Journal
JOURNAL OF INORGANIC BIOCHEMISTRY
Volume 129, Issue -, Pages 1-8Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jinorgbio.2013.07.033
Keywords
Iron; Cyclopentadienyl; Cytotoxicity; Heteroaromatic ligands; Organometallic; X-ray structure
Funding
- Fundacao para a Ciencia e Tecnologia [PTDC/QUI-QUI/101187/2008, PTDC/QUI-QUI/118077/2010, PEst-OE/QUI/UI0536/2011]
- Ciencia2007 Iniciative
- FCT [SFRH/BD/45871/2008]
- Fundação para a Ciência e a Tecnologia [PTDC/QUI-QUI/118077/2010, PTDC/QUI-QUI/101187/2008, SFRH/BD/45871/2008] Funding Source: FCT
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Four new compounds of general formula [FeCp(dppe)L][CF3SO3] with L = imidazole substituted ligands, and dppe = ethylenebis(diphenylphosphane) have been synthesized and characterized with the aim to evaluate their anticancer properties. The new compounds were fully characterized by spectroscopic and electrochemical methods and the structure of [Fe(eta(5)-C5H5)(dppe)(1-BuIm)] [CF3SO3] (1), [Fe(eta(5)-C5H5)(dppe) (ImH)][CF3SO3] (3) and [Fe(eta(5)-C5H5)(dppe)(1HmIm)][CF3SO3] (4) (where 1-Bulm = 1-butylimidazole, and 1HmIm = N-hydroxymethylimidazole) was determined by X-ray diffraction studies. Apparently, these compounds are the first reported 'Fe(eta(5)-C5H5)' half sandwich derivatives presenting high cytotoxic activity against a set a human tumor cell lines predicting their potential value as antitumor drugs. (C) 2013 Elsevier Inc. All rights reserved.
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