- Home
- Publications
- Publication Search
- Publication Details
Title
Novel Insights into the Roles of Rho Kinase in Cancer
Authors
Keywords
Rho kinase, Rho kinase pan-inhibitor, ROCK isoform-specific inhibitor, Cancer therapy
Journal
ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS
Volume 64, Issue 4, Pages 259-278
Publisher
Springer Nature
Online
2016-01-02
DOI
10.1007/s00005-015-0382-6
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Partial deletion of ROCK2 protects mice from high-fat diet-induced cardiac insulin resistance and contractile dysfunction
- (2015) Hesham Soliman et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Developing novel methods to search for substrates of protein kinases such as Rho-kinase
- (2015) Tomoki Nishioka et al. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
- RNAi profiling of primary human AML cells identifies ROCK1 as a therapeutic target and nominates fasudil as an antileukemic drug
- (2015) M. Wermke et al. BLOOD
- Morgana acts as an oncosuppressor in chronic myeloid leukemia
- (2015) A. Di Savino et al. BLOOD
- The regulatory roles of ROCK and MRCK kinases in the plasticity of cancer cell migration
- (2015) Vijay Pralhad Kale et al. CANCER LETTERS
- Rho Kinase Inhibitors Block Melanoma Cell Migration and Inhibit Metastasis
- (2015) Amine Sadok et al. CANCER RESEARCH
- Constitutive Activation of Myosin-Dependent Contractility Sensitizes Glioma Tumor-Initiating Cells to Mechanical Inputs and Reduces Tissue Invasion
- (2015) S. Y. Wong et al. CANCER RESEARCH
- ROCK1 and 2 differentially regulate actomyosin organization to drive cell and synaptic polarity
- (2015) Karen A. Newell-Litwa et al. JOURNAL OF CELL BIOLOGY
- Effect of 0.04% AR-13324, a ROCK, and Norepinephrine Transporter Inhibitor, on Aqueous Humor Dynamics in Normotensive Monkey Eyes
- (2015) Rong-Fang Wang et al. JOURNAL OF GLAUCOMA
- Effect of AR-13324 on Episcleral Venous Pressure in Dutch Belted Rabbits
- (2015) Jeffrey W. Kiel et al. JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS
- ROCK inhibition enhances microRNA function by promoting deadenylation of targeted mRNAs via increasing PAIP2 expression
- (2015) Takeshi Yoshikawa et al. NUCLEIC ACIDS RESEARCH
- Double-masked, Randomized, Dose–Response Study of AR-13324 versus Latanoprost in Patients with Elevated Intraocular Pressure
- (2015) Jason Bacharach et al. OPHTHALMOLOGY
- Cooperative induction of apoptosis in NRAS mutant melanoma by inhibition of MEK and ROCK
- (2015) Celia J. Vogel et al. Pigment Cell & Melanoma Research
- Systemic Delivery of MicroRNA-101 Potently Inhibits Hepatocellular Carcinoma In Vivo by Repressing Multiple Targets
- (2015) Fang Zheng et al. PLoS Genetics
- Fibronectin Matrix Formation is a Prerequisite for Colonization of Kidney Tumor Cells in Fibrin
- (2015) Lynn M. Knowles et al. Journal of Cancer
- ROCK Inhibition Facilitates In Vitro Expansion of Glioblastoma Stem-Like Cells
- (2015) Samantha G. Tilson et al. PLoS One
- Dissecting the Mechanisms of Doxorubicin and Oxidative Stress-Induced Cytotoxicity: The Involvement of Actin Cytoskeleton and ROCK1
- (2015) Lei Wei et al. PLoS One
- miR-124 Inhibits Growth and Invasion of Gastric Cancer by Targeting ROCK1
- (2014) Cong-Bing Hu et al. Asian Pacific Journal of Cancer Prevention
- Characterization of a modified ROCK2 protein that allows use of N6-ATP analogs for the identification of novel substrates
- (2014) Amber L Couzens et al. BMC BIOTECHNOLOGY
