Recent advances in iron complexes as potential anticancer agents

Cancer statistics, 2015

(2015) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Ferroquine and its derivatives: New generation of antimalarial agents

(2015) Waseem A. Wani et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Iron(iii) and nickel(ii) complexes as potential anticancer agents: synthesis, physicochemical and structural properties, cytotoxic activity and DNA interactions

(2015) Tülay Bal-Demirci et al.   NEW JOURNAL OF CHEMISTRY

Recent Advances in Multinuclear Complexes as Potential Anticancer and DNA Binding Agents

(2014) Kehua Wang et al.   Anti-Cancer Agents in Medicinal Chemistry

Anti-Cancer Iron(II) Complexes of Pentadentate N-Donor Ligands: Cytotoxicity, Transcriptomics Analyses, and Mechanisms of Action

(2014) Wai-Lun Kwong et al.   CHEMISTRY-A EUROPEAN JOURNAL

Iron(III) Catecholates for Cellular Imaging and Photocytotoxicity in Red Light

(2014) Uttara Basu et al.   Chemistry-An Asian Journal

Quantitative Analyses of ROS and RNS Production in Breast Cancer Cell Lines Incubated with Ferrocifens

(2014) Cong Lu et al.   ChemMedChem

Molecular Mechanism of Action of 2-Ferrocenyl-1,1-diphenylbut-1-ene on HL-60 Leukemia Cells

(2014) Alane Cabral de Oliveira et al.   ChemMedChem

Thioredoxin Reductase and its Inhibitors

(2014) Fulvio Saccoccia et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Dinitrosyl iron complexes with glutathione suppress experimental endometriosis in rats

(2014) Evgeniya N. Burgova et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Carbohydrate-Appended Tumor Targeting Iron(III) Complexes Showing Photocytotoxicity in Red Light

(2014) Uttara Basu et al.   INORGANIC CHEMISTRY

New water soluble bis-imidazolium salts with a saldach scaffold: Synthesis, characterization and in vitro cytotoxicity/bactericidal studies

(2014) Reda F.M. Elshaarawy et al.   INORGANICA CHIMICA ACTA

Evidence for Targeting Thioredoxin Reductases with Ferrocenyl Quinone Methides. A Possible Molecular Basis for the Antiproliferative Effect of Hydroxyferrocifens on Cancer Cells

(2014) Anna Citta et al.   JOURNAL OF MEDICINAL CHEMISTRY

Fluorinated Fe(III) Salophene Complexes: Optimization of Tumor Cell Specific Activity and Utilization of Fluorine Labeling for in Vitro Analysis

(2014) Irene Würtenberger et al.   JOURNAL OF MEDICINAL CHEMISTRY

Inhibition of ectopic glioma tumor growth by a potent ferrocenyl drug loaded into stealth lipid nanocapsules

(2014) Anne-Laure Lainé et al.   Nanomedicine-Nanotechnology Biology and Medicine

Platinum Compounds: A Hope for Future Cancer Chemotherapy

(2013) Imran Ali et al.   Anti-Cancer Agents in Medicinal Chemistry

The in vivo performance of ferrocenyl tamoxifen lipid nanocapsules in xenografted triple negative breast cancer

(2013) Anne-Laure Lainé et al.   BIOMATERIALS

Fe–salphen complexes from intracellular pH-triggered degradation of Fe3O4@Salphen-InIII CPPs for selectively killing cancer cells

(2013) Shuai Xu et al.   BIOMATERIALS

Advances in Copper Complexes as Anticancer Agents

(2013) Carlo Santini et al.   CHEMICAL REVIEWS

Synthesis, DNA binding, hemolysis assays and anticancer studies of copper(II), nickel(II) and iron(III) complexes of a pyrazoline-based ligand

(2013) Kishwar Saleem et al.   Future Medicinal Chemistry

Next-Generation Metal Anticancer Complexes: Multitargeting via Redox Modulation

(2013) Isolda Romero-Canelón et al.   INORGANIC CHEMISTRY

Synthesis, structure, NO donor activity of iron–sulfur nitrosyl complex with 2-aminophenol-2-yl and its antiproliferative activity against human cancer cells

(2013) N.A. Sanina et al.   JOURNAL OF COORDINATION CHEMISTRY

Important cytotoxicity of novel iron(II) cyclopentadienyl complexes with imidazole based ligands

(2013) Ana Cristina Gonçalves et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Highly efficient synthetic iron-dependent nucleases activate both intrinsic and extrinsic apoptotic death pathways in leukemia cancer cells

(2013) Adolfo Horn et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Potential Anticancer Heterometallic Fe–Au and Fe–Pd Agents: Initial Mechanistic Insights

(2013) Nicholas Lease et al.   JOURNAL OF MEDICINAL CHEMISTRY

Photodynamic therapy with glycoconjugated chlorin photosensitizer

(2013) Shiho Sakuma et al.   JOURNAL OF PORPHYRINS AND PHTHALOCYANINES

Biotin-conjugated tumour-targeting photocytotoxic iron(III) complexes

(2013) S. Saha et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES

Glucose conjugation for the specific targeting and treatment of cancer

(2013) Emilia C. Calvaresi et al.   Chemical Science

Redox activation of metal-based prodrugs as a strategy for drug delivery

(2012) Nora Graf et al.   ADVANCED DRUG DELIVERY REVIEWS

Photocontrolled Targeted Drug Delivery: Photocaged Biologically Active Folic Acid as a Light-Responsive Tumor-Targeting Molecule

(2012) Nien-Chu Fan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis, Cytotoxic Properties and Tubulin Polymerization Inhibitory Activity of Novel 2-Pyrazoline Derivatives

(2012) Mohamed Abdel-Aziz et al.   ARCHIV DER PHARMAZIE

Recent Advances in the Development of Thioredoxin Reductase Inhibitors as Anticancer Agents

(2012) Yang Liu et al.   CURRENT DRUG TARGETS

Anticancer Drug Design Using Scaffolds of β-Lactams, Sulfonamides, Quinoline, Quinoxaline and Natural Products. Drugs Advances in Clinical Trials

(2012) I. Balderas-Renteria et al.   CURRENT MEDICINAL CHEMISTRY

Molecules of Natural Origin, Semi-synthesis and Synthesis with Anti-Inflammatory and Anticancer Utilities

(2012) A. M. Lourenco et al.   CURRENT PHARMACEUTICAL DESIGN

New Therapeutic Strategies for Cancer and Neurodegeneration Emerging from Yeast Cell-based Systems

(2012) Clara Pereira et al.   CURRENT PHARMACEUTICAL DESIGN

Ferrocenyl catechols: synthesis, oxidation chemistry and anti-proliferative effects on MDA-MB-231 breast cancer cells

(2012) Yong Leng Kelvin Tan et al.   DALTON TRANSACTIONS

Recent advances in the therapeutic applications of pyrazolines

(2012) Mohamed R Shaaban et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Nuclear targeting terpyridine iron(II) complexes for cellular imaging and remarkable photocytotoxicity

(2012) Uttara Basu et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Platinum(II) and gold(I) complexes based on 1,1′-bis(diphenylphosphino)metallocene derivatives: Synthesis, characterization and biological activity of the gold complexes

(2012) Haris Bjelosevic et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

Arene ruthenium complexes with phosphinoferrocene amino acid conjugates: Synthesis, characterization and cytotoxicity

(2012) Jiří Tauchman et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

Synthesis of novel heterobimetallic copper(i) hydrazone Schiff base complexes: A comparative study on the effect of heterocyclic hydrazides towards interaction with DNA/protein, free radical scavenging and cytotoxicity

(2012) Palanisamy Sathyadevi et al.   Metallomics

Synthesis and synergistic antifungal activities of a pyrazoline based ligand and its copper(II) and nickel(II) complexes with conventional antifungals

(2012) Imran Ali et al.   MICROBIAL PATHOGENESIS

Tumor targeting in photodynamic therapy. From glycoconjugated photosensitizers to glycodendrimeric one. Concept, design and properties

(2012) Séverine Ballut et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Exploring the Versatility of Cycloplatinated Thiosemicarbazones as Antitumor and Antiparasitic Agents

(2012) Prinessa Chellan et al.   ORGANOMETALLICS

Effects of Curcumin on Nitrosyl-Iron Complex - Mediated DNA Cleavage and Cytotoxicity

(2012) Rong-Jen Shiau et al.   PLANTA MEDICA

Evaluation of in vitro cytotoxicity of one-dimensional chain [Fe(salen)(L)]n complexes against human cancer cell lines

(2012) Zdeněk Dvořák et al.   TOXICOLOGY IN VITRO

Synthesis, characterization and DNA binding properties of rutin–iron complex

(2012) Stalin Selvaraj et al.   RSC Advances

Synthesis and Anticancer Activity of Isatin-Based Pyrazolines and Thiazolidines Conjugates

(2011) Dmytro Havrylyuk et al.   ARCHIV DER PHARMAZIE

Effects of Metal Salophene and Saldach Complexes on Lymphoma and Leukemia Cells

(2011) Annegret Hille et al.   ARCHIV DER PHARMAZIE

Synthesis of Some Pyrazolines and Pyrimidines Derived from Polymethoxy Chalcones as Anticancer and Antimicrobial Agents

(2011) Sherif A.F. Rostom et al.   ARCHIV DER PHARMAZIE

Synthesis, characterization and anti-tumour activity of iron(III) Schiff base complexes with unsymmetric tetradentate ligands

(2011) Fahmideh Shabani et al.   BULLETIN OF THE CHEMICAL SOCIETY OF ETHIOPIA

Targeting cancer cells through iron(III) complexes of di(picolyl)amine modified silica core–shell nanospheres

(2011) Gen-Ping Tao et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Nano Anti-Cancer Drugs: Pros and Cons and Future Perspectives

(2011) I. Ali   CURRENT CANCER DRUG TARGETS

Advances in Nano Drugs for Cancer Chemotherapy

(2011) I. Ali et al.   CURRENT CANCER DRUG TARGETS

Designed Multiple Ligands for Cancer Therapy

(2011) N. M. O'Boyle et al.   CURRENT MEDICINAL CHEMISTRY

DNA binding, prominent DNA cleavage and efficient anticancer activities of Tris(diimine)iron(ii) complexes

(2011) Sethu Ramakrishnan et al.   DALTON TRANSACTIONS

Relationship between electrochemical potentials and substitution reaction rates of ferrocene-containing β-diketonato rhodium(i) complexes; Cytotoxicity of [Rh(FcCOCHCOPh)(cod)]

(2011) Jeanet Conradie et al.   DALTON TRANSACTIONS

Heterometallic platinum(ii) compounds with β-aminoethylferrocenes: synthesis, electrochemical behaviour and anticancer activity

(2011) Daniel Nieto et al.   DALTON TRANSACTIONS

Biological evaluation of twenty-eight ferrocenyl tetrasubstituted olefins: Cancer cell growth inhibition, ROS production and hemolytic activity

(2011) Alane Cabral de Oliveira et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, Characterization, and Reactivity of the Stable Iron Carbonyl Complex [Fe(CO)(N4Py)](ClO4)2: Photoactivated Carbon Monoxide Release, Growth Inhibitory Activity, and Peptide Ligation

(2011) Casey S. Jackson et al.   INORGANIC CHEMISTRY

Structure−Activity Relationship of Photocytotoxic Iron(III) Complexes of Modified Dipyridophenazine Ligands

(2011) Sounik Saha et al.   INORGANIC CHEMISTRY

Ferrocene-Conjugatedl-Tryptophan Copper(II) Complexes of Phenanthroline Bases Showing DNA Photocleavage Activity and Cytotoxicity

(2011) Tridib K. Goswami et al.   INORGANIC CHEMISTRY

Conjugates of ferrocene with biological compounds. Coordination to gold complexes and antitumoral properties

(2011) M. Concepción Gimeno et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Ribonucleotide reductase inhibition by metal complexes of Triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone): A combined experimental and theoretical study

(2011) Ana Popović-Bijelić et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

A cyclometalated diplatinum complex containing 1,1′-bis(diphenylphosphino)ferrocene as spacer ligand: Antitumor study

(2011) Hamidreza Samouei et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

Chemistry and biology of reactive oxygen species in signaling or stress responses

(2011) Bryan C Dickinson et al.   Nature Chemical Biology

Application of ferrocene and its derivatives in cancer research

(2011) Cátia Ornelas   NEW JOURNAL OF CHEMISTRY

Treatment of 9L Gliosarcoma in Rats by Ferrociphenol-Loaded Lipid Nanocapsules Based on a Passive Targeting Strategy via the EPR Effect

(2011) Ngoc Trinh Huynh et al.   PHARMACEUTICAL RESEARCH

Organometallic Iron(III)-Salophene Exerts Cytotoxic Properties in Neuroblastoma Cells via MAPK Activation and ROS Generation

(2011) Kyu Kwang Kim et al.   PLoS One

Synthesis, structural characterisation and cytotoxicity of new iron(III) complexes with pyrazolyl thiosemicabazones

(2011) Nitis Chandra Saha et al.   POLYHEDRON

Antitumor activities of ferrocene compounds

(2011) L. V. Snegur et al.   RUSSIAN CHEMICAL BULLETIN

Synthesis and biological evaluation of novel ferrocenyl curcuminoid derivatives

(2011) Anusch Arezki et al.   MedChemComm

New Potential Anticancer Agent of Carborane Derivatives: Selective Cellular Interaction and Activity of Ferrocene-Substituted Dithio-o-carborane Conjugates

(2010) Chunhui Wu et al.   BIOCONJUGATE CHEMISTRY

Synthesis, Cytotoxicity, and COMPARE Analysis of Ferrocene and [3]Ferrocenophane Tetrasubstituted Olefin Derivatives against Human Cancer Cells

(2010) Meral Görmen et al.   ChemMedChem

Organometallic cyclic polyphenols derived from 1,2-(α-keto tri or tetra methylene) ferrocene show strong antiproliferative activity on hormone-independent breast cancer cells

(2010) Damian Plazuk et al.   DALTON TRANSACTIONS

Influence of methoxy groups on the antiproliferative effects of [FeIII(salophene-OMe)Cl] complexes

(2010) Annegret Hille et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Iron containing anti-tumoral agents: unexpected apoptosis-inducing activity of a ferrocene amino acid derivative

(2010) Benjamin Kater et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

[FeIII(salophene)Cl], a potent iron salophene complex overcomes multiple drug resistance in lymphoma and leukemia cells

(2010) Soo-Young Lee et al.   LEUKEMIA RESEARCH

Interaction of calf thymus DNA with N,N′-Bis(3,4-dihydroxybenzylidene)-1,2-diaminobenzene ligands

(2010) M. -R. Azani et al.   Russian Journal of Physical Chemistry A

Thioredoxin reductase, an emerging target for anticancer metallodrugs. Enzyme inhibition by cytotoxic gold(iii) compounds studied with combined mass spectrometry and biochemical assays

(2010) Chiara Gabbiani et al.   MedChemComm

Ferrocenyl Quinone Methides as Strong Antiproliferative Agents: Formation by Metabolic and Chemical Oxidation of Ferrocenyl Phenols

(2009) Didier Hamels et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Simple route to ferrocenylalkyl nucleobases. Antitumor activityin vivo

(2009) Alexander A. Simenel et al.   APPLIED ORGANOMETALLIC CHEMISTRY

Relationship Between Anticancer Activity and Stereochemistry of Saldach Ligands and their Iron(III) Complexes

(2009) Annegret Hille et al.   ARCHIV DER PHARMAZIE

New caspase-independent but ROS-dependent apoptosis pathways are targeted in melanoma cells by an iron-containing cytosine analogue

(2009) Jeannine C. Franke et al.   BIOCHEMICAL PHARMACOLOGY

Comparative biological evaluation of two ethylene linked mixed binuclear ferrocene/ruthenium organometallic species

(2009) Ingo Ott et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Role of aromatic substituents on the antiproliferative effects of diphenyl ferrocenyl butene compounds

(2009) Ouardia Zekri et al.   DALTON TRANSACTIONS

Novel 1D chain Fe(III)-salen-like complexes involving anionic heterocyclic N-donor ligands. Synthesis, X-ray structure, magnetic, 57Fe Mössbauer, and biological activity studies

