Cell Type-specific Signaling Function of RhoA GTPase: Lessons from Mouse Gene Targeting

PDZ-RhoGEF and LARG Are Essential for Embryonic Development and Provide a Link between Thrombin and LPA Receptors and Rho Activation

(2013) Constantinos M. Mikelis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RhoA GTPase controls cytokinesis and programmed necrosis of hematopoietic progenitors

(2013) Xuan Zhou et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Small-molecule inhibitors targeting G-protein-coupled Rho guanine nucleotide exchange factors

(2013) X. Shang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rational Design of Small Molecule Inhibitors Targeting RhoA Subfamily Rho GTPases

(2012) Xun Shang et al.   CHEMISTRY & BIOLOGY

Left-Right Locomotor Circuitry Depends on RhoA-Driven Organization of the Neuroepithelium in the Developing Spinal Cord

(2012) K.-i. Katayama et al.   JOURNAL OF NEUROSCIENCE

RhoA: A therapeutic target for chronic myeloid leukemia

(2012) Poonam R Molli et al.   Molecular Cancer

A role for mDia, a Rho-regulated actin nucleator, in tangential migration of interneuron precursors

(2012) Ryota Shinohara et al.   NATURE NEUROSCIENCE

A Radial Glia-Specific Role of RhoA in Double Cortex Formation

(2012) Silvia Cappello et al.   NEURON

RhoA of the Rho Family Small GTPases Is Essential for B Lymphocyte Development

(2012) Shuangmin Zhang et al.   PLoS One

Rgnef (p190RhoGEF) Knockout Inhibits RhoA Activity, Focal Adhesion Establishment, and Cell Motility Downstream of Integrins

(2012) Nichol L. G. Miller et al.   PLoS One

RhoA is dispensable for axon guidance of sensory neurons in the mouse dorsal root ganglia

(2012) Jennifer R. Leslie et al.   Frontiers in Molecular Neuroscience

Megakaryocyte-specific RhoA deficiency causes macrothrombocytopenia and defective platelet activation in hemostasis and thrombosis

(2011) I. Pleines et al.   BLOOD

Rho signaling pathway and apical constriction in the early lens placode

(2011) Ricardo Moraes Borges et al.   GENESIS

RhoA GTPase Is Dispensable for Actomyosin Regulation but Is Essential for Mitosis in Primary Mouse Embryonic Fibroblasts

(2011) Jaime Melendez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RhoA protects the mouse heart against ischemia/reperfusion injury

(2011) Sunny Yang Xiang et al.   JOURNAL OF CLINICAL INVESTIGATION

The Small GTPase RhoA Is Required to Maintain Spinal Cord Neuroepithelium Organization and the Neural Stem Cell Pool

(2011) D. Herzog et al.   JOURNAL OF NEUROSCIENCE

RhoA is dispensable for skin development, but crucial for contraction and directed migration of keratinocytes

(2011) Ben Jackson et al.   MOLECULAR BIOLOGY OF THE CELL

Deficiency of mDia, an Actin Nucleator, Disrupts Integrity of Neuroepithelium and Causes Periventricular Dysplasia

(2011) Dean Thumkeo et al.   PLoS One

Mitogen-activated protein kinase kinase kinase 1 (MAP3K1) integrates developmental signals for eyelid closure

(2011) E. Geh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of RhoA in neural progenitor cells causes the disruption of adherens junctions and hyperproliferation

(2011) K.-i. Katayama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Balanced Rac1 and RhoA activities regulate cell shape and drive invagination morphogenesis in epithelia

(2011) B. K. Chauhan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular control of brain size: Regulators of neural stem cell life, death and beyond

(2010) Bertrand Joseph et al.   EXPERIMENTAL CELL RESEARCH

Trio Is a Key Guanine Nucleotide Exchange Factor Coordinating Regulation of the Migration and Morphogenesis of Granule Cells in the Developing Cerebellum

(2010) Ya-Jing Peng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Signaling Role of Cdc42 in Regulating Mammalian Physiology

(2010) Jaime Melendez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RhoA, a Possible Target for Treatment of Airway Hyperresponsiveness in Bronchial Asthma

(2010) Yoshihiko Chiba et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Motorized RhoGAP myosin IXb (Myo9b) controls cell shape and motility

(2010) P. J. Hanley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rho and Ras GTPases in Axon Growth, Guidance, and Branching

(2010) A. Hall et al.   Cold Spring Harbor Perspectives in Biology

ROCK1 functions as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability

(2009) S. Vemula et al.   BLOOD

Loss of the Rho GTPase activating protein p190-B enhances hematopoietic stem cell engraftment potential

(2009) H. Xu et al.   BLOOD

Rho kinase-1 mediates cardiac fibrosis by regulating fibroblast precursor cell differentiation

(2009) S. B. Haudek et al.   CARDIOVASCULAR RESEARCH

Apical constriction: A cell shape change that can drive morphogenesis

(2009) Jacob M. Sawyer et al.   DEVELOPMENTAL BIOLOGY

Cell migration during morphogenesis

(2009) Andy Aman et al.   DEVELOPMENTAL BIOLOGY

Effects of a Rho kinase inhibitor on pressure overload induced cardiac hypertrophy and associated diastolic dysfunction

(2008) Arintaya Phrommintikul et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Essential roles of mgcRacGAP in multilineage differentiation and survival of murine hematopoietic cells

(2008) Takayuki Yamada et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

B lymphocytes: how they develop and function

(2008) T. W. LeBien et al.   BLOOD

Mammalian Rho GTPases: new insights into their functions from in vivo studies

(2008) Sarah J. Heasman et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A critical role of Rho-kinase ROCK2 in the regulation of spine and synaptic function

(2008) Zikai Zhou et al.   NEUROPHARMACOLOGY