et al.   BREAST CANCER RESEARCH AND TREATMENT

Genetic Heterogeneity in Human Disease

(2010) Jon McClellan et al.   CELL

Statin myopathy: a review of recent progress

(2010) Andrew L Mammen et al.   CURRENT OPINION IN RHEUMATOLOGY

Assessment of High-Sensitivity C-Reactive Protein Levels as Diagnostic Discriminator of Maturity-Onset Diabetes of the Young Due to HNF1A Mutations

(2010) K. R. Owen et al.   DIABETES CARE

Maturity-onset diabetes of the young (MODY): how many cases are we missing?

(2010) B. M. Shields et al.   DIABETOLOGIA

Clinical Implications of Pharmacogenetic Variation on the Effects of Statins

(2010) Simran D.S. Maggo et al.   DRUG SAFETY

Variants in the ITPA Gene Protect Against Ribavirin-Induced Hemolytic Anemia and Decrease the Need for Ribavirin Dose Reduction

(2010) Alexander J. Thompson et al.   GASTROENTEROLOGY

Missense mutations in the APOL1 gene are highly associated with end stage kidney disease risk previously attributed to the MYH9 gene

(2010) Shay Tzur et al.   HUMAN GENETICS

Unraveling the genetic predisposition of ribavirin-induced anaemia

(2010) Tarik Asselah et al.   JOURNAL OF HEPATOLOGY

ITPA gene variants protect against anaemia in patients treated for chronic hepatitis C

(2010) Jacques Fellay et al.   NATURE

Biological, clinical and population relevance of 95 loci for blood lipids

(2010) Tanya M. Teslovich et al.   NATURE

Hundreds of variants clustered in genomic loci and biological pathways affect human height

(2010) Hana Lango Allen et al.   NATURE

A map of human genome variation from population-scale sequencing

(2010) Richard M. Durbin et al.   NATURE

Uncovering the roles of rare variants in common disease through whole-genome sequencing

(2010) Elizabeth T. Cirulli et al.   NATURE REVIEWS GENETICS

Ten Years On — The Human Genome and Medicine

(2010) Harold Varmus   NEW ENGLAND JOURNAL OF MEDICINE

Genomewide Association Studies and Assessment of the Risk of Disease

(2010) Teri A. Manolio   NEW ENGLAND JOURNAL OF MEDICINE

Value of genetic profiling for the prediction of coronary heart disease

(2009) Jeroen B. van der Net et al.   AMERICAN HEART JOURNAL

The genetics of statin-induced myopathy

(2009) Abhijit Ghatak et al.   ATHEROSCLEROSIS

Genome-wide association meta-analysis for total serum bilirubin levels

(2009) A. D. Johnson et al.   HUMAN MOLECULAR GENETICS

Clinical Applications of Diabetes Antibody Testing

(2009) Polly J. Bingley   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Germline Genetic Variation in an Organic Anion Transporter Polypeptide Associated With Methotrexate Pharmacokinetics and Clinical Effects

(2009) Lisa R. Treviño et al.   JOURNAL OF CLINICAL ONCOLOGY

The SLCO1B1*5Genetic Variant Is Associated With Statin-Induced Side Effects

(2009) Deepak Voora et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Finding the missing heritability of complex diseases

(2009) Teri A. Manolio et al.   NATURE

Beyond odds ratios — communicating disease risk based on genetic profiles

(2009) Peter Kraft et al.   NATURE REVIEWS GENETICS

Genetic Risk Prediction — Are We There Yet?

(2009) Peter Kraft et al.   NEW ENGLAND JOURNAL OF MEDICINE

Common Genetic Variation and Human Traits

(2009) David B. Goldstein   NEW ENGLAND JOURNAL OF MEDICINE

Potential etiologic and functional implications of genome-wide association loci for human diseases and traits

(2009) L. A. Hindorff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GWA studies: rewriting the story of IBD

(2009) Marcia L. Budarf et al.   TRENDS IN GENETICS

Prediction and Interaction in Complex Disease Genetics: Experience in Type 1 Diabetes

(2009) David G. Clayton   PLoS Genetics

Interpretation of Genetic Association Studies: Markers with Replicated Highly Significant Odds Ratios May Be Poor Classifiers

(2009) Johanna Jakobsdottir et al.   PLoS Genetics

Polymorphisms of the HNF1A Gene Encoding Hepatocyte Nuclear Factor-1α are Associated with C-Reactive Protein

(2008) Alexander P. Reiner et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Prediction of individual genetic risk of complex disease

(2008) Naomi R Wray et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Extending genome-wide association studies to copy-number variation

(2008) S. A. McCarroll   HUMAN MOLECULAR GENETICS

Personal genomes: The case of the missing heritability

(2008) Brendan Maher   NATURE

MYH9 is associated with nondiabetic end-stage renal disease in African Americans

(2008) W H Linda Kao et al.   NATURE GENETICS

Polymorphisms Associated with Cholesterol and Risk of Cardiovascular Events

(2008) Sekar Kathiresan et al.   NEW ENGLAND JOURNAL OF MEDICINE

SLCO1B1Variants and Statin-Induced Myopathy — A Genomewide Study

(2008)   NEW ENGLAND JOURNAL OF MEDICINE