Article
Chemistry, Inorganic & Nuclear
Anna Wieczorek-Blauz, Karolina Kowalczyk, Andrzej Blauz, Anna Makal, Sylwia Pawledzio, Chatchakorn Eurtivong, Homayon J. Arabshahi, Johannes Reynisson, Christian G. Hartinger, Blazej Rychlik, Damian Plazuk
Summary: Incorporating the ferrocenyl moiety into a bioactive molecule can significantly alter the activity of the resulting conjugate. By applying this strategy, ferrocenyl analogs of monastrol were designed with higher antiproliferative activity and KSP modulatory activity, attributed to the presence of the ferrocenyl group.
DALTON TRANSACTIONS
(2022)
Article
Chemistry, Inorganic & Nuclear
Juan Sanz Garcia, Marie Gaschard, Isabelle Navizet, Mehdi Sahihi, Siden Top, Yong Wang, Pascal Pigeon, Anne Vessieres, Michele Salmain, Gerard Jaouen
Summary: The family of ferrocifens, derived from the anti-oestrogen tamoxifen, exhibit a broad antitumor activity by generating reactive oxygen species and electrophilic quinone methides. In addition to their known targets, cathepsin B was unexpectedly identified as a new target for ferrocifens.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Medicinal
Damian Kulaga, Anna K. Drabczyk, Grzegorz Satala, Gniewomir Latacz, Karolina Rozga, Damian Plazuk, Jolanta Jaskowska
Summary: Arylpiperazine derivatives with dual 5-HT1A/5-HT7 action are widely used for treating central nervous system diseases; two newly designed 5-HT7 ligands showed good metabolic stability and different hepatotoxicity performances.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Raja Chouket, Agnes Pellissier-Tanon, Alienor Lahlou, Ruikang Zhang, Diana Kim, Marie-Aude Plamont, Mingshu Zhang, Xi Zhang, Pingyong Xu, Nicolas Desprat, Dominique Bourgeois, Agathe Espagne, Annie Lemarchand, Thomas Le Saux, Ludovic Jullien
Summary: By illuminating reversibly photoswitchable fluorophores with different intensities, extra kinetic dimensions are introduced to overcome the limitation of label discrimination in fluorescence imaging. This strategy allows for the identification and discrimination of spectrally similar fluorescent proteins in a shorter time frame, opening promising perspectives for expanding the multiplexing capabilities of fluorescence imaging.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Damian Kulaga, Anna Karolina Drabczyk, Grzegorz Satala, Gniewomir Latacz, Anna Boguszewska-Czubara, Damian Plazuk, Jolanta Jaskowska
Summary: In this study, novel 1,3,5-triazine derivatives were designed and synthesized as 5-HT7 receptor ligands. Two of the tested compounds showed high affinity and moderate metabolic stability, with low hepatotoxicity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Charles Fayolle, Pascal Pigeon, Nathalie Fischer-Durand, Michele Salmain, Olivier Buriez, Anne Vessieres, Eric Labbe
Summary: The first fluorescent ferrociphenol derivative has been synthesized, and its fluorescence properties were found to be dependent on the redox state of the ferrocene group. This compound could serve as a useful tool to study the biodistribution and redox state of ferrociphenols in cancer cells.
Article
Biochemistry & Molecular Biology
Patryk Rybczynski, Anna Kaczmarek-Kedziera, Alex Iglesias-Reguant, Damian Plazuk, Borys Osmialowski
Summary: The tautomeric equilibrium of a series of 1-benzamidoisoquinoline derivatives was investigated using NMR spectroscopy and computational chemistry. The substitution effect could control the equilibrium between different tautomers, with the relative content of the amide form varying depending on the substituent. Unlike 2-phenacylquinoline derivatives, the most stable tautomer in the 1-benzamidoisoquinoline series was an amide, except for the two most electron-accepting substituents. The inclusion of explicit solvent was necessary to reproduce the experimental tendencies observed in this system, particularly for the formation of strong intermolecular hydrogen bonds.
Article
Chemistry, Multidisciplinary
Karolina Kowalczyk, Andrzej Blauz, Daniel Moscoh Ayine-Tora, Christian G. Hartinger, Blazej Rychlik, Damian Plazuk
Summary: Derivatives of ispinesib and its (S) analogue, containing ferrocenyl moieties or bulky organic substituents, were prepared to combine multiple biologically-active components in a single molecule. Several of these compounds demonstrated higher antiproliferative activity than ispinesib, with nanomolar IC50 values against cell lines. The improved activity may be attributed to synergic effects of various factors such as KSP inhibitory activity due to the ispinesib core and ability to generate ROS and induce mitotic arrest.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Applied
Marta Glodek, Elizaveta F. Petrusevich, Damian Plazuk, Denis Jacquemin, Borys Osmialowski
Summary: A series of difluoroborate fluorescent dyes with intramolecular charge transfer were synthesized and their properties were studied using both experimental and computational approaches. The size of the polyaromatic hydrocarbon side chains affects the photophysical properties of the dyes, especially their fluorescence quantum yield. Interestingly, corannulene, which is typically considered to lower the emission brightness, exhibited the highest fluorescence quantum yield in the series. Additionally, weak H/F or H/H intramolecular repulsions impacted the properties of BF2-carrying fluorophores.
Article
Optics
Mateusz Chorobinski, Paulina Smialek, Marta Gordel-Wojcik, Elizaveta F. Petrusevich, Eugeniusz Zych, Damian Plazuk, Lukasz Skowronski, Beata Jedrzejewska
Summary: The photophysical and optical properties of 4-(4'-(diphenylamino)benzylidene)-2-phenyloxazol-5(4H)-ones with different peripheral substituents were investigated in various environments. The nature of the substituent on the phenyl ring and the solvent mixture influenced these properties. The brightest emission was observed in solid state for the dye with a phenyl group or no substituent in the para position, while the dye with a cyano functional group showed the strongest emission in chloroform. The spectroscopic behavior of the dyes depended on the solvent mixture.
JOURNAL OF LUMINESCENCE
(2023)
Article
Biotechnology & Applied Microbiology
Lucie Ludvikova, Emma Simon, Mathieu Deygas, Thomas Panier, Marie-Aude Plamont, Jean Ollion, Alison Tebo, Matthieu Piel, Ludovic Jullien, Lydia Robert, Thomas Le Saux, Agathe Espagne
Summary: We present a method to reduce photobleaching and phototoxicity of fluorescent proteins by exploiting the photophysical process of reverse intersystem crossing. Dual illumination with near-infrared light during fluorophore excitation reduces photobleaching effects by 1.5-9.2-fold and can be easily implemented on commercial microscopes, making it effective in both eukaryotic and prokaryotic cells with various fluorescent proteins.
NATURE BIOTECHNOLOGY
(2023)
Article
Spectroscopy
Elizaveta F. Petrusevich, Marta Glodek, Magda A. Antoniak, Tadeusz Muziol, Damian Plazuk, Agnieszka Siomra, Marcin Nyk, Borys Osmialowski, Robert Zalesny
Summary: In this study, the symmetry relaxation effects on one- and two-photon absorption spectra of two bichromophore systems were investigated. The results showed that the planarity and deviations from planarity of the biphenyl moiety affected the two-photon transition strengths. Additionally, the perpendicular arrangement of phenylene units in the biphenylene moiety led to a decrease in two-photon transition strengths. The difference in two-photon absorption cross section between the two compounds was attributed to differences in equilibrium geometry.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Multidisciplinary Sciences
Leonard Piroska, Alexis Fenyi, Scott Thomas, Marie-Aude Plamont, Virginie Redeker, Ronald Melki, Zoher Gueroui
Summary: α-Synuclein aggregation is associated with various synucleinopathies. Recent studies suggest that α-Synuclein can form liquid condensates. This study investigates the interaction between condensates and fibrillar structures. The results show that fibrils can trigger the evolution of liquid condensates into solid-like structures with pathological features. α-Synuclein that did not undergo phase separation did not elicit such changes. The findings propose a model where α-Synuclein within condensates fuels the growth of exogenous fibrillar seeds, thereby accelerating the propagation of pathogenic aggregates.
Article
Chemistry, Multidisciplinary
Mrinal Mandal, Hessam Sepasi Tehrani, Qianhua Mai, Emma Simon, Marie-Aude Plamont, Christine Rampon, Sophie Vriz, Isabelle Aujard, Thomas Le Saux, Ludovic Jullien
Summary: In this study, a series of hydrophobic and hydrophilic caged fluorophores based on a robust pyranine backbone were reported. These fluorophores can be used for the absolute quantification of light intensity in chemical and biological samples. The brightness of these fluorophores increases upon illumination, and their uncaging cross-sections have been thoroughly characterized.
