Article
Chemistry, Applied
Feng Wang, Yinghua Gao, Jiahui Zhang, Laixing Wang, Leilei Bao, Yan Qiu, Hui Jin, Yijia Yan, Yiping Han, Feng Hong, Zhi-Long Chen
Summary: A series of chlorophyll derivatives with fluorine-substituted alkyl side chains were designed and synthesized, showing excellent photodynamic anti-tumor effects. Among them, compound F-C4-Ppa exhibited the most outstanding anti-tumor effect and is a promising candidate for photodynamic therapy and photo-imaging diagnosis.
Article
Chemistry, Inorganic & Nuclear
Felipe Figueiroa Moreira, Juliana de Araujo Portes, Nathalia Florencia Barros Azeredo, Christiane Fernandes, Adolfo Horn Jr, Cristina Pinheiro Santiago, Bruna Barriquel Segat, Giovanni Finoto Caramori, Leticia Maria Pequeno Madureira, Dalber Ruben Sanchez Candela, Marcelo Monteiro Marques, Jackson Antonio Lamounier Camargos Resende, Wanderley de Souza, Renato Augusto DaMatta, Sergio Henrique Seabra
Summary: Chagas disease, caused by Trypanosoma cruzi, is a neglected tropical disease predominantly affecting Latin America. Two new mu-oxo Fe(iii) dinuclear complexes show promising anti-parasitic effects on T. cruzi epimastigotes in vitro, with low cytotoxicity and high selectivity indexes.
DALTON TRANSACTIONS
(2021)
Review
Chemistry, Multidisciplinary
Elizabeth A. Kras, Eric M. Snyder, Gregory E. Sokolow, Janet R. Morrow
Summary: Contrast agents are commonly used in MRI procedures to improve image quality. Clinically approved contrast agents are Gd(III) coordination complexes, but there is increasing interest in using biologically relevant metal ions such as Mn or Fe as replacements. This Account focuses on the aqueous coordination chemistry of high-spin Fe(III) complexes and their potential as MRI contrast agents. Different classes of Fe(III) MRI probes, including macrocyclic complexes and multinuclear complexes, are discussed. The goal is to develop Fe(III) agents that can clear as extracellular fluid agents and have similar profiles to Gd agents.
ACCOUNTS OF CHEMICAL RESEARCH
(2022)
Article
Chemistry, Inorganic & Nuclear
Zhanhua Wang, Chuan Gao, Xuwen Da, Yao Jian, Chao Zhang, Yishan Yao, Xuesong Wang, Qianxiong Zhou
Summary: Chemodynamic therapy using biocompatible hypocrellin A-Fe(iii) nanoparticles (HA-Fe(iii) NPs) shows promise for cancer treatment. These nanoparticles can be photo-activated by red light and generate reactive oxygen species (ROS), enhancing the effectiveness of CDT. In vivo experiments also demonstrate that HA-Fe(iii) NPs efficiently inhibit tumor growth upon red light irradiation at 628 nm.
DALTON TRANSACTIONS
(2022)
Article
Chemistry, Inorganic & Nuclear
Zhi-Jian Ouyang, Xiao-Ying Mo, Jia-Qi Ye, Xiao-Xuan Yu, Shu-Yuan Huang, Xiao-Ling Liu, Wen-Bin Chen, Song Gao, Wen Dong
Summary: Two ion-pair Fe(iii) complexes were synthesized by employing the tridentate ligand H(3)ATD, with one in low-spin state and the other undergoing high temperature spin crossover between 360 and 500 K. The magnetic measurements and magneto-structural relationship studies reveal the crucial role of interactions between the cation and anion in the high temperature Fe(iii) behavior.
DALTON TRANSACTIONS
(2021)
Article
Chemistry, Multidisciplinary
Dongxia Chen, Yaying Lin, Yifan Fan, Lingxuan Li, Chenlei Tan, Junjie Wang, Hongyu Lin, Jinhao Gao
Summary: A strategy called glycan metabolic fluorine labeling (MEFLA) has been developed for selectively tagging glycans of tumor cells, enabling in vitro tracking and assessment of glycosylation changes. This method shows high efficiency, specificity, and feasibility.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Sara M. A. Pinto, Ana R. R. Ferreira, Daniela S. S. Teixeira, Sandra C. C. Nunes, Ana L. M. Batista de Carvalho, Joseany M. S. Almeida, Zoltan Garda, Agnes Pallier, Alberto A. C. C. Pais, Christopher M. A. Brett, Eva Toth, Maria P. M. Marques, Mariette M. M. Pereira, Carlos F. G. C. Geraldes
Summary: A new fluorinated manganese porphyrin, (Mn-TPP-p-CF3), is capable of providing dual H-1 relaxivity and F-19 NMR response to redox changes based on the Mn(III)/Mn(II) equilibrium. The properties of H-1 relaxometry and F-19 NMR make it suitable for the detection of differential redox MRI. The physical-chemical characterization shows that the Mn(III)-F distance is well tailored to allow for adequate paramagnetic effect on F-19 T-1 and T-2 relaxation times.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Inorganic & Nuclear
Tabea Huss, Isabelle M. Dixon
Summary: Metal complexes with a 3d6 electron count are being considered as alternatives to 4d6-based photosensitizers, emitters, or photoredox catalysts. Fe(II) potential emitters based on strongly donating ligand sets have been proposed, which undergo oxidation to their 3d5 species. The geometry and electronic structure of 2LMCT states are investigated in this study.
INORGANIC CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Hossein Khorramdelazad, Kowsar Bagherzadeh, Ali Rahimi, Elaheh Safari, Gholamhossein Hassanshahi, Majid Khoshmirsafa, Milad Karimi, Mahdi Mohammadi, Ali Darehkordi, Reza Falak
Summary: The study discovered that a new compound, A1, can inhibit the proliferation of colorectal cancer cells, induce apoptosis and cell cycle arrest, and reduce the expression of CXCR4 receptor. This finding suggests that A1 could be a potential medication for the treatment of colorectal cancer by targeting CXCR4.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Chemistry, Physical
Ahmed M. Abu-Dief, Nashwa M. El-Metwaly, Seraj Omar Alzahrani, Fatmah Alkhatib, Matokah M. Abualnaja, Tarek El-Dabea, Mahmoud Abd El Aleem Ali Ali El-Remaily
Summary: New pharmacologically active complexes were prepared by coordinating Pd (II), Fe (III), and Cu (II) ions with a novel ligand MPTP. The complexes were characterized through various techniques, demonstrating high stability and bioactivity, suggesting their potential as promising bioactive agents.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Review
Oncology
Ernesto Rufino-Felipe, Raul Colorado-Peralta, Viviana Reyes-Marquez, Hugo Valdes, David Morales-Morales
Summary: In the past 20 years, N-Heterocyclic Carbene (NHC) ligands have been widely used in biological and medicinal chemistry due to their ability to synthesize a vast number of topologies. Fluorinated-NHC transition metal complexes, with fluorine or fluorinated fragments on their NHC moieties, have gained attention for their enhanced biological properties and potential in developing novel metallodrugs, particularly in cancer treatment.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Yanan Li, Menghuan Li, Li Liu, Chencheng Xue, Yang Fei, Xuan Wang, Yuchen Zhang, Kaiyong Cai, Yanli Zhao, Zhong Luo
Summary: This study reports a combinational strategy based on clinically tested constituents to selectively induce ferroptosis in metabolically reprogrammed tumor cells, providing a generally applicable therapy.
Article
Chemistry, Multidisciplinary
Rafaela T. Marques, Liliana P. Ferreira, Clara S. B. Gomes, Catia S. D. Lopes, Carlos E. S. Bernardes, Nirod Kumar Sarangi, Tia E. Keyes, Paulo N. Martinho
Summary: The storage of guest molecules in nonporous single crystals is an important development in the field of smart materials. We describe the synthesis and characterization of the new spin crossover Fe(III) compound [Fe(3-Br,5-ClsalEen)2]BPh4 center dot CH3CN center dot H2O (salEen = N-ethyl-N-(2-aminoethyl)salicylaldiminate) and its reversible single-crystal-to-single-crystal transformation upon desolvation and resolvation of the crystals. This compound behaves as a spin crossover sponge, and the desolvation/resolvation dynamics were studied through kinetic analysis.
CRYSTAL GROWTH & DESIGN
(2023)
Article
Chemistry, Multidisciplinary
Bijoy Dey, Jordi Cirera, Sakshi Mehta, Liliana P. Ferreira, Ramar Arumugam, Abhishake Mondal, Paulo N. Martinho, Vadapalli Chandrasekhar
Summary: Steric effects of ligand substituents on Fe(III) complexes were investigated, revealing that larger substituents maintain a high-spin state while smaller substituents exhibit spin-crossover behavior, due to the distortion of the complex structure.
CRYSTAL GROWTH & DESIGN
(2023)
Article
Environmental Sciences
Yuxuan Ye, Ning Yang, Lixi Xiao, Qiang Li, Fei Pan, Dongsheng Xia
Summary: In this study, the removal characteristics and mechanisms of Cr(III) complexes were evaluated using Fe(III) coagulation process. The results showed that Fe(III) effectively removed Cr(III)-acetate, while poor removal rate was observed for Cr(III)-citrate. The main removal mechanism of Cr(III)-acetate was precipitation, while Cr(III)-citrate removal relied on adsorption and sweeping effect of Fe floc.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)