Hepatic pyruvate and alanine metabolism are critical and complementary for maintenance of antioxidant capacity and resistance to oxidative insult

The Hepatic Mitochondrial Pyruvate Carrier as a Regulator of Systemic Metabolism and a Therapeutic Target for Treating Metabolic Disease

(2023) Kyle S. McCommis et al.   Biomolecules

Proteomics Indicates Lactate Dehydrogenase is Prognostic in Acetaminophen-induced Acute Liver Failure Patients and Reveals Altered Signaling Pathways

(2022) Joel H Vazquez et al.   TOXICOLOGICAL SCIENCES

Silencing alanine transaminase 2 in diabetic liver attenuates hyperglycemia by reducing gluconeogenesis from amino acids

(2022) Michael R. Martino et al.   Cell Reports

Interaction of RIPK1 and A20 modulates MAPK signaling in murine acetaminophen toxicity

(2021) Andrea Iorga et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exogenous phosphatidic acid reduces acetaminophen-induced liver injury in mice by activating hepatic interleukin-6 signaling through inter-organ crosstalk

(2021) Melissa M. Clemens et al.   Acta Pharmaceutica Sinica B

Mitochondrial pyruvate carrier inhibitors improve metabolic parameters in diet-induced obese mice

(2021) Wesley T. Hodges et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NASH (nonalcoholic steatohepatitis), diabetes, and macrovascular disease: multiple chronic conditions and a potential treatment at the metabolic root

(2020) Jerry Colca   EXPERT OPINION ON INVESTIGATIONAL DRUGS

A mitochondrial journey through acetaminophen hepatotoxicity

(2020) Anup Ramachandran et al.   FOOD AND CHEMICAL TOXICOLOGY

NADPH and Glutathione Redox Link TCA Cycle Activity to Endoplasmic Reticulum Homeostasis

(2020) Erica R. Gansemer et al.   iScience

The development and hepatotoxicity of acetaminophen: reviewing over a century of progress

(2020) Mitchell R. McGill et al.   DRUG METABOLISM REVIEWS

The inhibitor of glycerol 3-phosphate acyltransferase FSG67 blunts liver regeneration after acetaminophen overdose by altering GSK3β and Wnt/β-catenin signaling

(2019) Melissa M. Clemens et al.   FOOD AND CHEMICAL TOXICOLOGY

Pyruvate-Carboxylase-Mediated Anaplerosis Promotes Antioxidant Capacity by Sustaining TCA Cycle and Redox Metabolism in Liver

(2019) David A. Cappel et al.   Cell Metabolism

Acute liver failure

(2019) R Todd Stravitz et al.   LANCET

Disrupting Mitochondrial Pyruvate Uptake Directs Glutamine into the TCA Cycle away from Glutathione Synthesis and Impairs Hepatocellular Tumorigenesis

(2019) Sean C. Tompkins et al.   Cell Reports

Expression of mitochondrial membrane–linked SAB determines severity of sex-dependent acute liver injury

(2019) Sanda Win et al.   JOURNAL OF CLINICAL INVESTIGATION

Insulin sensitizer MSDC-0602K in non-alcoholic steatohepatitis: A randomized, double-blind, placebo-controlled phase IIb study

(2019) Stephen A. Harrison et al.   JOURNAL OF HEPATOLOGY

Identification of Serum Biomarkers to Distinguish Hazardous and Benign Aminotransferase Elevations

(2019) Joel H Vazquez et al.   TOXICOLOGICAL SCIENCES

Mice deficient in pyruvate dehydrogenase kinase 4 are protected against acetaminophen-induced hepatotoxicity

(2019) Luqi Duan et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Targeting the mitochondrial pyruvate carrier attenuates fibrosis in a mouse model of nonalcoholic steatohepatitis

(2017) Kyle S. McCommis et al.   HEPATOLOGY

Prevalence and predictors of over-the-counter medication use among adolescents in the United Arab Emirates

(2017) Caroline Barakat-Haddad et al.   EASTERN MEDITERRANEAN HEALTH JOURNAL

The mitochondrial pyruvate carrier mediates high fat diet-induced increases in hepatic TCA cycle capacity