Article
Biochemistry & Molecular Biology
Anne Vessieres, Emie Quissac, Nolwenn Lemaire, Agusti Alentorn, Patrycja Domeracka, Pascal Pigeon, Marc Sanson, Ahmed Idbaih, Maite Verreault
Summary: Members of the iron-based ferrocifen family exhibit varying cytotoxic effects on GBM, with differences in response patterns and higher efficacy in certain compounds. The study reveals insights into the mechanisms of action of certain ferrocifens and advocates for a molecular-based personalized approach in the future treatment of GBM.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Inorganic & Nuclear
Vaibhav Bedi, Dipendu Mandal, Zahid Hussain, Shi-Ming Chen, Yile Wu, Zheng-Wang Qu, Stefan Grimme, Douglas W. Stephan
Summary: The reaction of (tBuO(2)CN)(2) with 9-BBN leads to the formation of a bicyclic heterocyclic compound, while its reactions with BF3 or [Et3Si][B(C6F5)(4)] result in the isolation of different compounds. Computational studies reveal that the steric and electronic properties of the Lewis acid are important in the formation of one of the compounds.
DALTON TRANSACTIONS
(2024)
Article
Chemistry, Inorganic & Nuclear
Chisa Itoh, Haruka Yoshino, Taku Kitayama, Wataru Kosaka, Hitoshi Miyasaka
Summary: A new synthetic route for constructing functional paddlewheel diruthenium(II,II) complexes was developed, utilizing Schiff base condensation reactions. The attached Schiff base groups significantly affected the electronic states of the resulting complexes, as revealed by cyclic voltammetry and DFT calculations.
DALTON TRANSACTIONS
(2024)
Article
Chemistry, Inorganic & Nuclear
Danrui Ni, Haozhe Wang, Xianghan Xu, Weiwei Xie, Robert J. Cava
Summary: A layered rhombohedral polymorph of indium(iii) triiodide is synthesized at high pressure and temperature. It has an orange color, which is different from ambient pressure InI3, which has a monoclinic molecular structure and a light-yellow color.
DALTON TRANSACTIONS
(2024)
Review
Chemistry, Inorganic & Nuclear
Juan Carlos Perez-Sanchez, Raquel P. Herrera, M. Concepcion Gimeno
Summary: Gold(II) complexes have been less utilized in catalysis compared to their gold(I) and gold(III) counterparts. However, gold(II) complexes offer potential in homo-coupling and cross-coupling reactions, as they are more easily accessible through simplified oxidation and reduction processes. Gold(II) exhibits characteristics of both soft acid gold(I) and hard acid gold(III). This review explores the unique reactivity and potential applications of gold(II) species, highlighting their significance in catalytic transformations.
DALTON TRANSACTIONS
(2024)
Article
Chemistry, Inorganic & Nuclear
Nighat Yousuf, Yanping Ma, Qaiser Mahmood, Wenjuan Zhang, Yizhou Wang, Hassan Saeed, Wen-Hua Sun
Summary: In this study, a series of structurally rigid cyclooctyl-fused iminopyridine iron complexes were synthesized and used with methylaluminoxane for isoprene polymerization. The extent of steric hindrance of the ligand framework was found to significantly affect catalytic performance, with less hindrance leading to better activity and stability.
DALTON TRANSACTIONS
(2024)
Article
Chemistry, Inorganic & Nuclear
Chenghao Song, Huiwei Du, Menglei Xu, Jie Yang, Xinyu Zhang, Jungan Wang, Yuanfang Zhang, Chengjun Gu, Rui Li, Tao Hong, Jingji Zhang, Jiangying Wang, Yongchun Ye
Summary: This study improves the performance of perovskite solar cells by using a dual-hole transport layer strategy. This strategy enhances the charge transfer efficiency of the transport layer, reduces charge recombination, and improves the quality of the perovskite film layer. Ultimately, the stability of the device is enhanced.
DALTON TRANSACTIONS
(2024)
Article
Chemistry, Inorganic & Nuclear
Mahender Singh, Aakash Yadav, Ranjit Singh, Chullikkattil P. Pradeep
Summary: A new aryl selenonium polyoxometalate hybrid was developed and compared with an aryl sulfonium polyoxometalate hybrid in terms of their photocatalytic properties. It was found that the aryl selenonium hybrid exhibited better catalytic performance, which could be attributed to the larger atomic radii of selenium stabilizing the photogenerated electron-hole pair more efficiently. Additionally, the generation of elemental selenium through cleavage of C-Se bonds during catalysis was observed.
DALTON TRANSACTIONS
(2024)
Article
Chemistry, Inorganic & Nuclear
Yuhan Xie, Boyu Dong, Xuemin Wang, Siyuan Wang, Jinxi Chen, Yongbing Lou
Summary: This study successfully fabricated visible-light-responsive three-dimensional core-shell CoSe2/ZnIn2S4 heterostructures and achieved attractive activity in photocatalytic hydrogen evolution. The presence of CoSe2 improved light absorption and accelerated charge transfer kinetics. The strong interaction between CoSe2 and ZnIn2S4 reduced charge recombination, further enhancing photocatalytic activity for hydrogen evolution.
DALTON TRANSACTIONS
(2024)
Article
Chemistry, Inorganic & Nuclear
Andre L. de O. Batista, Joao Marcos T. Palheta, Mauricio J. Piotrowski, Celso R. C. Rego, Diego Guedes-Sobrinho, Alexandre C. Dias
Summary: This study presents a simulation protocol that provides a solid foundation for exploring two-dimensional materials. Using the TiBr2 2H monolayer as an example, the study reveals its promising properties for optoelectronic and valleytronic applications, including its stability, spin-orbit coupling effects, and optical helicity selection rule.
DALTON TRANSACTIONS
(2024)
Article
Chemistry, Inorganic & Nuclear
Jiang Jiang, Zi-Wei Li, Zhi-Zhuan Zhang, Bin Tan, Zhao-Feng Wu, Xiao-Ying Huang
Summary: In this work, two metal organic frameworks (MOFs) containing {Cu2I2} clusters, Eu-CuI-INA and Sr-K-CuI-INA, were synthesized and characterized. Both materials have a three-dimensional structure with {Cu2I2} clusters coordinated by INA(-) ligands and Eu3+ or Sr2+ ions. The Sr-K-CuI-INA material exhibited sensitive fluorescence sensing behaviors towards cysteine and nitro-bearing molecules, showing potential applications in bio and explosive molecule sensing. This work provides a good reference for designing fluorescent MOF probes containing CuI molecules.
DALTON TRANSACTIONS
(2024)
Article
Chemistry, Inorganic & Nuclear
Zhiya Lin, Jiasheng Wu, Qianwen Ye, Yulong Chen, Hai Jia, Xiaohui Huang, Shaoming Ying
Summary: Na-ion batteries (NIBs) have attracted great interest as a potential technology for grid-scale energy storage due to the wide distribution, low cost, and environmental friendliness of sodium resources. However, their implementation is hindered by low rate capability and cycling stability caused by the large ionic size of Na+. In this study, a three-dimensional nanoarchitectured coral-like CoSe2@N-doped carbon (CL-CoSe2@NC) was synthesized, and it exhibited improved sodium storage properties with better electrode kinetics and a stable SEI film.
DALTON TRANSACTIONS
(2024)
Article
Chemistry, Inorganic & Nuclear
Ya-Qiong Zhang, Yu Zhang, Guoping Zeng, Rong-Zhen Liao, Man Li
Summary: The mechanism and selectivity of CO2 reduction under visible light were investigated using density functional calculations. The results showed that a tetradentate PNNP-type Iridium(III) complex exhibited high activity and selectivity in the reaction.
DALTON TRANSACTIONS
(2024)
Article
Chemistry, Inorganic & Nuclear
Sanyukta Ghosh, Shubhanth Jain, Soumya Ranjan Mishra, Gerda Rogl, Peter Rogl, Ernst Bauer, B. S. Murty, A. Govindaraj, Ramesh Chandra Mallik
Summary: In this study, reduced graphene oxide (rGO) was uniformly dispersed in the In0.5Co4Sb12 bulk material by ultrasonication, which effectively reduced the lattice thermal conductivity and improved the thermoelectric efficiency.
DALTON TRANSACTIONS
(2024)
Article
Chemistry, Inorganic & Nuclear
Mika Takeuchi, Yutaka Amao
Summary: This study developed an effective visible-light driven system for fumaric acid production using renewable resources such as biomass derivatives, providing an alternative to the current petroleum-based synthesis methods.
DALTON TRANSACTIONS
(2024)
Article
Chemistry, Inorganic & Nuclear
Juan Jian, Meiting Wang, Zhuo Wang, Jingwen Meng, Yuqin Yang, Limin Chang
Summary: Developing low-cost and self-supported bifunctional catalysts is crucial for highly efficient water splitting devices. In this study, nano-NiFe2O4 was directly grown onto iron foil surface and Sn4+ was introduced into the NiFe2O4. The resulting Sn-NiFe2O4/IF showed low overpotentials and high current densities during oxygen evolution reaction (OER) and hydrogen evolution reaction (HER), making it a promising catalyst for large-scale hydrogen production.
DALTON TRANSACTIONS
(2024)
