Article
Biology
ShylajaNaciyar Mohandass, Mangalalakshmi Ragavan, Dineshbabu Gnanasekaran, Uma Lakshmanan, Prabaharan Dharmar, Sushanta Kumar Saha
Summary: Synthetic azo dyes are widely used but their improper discharge poses a threat to the environment. Genetically modified cyanobacteria with enhanced H2O2 accumulation through SOD overexpression can effectively degrade these dyes, suggesting a valuable bioremediation strategy.
Article
Biochemistry & Molecular Biology
Adriana Miller, Agnieszka Matera-Witkiewicz, Aleksandra Mikolajczyk, Joanna Watly, Dean Wilcox, Danuta Witkowska, Magdalena Rowinska-Zyrek
Summary: The study found that surfactant-associated anionic peptides have affinity for Zn(II) and Cu(II) ions and can bind in a net entropically-driven process. However, these metal ions do not enhance the membrane disrupting ability of these peptides or influence their antimicrobial activity against human pathogens.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Dong-Dong Wu, Sheng Jin, Ruo-Xiao Cheng, Wen-Jie Cai, Wen-Long Xue, Qing-Qing Zhang, Le-Jie Yang, Qi Zhu, Meng-Yao Li, Ge Lin, Yi-Zhen Wang, Xue-Pan Mu, Yu Wang, Igor Ying Zhang, Qi Zhang, Ying Chen, Sheng-Yang Cai, Bo Tan, Ye Li, Yun-Qian Chen, Pu-Juan Zhang, Chen Sun, Yue Yin, Ming-Jie Wang, Yi-Zhun Zhu, Bei-Bei Tao, Jia-Hai Zhou, Wei-Xue Huang, Yi-Chun Zhu
Summary: This study investigates the possibility of a mechanism beyond post-translational modifications to regulate protein function. It shows that hydrogen sulfide (H2S) can bind to the active-site copper of Cu/Zn-SOD, enhancing electrostatic forces and facilitating electron transfer. The physiological relevance of this H2S effect is demonstrated in in vitro and in vivo models where the cardioprotective effects of H2S depend on Cu/Zn-SOD.
Article
Nanoscience & Nanotechnology
Xiangshi Sun, Kongtong Yu, Yulin Zhou, Shiyan Dong, Wenji Hu, Yating Sun, Yuhuan Li, Jing Xie, Robert J. Lee, Fengying Sun, Yifan Ma, Shengnian Wang, Betty Y. S. Kim, Yifan Wang, Zhaogang Yang, Wen Jiang, Youxin Li, Lesheng Teng
Summary: The newly synthesized amphiphilic polymers can self-assemble into micellar nanoparticles with favorable hydrolysis kinetics, biocompatibility, and long circulation time. These materials not only exhibit better inflammation-targeting effects, but also do not induce an acidic microenvironment during degradation.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Biochemistry & Molecular Biology
Bindu Chandrasekharan, Claudia Montllor-Albalate, Alyson E. Colin, Joshua L. Andersen, Young C. Jang, Amit R. Reddi
Summary: Cu/Zn superoxide dismutase (Sod1) catalyzes the breakdown of superoxide radicals into oxygen and hydrogen peroxide, which acts as a signaling molecule. In yeast, Sod1 is involved in a redox signaling pathway that connects nutrient availability to energy metabolism control. This pathway stabilizes plasma membrane kinases Yck1/2, promoting glycolytic growth and repressing respiration.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Chemistry, Physical
Maxwell O. Nwokelo, David C. Izuogu, Obinna C. Okpareke, Collins U. Ibeji, Ebube E. Oyeka, Joseph R. Lane, Jonnie N. Asegbeloyin
Summary: The novel Schiff base compound TB-SHOPA and its metal complexes were synthesized, characterized, and analyzed using various methods. It was found that the Co(II) and Zn(II) metal complexes exhibited better antimicrobial activities.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Chemistry, Multidisciplinary
Ahmet Can Timucin, Suleyman Selim Cinaroglu, Osman Ugur Sezerman, Emel Timucin
Summary: The metallation status of human Cu/Zn superoxide dismutase 1 (SOD1) is crucial in the development of amyotrophic lateral sclerosis (ALS). Mutations at the ALS-linked positions H63R and K136A significantly affect dimer dynamics, leading to demetallation and potential ALS toxicity. This study highlights the potential use of atomistic simulations in studying disease variants related to SOD1.