(2009) Radovan Herchel et al.   DALTON TRANSACTIONS

Synthesis, oxidation chemistry and cytotoxicity studies on ferrocene derivatives of diethylstilbestrol

(2009) Yong Leng Kelvin Tan et al.   DALTON TRANSACTIONS

An Iron Complex of Dipyridophenazine as a Potent Photocytotoxic Agent in Visible Light

(2009) Sounik Saha et al.   INORGANIC CHEMISTRY

Dose effect activity of ferrocifen-loaded lipid nanocapsules on a 9L-glioma model

(2009) E. Allard et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

[N,N′-Bis(salicylidene)-1,2-phenylenediamine]metal complexes with cell death promoting properties

(2009) Annegret Hille et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

The first iron(III) complexes with cyclin-dependent kinase inhibitors: Magnetic, spectroscopic (IR, ES+ MS, NMR, 57Fe Mössbauer), theoretical, and biological activity studies

(2009) Zdeněk Trávníček et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Conjugation of 2-(1′-Hexyloxyethyl)-2-devinylpyropheophorbide-a (HPPH) to Carbohydrates Changes its Subcellular Distribution and Enhances Photodynamic Activity in Vivo†

(2009) Xiang Zheng et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synergistic antitumor effect of curcumin and dinitrosyl iron complexes for against melanoma cells

(2009) Yu-Der Wen et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

Local Delivery of Ferrociphenol Lipid Nanocapsules Followed by External Radiotherapy as a Synergistic Treatment Against Intracranial 9L Glioma Xenograft

(2009) Emilie Allard et al.   PHARMACEUTICAL RESEARCH

Porphyrin-Carbohydrate Conjugates: Impact of Carbohydrate Moieties in Photodynamic Therapy (PDT)

(2008) Xiang Zheng et al.   Anti-Cancer Agents in Medicinal Chemistry

Cancer cell iron metabolism and the development of potent iron chelators as anti-tumour agents

(2008) D.R. Richardson et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Novel iron complexes bearing N6-substituted adenosine derivatives: Synthesis, magnetic, 57Fe Mössbauer, DFT, and in vitro cytotoxicity studies

(2008) Zdeněk Trávníček et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Pre-clinical antitumour evaluation of Biphosphinic Palladacycle Complex in human leukaemia cells

(2008) Carlos R. Oliveira et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Reactivity and Antiproliferative Activity of Ferrocenyl-Tamoxifen Adducts with Cyclodextrins against Hormone-Independent Breast-Cancer Cell Lines

(2008) Olivier Buriez et al.   CHEMISTRY-A EUROPEAN JOURNAL

Synthesis and Structure-Activity Relationships of Ferrocenyl Tamoxifen Derivatives with Modified Side Chains

(2008) Anh Nguyen et al.   CHEMISTRY-A EUROPEAN JOURNAL

Structural and biological investigation of ferrocene-substituted 3-methylidene-1,3-dihydro-2H-indol-2-ones

(2008) John Spencer et al.   DALTON TRANSACTIONS

Lipid nanocapsules loaded with an organometallic tamoxifen derivative as a novel drug-carrier system for experimental malignant gliomas

(2008) Emilie Allard et al.   JOURNAL OF CONTROLLED RELEASE

Evaluation of cytotoxic properties of organometallic ferrocifens on melanocytes, primary and metastatic melanoma cell lines

(2008) Q. Michard et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Synthesis and Structure–Activity Relationships of the First Ferrocenyl-Aryl-Hydantoin Derivatives of the Nonsteroidal Antiandrogen Nilutamide

(2008) Olivier Payen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Iron(III)-Salophene: An Organometallic Compound with Selective Cytotoxic and Anti-Proliferative Properties in Platinum-Resistant Ovarian Cancer Cells

(2008) Thilo S. Lange et al.   PLoS One

Ferrocenoyl Pyridine Arene Ruthenium Complexes with Anticancer Properties:  Synthesis, Structure, Electrochemistry, and Cytotoxicity

(2007) Mathieu Auzias et al.   INORGANIC CHEMISTRY

Nanoparticles loaded with ferrocenyl tamoxifen derivatives for breast cancer treatment

(2007) Anh Nguyen et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS