Review
Engineering, Biomedical
Xiaohua Zheng, Yilan Jin, Xiao Liu, Tianqing Liu, Weiqi Wang, Haijun Yu
Summary: Reactive species-based cancer therapies have gained significant attention for their simplicity, controllability, and efficacy. Utilizing nanomaterials for photo-controlled generation of highly reactive radical species is a promising approach for cancer treatment, showing potential synergistic effects with other therapeutic modalities.
BIOACTIVE MATERIALS
(2021)
Review
Agronomy
Rupal Singh Tomar, Sunita Kataria, Anjana Jajoo
Summary: This article explores the recent research on signaling and mechanisms for salt tolerance in plants, focusing on the role of the salt overly sensitive system (SOS) and related antiporters proteins and mitogen-activated protein kinase cascades under salt stress. It also highlights the differential expression of various antioxidative enzymes in C3, C4 and CAM plants.
JOURNAL OF AGRONOMY AND CROP SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Anne Abot, Steven Fried, Patrice D. Cani, Claude Knauf
Summary: The role of reactive oxygen/nitrogen species as friend or foe messengers in the body is well studied, with their effects depending on concentration in tissues. The intestine, affected by oxidation and inflammation, plays a crucial role in diabetic symptoms. Controlling levels of intestinal reactive oxygen/nitrogen species is a complex balance with potential therapeutic implications.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Article
Chemistry, Physical
Zhiling Zhao, Eunkyoung Kim, Dana Motabar, William E. Bentley, Gregory F. Payne
Summary: Redox bioelectronics utilizes electrochemical methods to connect with biology's native redox modality, which involves electron exchange through redox reactions. This study explores electrodes coated with redox-active but non-conducting catechol-containing hydrogels, which are emerging as important materials in redox-based bioelectronics. By increasing the dimensionality of dynamic optical measurements and employing a deterministic network model, the researchers reveal the intrinsic structure of the additional data, enhancing their capabilities for signal detection and interpretation in redox-based bioelectronics.
CHEMISTRY OF MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Jia Liu, Lin Shi, Yang Wang, Mingyi Li, Cheng Zhou, Lifang Zhang, Chundong Yao, Ye Yuan, Daan Fu, Yan Deng, Miaodeng Liu, Guobin Wang, Lin Wang, Zheng Wang
Summary: A nanosized ruthenium-based metal-organic framework (Ru-MOF) with high porosity and versatile reactive oxygen and nitrogen species (RONS) scavenging activities has been developed for treating inflammatory diseases.
Article
Chemistry, Analytical
Marita A. Cardoso, Abel J. Duarte, Helena M. R. Goncalves
Summary: Three sets of functionalized carbon dots were synthesized and tested as nitric oxide sensors, showing high sensitivity and affinity towards the analyte.
ANALYTICA CHIMICA ACTA
(2022)
Review
Immunology
Si-yue Zhai, Michael G. Kong, Yu-min Xia
Summary: Skin diseases can be categorized into infectious diseases, non-infectious inflammatory diseases, cancers, and wounds. The underlying causes include microbial infections, autoimmune responses, abnormal cellular proliferation or differentiation, and excessive production of inflammatory factors. Cold atmospheric plasma (CAP), as an innovative and non-invasive therapeutic approach, has shown promising efficacy in dermatology by inhibiting infections, promoting wound healing, suppressing cancer growth, and improving psoriasis or vitiligo lesions. This review summarizes recent advances in CAP therapies for various skin diseases and proposes future strategies for increasing effectiveness and expanding clinical indications.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Luisa M. Sandalio, Aurelio M. Collado-Arenal, Maria C. Romero-Puertas
Summary: Plant peroxisomes are dynamic organelles participating in a variety of metabolic processes and cell responses to the environment. This review focuses on the interactions and effects of reactive species such as ROS, RNS, CRS, and SRS in peroxisomes, as well as their role in regulating the redox/ROS homeostasis and plasticity of peroxisomes. The review also highlights the important role of H2O2-dependent peroxisomal retrograde signaling and discusses the specific peroxisomal footprint.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Saad S. Al-Shehri
Summary: The innate immune system plays a crucial role in fighting pathogens, with reactive oxygen and nitrogen species serving as key components. However, high concentrations of these reactive species may damage microbial biomolecules. The system can generate more biocidal agents through interactions between its components, and deficiencies in these antimicrobial agents can lead to severe infections and immunocompromised diseases.
Review
Biochemistry & Molecular Biology
Masuko Ushio-Fukai, Dipankar Ash, Sheela Nagarkoti, Eric J. Belin de Chantemele, David J. R. Fulton, Tohru Fukai
Summary: Reactive oxygen species (ROS) and reactive nitrogen species (RNS) play important roles as signaling molecules at physiological levels, but excess levels are associated with cardiovascular disease. Cells regulate ROS and RNS levels by controlling metabolic pathways, with implications for disease treatment strategies.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Engineering, Environmental
Liying Zhang, Pei Xie, Hang Wu, Jiulong Zhao, Shige Wang
Summary: In this study, a two-dimensional MoSe2@PVP nanosheets were fabricated as an artificial enzyme to treat acute pancreatitis (AP) by eliminating reactive oxygen species (ROS) and reactive nitrogen species (RNS). The nanosheets showed good biocompatibility and demonstrated excellent ROS and RNS scavenging abilities. In vivo experiments on an animal model of AP confirmed the therapeutic effect of the nanosheets in reducing the levels of certain inflammatory factors.
CHEMICAL ENGINEERING JOURNAL
(2022)
Review
Biochemistry & Molecular Biology
Sulagna Dutta, Pallav Sengupta, Sanghamitra Das, Petr Slama, Shubhadeep Roychoudhury
Summary: Reactive nitrogen species (RNS) play important roles in male reproduction, but excessive levels can impair fertility by affecting testicular functions and compromising semen quality. High RNS levels lead to abnormalities in germ cells and gametes, and severely impact maturation and fertilization processes. Conventional semen analyses are not reliable predictors for assisted reproductive technology outcomes in cases of male infertility, highlighting the need for novel assessment and treatment methods.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Plant Sciences
Vikas Mangal, Milan Kumar Lal, Rahul Kumar Tiwari, Muhammad Ahsan Altaf, Salej Sood, Dharmendra Kumar, Vinay Bharadwaj, Brajesh Singh, Rajesh Kumar Singh, Tariq Aftab
Summary: Salinity stress has negative effects on plant growth and development. Reactive oxygen species, reactive nitrogen species, and reactive sulfur species play important roles in regulating ion homeostasis and salt tolerance.
JOURNAL OF PLANT GROWTH REGULATION
(2023)
Review
Materials Science, Biomaterials
Phuong Le Thi, Dieu Linh Tran, Thai Thanh Hoang Thi, Yunki Lee, Ki Dong Park
Summary: The dual role of reactive oxygen and nitrogen species (RONS) in physiological and pathological processes has been widely studied. Injectable hydrogels have emerged as promising biomaterials for controlling RONS levels and have shown potential in regenerative medicine and tissue engineering applications.
REGENERATIVE BIOMATERIALS
(2022)
Review
Biology
Urszula Krasuska, Agnieszka Wal, Pawel Staszek, Katarzyna Ciacka, Agnieszka Gniazdowska
Summary: Carnivorous plants attract and digest animals using specialised traps, with the involvement of reactive oxygen and nitrogen species (RONS) that play various roles in digestion, including antimicrobial activities and signal transduction.
Article
Chemistry, Multidisciplinary
Anna Larsson, Soodabeh Majdi, Alexander Oleinick, Irina Svir, Johan Dunevall, Christian Amatore, Andrew G. Ewing
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2020)
Article
Chemistry, Multidisciplinary
Lin Ren, Alexander Oleinick, Irina Svir, Christian Amatore, Andrew G. Ewing
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2020)
Article
Chemistry, Analytical
Lena Beauzamy, Jerome Delacotte, Benjamin Bailleul, Kenya Tanaka, Shuji Nakanishi, Francis-Andre Wollman, Frederic Lemaitre
ANALYTICAL CHEMISTRY
(2020)
Article
Chemistry, Multidisciplinary
Manon Guille-Collignon, Jerome Delacotte, Frederic Lemaitre, Eric Labbe, Olivier Buriez
Summary: Recent works focusing on the modulation of organic fluorescent or fluorogenic molecules by electrochemistry highlight the smart use of known molecules, the design of new ones, and the development of instrumentation providing molecular-level time- and space-resolved information.
Article
Biochemical Research Methods
Yann Bouret, Manon Guille-Collignon, Frederic Lemaitre
Summary: Amperometry with ultramicroelectrodes is a routine technique for investigating neurotransmitter secretion by vesicular exocytosis at the single-cell level. The electrochemical detection may lead to acidification of the cell-electrode cleft, but a more general model taking into account buffer species movement and regeneration confirms the robustness of this technique. This model ensures that the pH within the cleft remains at its physiological value during usual exocytotic cell frequencies, regardless of the electrochemical detection of vesicular release.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Electrochemistry
Adnan Sayegh, Luca A. Perego, Marc Arderiu Romero, Louis Escudero, Jerome Delacotte, Manon Guille-Collignon, Laurence Grimaud, Benjamin Bailleul, Frederic Lemaitre
Summary: This study focuses on extracting energy from oxygenic photosynthesis by rerouting electron flow using intact photosynthetic organisms to generate photocurrent. Researchers found that some quinones can interact with the embedded photosynthetic chain, but the balance between toxicity and bioelectricity production needs to be considered.
