Alternative rapamycin treatment regimens mitigate the impact of rapamycin on glucose homeostasis and the immune system

Rapamycin-induced metabolic defects are reversible in both lean and obese mice

(2016) Yuhong Liu et al.   Aging-US

Rapamycin-mediated mTORC2 inhibition is determined by the relative expression of FK506-binding proteins

(2015) Katherine H. Schreiber et al.   AGING CELL

Weekly administration of rapamycin improves survival and biomarkers in obese male mice on high-fat diet

(2014) Olga V. Leontieva et al.   AGING CELL

Depletion of Rictor, an essential protein component of mTORC2, decreases male lifespan

(2014) Dudley W. Lamming et al.   AGING CELL

Immune Memory–Boosting Dose of Rapamycin Impairs Macrophage Vesicle Acidification and Curtails Glycolysis in Effector CD8 Cells, Impairing Defense against Acute Infections

(2014) Emily L. Goldberg et al.   JOURNAL OF IMMUNOLOGY

Myeloid-Specific Rictor Deletion Induces M1 Macrophage Polarization and Potentiates In Vivo Pro-Inflammatory Response to Lipopolysaccharide

(2014) William T. Festuccia et al.   PLoS One

Beneficial Metabolic Effects of Rapamycin Are Associated with Enhanced Regulatory Cells in Diet-Induced Obese Mice

(2014) Kassem Makki et al.   PLoS One

The small GTPase Rheb is required for spermatogenesis but not oogenesis

(2014) M D Baker et al.   REPRODUCTION

mTOR inhibition improves immune function in the elderly

(2014) J. B. Mannick et al.   Science Translational Medicine

Young and old genetically heterogeneous HET3 mice on a rapamycin diet are glucose intolerant but insulin sensitive

(2013) Dudley W. Lamming et al.   AGING CELL

eRapa Restores a Normal Life Span in a FAP Mouse Model

(2013) P. Hasty et al.   Cancer Prevention Research

Evidence for Rapamycin Toxicity in Pancreatic β-Cells and a Review of the Underlying Molecular Mechanisms

(2013) Adam D. Barlow et al.   DIABETES

Prostaglandin E2 Receptor, EP3, Is Induced in Diabetic Islets and Negatively Regulates Glucose- and Hormone-Stimulated Insulin Secretion

(2013) M. E. Kimple et al.   DIABETES

Hepatic signaling by the mechanistic target of rapamycin complex 2 (mTORC2)

(2013) Dudley W. Lamming et al.   FASEB JOURNAL

Rapalogs and mTOR inhibitors as anti-aging therapeutics

(2013) Dudley W. Lamming et al.   JOURNAL OF CLINICAL INVESTIGATION

mTOR is a key modulator of ageing and age-related disease

(2013) Simon C. Johnson et al.   NATURE

The TSC-mTOR pathway regulates macrophage polarization

(2013) Vanessa Byles et al.   Nature Communications

Increased Mammalian Lifespan and a Segmental and Tissue-Specific Slowing of Aging after Genetic Reduction of mTOR Expression

(2013) J. Julie Wu et al.   Cell Reports

Rapamycin slows aging in mice

(2012) John E. Wilkinson et al.   AGING CELL

Regulation of Immune Responses by mTOR

(2012) Jonathan D. Powell et al.   Annual Review of Immunology

Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice

(2012) Vladimir N. Anisimov et al.   CELL CYCLE

Enteric-delivered rapamycin enhances resistance of aged mice to pneumococcal pneumonia through reduced cellular senescence

(2012) Cecilia A. Hinojosa et al.   EXPERIMENTAL GERONTOLOGY

Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity

(2012) D. W. Lamming et al.   SCIENCE

Sirolimus Enhances the Magnitude and Quality of Viral-Specific CD8+ T-Cell Responses to Vaccinia Virus Vaccination in Rhesus Macaques

(2011) A. P. Turner et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Rictor/mTORC2 Is Essential for Maintaining a Balance Between β-Cell Proliferation and Cell Size

(2011) Yanyun Gu et al.   DIABETES

Rapamycin induces glucose intolerance in mice by reducing islet mass, insulin content, and insulin sensitivity

(2011) Shi-Bing Yang et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Rapamycin Extends Maximal Lifespan in Cancer-Prone Mice

(2010) Vladimir N. Anisimov et al.   AMERICAN JOURNAL OF PATHOLOGY

Fat Cell-Specific Ablation of Rictor in Mice Impairs Insulin-Regulated Fat Cell and Whole-Body Glucose and Lipid Metabolism

(2010) A. Kumar et al.   DIABETES

Chronic Rapamycin Treatment Causes Glucose Intolerance and Hyperlipidemia by Upregulating Hepatic Gluconeogenesis and Impairing Lipid Deposition in Adipose Tissue

(2010) V. P. Houde et al.   DIABETES

Mammalian Target of Rapamycin Protein Complex 2 Regulates Differentiation of Th1 and Th2 Cell Subsets via Distinct Signaling Pathways

(2010) Keunwook Lee et al.   IMMUNITY

Surrogate measures of insulin resistance: of rats, mice, and men

(2009) Kieren Mather   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span

(2009) C. Selman et al.   SCIENCE

The emerging safety profile of mTOR inhibitors, a novel class of anticancer agents

(2009) Kamalesh Sankhala et al.   Targeted Oncology