Rho guanine nucleotide exchange factors: regulators of Rho GTPase activity in development and disease

Obscurins: Unassuming giants enter the spotlight

(2013) Nicole A. Perry et al.   IUBMB LIFE

PDZ-RhoGEF and LARG Are Essential for Embryonic Development and Provide a Link between Thrombin and LPA Receptors and Rho Activation

(2013) Constantinos M. Mikelis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting the Vav3 oncogene enhances docetaxel-induced apoptosis through the inhibition of androgen receptor phosphorylation in LNCaP prostate cancer cells under chronic hypoxia

(2013) Takeo Nomura et al.   Molecular Cancer

Development of PI3K inhibitors: lessons learned from early clinical trials

(2013) Jordi Rodon et al.   Nature Reviews Clinical Oncology

Neuronal Rho GEFs in Synaptic Physiology and Behavior

(2013) Megan B. Miller et al.   NEUROSCIENTIST

AKAP13 Rho-GEF and PKD-Binding Domain Deficient Mice Develop Normally but Have an Abnormal Response to β-Adrenergic-Induced Cardiac Hypertrophy

(2013) Matthew J. Spindler et al.   PLoS One

Small-molecule inhibitors targeting G-protein-coupled Rho guanine nucleotide exchange factors

(2013) X. Shang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Andrographolide derivatives inhibit guanine nucleotide exchange and abrogate oncogenic Ras function

(2013) H. J. Hocker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ECT2 and RASAL2 Mediate Mesenchymal-Amoeboid Transition In Human Astrocytoma Cells

(2012) Adrienne Weeks et al.   AMERICAN JOURNAL OF PATHOLOGY

Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-Mediated Activation

(2012) Qi Sun et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Rho family GTPases

(2012) Alan Hall   BIOCHEMICAL SOCIETY TRANSACTIONS

A Landscape of Driver Mutations in Melanoma

(2012) Eran Hodis et al.   CELL

Rational Design of Small Molecule Inhibitors Targeting RhoA Subfamily Rho GTPases

(2012) Xun Shang et al.   CHEMISTRY & BIOLOGY

Rho-associated kinases in tumorigenesis: re-considering ROCK inhibition for cancer therapy

(2012) Nicola Rath et al.   EMBO REPORTS

BRCT domains: A little more than kin, and less than kind

(2012) Dietlind L. Gerloff et al.   FEBS LETTERS

Ras/MAPK syndromes and childhood hemato-oncological diseases

(2012) Yoko Aoki et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

FGD1 as a central regulator of extracellular matrix remodelling - lessons from faciogenital dysplasia

(2012) E. Genot et al.   JOURNAL OF CELL SCIENCE

Clinical Significance of Increased Guanine Nucleotide Exchange Factor Vav3 Expression in Human Gastric Cancer

(2012) Kai-Yuan Lin et al.   MOLECULAR CANCER RESEARCH

A gene trap knockout of the Tiam-1 protein results in malformation of the early embryonic brain

(2012) Sooyeon Yoo et al.   MOLECULES AND CELLS

Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma

(2012) Michael Krauthammer et al.   NATURE GENETICS

Protein kinase C, an elusive therapeutic target?

(2012) Daria Mochly-Rosen et al.   NATURE REVIEWS DRUG DISCOVERY

Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity

(2012) T. Maurer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rho GEFs and Cancer: Linking Gene Expression and Metastatic Dissemination

(2012) L. Barrio-Real et al.   Science Signaling

The Rho Exchange Factors Vav2 and Vav3 Control a Lung Metastasis-Specific Transcriptional Program in Breast Cancer Cells

(2012) C. Citterio et al.   Science Signaling

Kalirin, a Key Player in Synapse Formation, Is Implicated in Human Diseases

(2012) Prashant Mandela et al.   NEURAL PLASTICITY

De novo Xq11.11 microdeletion including ARHGEF9 in a boy with mental retardation, epilepsy, macrosomia, and dysmorphic features

(2011) Gaetan Lesca et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

BRCT domains

(2011) Charles Chung Yun Leung et al.   CELL CYCLE

Mimicking GEFs: a common theme for bacterial pathogens

(2011) Robert C. Orchard et al.   CELLULAR MICROBIOLOGY

Clinical Validation of Colorectal Cancer Biomarkers Identified from Bioinformatics Analysis of Public Expression Data

(2011) Y. Jung et al.   CLINICAL CANCER RESEARCH

Early Requirement of Rac1 in a Mouse Model of Pancreatic Cancer

(2011) Irina Heid et al.   GASTROENTEROLOGY

Dysregulation of Rho GTPases in the αPix/Arhgef6 mouse model of X-linked intellectual disability is paralleled by impaired structural and synaptic plasticity and cognitive deficits

(2011) Ger J.A. Ramakers et al.   HUMAN MOLECULAR GENETICS

Methylation status of T-lymphoma invasion and metastasis 1 promoter and its overexpression in colorectal cancer

(2011) He Jin et al.   HUMAN PATHOLOGY

Expression of T-cell lymphoma invasion and metastasis 2 (TIAM2) promotes proliferation and invasion of liver cancer

(2011) Jia-Shing Chen et al.   INTERNATIONAL JOURNAL OF CANCER

Loss-of-function mutation of collybistin is responsible for X-linked mental retardation associated with epilepsy

(2011) Keiko Shimojima et al.   JOURNAL OF HUMAN GENETICS

The 'invisible hand': regulation of RHO GTPases by RHOGDIs

(2011) Rafael Garcia-Mata et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A novel nuclear role for the Vav3 nucleotide exchange factor in androgen receptor coactivation in prostate cancer

(2011) S Rao et al.   ONCOGENE

APCcdh1 Mediates Degradation of the Oncogenic Rho-GEF Ect2 after Mitosis

(2011) Caroline Liot et al.   PLoS One

P-Rex1 is required for efficient melanoblast migration and melanoma metastasis

(2011) Colin R. Lindsay et al.   Nature Communications

Structural and Energetic Mechanisms of Cooperative Autoinhibition and Activation of Vav1

(2010) Bingke Yu et al.   CELL

Guanine nucleotide exchange factors for RhoGTPases: Good therapeutic targets for cancer therapy?

(2010) Galit Lazer et al.   CELLULAR SIGNALLING

A bacterial effector targets host DH-PH domain RhoGEFs and antagonizes macrophage phagocytosis

(2010) Na Dong et al.   EMBO JOURNAL

Loss of Lsc/p115 Protein Leads to Neuronal Hypoplasia in the Esophagus and an Achalasia-Like Phenotype in Mice

(2010) Eugen Zizer et al.   GASTROENTEROLOGY

Bacterial Guanine Nucleotide Exchange Factors SopE-Like and WxxxE Effectors

(2010) R. Bulgin et al.   INFECTION AND IMMUNITY

The Rho Guanine Nucleotide Exchange Factor AKAP13 (BRX) Is Essential for Cardiac Development in Mice

(2010) Chantal M. Mayers et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Trio Is a Key Guanine Nucleotide Exchange Factor Coordinating Regulation of the Migration and Morphogenesis of Granule Cells in the Developing Cerebellum

(2010) Ya-Jing Peng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of the Rac-GEF P-Rex1 as an Essential Mediator of ErbB Signaling in Breast Cancer

(2010) Maria Soledad Sosa et al.   MOLECULAR CELL

P-Rex1 participates in Neuregulin-ErbB signal transduction and its expression correlates with patient outcome in breast cancer

(2010) J C Montero et al.   ONCOGENE

Epithelial Cell Transforming Sequence 2 in Human Oral Cancer

(2010) Manabu Iyoda et al.   PLoS One

Common Themes in the Design and Function of Bacterial Effectors

(2009) Jorge E. Galán   Cell Host & Microbe

The PHCCEx domain of Tiam1/2 is a novel protein- and membrane-binding module

(2009) Shin-ichi Terawaki et al.   EMBO JOURNAL

The adenomatous polyposis coli-associated exchange factors Asef and Asef2 are required for adenoma formation in ApcMin/+mice

(2009) Yoshihiro Kawasaki et al.   EMBO REPORTS

The Adenomatous Polyposis Coli-associated Guanine Nucleotide Exchange Factor Asef Is Involved in Angiogenesis

(2009) Yoshihiro Kawasaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Immature Dendritic Cell Migration by RhoA Guanine Nucleotide Exchange Factor Arhgef5

(2009) Zhenglong Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Obscurin determines the architecture of the longitudinal sarcoplasmic reticulum

(2009) S. Lange et al.   JOURNAL OF CELL SCIENCE

The haematopoietic specific signal transducer Vav1 is aberrantly expressed in lung cancer and plays a role in tumourigenesis

(2009) Galit Lazer et al.   JOURNAL OF PATHOLOGY

Ect2 links the PKCι–Par6α complex to Rac1 activation and cellular transformation

(2009) V Justilien et al.   ONCOGENE

Upregulation of PIP3-dependent Rac exchanger 1 (P-Rex1) promotes prostate cancer metastasis

(2009) J Qin et al.   ONCOGENE

Kalirin regulates cortical spine morphogenesis and disease-related behavioral phenotypes

(2009) M. E. Cahill et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of Rho GTPases by DOCK Exchange Factors Is Mediated by a Nucleotide Sensor

(2009) J. Yang et al.   SCIENCE

Activation of the PI3K Pathway in Cancer Through Inhibition of PTEN by Exchange Factor P-REX2a

(2009) B. Fine et al.   SCIENCE

Plk1 Self-Organization and Priming Phosphorylation of HsCYK-4 at the Spindle Midzone Regulate the Onset of Division in Human Cells

(2009) Mark E. Burkard et al.   PLOS BIOLOGY

Polo-Like Kinase 1 Directs Assembly of the HsCyk-4 RhoGAP/Ect2 RhoGEF Complex to Initiate Cleavage Furrow Formation

(2009) Benjamin A. Wolfe et al.   PLOS BIOLOGY

The Guanine Nucleotide Exchange Factors Trio, Ect2, and Vav3 Mediate the Invasive Behavior of Glioblastoma

(2008) Bodour Salhia et al.   AMERICAN JOURNAL OF PATHOLOGY

Targeted Overexpression of Vav3 Oncogene in Prostatic Epithelium Induces Nonbacterial Prostatitis and Prostate Cancer

(2008) Y. Liu et al.   CANCER RESEARCH

Involvement of Epithelial Cell Transforming Sequence-2 Oncoantigen in Lung and Esophageal Cancer Progression

(2008) D. Hirata et al.   CLINICAL CANCER RESEARCH

A balanced chromosomal translocation disruptingARHGEF9is associated with epilepsy, anxiety, aggression, and mental retardation

(2008) Vera M. Kalscheuer et al.   HUMAN MUTATION

Tiam1-deficiency impairs mammary tumor formation in MMTV-c-neu but not in MMTV-c-myc mice

(2008) K. Strumane et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Kalirin-7 Is Required for Synaptic Structure and Function

(2008) X.-M. Ma et al.   JOURNAL OF NEUROSCIENCE

 PIX Rho GTPase Guanine Nucleotide Exchange Factor Regulates Lymphocyte Functions and Antigen Receptor Signaling

(2008) K. Missy et al.   MOLECULAR AND CELLULAR BIOLOGY

Ras oncogenes: split personalities

(2008) Antoine E. Karnoub et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

P-Rex2 regulates Purkinje cell dendrite morphology and motor coordination

(2008) S. Donald et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ligand-Independent Activation of Androgen Receptors by Rho GTPase Signaling in Prostate Cancer

(2007) Leah S. Lyons et al.   MOLECULAR ENDOCRINOLOGY