FRONTIERS IN CHEMISTRY
(2021)
Article
Plant Sciences
Li Tian, Junjiao Li, Caimin Huang, Dandan Zhang, Yan Xu, Xingyong Yang, Jian Song, Dan Wang, Nianwei Qiu, Dylan P. G. Short, Patrik Inderbitzin, Krishna Subbarao, Jieyin Chen, Xiaofeng Dai
Summary: The accumulation of ROS is a common defense mechanism in higher plants against pathogen attack. Previous studies showed that Cu/Zn-SOD1 (VdSOD1) in plants is upregulated following infection, indicating its role in pathogen virulence. Deletion of VdSOD1 leads to increased sensitivity to ROS generator menadione and relies on Golgi reassembly stacking protein for secretion. Overall, VdSOD1 plays a significant role in scavenging ROS and promoting virulence in V. dahliae.
MOLECULAR PLANT PATHOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Martha Zoumpoulaki, Gabrielle Schanne, Nicolas Delsuc, Hugues Preud'homme, Elodie Quevrain, Nicolas Eskenazi, Geraldine Gazzah, Regis Guillot, Philippe Seksik, Joelle Vinh, Ryszard Lobinski, Clotilde Policar
Summary: The detection and quantification of exogenous metal complexes are crucial in understanding their activity in complex biological media. This study used ion mobility spectrometry-mass spectrometry (IMS-MS) to demonstrate the intracellular presence and concentration of Mn1 and Mn1P complexes, which are superoxide dismutase (SOD) mimics, in cells.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Physical
C. E. Satheesh, P. Murali Krishna, P. Raghavendra Kumar, P. A. Suchetan, Shivakumar, S. Foro
Summary: New Schiff base ligands and their metal complexes have been synthesized and characterized. The structures of ligands and complexes were determined using various spectroscopic techniques. The binding interaction of these compounds with DNA was assessed.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Review
Chemistry, Inorganic & Nuclear
Alec Bigness, Shivaiah Vaddypally, Michael J. Zdilla, Jose L. Mendoza-Cortes
Summary: Heterocubane is a molecular species with a cube-shaped core found in nature, playing a crucial role in important biological reactions. Limited reviews have focused on the significance of the cluster outside of biology, or on the impact of the global coordination environment on reactivity and electronic structure. Understanding the synthetic chemistry of heterocubanes in the context of coordination environment and geometry offers insights into their connection to natural systems.
COORDINATION CHEMISTRY REVIEWS
(2022)
Article
Chemistry, Multidisciplinary
Andrea Capucciati, Enrico Monzani, Michela Sturini, Stefania Nicolis, Fabio A. Zucca, Luigi Bubacco, Marco Bortolus, Luigi Zecca, Luigi Casella
Summary: The study uses water-soluble melanin-protein-Fe/Cu conjugates derived from norepinephrine and fibrillar beta-lactoglobulin as reliable models for human brain locus coeruleus neuromelanin (NM). Iron and copper promote catecholamine oxidation and tend to remain coupled in oligonuclear aggregates. The Fe-Cu clusters are EPR silent and affect the H-1 NMR spectra of the conjugates.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Inorganic & Nuclear
Meiqi Liu, Hua Yang, Dacheng Li, Qingxia Yao, Huannan Wang, Zhen Zhang, Jianmin Dou
Summary: The newly synthesized complex 1 exhibited high selective fluorescence quenching effect for Fe3+ and Cu2+ in aqueous solution, while complex 2 demonstrated more efficient anticancer activities against a range of tumor cell lines.