Article
Chemistry, Analytical
Fatma Ben Trad, Vincent Wieczny, Jerome Delacotte, Mathieu Morel, Manon Guille-Collignon, Stephane Arbault, Frederic Lemaitre, Neso Sojic, Eric Labbe, Olivier Buriez
Summary: The characterization of release events from liposomes has been quantitatively addressed using an electro-chemiluminescence (ECL) imaging strategy. By combining amperometry, epifluorescence imaging, and ECL imaging, the opening of liposomes and the subsequent release of their content can be monitored and imaged. This approach offers advantages over traditional techniques and is suitable for studying membrane rupture/permeation events.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Juan Sanz Garcia, Marie Gaschard, Isabelle Navizet, Mehdi Sahihi, Siden Top, Yong Wang, Pascal Pigeon, Anne Vessieres, Michele Salmain, Gerard Jaouen
Summary: The family of ferrocifens, derived from the anti-oestrogen tamoxifen, exhibit a broad antitumor activity by generating reactive oxygen species and electrophilic quinone methides. In addition to their known targets, cathepsin B was unexpectedly identified as a new target for ferrocifens.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2022)
Article
Electrochemistry
Justine Pandard, Na Pan, Eric Ait-Yahiatene, Laurence Grimaud, Frederic Lemaitre, Manon Guille-Collignon
Summary: In this study, four new fluorescent false neurotransmitters (FFN) probes were synthesized and their spectroscopic and electrochemical properties were investigated. The results showed that one of the probes (FFN122) had the optimal suitability for fluorescence microscopy. However, it was found that this probe did not accumulate into secretory vesicles of model cells. Therefore, FFN42 is currently the best bioelectrofluorescent compromise. Additionally, the effects of a transparent and conducting indium tin oxide (ITO) microdevice on electrochemical performances and reusability were examined.
Article
Biochemistry & Molecular Biology
Charles Fayolle, Pascal Pigeon, Nathalie Fischer-Durand, Michele Salmain, Olivier Buriez, Anne Vessieres, Eric Labbe
Summary: The first fluorescent ferrociphenol derivative has been synthesized, and its fluorescence properties were found to be dependent on the redox state of the ferrocene group. This compound could serve as a useful tool to study the biodistribution and redox state of ferrociphenols in cancer cells.
Article
Biochemistry & Molecular Biology
Samuel Guilbault, Patrick Garrigue, Leo Garnier, Justine Pandard, Frederic Lemaitre, Manon Guille-Collignon, Neso Sojic, Stephane Arbault
Summary: This study developed optoelectrodes that combine the advantages of optical fibers and microelectrodes, enabling remote imaging, optogenetic stimulation, and simultaneous detection of neurosecretory activities. The optoelectrodes demonstrated analytical performance equivalent to carbon microelectrodes and allowed for remote imaging of single cells and in situ electrochemical sensing.
BIOELECTROCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Armelle Rancillac, Emeric Scharbarg, Augustin Walter, Laure Lecoin, Thierry Gallopin, Frederic Lemaitre, Manon Guille-Collignon, Nathalie Rouach
Summary: Prostaglandin D2 (PGD2) is a potent sleep-promoting molecule that activates sleep-promoting neurons in the ventrolateral preoptic nucleus (VLPO) through astrocyte-derived adenosine, controlling local blood flow and sleep.
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Anne Vessieres, Emie Quissac, Nolwenn Lemaire, Agusti Alentorn, Patrycja Domeracka, Pascal Pigeon, Marc Sanson, Ahmed Idbaih, Maite Verreault
Summary: Members of the iron-based ferrocifen family exhibit varying cytotoxic effects on GBM, with differences in response patterns and higher efficacy in certain compounds. The study reveals insights into the mechanisms of action of certain ferrocifens and advocates for a molecular-based personalized approach in the future treatment of GBM.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Physical
Lena Beauzamy, Frederic Lemaitre, Julien Derr
SUSTAINABLE ENERGY & FUELS
(2020)
Review
Chemistry, Analytical
Manon Guille-Collignon, Frederic Lemaitre
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2020)