Silencing alanine transaminase 2 in diabetic liver attenuates hyperglycemia by reducing gluconeogenesis from amino acids

Thyroid hormone regulates glutamine metabolism and anaplerotic fluxes by inducing mitochondrial glutamate aminotransferase GPT2

(2022) Annunziata Gaetana Cicatiello et al.   Cell Reports

Skyline for Small Molecules: A Unifying Software Package for Quantitative Metabolomics

(2020) Kendra J. Adams et al.   JOURNAL OF PROTEOME RESEARCH

Pyruvate-Carboxylase-Mediated Anaplerosis Promotes Antioxidant Capacity by Sustaining TCA Cycle and Redox Metabolism in Liver

(2019) David A. Cappel et al.   Cell Metabolism

Liver Function and Risk of Type 2 Diabetes: Bidirectional Mendelian Randomization Study

(2019) N. Maneka G. De Silva et al.   DIABETES

Mechanisms of Insulin Action and Insulin Resistance

(2018) Max C. Petersen et al.   PHYSIOLOGICAL REVIEWS

Salmon provides fast and bias-aware quantification of transcript expression

(2017) Rob Patro et al.   NATURE METHODS

Mutations in mitochondrial enzyme GPT2 cause metabolic dysfunction and neurological disease with developmental and progressive features

(2016) Qing Ouyang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer

(2016) Yujun Hao et al.   Nature Communications

Hepatic Mitochondrial Pyruvate Carrier 1 Is Required for Efficient Regulation of Gluconeogenesis and Whole-Body Glucose Homeostasis

(2015) Lawrence R. Gray et al.   Cell Metabolism

Loss of Mitochondrial Pyruvate Carrier 2 in the Liver Leads to Defects in Gluconeogenesis and Compensation via Pyruvate-Alanine Cycling

(2015) Kyle S. McCommis et al.   Cell Metabolism

Hepatic ALT isoenzymes are elevated in gluconeogenic conditions including diabetes and suppressed by insulin at the protein level

(2015) Kun Qian et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

Why weight? Modelling sample and observational level variability improves power in RNA-seq analyses

(2015) Ruijie Liu et al.   NUCLEIC ACIDS RESEARCH

Drosophila melanogaster Activating Transcription Factor 4 Regulates Glycolysis During Endoplasmic Reticulum Stress

(2015) Ji Eun Lee et al.   G3-Genes Genomes Genetics

Activating transcription factor 4 mediates up-regulation of alanine aminotransferase 2 gene expression under metabolic stress

(2014) María C. Salgado et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase

(2014) Anila K. Madiraju et al.   NATURE

Mitochondrial Pyruvate Carrier 2 Hypomorphism in Mice Leads to Defects in Glucose-Stimulated Insulin Secretion

(2014) Patrick A. Vigueira et al.   Cell Reports

featureCounts: an efficient general purpose program for assigning sequence reads to genomic features

(2013) Y. Liao et al.   BIOINFORMATICS

ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death

(2013) Jaeseok Han et al.   NATURE CELL BIOLOGY

RSeQC: quality control of RNA-seq experiments

(2012) Liguo Wang et al.   BIOINFORMATICS

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Insulin resistance is associated with a metabolic profile of altered protein metabolism in Chinese and Asian-Indian men

(2010) E. S. Tai et al.   DIABETOLOGIA

Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state

(2010) Marc Foretz et al.   JOURNAL OF CLINICAL INVESTIGATION

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

GAGE: generally applicable gene set enrichment for pathway analysis

(2009) Weijun Luo et al.   BMC BIOINFORMATICS

ALT1-encoded alanine aminotransferase plays a central role in the metabolism of alanine in Saccharomyces cerevisiae

(2009) Florencia García-Campusano et al.   CANADIAN JOURNAL OF MICROBIOLOGY

A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance

(2009) Christopher B. Newgard et al.   Cell Metabolism

Atf4 Regulates Obesity, Glucose Homeostasis, and Energy Expenditure

(2009) J. Seo et al.   DIABETES

Detection of the mitochondrial and catalytically active alanine aminotransferase in human tissues and plasma

(2009) Glinghammar   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Increased hepatic expression is a major determinant of serum alanine aminotransferase elevation in mice with nonalcoholic steatohepatitis

(2009) Rui Liu et al.   LIVER INTERNATIONAL

Liver, Muscle, and Adipose Tissue Insulin Action Is Directly Related to Intrahepatic Triglyceride Content in Obese Subjects

(2008) Kevin M. Korenblat et al.   GASTROENTEROLOGY

Alanine aminotransferase isoenzymes: Molecular cloning and quantitative analysis of tissue expression in rats and serum elevation in liver toxicity

(2008) Rong-Ze Yang et al.   HEPATOLOGY