INORGANICA CHIMICA ACTA
(2021)
Article
Multidisciplinary Sciences
Bowen Yang, Heliang Yao, Jiacai Yang, Chang Chen, Jianlin Shi
Summary: The study constructs a two-dimensional metal-organic framework nanosheet catalyst that mimics the coordination environments of natural enzymes, and demonstrates its anti-inflammatory and anti-arthritic effects.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Applied
Laila H. Abdel-Rahman, Abdel-Mawgoud M. Abdel-Mawgoud, Shaaban K. Mohamed, Mohamed R. Shehata, Mohamed Abdel-Hameed, Mahmoud Abd El Aleem Ali Ali El-Remaily
Summary: The current study involves the synthesis and characterization of a Schiff base ligand and its metal complexes. The coordination modes and molecular geometries of the ligand were determined by spectral data and density functional calculations. The antimicrobial and cytotoxic activities of the ligand and metal complexes were evaluated, with CuL showing the highest inhibitory and cytotoxic effects.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Jing-Jing Zhang, Mohamed A. Abu el Maaty, Henrik Hoffmeister, Claudia Schmidt, Julienne K. Muenzner, Rainer Schobert, Stefan Wolfl, Ingo Ott
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2020)
Article
Chemistry, Multidisciplinary
Maria Gil-Moles, Uttara Basu, Rolf Bussing, Henrik Hoffmeister, Sebastian Turck, Agnieszka Varchmin, Ingo Ott
CHEMISTRY-A EUROPEAN JOURNAL
(2020)
Article
Pharmacology & Pharmacy
Dennis Bruening, Kathrin Hatlapatka, Verena Lier-Glaubitz, Vincent Andermark, Stephan Scherneck, Ingo Ott, Ingo Rustenbeck
Summary: The NADPH-thioredoxin system plays a critical role in maintaining beta cell viability, but may have a limiting effect on glucose-induced insulin secretion.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Katharina Butsch, Alexander Haseloer, Simon Schmitz, Ingo Ott, Julia Schur, Axel Klein
Summary: Three complexes containing the non-innocent anionic ligand opo(-) were synthesized and characterized using spectroscopic techniques. The compounds show distinct electronic and optical properties, with potential antiproliferative activities against cancer cell lines.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Medicinal
Rolf Buessing, Bianka Karge, Petra Lippmann, Peter G. Jones, Mark Broenstrup, Ingo Ott
Summary: The study demonstrates that gold complexes exhibit strong antibacterial effects against Gram-positive bacteria and efficiently inhibit bacterial thioredoxin reductase. Both gold(I) and gold(III) analogues show comparable efficacy in most assays.
Article
Chemistry, Inorganic & Nuclear
Daniel Menia, Holger Kopacka, Klaus Wurst, Thomas Mueller, Petra Lippmann, Ingo Ott, Benno Bildstein
Summary: Cobaltoceniumselenolate coordination with Au(I) metal centers results in highly colored, stable compounds with good anticancer activity against various standard cancer cell lines. Characterization of these complexes was done through various analytical techniques such as NMR, IR, UV-Vis, HR-MS and single crystal XRD.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Anja Busemann, Ingrid Flaspohler, Xue-Quan Zhou, Claudia Schmidt, Sina K. Goetzfried, Vincent H. S. van Rixel, Ingo Ott, Maxime A. Siegler, Sylvestre Bonnet
Summary: Two analogs complexes of a known ruthenium complex were synthesized and evaluated for their photochemistry and phototoxicity, showing higher cellular uptake and cytotoxicity than the conventional complex. The compounds were found to be promising candidates for photoactivated chemotherapy due to their enhanced cellular uptake and cytotoxicity after light activation.
JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
(2021)
Article
Oncology
Jerneja Kladnik, James P. C. Coverdale, Jakob Kljun, Hilke Burmeister, Petra Lippman, Francesca G. Ellis, Alan M. Jones, Ingo Ott, Isolda Romero-Canelon, Iztok Turel
Summary: Ovarian cancer is a common cancer in the developing world, and resistance to platinum-based anticancer agents is a growing concern in treatment. A new family of organoruthenium(II) pyrithione complexes were explored for their efficacy towards platinum-resistant ovarian cancer cells, showing high potency and a unique mechanism of action compared to platinum agents. This study highlights the development of next-generation anticancer agents that can overcome resistance to existing therapies and the potential of transition metal complexes in multi-targeting mechanisms.