- The effect of ROCK-1 activity change on the adhesive and invasive ability of Y79 retinoblastoma cells
- (2014) Jing Wang et al. BMC CANCER
- The Rho-kinase inhibitor HA-1077 suppresses proliferation/migration and induces apoptosis of urothelial cancer cells
- (2014) Hideyuki Abe et al. BMC CANCER
- Movers and shakers: cell cytoskeleton in cancer metastasis
- (2014) C M Fife et al. BRITISH JOURNAL OF PHARMACOLOGY
- A novel selective multikinase inhibitor of ROCK and MRCK effectively blocks cancer cell migration and invasion
- (2014) Vijay Pralhad Kale et al. CANCER LETTERS
- Molecular Pathways: Targeting the Kinase Effectors of RHO-Family GTPases
- (2014) T. Y. Prudnikova et al. CLINICAL CANCER RESEARCH
- Effects of K-115, a Rho-Kinase Inhibitor, on Aqueous Humor Dynamics in Rabbits
- (2014) Tomoyuki Isobe et al. CURRENT EYE RESEARCH
- Role of Rho kinases in abnormal and normal hematopoiesis
- (2014) Raghuveer Singh Mali et al. CURRENT OPINION IN HEMATOLOGY
- Ripasudil: First Global Approval
- (2014) Karly P. Garnock-Jones DRUGS
- Discovery of a benzofuran derivative (MBPTA) as a novel ROCK inhibitor that protects against MPP+-induced oxidative stress and cell death in SH-SY5Y cells
- (2014) Cheong-Meng Chong et al. FREE RADICAL BIOLOGY AND MEDICINE
- Loss of SMAD4 Alters BMP Signaling to Promote Colorectal Cancer Cell Metastasis via Activation of Rho and ROCK
- (2014) Philip W. Voorneveld et al. GASTROENTEROLOGY
- Intranasal delivery of FSD-C10, a novel Rho kinase inhibitor, exhibits therapeutic potential in experimental autoimmune encephalomyelitis
- (2014) Yan-Hua Li et al. IMMUNOLOGY
- Fatty liver creates a pro-metastatic microenvironment for hepatocellular carcinoma through activation of hepatic stellate cells
- (2014) Yoshihiro Mikuriya et al. INTERNATIONAL JOURNAL OF CANCER
- SDF-1α stiffens myeloma bone marrow mesenchymal stromal cells through the activation of RhoA-ROCK-Myosin II
- (2014) Dong Soon Choi et al. INTERNATIONAL JOURNAL OF CANCER
- Combined MicroRNA-340 and ROCK1 mRNA Profiling Predicts Tumor Progression and Prognosis in Pediatric Osteosarcoma
- (2014) Haiqing Cai et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Design of Novel Rho Kinase Inhibitors Using Energy Based Pharmacophore Modeling, Shape-Based Screening, in Silico Virtual Screening, and Biological Evaluation
- (2014) Ram Kumar Mishra et al. Journal of Chemical Information and Modeling
- KAP regulates ROCK2 and Cdk2 in an RNA-activated glioblastoma invasion pathway
- (2014) H Li et al. ONCOGENE
- Androgen-regulated microRNA-135a decreases prostate cancer cell migration and invasion through downregulating ROCK1 and ROCK2
- (2014) A Kroiss et al. ONCOGENE
- Downregulation of ROCK2 through Nanocomplex Sensitizes the Cytotoxic Effect of Temozolomide in U251 Glioma Cells
- (2014) Xiaojun Wen et al. PLoS One
- MicroRNA 135a Suppresses Lymph Node Metastasis through Down-Regulation of ROCK1 in Early Gastric Cancer
- (2014) Ji-Young Shin et al. PLoS One
- ROCK Inhibition Activates MCF-7 Cells
- (2014) Seungwon Yang et al. PLoS One
- Multimodal Effects of Small Molecule ROCK and LIMK Inhibitors on Mitosis, and Their Implication as Anti-Leukemia Agents
- (2014) Yusuke Oku et al. PLoS One
- ROCK1 Deficiency Enhances Protective Effects of Antioxidants against Apoptosis and Cell Detachment
- (2014) Michelle Surma et al. PLoS One
- Conditionally Reprogrammed Normal and Transformed Mouse Mammary Epithelial Cells Display a Progenitor-Cell–Like Phenotype
- (2014) Francisco R. Saenz et al. PLoS One
- Selective oral ROCK2 inhibitor down-regulates IL-21 and IL-17 secretion in human T cells via STAT3-dependent mechanism
- (2014) Alexandra Zanin-Zhorov et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- miR-145 inhibits osteosarcoma cells proliferation and invasion by targeting ROCK1
- (2014) Enqi Li et al. TUMOR BIOLOGY
- MiR-186 targets ROCK1 to suppress the growth and metastasis of NSCLC cells
- (2014) Guanghui Cui et al. TUMOR BIOLOGY
- Knockdown of Rho-associated protein kinase 1 suppresses proliferation and invasion of glioma cells
- (2014) Peng Zhang et al. TUMOR BIOLOGY
- Rho/ROCK signaling in motility and metastasis of gastric cancer
- (2014) Tasuku Matsuoka WORLD JOURNAL OF GASTROENTEROLOGY
- RhoA/ROCK/PTEN signaling is involved in AT-101-mediated apoptosis in human leukemia cells in vitro and in vivo
- (2014) G Li et al. Cell Death & Disease
- Phase 2 Randomized Clinical Study of a Rho Kinase Inhibitor, K-115, in Primary Open-Angle Glaucoma and Ocular Hypertension
- (2013) Hidenobu Tanihara et al. AMERICAN JOURNAL OF OPHTHALMOLOGY
- Radiation Induces Diffusible Feeder Cell Factor(s) That Cooperate with ROCK Inhibitor to Conditionally Reprogram and Immortalize Epithelial Cells
- (2013) Nancy Palechor-Ceron et al. AMERICAN JOURNAL OF PATHOLOGY
- ROCK1 isoform-specific deletion reveals a role for diet-induced insulin resistance
- (2013) Seung-Hwan Lee et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Rho/Rho-Associated Coiled-Coil Forming Kinase Pathway as Therapeutic Targets for Statins in Atherosclerosis
- (2013) Naoki Sawada et al. ANTIOXIDANTS & REDOX SIGNALING
- Crucial Role of ROCK2 in Vascular Smooth Muscle Cells for Hypoxia-Induced Pulmonary Hypertension in Mice
- (2013) Toru Shimizu et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- MicroRNA-340 suppresses osteosarcoma tumor growth and metastasis by directly targeting ROCK1
- (2013) Xin Zhou et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Direct targeting of SUZ12/ROCK2 by miR-200b/c inhibits cholangiocarcinoma tumourigenesis and metastasis
- (2013) F Peng et al. BRITISH JOURNAL OF CANCER
- Ocular hypotensive efficacy, safety and systemic absorption of AR-12286 ophthalmic solution in normal volunteers
- (2013) Casey Kopczynski et al. BRITISH JOURNAL OF OPHTHALMOLOGY
- Dissecting the roles of ROCK isoforms in stress-induced cell detachment
- (2013) Jianjian Shi et al. CELL CYCLE
- Discovery of Novel Scaffolds for Rho Kinase 2 Inhibitor Through TRFRET- Based High Throughput Screening Assay
- (2013) Kwang-Seok Oh et al. COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
- Rho-associated coiled-coil kinase (ROCK) signaling and disease
- (2013) Alice V. Schofield et al. CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY
- Advances in the studies of roles of Rho/Rho-kinase in diseases and the development of its inhibitors
- (2013) Ronggui Guan et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Cardiovascular effects of a novel selective Rho kinase inhibitor, 2-(1H-indazole-5-yl)amino-4-methoxy-6-piperazino triazine (DW1865)
- (2013) Kwang-Seok Oh et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Rho kinase inhibitors: a patent review (2012 – 2013)
- (2013) Yangbo Feng et al. EXPERT OPINION ON THERAPEUTIC PATENTS
- Rho Kinases in Cardiovascular Physiology and Pathophysiology
- (2013) Jianjian Shi et al. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
- Pharmacologic Inhibition of ROCK2 Suppresses Amyloid- Production in an Alzheimer's Disease Mouse Model
- (2013) J. H. Herskowitz et al. JOURNAL OF NEUROSCIENCE
- MiR-126 suppresses colon cancer cell proliferation and invasion via inhibiting RhoA/ROCK signaling pathway
- (2013) Nan Li et al. MOLECULAR AND CELLULAR BIOCHEMISTRY
- MicroRNA-148a suppresses epithelial-to-mesenchymal transition by targeting ROCK1 in non-small cell lung cancer cells
- (2013) Jipeng Li et al. MOLECULAR AND CELLULAR BIOCHEMISTRY
- The Rho Guanine Nucleotide Exchange Factor Syx Regulates the Balance of Dia and ROCK Activities To Promote Polarized-Cancer-Cell Migration
- (2013) J. C. Dachsel et al. MOLECULAR AND CELLULAR BIOLOGY
- Noncanonical NOTCH Signaling Limits Self-Renewal of Human Epithelial and Induced Pluripotent Stem Cells through ROCK Activation
- (2013) Takashi Yugawa et al. MOLECULAR AND CELLULAR BIOLOGY
- Discovery of Rho-kinase inhibitors by docking-based virtual screening
- (2013) Mingyun Shen et al. Molecular BioSystems
- Opposing Signaling of ROCK1 and ROCK2 Determines the Switching of Substrate Specificity and the Mode of Migration of Glioblastoma Cells
- (2013) Sonja Mertsch et al. MOLECULAR NEUROBIOLOGY
- Identification of novel ROCK inhibitors with anti-migratory and anti-invasive activities
- (2013) R A Patel et al. ONCOGENE
- ROCK has a crucial role in regulating prostate tumor growth through interaction with c-Myc
- (2013) C Zhang et al. ONCOGENE
- Role of Rho-Kinase Gene Polymorphisms and Protein Expressions in Colorectal Cancer Development
- (2013) Ibrahim Sari et al. PATHOBIOLOGY
- microRNA-124 Inhibits Migration and Invasion by Down-Regulating ROCK1 in Glioma
- (2013) Liwen An et al. PLoS One
- Activation of Rac-1 and RhoA Contributes to Podocyte Injury in Chronic Kidney Disease
- (2013) Andrea Babelova et al. PLoS One
- Hypoxia-inducible factors mediate coordinated RhoA-ROCK1 expression and signaling in breast cancer cells
- (2013) D. M. Gilkes et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Metabolic actions of Rho-kinase in periphery and brain
- (2013) Hu Huang et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- The Selective Rho-kinase Inhibitor Azaindole-1 Has Long-lasting Erectile Activity in the Rat
- (2013) George F. Lasker et al. UROLOGY
- Triptolide induces apoptosis in human leukemia cells through caspase-3-mediated ROCK1 activation and MLC phosphorylation
- (2013) L Liu et al. Cell Death & Disease
- Distinct roles for ROCK1 and ROCK2 in the regulation of cell detachment
- (2013) Jianjian Shi et al. Cell Death & Disease
- RhoA modulates functional and physical interaction between ROCK1 and Erk1/2 in selenite-induced apoptosis of leukaemia cells
- (2013) F Li et al. Cell Death & Disease
- Effect and Reporting Bias of RhoA/ROCK-Blockade Intervention on Locomotor Recovery After Spinal Cord Injury
- (2013) Ralf Watzlawick et al. JAMA Neurology
- Phase 1 Clinical Trials of a Selective Rho Kinase Inhibitor, K-115
- (2013) Hidenobu Tanihara JAMA Ophthalmology
- Selective ROCK2 inhibition in focal cerebral ischemia
- (2013) Jeong Hyun Lee et al. Annals of Clinical and Translational Neurology
- ROCKII Ser1366phosphorylation reflects the activation status
- (2012) Hsiang-Hao Chuang et al. BIOCHEMICAL JOURNAL
- The RhoA-ROCK-PTEN pathway as a molecular switch for anchorage dependent cell behavior
- (2012) Seungwon Yang et al. BIOMATERIALS
- ROCK Cooperated with ET-1 to Induce Epithelial to Mesenchymal Transition through SLUG in Human Ovarian Cancer Cells
- (2012) Jin PENG et al. BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
- The Rho kinase inhibitor azaindole-1 has long-acting vasodilator activity in the pulmonary vascular bed of the intact chest rat
- (2012) Edward A. Pankey et al. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
- Inhibition of the Rho/ROCK pathway enhances the efficacy of cisplatin through the blockage of hypoxia-inducible factor-1α in human ovarian cancer cells
- (2012) Tsuyoshi Ohta et al. CANCER BIOLOGY & THERAPY
- The Rho kinase inhibitor fasudil is involved in p53-mediated apoptosis in human hepatocellular carcinoma cells
- (2012) Yuko Takeba et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Induction of the Stem-like Cell Regulator CD44 by Rho Kinase Inhibition Contributes to the Maintenance of Colon Cancer-Initiating Cells
- (2012) H. Ohata et al. CANCER RESEARCH
- ROCK1 and ROCK2 Are Required for Non-Small Cell Lung Cancer Anchorage-Independent Growth and Invasion
- (2012) D. Vigil et al. CANCER RESEARCH
- RKI-1447 Is a Potent Inhibitor of the Rho-Associated ROCK Kinases with Anti-Invasive and Antitumor Activities in Breast Cancer
- (2012) R. A. Patel et al. CANCER RESEARCH
- MiRNA-335 suppresses neuroblastoma cell invasiveness by direct targeting of multiple genes from the non-canonical TGF-β signalling pathway
- (2012) Jennifer Lynch et al. CARCINOGENESIS
- Identification of somatic mutations in non-small cell lung carcinomas using whole-exome sequencing
- (2012) Pengyuan Liu et al. CARCINOGENESIS
- Proteomic Screening for Rho-kinase Substrates by Combining Kinase and Phosphatase Inhibitors with 14-3-3ζ Affinity Chromatography
- (2012) Tomoki Nishioka et al. CELL STRUCTURE AND FUNCTION
- Rock1 & 2 Perform Overlapping and Unique Roles in Angiogenesis and Angiosarcoma Tumor Progression
- (2012) J. Montalvo et al. CURRENT MOLECULAR MEDICINE
- Rho-associated kinases in tumorigenesis: re-considering ROCK inhibition for cancer therapy
- (2012) Nicola Rath et al. EMBO REPORTS
- Regulation of Glucose Transport by ROCK1 Differs from That of ROCK2 and Is Controlled by Actin Polymerization
- (2012) Kwang-Hoon Chun et al. ENDOCRINOLOGY
- NG2-mediated Rho activation promotes amoeboid invasiveness of cancer cells
- (2012) Daniela Paňková et al. EUROPEAN JOURNAL OF CELL BIOLOGY
- p210bcr-abl induces amoeboid motility by recruiting ADF/destrin through RhoA/ROCK1
- (2012) Tristan Rochelle et al. FASEB JOURNAL
- miR148b is a major coordinator of breast cancer progression in a relapse-associated microRNA signature by targeting ITGA5, ROCK1, PIK3CA, NRAS, and CSF1
- (2012) Daniela Cimino et al. FASEB JOURNAL
- Targeting Rho GTPase signaling for cancer therapy
- (2012) Katerina Mardilovich et al. Future Oncology
- RhoE is frequently down-regulated in hepatocellular carcinoma (HCC) and suppresses HCC invasion through antagonizing the Rho/Rho-Kinase/Myosin phosphatase target pathway
- (2012) Wei Ma et al. HEPATOLOGY
- Microarray-based copy number analysis of neurofibromatosis type-1 (NF1)-associated malignant peripheral nerve sheath tumors reveals a role for Rho-GTPase pathway genes in NF1 tumorigenesis
- (2012) Meena Upadhyaya et al. HUMAN MUTATION
- Novel Mechanism for Negatively Regulating Rho-Kinase (ROCK) Signaling through Coronin1B Protein in Neuregulin 1 (NRG-1)-induced Tumor Cell Motility
- (2012) Manish K. Rana et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Regulation of ROCK Activity in Cancer
- (2012) Marie Morgan-Fisher et al. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
- The Rho kinase inhibitor SAR407899 potently inhibits endothelin-1-induced constriction of renal resistance arteries
- (2012) Olaf Grisk et al. JOURNAL OF HYPERTENSION
- Fragment-Based and Structure-Guided Discovery and Optimization of Rho Kinase Inhibitors
- (2012) Rongshi Li et al. JOURNAL OF MEDICINAL CHEMISTRY
- Erectile properties of the Rho-kinase inhibitor SAR407899 in diabetic animals and human isolated corpora cavernosa
- (2012) Fabio Guagnini et al. Journal of Translational Medicine
- A Collapsin Response Mediator Protein 2 Isoform Controls Myosin II-Mediated Cell Migration and Matrix Assembly by Trapping ROCK II
- (2012) A. Yoneda et al. MOLECULAR AND CELLULAR BIOLOGY
- FilGAP, a Rho/Rho-associated protein kinase–regulated GTPase-activating protein for Rac, controls tumor cell migration
- (2012) Koji Saito et al. MOLECULAR BIOLOGY OF THE CELL
- RhoA as a Mediator of Clinically Relevant Androgen Action in Prostate Cancer Cells
- (2012) Lucy J. Schmidt et al. MOLECULAR ENDOCRINOLOGY
- The Vasorelaxant Mechanisms of a Rho Kinase Inhibitor DL0805 in Rat Thoracic Aorta
- (2012) Lili Gong et al. MOLECULES
- The Rho/ROCK pathway for lysophosphatidic acid-induced proteolytic enzyme expression and ovarian cancer cell invasion
- (2012) K J Jeong et al. ONCOGENE
- Differential Regulation of Adhesion Complex Turnover by ROCK1 and ROCK2
- (2012) Frances E. Lock et al. PLoS One
- MicroRNA-1280 Inhibits Invasion and Metastasis by Targeting ROCK1 in Bladder Cancer
- (2012) Shahana Majid et al. PLoS One
- Cooperative Anti-Invasive Effect of Cdc42/Rac1 Activation and ROCK Inhibition in SW620 Colorectal Cancer Cells with Elevated Blebbing Activity
- (2012) Marion de Toledo et al. PLoS One
- Conditionally reprogrammed cells represent a stem-like state of adult epithelial cells
- (2012) F. A. Suprynowicz et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- ROCK1 Inhibition Promotes the Self-Renewal of a Novel Mouse Mammary Cancer Stem Cell
- (2012) David J. Castro et al. STEM CELLS
- Pyridylthiazole-based ureas as inhibitors of Rho associated protein kinases (ROCK1 and 2)
- (2012) Roberta Pireddu et al. MedChemComm
- ROCK Inhibitor and Feeder Cells Induce the Conditional Reprogramming of Epithelial Cells
- (2011) Xuefeng Liu et al. AMERICAN JOURNAL OF PATHOLOGY
- 7-Chloro-6-piperidin-1-yl-quinoline-5,8-dione (PT-262), a novel ROCK inhibitor blocks cytoskeleton function and cell migration
- (2011) Chih-Chien Tsai et al. BIOCHEMICAL PHARMACOLOGY
- The Rho-kinase inhibitor inhibits proliferation and metastasis of small cell lung cancer
- (2011) Xueying Yang et al. BIOMEDICINE & PHARMACOTHERAPY
- Rho Kinase Regulates the Survival and Transformation of Cells Bearing Oncogenic Forms of KIT, FLT3, and BCR-ABL
- (2011) Raghuveer Singh Mali et al. CANCER CELL
- Actomyosin-Mediated Cellular Tension Drives Increased Tissue Stiffness and β-Catenin Activation to Induce Epidermal Hyperplasia and Tumor Growth
- (2011) Michael S. Samuel et al. CANCER CELL
- Spatial Regulation of RhoA Activity during Pancreatic Cancer Cell Invasion Driven by Mutant p53
- (2011) P. Timpson et al. CANCER RESEARCH
- RhoA/ROCK signaling mediates plasticity of scirrhous gastric carcinoma motility
- (2011) Tasuku Matsuoka et al. CLINICAL & EXPERIMENTAL METASTASIS
- MicroRNA-148a Suppresses Tumor Cell Invasion and Metastasis by Downregulating ROCK1 in Gastric Cancer
- (2011) B. Zheng et al. CLINICAL CANCER RESEARCH
- The putative tumour suppressor microRNA-124 modulates hepatocellular carcinoma cell aggressiveness by repressing ROCK2 and EZH2
- (2011) Fang Zheng et al. GUT
- Candidate driver genes in microsatellite-unstable colorectal cancer
- (2011) Pia Alhopuro et al. INTERNATIONAL JOURNAL OF CANCER
- N,N′-Dinitrosopiperazine-mediated Ezrin Protein Phosphorylation via Activation of Rho Kinase and Protein Kinase C Is Involved in Metastasis of Nasopharyngeal Carcinoma 6-10B Cells
- (2011) Faqing Tang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- RhoA and RhoC have distinct roles in migration and invasion by acting through different targets
- (2011) Francisco M. Vega et al. JOURNAL OF CELL BIOLOGY
- Cytosolic p120-catenin regulates growth of metastatic lobular carcinoma through Rock1-mediated anoikis resistance
- (2011) Ron C.J. Schackmann et al. JOURNAL OF CLINICAL INVESTIGATION
- Inhibition of Rho-associated coiled-coil containing protein kinase enhances the activation of epidermal growth factor receptor in pancreatic cancer cells
- (2011) Masanori Nakashima et al. Molecular Cancer
- Rho-Kinase in Development and Heart Failure: Insights From Genetic Models
- (2011) Jianjian Shi et al. PEDIATRIC CARDIOLOGY
- ROCK Inhibitor Y-27632 Suppresses Dissociation-Induced Apoptosis of Murine Prostate Stem/Progenitor Cells and Increases Their Cloning Efficiency
- (2011) Li Zhang et al. PLoS One
- Peptide Substrates for Rho-Associated Kinase 2 (Rho-Kinase 2/ROCK2)
- (2011) Jeong-Hun Kang et al. PLoS One
- Vascular endothelial growth factor C promotes cervical cancer metastasis via up-regulation and activation of RhoA/ROCK-2/moesin cascade
- (2010) Mian He et al. BMC CANCER
- RACK1 promotes breast carcinoma migration/metastasis via activation of the RhoA/Rho kinase pathway
- (2010) Xi-Xi Cao et al. BREAST CANCER RESEARCH AND TREATMENT
- Tumour suppressor microRNA-584 directly targets oncogene Rock-1 and decreases invasion ability in human clear cell renal cell carcinoma
- (2010) K Ueno et al. BRITISH JOURNAL OF CANCER
- Effect of fasudil on growth, adhesion, invasion, and migration of 95D lung carcinoma cells in vitro
- (2010) Xueying Yang et al. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
- BRCA2 and Nucleophosmin Coregulate Centrosome Amplification and Form a Complex with the Rho Effector Kinase ROCK2
- (2010) H.-F. Wang et al. CANCER RESEARCH
- HA1077, a Rho kinase inhibitor, suppresses glioma-induced angiogenesis by targeting the Rho-ROCK and the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase (MEK/ERK) signal pathways
- (2010) Hiromichi Nakabayashi et al. CANCER SCIENCE
- Rho-kinase/ROCK: A key regulator of the cytoskeleton and cell polarity
- (2010) Mutsuki Amano et al. Cytoskeleton
- Morgana/chp-1, a ROCK Inhibitor Involved in Centrosome Duplication and Tumorigenesis
- (2010) Roberta Ferretti et al. DEVELOPMENTAL CELL
- Rho-kinase inhibitor upregulates migration by altering focal adhesion formation via the Akt pathway in colon cancer cells
- (2010) Seiji Adachi et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- The MicroRNA miR-139 Suppresses Metastasis and Progression of Hepatocellular Carcinoma by Down-regulating Rho-Kinase 2
- (2010) Carmen Chak–Lui Wong et al. GASTROENTEROLOGY
- Downregulation of the Rho GTPase signaling pathway is involved in the microRNA-138-mediated inhibition of cell migration and invasion in tongue squamous cell carcinoma
- (2010) Lu Jiang et al. INTERNATIONAL JOURNAL OF CANCER
- Fasudil Inhibits Lysophosphatidic Acid-Induced Invasiveness of Human Ovarian Cancer Cells
- (2010) Seiji Ogata et al. INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
- Src-dependent phosphorylation of ROCK participates in regulation of focal adhesion dynamics
- (2010) H.-H. Lee et al. JOURNAL OF CELL SCIENCE
- Rho kinase inhibitor fasudil suppresses migration and invasion though down-regulating the expression of VEGF in lung cancer cell line A549
- (2010) Fang Zhu et al. MEDICAL ONCOLOGY
- Activating ROCK1 somatic mutations in human cancer
- (2010) P A Lochhead et al. ONCOGENE
- Association Between the Thr431Asn Polymorphism of the ROCK2 Gene and Risk of Developing Metastases of Breast Cancer
- (2010) Mehmet E. Kalender et al. ONCOLOGY RESEARCH
- A Proteomic Approach for Comprehensively Screening Substrates of Protein Kinases Such as Rho-Kinase
- (2010) Mutsuki Amano et al. PLoS One
- Inhibition of Rho-Associated Kinase Signaling Prevents Breast Cancer Metastasis to Human Bone
- (2009) S. Liu et al. CANCER RESEARCH
- TrkBT1 Induces Liver Metastasis of Pancreatic Cancer Cells by Sequestering Rho GDP Dissociation Inhibitor and Promoting RhoA Activation
- (2009) Z. Li et al. CANCER RESEARCH
- Rho-kinase 2 is frequently overexpressed in hepatocellular carcinoma and involved in tumor invasion
- (2009) Carmen Chak-Lui Wong et al. HEPATOLOGY
- Pharmacological Characterization of SAR407899, a Novel Rho-Kinase Inhibitor
- (2009) Matthias Löhn et al. HYPERTENSION
- Integration of virtual screening with high-throughput screening for the identification of novel Rho-kinase I inhibitors
- (2009) Li-Li Gong et al. JOURNAL OF BIOTECHNOLOGY
- The nuts and bolts of AGC protein kinases
- (2009) Laura R. Pearce et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- N-terminus-mediated dimerization of ROCK-I is required for RhoE binding and actin reorganization
- (2008) Ritu Garg et al. BIOCHEMICAL JOURNAL
- The hydrophobic motif of ROCK2 requires association with the N-terminal extension for kinase activity
- (2008) Amber L. Couzens et al. BIOCHEMICAL JOURNAL
- Possible role of the RhoC/ROCK pathway in progression of clear cell renal cell carcinoma
- (2008) Hideyuki ABE et al. BIOMEDICAL RESEARCH-TOKYO
- Comparative gene expression profiling in three primary human cell lines after treatment with a novel inhibitor of Rho kinase or atorvastatin
- (2008) Marjan Boerma et al. BLOOD COAGULATION & FIBRINOLYSIS
- Mechanism of multi-site phosphorylation from a ROCK-I:RhoE complex structure
- (2008) David Komander et al. EMBO JOURNAL
- Indole-3-carbinol inhibits MDA-MB-231 breast cancer cell motility and induces stress fibers and focal adhesion formation by activation of Rho kinase activity
- (2008) Christine T. Brew et al. INTERNATIONAL JOURNAL OF CANCER
- Structure Basis and Unconventional Lipid Membrane Binding Properties of the PH-C1 Tandem of Rho Kinases
- (2008) Wenyu Wen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Discovery of Substituted 4-(Pyrazol-4-yl)-phenylbenzodioxane-2-carboxamides as Potent and Highly Selective Rho Kinase (ROCK-II) Inhibitors
- (2008) Yangbo Feng et al. JOURNAL OF MEDICINAL CHEMISTRY
- PDK1 regulates cancer cell motility by antagonising inhibition of ROCK1 by RhoE
- (2008) Sophie Pinner et al. NATURE CELL BIOLOGY
- Loss of mir-146a function in hormone-refractory prostate cancer
- (2008) S.-L. Lin et al. RNA
Create your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create NowBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started