- Home
- Publications
- Publication Search
- Publication Details
Title
Novel strategies for anti-aging drug discovery
Authors
Keywords
-
Journal
Expert Opinion on Drug Discovery
Volume 12, Issue 9, Pages 955-966
Publisher
Informa UK Limited
Online
2017-07-11
DOI
10.1080/17460441.2017.1349750
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Antiaging Effect of Metformin on Brain in Naturally Aged and Accelerated Senescence Model of Rat
- (2017) Geetika Garg et al. REJUVENATION RESEARCH
- Caloric restriction improves health and survival of rhesus monkeys
- (2017) Julie A. Mattison et al. Nature Communications
- Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors
- (2016) Yi Zhu et al. AGING CELL
- mTORC1 signalling and eIF4E/4E-BP1 translation initiation factor stoichiometry influence recombinant protein productivity from GS-CHOK1 cells
- (2016) L. Josse et al. BIOCHEMICAL JOURNAL
- Aspirin/antiplatelet agent use improves disease-free survival and reduces the risk of distant metastases in Stage II and III triple-negative breast cancer patients
- (2016) J. Shiao et al. BREAST CANCER RESEARCH AND TREATMENT
- Metformin as a Tool to Target Aging
- (2016) Nir Barzilai et al. Cell Metabolism
- Comparison of acarbose and metformin therapy in newly diagnosed type 2 diabetic patients with overweight and/or obesity
- (2016) Weiping Sun et al. CURRENT MEDICAL RESEARCH AND OPINION
- Acarbose reduces body weight irrespective of glycemic control in patients with diabetes: results of a worldwide, non-interventional, observational study data pool
- (2016) Oliver Schnell et al. JOURNAL OF DIABETES AND ITS COMPLICATIONS
- Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL
- (2016) Reut Yosef et al. Nature Communications
- Telomere and Telomerase Therapeutics in Cancer
- (2016) Yucheng Xu et al. Genes
- Rapamycin-induced metabolic defects are reversible in both lean and obese mice
- (2016) Yuhong Liu et al. Aging-US
- Calorie restriction mimetics: Can you have your cake and eat it, too?
- (2015) Donald K. Ingram et al. AGEING RESEARCH REVIEWS
- Alternative rapamycin treatment regimens mitigate the impact of rapamycin on glucose homeostasis and the immune system
- (2015) Sebastian I. Arriola Apelo et al. AGING CELL
- The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs
- (2015) Yi Zhu et al. AGING CELL
- Pegvisomant treatment in patients with acromegaly in clinical practice: The French ACROSTUDY
- (2015) Philippe Chanson et al. ANNALES D ENDOCRINOLOGIE
- Essential role for autophagy in life span extension
- (2015) Frank Madeo et al. JOURNAL OF CLINICAL INVESTIGATION
- Cellular senescence in aging and age-related disease: from mechanisms to therapy
- (2015) Bennett G Childs et al. NATURE MEDICINE
- Human telomere biology: A contributory and interactive factor in aging, disease risks, and protection
- (2015) E. H. Blackburn et al. SCIENCE
- The effects of graded levels of calorie restriction: II. Impact of short term calorie and protein restriction on circulating hormone levels, glucose homeostasis and oxidative stress in male C57BL/6 mice
- (2015) Sharon E. Mitchell et al. Oncotarget
- Autophagy is required for extension of yeast chronological life span by rapamycin
- (2014) Ashley L. Alvers et al. Autophagy
- mTOR and autophagy in normal brain aging and caloric restriction ameliorating age-related cognition deficits
- (2014) Fengying Yang et al. BEHAVIOURAL BRAIN RESEARCH
- Lifespan extension and cancer prevention in HER-2/neu transgenic mice treated with low intermittent doses of rapamycin
- (2014) Irina G Popovich et al. CANCER BIOLOGY & THERAPY
- An Effective Approach to Prevent Immune Rejection of Human ESC-Derived Allografts
- (2014) Zhili Rong et al. Cell Stem Cell
- The GH-IGF1 axis and longevity. The paradigm of IGF1 deficiency
- (2014) Zvi Laron Hormones-International Journal of Endocrinology and Metabolism
- Telomerase-Based Pharmacologic Enhancement of Antiviral Function of Human CD8+ T Lymphocytes
- (2014) S. R. Fauce et al. JOURNAL OF IMMUNOLOGY
- Effects of Resveratrol on Memory Performance, Hippocampal Functional Connectivity, and Glucose Metabolism in Healthy Older Adults
- (2014) A. V. Witte et al. JOURNAL OF NEUROSCIENCE
- Metformin—mode of action and clinical implications for diabetes and cancer
- (2014) Ida Pernicova et al. Nature Reviews Endocrinology
- Mice Fed Rapamycin Have an Increase in Lifespan Associated with Major Changes in the Liver Transcriptome
- (2014) Wilson C. Fok et al. PLoS One
- mTOR inhibition improves immune function in the elderly
- (2014) J. B. Mannick et al. Science Translational Medicine
- The SIRT1 Activator SRT1720 Extends Lifespan and Improves Health of Mice Fed a Standard Diet
- (2014) Sarah J. Mitchell et al. Cell Reports
- Autophagy in ageing and ageing-associated diseases
- (2013) Li-qiang He et al. ACTA PHARMACOLOGICA SINICA
- Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males
- (2013) David E. Harrison et al. AGING CELL