Article
Chemistry, Applied
Thomas Scattolin, Petra Lippmann, Marek Belis, Kristof van Hecke, Ingo Ott, Steven P. Nolan
Summary: A straightforward synthetic route to new N-heterocyclic carbene (NHC)-gold-steroidyl complexes is reported, which displayed good cytotoxicity against cancer cells.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Tomer Babu, Hiba Ghareeb, Uttara Basu, Hemma Schueffl, Sarah Theiner, Petra Heffeter, Gunda Koellensperger, Norman Metanis, Valentina Gandin, Ingo Ott, Claudia Schmidt, Dan Gibson
Summary: Au-I-carbene and Pt-IV-Au-I-carbene prodrugs exhibit low to sub-mu M activity against various cancer cell lines and overcome cisplatin resistance. The most potent prodrug is achieved by linking a cisplatin-derived Pt-IV(phenylbutyrate) complex to an Au-I-phenylimidazolylidene complex 2. In vivo tests on Lewis Lung Carcinoma demonstrate that the prodrug Pt-IV(phenylbutyrate)-Au-I-carbene (7) and the co-administration of cisplatin:phenylbutyrate:2 efficiently inhibit tumor growth (approximately 95%), surpassing the effectiveness of 2 (75%) or cisplatin (84%), while only causing 5% body weight loss compared to 14% for 2, 20% for cisplatin, and >30% for the co-administration.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Inorganic & Nuclear
Reinhard Thaler, Holger Kopacka, Klaus Wurst, Thomas Mueller, Florian R. Neururer, Stephan Hohloch, Petra Lippmann, Ingo Ott, Benno Bildstein
Summary: New clathrochelate complexes of manganese, iron, and cobalt containing organometallic manganese moieties cymantrene or tromancenium were synthesized via self-assembly from dioximes, metal templates, and boronic acid pinacol esters. These complexes are air-stable, highly colored, oligometallic assemblies with complicated magnetic and electrochemical properties. The tetrametallic complexes with tromanceniumyl substituents exhibit promising anticancer activity against different tumor cell lines.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Maria Gil-Moles, Cillian O'Beirne, Igor V. V. Esarev, Petra Lippmann, Matthias Tacke, Jindrich Cinatl, Denisa Bojkova, Ingo Ott
Summary: The ongoing SARS-CoV-2 pandemic has led to a high demand for innovative antiviral drugs. In this study, silver NHC complexes with chloride or iodide ligands were found to be potent inhibitors of the SARS-CoV-2 papain-like protease (PLpro), but inactive against another SARS-CoV-2 protease, 3C-like protease (3CL(pro)). Mechanistic studies showed that the complexes could remove zinc from the zinc binding domain of PLpro, which was a relevant factor for their activity. In addition, enzyme kinetic experiments revealed that the complexes were uncompetitive inhibitors, offering advantages in selectivity. The silver NHC complexes with iodide ligands showed low or no host cell toxicity and showed strong effects on viral replication in SARS-CoV-2-infected cells, making them promising candidates for future antiviral drugs.
RSC MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Mihyun Park, Claudia Schmidt, Sebastian Tuerck, Franziska Hanusch, Simone V. Hirmer, Ingo Ott, Angela Casini, Shigeyoshi Inoue
Summary: A dinuclear gold(I) complex with a strongly donating bis-N-heterocyclic imine ligand was synthesized and characterized. It showed highly selective anticancer effects against non-small cell lung cancer cells, particularly A549 cells. The anticancer effects were not correlated with the amount of gold uptake by the cells but correlated with its selective inhibition of cancer cells overexpressing a specific enzyme.
Article
Chemistry, Multidisciplinary
Mauro Safir Filho, Thomas Scattolin, Pascal Dao, Nikolaos Tzouras, Rachid Benhida, Marina Saab, Kristof Van Hecke, Petra Lippmann, Anthony R. Martin, Ingo Ott, Steven P. Nolan
Summary: A simple and eco-friendly method for synthesizing gold-NHC complexes bearing different thiosugars was reported. The obtained complexes showed strong cytotoxic activities against selected cancer cell lines.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Tatiyana Serebryanskaya, Mikhail A. Kinzhalov, Vladimir Bakulev, Georgii Alekseev, Anastasiia Andreeva, Pavel Gushchin, Aleksandra Protas, Andrey S. Smirnov, Taras L. Panikorovskii, Petra Lippmann, Ingo Ott, Cyril M. Verbilo, Alexander Zuraev, Alexander S. Bunev, Vadim P. Boyarskiy, Nina A. Kasyanenko
NEW JOURNAL OF CHEMISTRY
(2020)
