Rho GTPases: Anti- or pro-neoplastic targets?

Novel Insights into the Roles of Rho Kinase in Cancer

(2016) Lei Wei et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Opposite RHOA functions within the ATLL category

(2016) S. Ishikawa   BLOOD

Integrated mate-pair and RNA sequencing identifies novel, targetable gene fusions in peripheral T-cell lymphoma

(2016) R. L. Boddicker et al.   BLOOD

Rho GTPase Transcriptome Analysis Reveals Oncogenic Roles for Rho GTPase-Activating Proteins in Basal-like Breast Cancers

(2016) Campbell D. Lawson et al.   CANCER RESEARCH

Temporal-specific roles of Rac1 during vascular development and retinal angiogenesis

(2016) Nijiro Nohata et al.   DEVELOPMENTAL BIOLOGY

Cdc42 and Rac1 activity is reduced in human pheochromocytoma and correlates with FARP1 and ARHGEF1 expression

(2016) Pauline Croisé et al.   ENDOCRINE-RELATED CANCER

Whole-Exome Sequencing Analyses of Inflammatory Bowel Disease−Associated Colorectal Cancers

(2016) Ana I. Robles et al.   GASTROENTEROLOGY

A combinatorial strategy for treating KRAS-mutant lung cancer

(2016) Eusebio Manchado et al.   NATURE

Distinct patterns of somatic genome alterations in lung adenocarcinomas and squamous cell carcinomas

(2016) Joshua D Campbell et al.   NATURE GENETICS

Unsupervised detection of cancer driver mutations with parsimony-guided learning

(2016) Runjun D Kumar et al.   NATURE GENETICS

Truncating PREX2 mutations activate its GEF activity and alter gene expression regulation in NRAS-mutant melanoma

(2016) Yonathan Lissanu Deribe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Suppression of KRas-mutant cancer through the combined inhibition of KRAS with PLK1 and ROCK

(2016) Jieqiong Wang et al.   Nature Communications

Rho-associated kinase (ROCK) function is essential for cell cycle progression, senescence and tumorigenesis

(2016) Sandra Kümper et al.   eLife

Cancer Stem Cells and Radioresistance: Rho/ROCK Pathway Plea Attention

(2016) Annapurna Pranatharthi et al.   Stem Cells International

Variegated RHOA mutations in adult T-cell leukemia/lymphoma

(2015) Y. Nagata et al.   BLOOD

Rho regulation: DLC proteins in space and time

(2015) Anja C. Braun et al.   CELLULAR SIGNALLING

Approaches of targeting Rho GTPases in cancer drug discovery

(2015) Yuan Lin et al.   Expert Opinion on Drug Discovery

RHOA mutation may be associated with diffuse-type gastric cancer progression, but is it gain or loss?

(2015) Masahiro Maeda et al.   Gastric Cancer

Clinicopathological characteristics ofRHOAmutations in a Central European gastric cancer cohort

(2015) Christoph Röcken et al.   JOURNAL OF CLINICAL PATHOLOGY

Rho Kinase (ROCK) Inhibitors and Their Therapeutic Potential

(2015) Yangbo Feng et al.   JOURNAL OF MEDICINAL CHEMISTRY

Whole genomes redefine the mutational landscape of pancreatic cancer

(2015) Nicola Waddell et al.   NATURE

Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity

(2015) Matthew T Chang et al.   NATURE BIOTECHNOLOGY

Integrated molecular analysis of adult T cell leukemia/lymphoma

(2015) Keisuke Kataoka et al.   NATURE GENETICS

Inactivating mutations in GNA13 and RHOA in Burkitt’s lymphoma and diffuse large B-cell lymphoma: a tumor suppressor function for the Gα13/RhoA axis in B cells

(2015) M O'Hayre et al.   ONCOGENE

A role for Rac1 activity in malignant progression of sebaceous skin tumors

(2015) D Frances et al.   ONCOGENE

Cooperative induction of apoptosis in NRAS mutant melanoma by inhibition of MEK and ROCK

(2015) Celia J. Vogel et al.   Pigment Cell & Melanoma Research

Loss of RhoA Exacerbates, Rather Than Dampens, Oncogenic K-Ras Induced Lung Adenoma Formation in Mice

(2015) Inuk Zandvakili et al.   PLoS One

The RHOA G17V gene mutation occurs frequently in peripheral T-cell lymphoma and is associated with a characteristic molecular signature

(2014) R. Manso et al.   BLOOD

Mechanism and consequences of RAF kinase activation by small-molecule inhibitors

(2014) M Holderfield et al.   BRITISH JOURNAL OF CANCER

Targeting Rho-GTPases in immune cell migration and inflammation

(2014) Maté Biro et al.   BRITISH JOURNAL OF PHARMACOLOGY

RhoA Mutations Identified in Diffuse Gastric Cancer

(2014) Jin Zhou et al.   CANCER CELL

The RhoGEF GEF-H1 Is Required for Oncogenic RAS Signaling via KSR-1

(2014) Jane Cullis et al.   CANCER CELL

CDC42 Inhibition Suppresses Progression of Incipient Intestinal Tumors

(2014) R. Sakamori et al.   CANCER RESEARCH

The RAC1 P29S Hotspot Mutation in Melanoma Confers Resistance to Pharmacological Inhibition of RAF