- The Hallmarks of Aging
- (2013) Carlos López-Otín et al. CELL
- Aspirin extends the lifespan of Caenorhabditis elegans via AMPK and DAF-16/FOXO in dietary restriction pathway
- (2013) Qin-Li Wan et al. EXPERIMENTAL GERONTOLOGY
- The effects of dietary restriction on oxidative stress in rodents
- (2013) Michael E. Walsh et al. FREE RADICAL BIOLOGY AND MEDICINE
- Rapamycin extends murine lifespan but has limited effects on aging
- (2013) Frauke Neff et al. JOURNAL OF CLINICAL INVESTIGATION
- Rapalogs and mTOR inhibitors as anti-aging therapeutics
- (2013) Dudley W. Lamming et al. JOURNAL OF CLINICAL INVESTIGATION
- Rapamycin Extends Life and Health in C57BL/6 Mice
- (2013) Yiqiang Zhang et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- mTOR is a key modulator of ageing and age-related disease
- (2013) Simon C. Johnson et al. NATURE
- The GH/IGF-1 axis in ageing and longevity
- (2013) Riia K. Junnila et al. Nature Reviews Endocrinology
- Nicotinamide riboside restores cognition through an upregulation of proliferator-activated receptor-γ coactivator 1α regulated β-secretase 1 degradation and mitochondrial gene expression in Alzheimer's mouse models
- (2013) Bing Gong et al. NEUROBIOLOGY OF AGING
- A Novel Telomerase Activator Suppresses Lung Damage in a Murine Model of Idiopathic Pulmonary Fibrosis
- (2013) Claude Jourdan Le Saux et al. PLoS One
- Resveratrol Up-Regulates the Erythrocyte Plasma Membrane Redox System and Mitigates Oxidation-Induced Alterations in Erythrocytes During Aging in Humans
- (2013) Kanti Bhooshan Pandey et al. REJUVENATION RESEARCH
- mTOR Signaling in Growth Control and Disease
- (2012) Mathieu Laplante et al. CELL
- Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice
- (2012) Vladimir N. Anisimov et al. CELL CYCLE
- TOR Signaling and Rapamycin Influence Longevity by Regulating SKN-1/Nrf and DAF-16/FoxO
- (2012) Stacey Robida-Stubbs et al. Cell Metabolism
- SIRT1 Is Required for AMPK Activation and the Beneficial Effects of Resveratrol on Mitochondrial Function
- (2012) Nathan L. Price et al. Cell Metabolism
- Current Applications of Human Pluripotent Stem Cells: Possibilities and Challenges
- (2012) Pai-Jiun Ho et al. CELL TRANSPLANTATION
- Ageing as a Risk Factor for Disease
- (2012) Teresa Niccoli et al. CURRENT BIOLOGY
- Telomerase gene therapy: a novel approach to combat aging
- (2012) Virginia Boccardi et al. EMBO Molecular Medicine
- Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer
- (2012) Bruno Bernardes de Jesus et al. EMBO Molecular Medicine
- Aspirin Inhibits mTOR Signaling, Activates AMP-Activated Protein Kinase, and Induces Autophagy in Colorectal Cancer Cells
- (2012) Farhat V.N. Din et al. GASTROENTEROLOGY
- The role of neuronal AMPK as a mediator of nutritional regulation of food intake and energy homeostasis
- (2012) Gustavo D. Pimentel et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Circadian modulation of human erythrocyte plasma membrane redox system by melatonin
- (2012) Shilpa Chakravarty et al. NEUROSCIENCE LETTERS
- Greater insulin sensitivity in calorie restricted rats occurs with unaltered circulating levels of several important myokines and cytokines
- (2012) Naveen Sharma et al. Nutrition & Metabolism
- Resveratrol supplementation improves glycemic control in type 2 diabetes mellitus
- (2012) Jayesh Kumar Bhatt et al. NUTRITION RESEARCH
- Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity
- (2012) D. W. Lamming et al. SCIENCE
- AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network
- (2011) Antero Salminen et al. AGEING RESEARCH REVIEWS
- The telomerase activator TA-65 elongates short telomeres and increases health span of adult/old mice without increasing cancer incidence
- (2011) Bruno Bernardes de Jesus et al. AGING CELL
- AMP-activated protein kinase: a cellular energy sensor with a key role in metabolic disorders and in cancer
- (2011) D. Grahame Hardie BIOCHEMICAL SOCIETY TRANSACTIONS
- Regulation of FoxO transcription factors by acetylation and protein–protein interactions
- (2011) Hiroaki Daitoku et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Effects of 2-deoxyglucose and dehydroepiandrosterone on intracellular NAD+ level, SIRT1 activity and replicative lifespan of human Hs68 cells
- (2011) Nae-Cherng Yang et al. BIOGERONTOLOGY
- Cross-Talk between AMPK and mTOR in Regulating Energy Balance
- (2011) Jia Xu et al. CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
- Rapamycin induces glucose intolerance in mice by reducing islet mass, insulin content, and insulin sensitivity
- (2011) Shi-Bing Yang et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- Erythrocyte plasma membrane redox system may determine maximum life span
- (2011) Syed Ibrahim Rizvi et al. MEDICAL HYPOTHESES
- Efficacy and Safety of Sirolimus in Lymphangioleiomyomatosis
- (2011) Francis X. McCormack et al. NEW ENGLAND JOURNAL OF MEDICINE
- Calorie Restriction: Is AMPK a Key Sensor and Effector?
- (2011) Carles Cantó et al. PHYSIOLOGY
- 2-Deoxy-D-Glucose Treatment of Endothelial Cells Induces Autophagy by Reactive Oxygen Species-Mediated Activation of the AMP-Activated Protein Kinase
- (2011) Qilong Wang et al. PLoS One
- The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression
- (2010) Jean-Philippe Coppé et al. Annual Review of Pathology-Mechanisms of Disease
- Regulation of SIRT1 in cellular functions: Role of polyphenols
- (2010) Sangwoon Chung et al. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
- Resveratrol attenuates 6-hydroxydopamine-induced oxidative damage and dopamine depletion in rat model of Parkinson's disease
- (2010) Mohd.Moshahid Khan et al. BRAIN RESEARCH
- Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster
- (2010) Ivana Bjedov et al. Cell Metabolism
- Glycolytic inhibition as a strategy for developing calorie restriction mimetics
- (2010) Donald K. Ingram et al. EXPERIMENTAL GERONTOLOGY
- Does Accumulation of Advanced Glycation End Products Contribute to the Aging Phenotype?
- (2010) R. D. Semba et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Markers of Oxidative Stress in Erythrocytes and Plasma During Aging in Humans
- (2010) Kanti Bhooshan Pandey et al. Oxidative Medicine and Cellular Longevity
- Regulation of Mammalian Autophagy in Physiology and Pathophysiology
- (2010) Brinda Ravikumar et al. PHYSIOLOGICAL REVIEWS
- A Natural Product Telomerase Activator As Part of a Health Maintenance Program
- (2010) Calvin B. Harley et al. REJUVENATION RESEARCH
- Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy
- (2010) E Morselli et al. Cell Death & Disease
- Short Telomeres are Sufficient to Cause the Degenerative Defects Associated with Aging
- (2009) Mary Armanios et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Resveratrol inhibits right ventricular hypertrophy induced by monocrotaline in rats
- (2009) Dan-Li Yang et al. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
- Ethical Issues in Stem Cell Research
- (2009) Bernard Lo et al. ENDOCRINE REVIEWS
- The somatotropic axis and aging: Mechanisms and persistent questions about practical implications
- (2009) Andrzej Bartke EXPERIMENTAL GERONTOLOGY
- Life-Span Extension in Mice by Preweaning Food Restriction and by Methionine Restriction in Middle Age
- (2009) L. Sun et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
- (2009) David E. Harrison et al. NATURE
- Protective Effect of Resveratrol against Kainate-induced Temporal Lobe Epilepsy in Rats
- (2009) Zheng Wu et al. NEUROCHEMICAL RESEARCH
- Chronic ingestion of 2-deoxy-d-glucose induces cardiac vacuolization and increases mortality in rats
- (2009) Robin K. Minor et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice
- (2008) Randy Strong et al. AGING CELL
- Neural Stem Cells and Alzheimer's Disease: Challenges and Hope
- (2008) Zhongling Feng et al. American Journal of Alzheimers Disease and Other Dementias
- Telomerase Reverse Transcriptase Delays Aging in Cancer-Resistant Mice
- (2008) Antonia Tomás-Loba et al. CELL
- Mechanisms and Functional Implications of Adult Neurogenesis
- (2008) Chunmei Zhao et al. CELL
- Resveratrol Delays Age-Related Deterioration and Mimics Transcriptional Aspects of Dietary Restriction without Extending Life Span
- (2008) Kevin J. Pearson et al. Cell Metabolism
- Stem Cell Clinics Online: The Direct-to-Consumer Portrayal of Stem Cell Medicine
- (2008) Darren Lau et al. Cell Stem Cell
- Sirolimus Is Associated with New-Onset Diabetes in Kidney Transplant Recipients
- (2008) O. Johnston et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer's disease
- (2008) Saravanan S. Karuppagounder et al. NEUROCHEMISTRY INTERNATIONAL
- Ascorbate Recycling by Erythrocytes During Aging in Humans
- (2008) Syed Ibrahim Rizvi et al. REJUVENATION RESEARCH
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now