(2017) Adam J. Rauckhorst et al.   Molecular Metabolism

N-acetylcysteine for non-paracetamol drug-induced liver injury: a systematic review

(2016) Mohamed Farouk Chughlay et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

c-Jun N-terminal kinase mediates mouse liver injury through a novel Sab (SH3BP5)-dependent pathway leading to inactivation of intramitochondrial Src

(2016) Sanda Win et al.   HEPATOLOGY

Mutations in mitochondrial enzyme GPT2 cause metabolic dysfunction and neurological disease with developmental and progressive features

(2016) Qing Ouyang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial pyruvate transport: a historical perspective and future research directions

(2015) Kyle S. McCommis et al.   BIOCHEMICAL JOURNAL

Hepatic Mitochondrial Pyruvate Carrier 1 Is Required for Efficient Regulation of Gluconeogenesis and Whole-Body Glucose Homeostasis

(2015) Lawrence R. Gray et al.   Cell Metabolism

Loss of Mitochondrial Pyruvate Carrier 2 in the Liver Leads to Defects in Gluconeogenesis and Compensation via Pyruvate-Alanine Cycling

(2015) Kyle S. McCommis et al.   Cell Metabolism

Loss of function mutation in glutamic pyruvate transaminase 2 (GPT2) causes developmental encephalopathy

(2015) Katrina Celis et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Glutamine Oxidation Maintains the TCA Cycle and Cell Survival during Impaired Mitochondrial Pyruvate Transport

(2014) Chendong Yang et al.   MOLECULAR CELL

Lower susceptibility of female mice to acetaminophen hepatotoxicity: Role of mitochondrial glutathione, oxidant stress and c-jun N-terminal kinase

(2014) Kuo Du et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Circulating acylcarnitines as biomarkers of mitochondrial dysfunction after acetaminophen overdose in mice and humans

(2013) Mitchell R. McGill et al.   ARCHIVES OF TOXICOLOGY

Receptor interacting protein kinase 3 is a critical early mediator of acetaminophen-induced hepatocyte necrosis in mice

(2013) Anup Ramachandran et al.   HEPATOLOGY

Metabolism and Disposition of Acetaminophen: Recent Advances in Relation to Hepatotoxicity and Diagnosis

(2013) Mitchell R. McGill et al.   PHARMACEUTICAL RESEARCH

Identification of a Mitochondrial Target of Thiazolidinedione Insulin Sensitizers (mTOT)—Relationship to Newly Identified Mitochondrial Pyruvate Carrier Proteins

(2013) Jerry R. Colca et al.   PLoS One

Plasma and liver acetaminophen-protein adduct levels in mice after acetaminophen treatment: Dose–response, mechanisms, and clinical implications

(2013) Mitchell R. McGill et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Isoform-specific alanine aminotransferase measurement can distinguish hepatic from extrahepatic injury in humans

(2012) INGALILL RAFTER et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation

(2012) Mitchell R. McGill et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification and Functional Expression of the Mitochondrial Pyruvate Carrier

(2012) S. Herzig et al.   SCIENCE

A Mitochondrial Pyruvate Carrier Required for Pyruvate Uptake in Yeast, Drosophila, and Humans

(2012) D. K. Bricker et al.   SCIENCE

Metabolic Adaptive ALT Isoenzyme Response in Livers of C57/BL6 Mice Treated with Dexamethasone

(2012) William J. Reagan et al.   TOXICOLOGIC PATHOLOGY

Serum Metabolomics Reveals Irreversible Inhibition of Fatty Acid β-Oxidation through the Suppression of PPARα Activation as a Contributing Mechanism of Acetaminophen-Induced Hepatotoxicity

(2009) Chi Chen et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Novel mechanisms of protection against acetaminophen hepatotoxicity in mice by glutathione and N-acetylcysteine

(2009) Chieko Saito et al.   HEPATOLOGY

Medication Use Among Children

(2009) L. Vernacchio et al.   PEDIATRICS

Determination of enzymatic source of alanine aminotransferase activity in serum from dogs with liver injury

(2009) Masafumi Miyazaki et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Alanine aminotransferase isoenzymes: Molecular cloning and quantitative analysis of tissue expression in rats and serum elevation in liver toxicity

(2008) Rong-Ze Yang et al.   HEPATOLOGY