Rho-associated kinase (ROCK) function is essential for cell cycle progression, senescence and tumorigenesis

Rho Kinase Inhibitors Block Melanoma Cell Migration and Inhibit Metastasis

(2015) Amine Sadok et al.   CANCER RESEARCH

Competition for actin between two distinct F-actin networks defines a bistable switch for cell polarization

(2015) Alexis J. Lomakin et al.   NATURE CELL BIOLOGY

ROCK1 is a potential combinatorial drug target for BRAF mutant melanoma

(2014) M. A. Smit et al.   Molecular Systems Biology

Systematic evaluation of quantotypic peptides for targeted analysis of the human kinome

(2014) Jonathan D Worboys et al.   NATURE METHODS

Physiological roles of Rho and Rho effectors in mammals

(2013) Dean Thumkeo et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Opposing Signaling of ROCK1 and ROCK2 Determines the Switching of Substrate Specificity and the Mode of Migration of Glioblastoma Cells

(2013) Sonja Mertsch et al.   MOLECULAR NEUROBIOLOGY

Distinct roles for ROCK1 and ROCK2 in the regulation of cell detachment

(2013) Jianjian Shi et al.   Cell Death & Disease

ROCK1 and ROCK2 Are Required for Non-Small Cell Lung Cancer Anchorage-Independent Growth and Invasion

(2012) D. Vigil et al.   CANCER RESEARCH

The GATA2 Transcriptional Network Is Requisite for RAS Oncogene-Driven Non-Small Cell Lung Cancer

(2012) Madhu S. Kumar et al.   CELL

AT13148 Is a Novel, Oral Multi-AGC Kinase Inhibitor with Potent Pharmacodynamic and Antitumor Activity

(2012) T. A. Yap et al.   CLINICAL CANCER RESEARCH

Genetic Deletion of RALA and RALB Small GTPases Reveals Redundant Functions in Development and Tumorigenesis

(2012) Pascal Peschard et al.   CURRENT BIOLOGY

Cks1 Promotion of S Phase Entry and Proliferation Is Independent of p27Kip1 Suppression

(2012) A. Hoellein et al.   MOLECULAR AND CELLULAR BIOLOGY

Cyclin-dependent kinase 1 (Cdk1) is essential for cell division and suppression of DNA re-replication but not for liver regeneration

(2012) M. K. Diril et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Actomyosin-Mediated Cellular Tension Drives Increased Tissue Stiffness and β-Catenin Activation to Induce Epidermal Hyperplasia and Tumor Growth

(2011) Michael S. Samuel et al.   CANCER CELL

A chemical biology screen reveals a role for Rab21-mediated control of actomyosin contractility in fibroblast-driven cancer invasion

(2009) S Hooper et al.   BRITISH JOURNAL OF CANCER

Oncogenic Braf Induces Melanocyte Senescence and Melanoma in Mice

(2009) Nathalie Dhomen et al.   CANCER CELL

Combination of FASP and StageTip-Based Fractionation Allows In-Depth Analysis of the Hippocampal Membrane Proteome

(2009) Jacek R. Wiśniewski et al.   JOURNAL OF PROTEOME RESEARCH

RhoA Regulates G1-S Progression of Gastric Cancer Cells by Modulation of Multiple INK4 Family Tumor Suppressors

(2009) S. Zhang et al.   MOLECULAR CANCER RESEARCH

BrafV600E cooperates with Pten loss to induce metastatic melanoma

(2009) David Dankort et al.   NATURE GENETICS

Protocols to detect senescence-associated beta-galactosidase (SA-βgal) activity, a biomarker of senescent cells in culture and in vivo

(2009) Florence Debacq-Chainiaux et al.   Nature Protocols

Conditional mouse lung cancer models using adenoviral or lentiviral delivery of Cre recombinase

(2009) Michel DuPage et al.   Nature Protocols

Distinct Roles for ROCK1 and ROCK2 in the Regulation of Keratinocyte Differentiation

(2009) Frances E. Lock et al.   PLoS One

Rac Activation and Inactivation Control Plasticity of Tumor Cell Movement

(2008) Victoria Sanz-Moreno et al.   CELL

The actin cytoskeleton in cancer cell motility

(2008) Michael F. Olson et al.   CLINICAL & EXPERIMENTAL METASTASIS

Cyclin-Dependent Kinase-Associated Proteins Cks1 and Cks2 Are Essential during Early Embryogenesis and for Cell Cycle Progression in Somatic Cells

(2008) H.-S. Martinsson-Ahlzen et al.   MOLECULAR AND CELLULAR BIOLOGY

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY