Rho-associated kinases in tumorigenesis: re-considering ROCK inhibition for cancer therapy

ROCKII Ser1366phosphorylation reflects the activation status

(2012) Hsiang-Hao Chuang et al.   BIOCHEMICAL JOURNAL

MiRNA-335 suppresses neuroblastoma cell invasiveness by direct targeting of multiple genes from the non-canonical TGF-β signalling pathway

(2012) Jennifer Lynch et al.   CARCINOGENESIS

Identification of somatic mutations in non-small cell lung carcinomas using whole-exome sequencing

(2012) Pengyuan Liu et al.   CARCINOGENESIS

The GATA2 Transcriptional Network Is Requisite for RAS Oncogene-Driven Non-Small Cell Lung Cancer

(2012) Madhu S. Kumar et al.   CELL

Lysyl Oxidase: From Basic Science to Future Cancer Treatment

(2012) Takeshi Nishioka et al.   CELL STRUCTURE AND FUNCTION

Targeting Rho GTPase signaling for cancer therapy

(2012) Katerina Mardilovich et al.   Future Oncology

The extracellular matrix: A dynamic niche in cancer progression

(2012) Pengfei Lu et al.   JOURNAL OF CELL BIOLOGY

Fragment-Based and Structure-Guided Discovery and Optimization of Rho Kinase Inhibitors

(2012) Rongshi Li et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure of Shroom domain 2 reveals a three-segmented coiled-coil required for dimerization, Rock binding, and apical constriction

(2012) Swarna Mohan et al.   MOLECULAR BIOLOGY OF THE CELL

RhoA: A therapeutic target for chronic myeloid leukemia

(2012) Poonam R Molli et al.   Molecular Cancer

Differential Regulation of Adhesion Complex Turnover by ROCK1 and ROCK2

(2012) Frances E. Lock et al.   PLoS One

Rho Kinase Regulates the Survival and Transformation of Cells Bearing Oncogenic Forms of KIT, FLT3, and BCR-ABL

(2011) Raghuveer Singh Mali et al.   CANCER CELL

ROCK and JAK1 Signaling Cooperate to Control Actomyosin Contractility in Tumor Cells and Stroma

(2011) Victoria Sanz-Moreno et al.   CANCER CELL

Actomyosin-Mediated Cellular Tension Drives Increased Tissue Stiffness and β-Catenin Activation to Induce Epidermal Hyperplasia and Tumor Growth

(2011) Michael S. Samuel et al.   CANCER CELL

The putative tumour suppressor microRNA-124 modulates hepatocellular carcinoma cell aggressiveness by repressing ROCK2 and EZH2

(2011) Fang Zheng et al.   GUT

Mechanisms by Which the Extracellular Matrix and Integrin Signaling Act to Regulate the Switch Between Tumor Suppression and Tumor Promotion

(2011) Patricia J. Keely   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

Deep sequencing of gastric carcinoma reveals somatic mutations relevant to personalized medicine

(2011) Joanna D Holbrook et al.   Journal of Translational Medicine

Balancing forces: architectural control of mechanotransduction

(2011) Christopher C. DuFort et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Crystal Structure of a Coiled-Coil Domain from Human ROCK I

(2011) Daqi Tu et al.   PLoS One

Co-Crystal Structures of Inhibitors with MRCKβ, a Key Regulator of Tumor Cell Invasion

(2011) Timo Heikkila et al.   PLoS One

Resistance to MEK Inhibitors: Should We Co-Target Upstream?

(2011) P. I. Poulikakos et al.   Science Signaling

Substituted 2H-isoquinolin-1-ones as potent Rho-kinase inhibitors: Part 2, optimization for blood pressure reduction in spontaneously hypertensive rats

(2010) John D. Ginn et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Substituted 2H-isoquinolin-1-ones as potent Rho-kinase inhibitors: Part 3, aryl substituted pyrrolidines

(2010) Todd Bosanac et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Tumour suppressor microRNA-584 directly targets oncogene Rock-1 and decreases invasion ability in human clear cell renal cell carcinoma

(2010) K Ueno et al.   BRITISH JOURNAL OF CANCER

Effective Targeting of Quiescent Chronic Myelogenous Leukemia Stem Cells by Histone Deacetylase Inhibitors in Combination with Imatinib Mesylate

(2010) Bin Zhang et al.   CANCER CELL

Hedgehog signaling and therapeutics in pancreatic cancer

(2010) F. C. Kelleher   CARCINOGENESIS

Rho-kinase/ROCK: A key regulator of the cytoskeleton and cell polarity

(2010) Mutsuki Amano et al.   Cytoskeleton

The MicroRNA miR-139 Suppresses Metastasis and Progression of Hepatocellular Carcinoma by Down-regulating Rho-Kinase 2

(2010) Carmen Chak–Lui Wong et al.   GASTROENTEROLOGY

Downregulation of the Rho GTPase signaling pathway is involved in the microRNA-138-mediated inhibition of cell migration and invasion in tongue squamous cell carcinoma

(2010) Lu Jiang et al.   INTERNATIONAL JOURNAL OF CANCER

Rho Kinase-2 Activation in Human Endothelial Cells Drives Lysophosphatidic Acid-mediated Expression of Cell Adhesion Molecules via NF-κB p65

(2010) Hideaki Shimada et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Src-dependent phosphorylation of ROCK participates in regulation of focal adhesion dynamics

(2010) H.-H. Lee et al.   JOURNAL OF CELL SCIENCE

Abnormal methylation of GRAF promoter Chinese patients with acute myeloid leukemia

(2010) Jun Qian et al.   LEUKEMIA RESEARCH

Activating ROCK1 somatic mutations in human cancer

(2010) P A Lochhead et al.   ONCOGENE

Regulation of ROCKII by localization to membrane compartments and binding to DynaminI

(2009) Sylvester Tumusiime et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The cytoskeleton and cancer

(2009) Alan Hall   CANCER AND METASTASIS REVIEWS

Tissue selective expression of conditionally-regulated ROCK by gene targeting to a defined locus

(2009) Michael S. Samuel et al.   GENESIS

The nuts and bolts of AGC protein kinases

(2009) Laura R. Pearce et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Distinct Roles for ROCK1 and ROCK2 in the Regulation of Keratinocyte Differentiation

(2009) Frances E. Lock et al.   PLoS One

MiR-21 is an EGFR-regulated anti-apoptotic factor in lung cancer in never-smokers

(2009) M. Seike et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer

(2009) K. P. Olive et al.   SCIENCE

Comparative gene expression profiling in three primary human cell lines after treatment with a novel inhibitor of Rho kinase or atorvastatin

(2008) Marjan Boerma et al.   BLOOD COAGULATION & FIBRINOLYSIS

Therapeutic potential of RhoA/Rho kinase inhibitors in pulmonary hypertension

(2008) M Oka et al.   BRITISH JOURNAL OF PHARMACOLOGY

Regulating the Conversion between Rounded and Elongated Modes of Cancer Cell Movement

(2008) Daniel R. Croft et al.   CANCER CELL

Microenvironment Determines Lineage Fate in a Human Model of MLL-AF9 Leukemia

(2008) Junping Wei et al.   CANCER CELL

Downregulation of miR-138 is associated with overexpression of human telomerase reverse transcriptase protein in human anaplastic thyroid carcinoma cell lines

(2008) Shingo Mitomo et al.   CANCER SCIENCE

Rac Activation and Inactivation Control Plasticity of Tumor Cell Movement

(2008) Victoria Sanz-Moreno et al.   CELL

The actin cytoskeleton in cancer cell motility

(2008) Michael F. Olson et al.   CLINICAL & EXPERIMENTAL METASTASIS

Mature miR-184 as Potential Oncogenic microRNA of Squamous Cell Carcinoma of Tongue

(2008) T.-S. Wong et al.   CLINICAL CANCER RESEARCH

Applications for ROCK kinase inhibition

(2008) Michael F Olson   CURRENT OPINION IN CELL BIOLOGY

Shroom3-mediated recruitment of Rho kinases to the apical cell junctions regulates epithelial and neuroepithelial planar remodeling

(2008) T. Nishimura et al.   DEVELOPMENT

Mechanism of multi-site phosphorylation from a ROCK-I:RhoE complex structure

(2008) David Komander et al.   EMBO JOURNAL

Structure Basis and Unconventional Lipid Membrane Binding Properties of the PH-C1 Tandem of Rho Kinases

(2008) Wenyu Wen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PDK1 regulates cancer cell motility by antagonising inhibition of ROCK1 by RhoE

(2008) Sophie Pinner et al.   NATURE CELL BIOLOGY

A critical role of Rho-kinase ROCK2 in the regulation of spine and synaptic function

(2008) Zikai Zhou et al.   NEUROPHARMACOLOGY

Loss of mir-146a function in hormone-refractory prostate cancer

(2008) S.-L. Lin et al.   RNA