Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer

A recurrent inactivating mutation in RHOA GTPase in angioimmunoblastic T cell lymphoma

(2014) Hae Yong Yoo et al.   NATURE GENETICS

Somatic RHOA mutation in angioimmunoblastic T cell lymphoma

(2014) Mamiko Sakata-Yanagimoto et al.   NATURE GENETICS

Recurrent mutations in epigenetic regulators, RHOA and FYN kinase in peripheral T cell lymphomas

(2014) Teresa Palomero et al.   NATURE GENETICS

Cadherin-17 induces tumorigenesis and lymphatic metastasis in gastric cancer through activation of NFκB signaling pathway

(2013) Jin Wang et al.   CANCER BIOLOGY & THERAPY

Genomic landscape of copy number aberrations enables the identification of oncogenic drivers in hepatocellular carcinoma

(2013) Kai Wang et al.   HEPATOLOGY

DNA polymerase ɛ and δ exonuclease domain mutations in endometrial cancer

(2013) David N. Church et al.   HUMAN MOLECULAR GENETICS

Integrated genomic characterization of endometrial carcinoma

(2013) Gad Getz et al.   NATURE

Mutational heterogeneity in cancer and the search for new cancer-associated genes

(2013) Michael S. Lawrence et al.   NATURE

Exome and whole-genome sequencing of esophageal adenocarcinoma identifies recurrent driver events and mutational complexity

(2013) Austin M Dulak et al.   NATURE GENETICS

Methylation-Dependent Activation of CDX1 through NF-κB

(2012) Tilman T. Rau et al.   AMERICAN JOURNAL OF PATHOLOGY

Strelka: accurate somatic small-variant calling from sequenced tumor–normal sample pairs

(2012) Christopher T. Saunders et al.   BIOINFORMATICS

Aberrant upregulation ofASCL2by promoter demethylation promotes the growth and resistance to 5-fluorouracil of gastric cancer cells

(2012) Oh-Hyung Kwon et al.   CANCER SCIENCE

Genomic Landscape of Non-Small Cell Lung Cancer in Smokers and Never-Smokers

(2012) Ramaswamy Govindan et al.   CELL

A Landscape of Driver Mutations in Melanoma

(2012) Eran Hodis et al.   CELL

A comprehensive survey of genomic alterations in gastric cancer reveals systematic patterns of molecular exclusivity and co-occurrence among distinct therapeutic targets

(2012) Niantao Deng et al.   GUT

An α-E-catenin (CTNNA1) mutation in hereditary diffuse gastric cancer

(2012) Ian J Majewski et al.   JOURNAL OF PATHOLOGY

Comprehensive molecular characterization of human colon and rectal cancer

(2012)   NATURE

Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors

(2012) Bon-Kyoung Koo et al.   NATURE

Dclk1 distinguishes between tumor and normal stem cells in the intestine

(2012) Yuki Nakanishi et al.   NATURE GENETICS

Exome sequencing of gastric adenocarcinoma identifies recurrent somatic mutations in cell adhesion and chromatin remodeling genes

(2012) Zhi Jiang Zang et al.   NATURE GENETICS

CDX1 confers intestinal phenotype on gastric epithelial cells via induction of stemness-associated reprogramming factors SALL4 and KLF5

(2012) Y. Fujii et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Methylation Subtypes and Large-Scale Epigenetic Alterations in Gastric Cancer

(2012) H. Zouridis et al.   Science Translational Medicine

Whole-genome reconstruction and mutational signatures in gastric cancer

(2012) Niranjan Nagarajan et al.   GENOME BIOLOGY

Classification of Epstein-Barr Virus-Positive Gastric Cancers by Definition of DNA Methylation Epigenotypes

(2011) K. Matsusaka et al.   CANCER RESEARCH

ARID1A, a Factor That Promotes Formation of SWI/SNF-Mediated Chromatin Remodeling, Is a Tumor Suppressor in Gynecologic Cancers

(2011) B. Guan et al.   CANCER RESEARCH

RhoA/ROCK signaling mediates plasticity of scirrhous gastric carcinoma motility

(2011) Tasuku Matsuoka et al.   CLINICAL & EXPERIMENTAL METASTASIS

Multiple developmental programs are altered by loss of Zic1 and Zic4 to cause Dandy-Walker malformation cerebellar pathogenesis

(2011) M. C. Blank et al.   DEVELOPMENT

Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancer

(2011) Kai Wang et al.   NATURE GENETICS

Controlled gene expression in primary Lgr5 organoid cultures

(2011) Bon-Kyoung Koo et al.   NATURE METHODS

CREST maps somatic structural variation in cancer genomes with base-pair resolution

(2011) Jianmin Wang et al.   NATURE METHODS

KEGG for integration and interpretation of large-scale molecular data sets

(2011) M. Kanehisa et al.   NUCLEIC ACIDS RESEARCH

GISTIC2.0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers

(2011) Craig H Mermel et al.   GENOME BIOLOGY

Identifying cancer driver genes in tumor genome sequencing studies

(2010) Ahrim Youn et al.   BIOINFORMATICS

KIAA0495/PDAM Is Frequently Downregulated in Oligodendroglial Tumors and Its Knockdown by siRNA Induces Cisplatin Resistance in Glioma Cells

(2010) Jesse Chung-Sean Pang et al.   BRAIN PATHOLOGY

Lgr5+ve Stem Cells Drive Self-Renewal in the Stomach and Build Long-Lived Gastric Units In Vitro

(2010) Nick Barker et al.   Cell Stem Cell

Short rare MUC6 minisatellites-5 alleles influence susceptibility to gastric carcinoma by regulating gene

(2010) Jeong-Ah Kwon et al.   HUMAN MUTATION

Transcription Factor Achaete Scute-Like 2 Controls Intestinal Stem Cell Fate

(2009) Laurens G. van der Flier et al.   CELL

A comprehensive catalogue of somatic mutations from a human cancer genome

(2009) Erin D. Pleasance et al.   NATURE

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

Cancer outlier detection based on likelihood ratio test

(2008) Jianhua Hu   BIOINFORMATICS

Normalization of Illumina Infinium whole-genome SNP data improves copy number estimates and allelic intensity ratios

(2008) Johan Staaf et al.   BMC BIOINFORMATICS