(2014) Ian R. Watson et al.   CANCER RESEARCH

RecurrentRHOAmutations in pediatric Burkitt lymphoma treated according to the NHL-BFM protocols

(2014) Marius Rohde et al.   GENES CHROMOSOMES & CANCER

PAK1 mediates pancreatic cancer cell migration and resistance to MET inhibition

(2014) Wei Zhou et al.   JOURNAL OF PATHOLOGY

Comprehensive molecular characterization of gastric adenocarcinoma

(2014) Adam J. Bass et al.   NATURE

Discovery and saturation analysis of cancer genes across 21 tumour types

(2014) Michael S. Lawrence et al.   NATURE

Recurrent gain-of-function mutations of RHOA in diffuse-type gastric carcinoma

(2014) Miwako Kakiuchi et al.   NATURE GENETICS

A recurrent inactivating mutation in RHOA GTPase in angioimmunoblastic T cell lymphoma

(2014) Hae Yong Yoo et al.   NATURE GENETICS

Somatic RHOA mutation in angioimmunoblastic T cell lymphoma

(2014) Mamiko Sakata-Yanagimoto et al.   NATURE GENETICS

Recurrent mutations in epigenetic regulators, RHOA and FYN kinase in peripheral T cell lymphomas

(2014) Teresa Palomero et al.   NATURE GENETICS

Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer

(2014) Kai Wang et al.   NATURE GENETICS

RHOA inactivation enhances Wnt signalling and promotes colorectal cancer

(2014) Paulo Rodrigues et al.   Nature Communications

Rho GTPases and cancer

(2013) Hui Li et al.   BIOFACTORS

RAS and RHO Families of GTPases Directly Regulate Distinct Phosphoinositide 3-Kinase Isoforms

(2013) Ralph Fritsch et al.   CELL

RAC1b overexpression in papillary thyroid carcinoma: a role to unravel

(2013) Ana Luísa Silva et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Cdc42 Coordinates Proliferation, Polarity, Migration, and Differentiation of Small Intestinal Epithelial Cells in Mice

(2013) Jaime Melendez et al.   GASTROENTEROLOGY

Cell Type-specific Signaling Function of RhoA GTPase: Lessons from Mouse Gene Targeting

(2013) Xuan Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RhoB Promotes Cancer Initiation by Protecting Keratinocytes from UVB-Induced Apoptosis but Limits Tumor Aggressiveness

(2013) Nicolas Meyer et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

RhoA, RhoB and RhoC have different roles in cancer cell migration

(2013) A.J. RIDLEY   JOURNAL OF MICROSCOPY

Crosstalk of Ras and Rho: activation of RhoA abates Kras-induced liver tumorigenesis in transgenic zebrafish models

(2013) T W Chew et al.   ONCOGENE

Rho guanine nucleotide exchange factors: regulators of Rho GTPase activity in development and disease

(2013) D R Cook et al.   ONCOGENE

Regulation of Small GTPases by GEFs, GAPs, and GDIs

(2013) Jacqueline Cherfils et al.   PHYSIOLOGICAL REVIEWS

Small-molecule inhibitors targeting G-protein-coupled Rho guanine nucleotide exchange factors

(2013) X. Shang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RHOA-FAK Is a Required Signaling Axis for the Maintenance of KRAS-Driven Lung Adenocarcinomas

(2013) Georgia Konstantinidou et al.   Cancer Discovery

Rho family GTPases

(2012) Alan Hall   BIOCHEMICAL SOCIETY TRANSACTIONS

p21-Activated Kinase 1 Is Required for Efficient Tumor Formation and Progression in a Ras-Mediated Skin Cancer Model

(2012) H. Y. Chow et al.   CANCER RESEARCH

The GATA2 Transcriptional Network Is Requisite for RAS Oncogene-Driven Non-Small Cell Lung Cancer

(2012) Madhu S. Kumar et al.   CELL

A Landscape of Driver Mutations in Melanoma

(2012) Eran Hodis et al.   CELL

Mapping the Hallmarks of Lung Adenocarcinoma with Massively Parallel Sequencing

(2012) Marcin Imielinski et al.   CELL

Cdc42 Activity Regulates Hematopoietic Stem Cell Aging and Rejuvenation

(2012) Maria Carolina Florian et al.   Cell Stem Cell

Rational Design of Small Molecule Inhibitors Targeting RhoA Subfamily Rho GTPases

(2012) Xun Shang et al.   CHEMISTRY & BIOLOGY

Rational Design of Small Molecule Inhibitors Targeting the Rac GTPase-p67phox Signaling Axis in Inflammation

(2012) Emily E. Bosco et al.   CHEMISTRY & BIOLOGY

Rho-associated kinases in tumorigenesis: re-considering ROCK inhibition for cancer therapy

(2012) Nicola Rath et al.   EMBO REPORTS

The Ras protein superfamily: Evolutionary tree and role of conserved amino acids

(2012) Ana Maria Rojas et al.   JOURNAL OF CELL BIOLOGY

Regulation of ROCK Activity in Cancer

(2012) Marie Morgan-Fisher et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Cooperative Activation of PI3K by Ras and Rho Family Small GTPases

(2012) Hee Won Yang et al.   MOLECULAR CELL

Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma

(2012) Michael Krauthammer et al.   NATURE GENETICS

RASMutations in Cutaneous Squamous-Cell Carcinomas in Patients Treated with BRAF Inhibitors

(2012) Fei Su et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Rac1 splice form Rac1b promotes K-ras-induced lung tumorigenesis

(2012) C Zhou et al.   ONCOGENE

Essential Role of Cdc42 in Ras-Induced Transformation Revealed by Gene Targeting

(2012) Kristy R. Stengel et al.   PLoS One

Rho GEFs and Cancer: Linking Gene Expression and Metastatic Dissemination

(2012) L. Barrio-Real et al.   Science Signaling

Inhibition of Rac GTPase signaling and downstream prosurvival Bcl-2 proteins as combination targeted therapy in MLL-AF9 leukemia

(2011) B. Mizukawa et al.   BLOOD

Identification of Novel Ras-Cooperating Oncogenes inDrosophila melanogaster: A RhoGEF/Rho-Family/JNK Pathway Is a Central Driver of Tumorigenesis

(2011) Anthony M. Brumby et al.   GENETICS

RASMutations Are Associated With the Development of Cutaneous Squamous Cell Tumors in Patients Treated With RAF Inhibitors

(2011) Patrick A. Oberholzer et al.   JOURNAL OF CLINICAL ONCOLOGY

The 'invisible hand': regulation of RHO GTPases by RHOGDIs

(2011) Rafael Garcia-Mata et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

K-Ras Mediated Murine Epidermal Tumorigenesis Is Dependent upon and Associated with Elevated Rac1 Activity

(2011) Michael S. Samuel et al.   PLoS One

Rnd proteins: Multifunctional regulators of the cytoskeleton and cell cycle progression

(2010) Philippe Riou et al.   BIOESSAYS

Rac and Rho GTPases in cancer cell motility control

(2010) Matteo Parri et al.   Cell Communication and Signaling

Pleiotropic Functions of Rho GTPase Signaling: A Trojan Horse or Achilles Heel for Breast Cancer Treatment?

(2010) P.R. McHenry et al.   CURRENT DRUG TARGETS

RhoGDI signaling provides targets for cancer therapy

(2010) Michael A. Harding et al.   EUROPEAN JOURNAL OF CANCER

Comparative proteomic analysis identifies proteins associated with the development and progression of colorectal carcinoma

(2010) Liang Zhao et al.   FEBS Journal

Cancer Drug-Resistance and a Look at Specific Proteins: Rho GDP-Dissociation Inhibitor 2, Y-Box Binding Protein 1, and HSP70/90 Organizing Protein in Proteomics Clinical Application

(2010) Helena Skalnikova et al.   JOURNAL OF PROTEOME RESEARCH

Rac1 is crucial for Ras-dependent skin tumor formation by controlling Pak1-Mek-Erk hyperactivation and hyperproliferation in vivo

(2010) Z Wang et al.   ONCOGENE

Formin-like 2 drives amoeboid invasive cell motility downstream of RhoC

(2010) T M Kitzing et al.   ONCOGENE

Loss of RhoB Expression Promotes Migration and Invasion of Human Bronchial Cells Via Activation of AKT1

(2009) E. Bousquet et al.   CANCER RESEARCH

Cancer-Specific High-Throughput Annotation of Somatic Mutations: Computational Prediction of Driver Missense Mutations

(2009) H. Carter et al.   CANCER RESEARCH

RhoA Regulates G1-S Progression of Gastric Cancer Cells by Modulation of Multiple INK4 Family Tumor Suppressors

(2009) S. Zhang et al.   MOLECULAR CANCER RESEARCH

Consensus transcriptome signature of perineural invasion in pancreatic carcinoma

(2009) I. Abiatari et al.   MOLECULAR CANCER THERAPEUTICS

Activation of the PI3K Pathway in Cancer Through Inhibition of PTEN by Exchange Factor P-REX2a

(2009) B. Fine et al.   SCIENCE

Rho GTPases in cancer cell biology

(2008) Francisco M. Vega et al.   FEBS LETTERS

B-RafV600E Cooperates With Alternative Spliced Rac1b to Sustain Colorectal Cancer Cell Survival

(2008) Paulo Matos et al.   GASTROENTEROLOGY

Continuous Cell Injury Promotes Hepatic Tumorigenesis in Cdc42-Deficient Mouse Liver

(2008) Jolanda van Hengel et al.   GASTROENTEROLOGY

Overexpression of Rho GDP-Dissociation Inhibitor Alpha Is Associated with Tumor Progression and Poor Prognosis of Colorectal Cancer

(2008) Liang Zhao et al.   JOURNAL OF PROTEOME RESEARCH

Mammalian Rho GTPases: new insights into their functions from in vivo studies

(2008) Sarah J. Heasman et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY