Metabolism and Disposition of Acetaminophen: Recent Advances in Relation to Hepatotoxicity and Diagnosis
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Title
Metabolism and Disposition of Acetaminophen: Recent Advances in Relation to Hepatotoxicity and Diagnosis
Authors
Keywords
acetaminophen, drug metabolism, drug transporters, hepatotoxicity, nuclear receptors
Journal
PHARMACEUTICAL RESEARCH
Volume 30, Issue 9, Pages 2174-2187
Publisher
Springer Nature
Online
2013-03-06
DOI
10.1007/s11095-013-1007-6
References
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Note: Only part of the references are listed.- Models of drug-induced liver injury for evaluation of phytotherapeutics and other natural products
- (2013) Hartmut Jaeschke et al. FOOD AND CHEMICAL TOXICOLOGY
- AMAP, the alleged non-toxic isomer of acetaminophen, is toxic in rat and human liver
- (2012) Mackenzie Hadi et al. ARCHIVES OF TOXICOLOGY
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- (2012) J. Fraczek et al. ARCHIVES OF TOXICOLOGY
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- (2012) Isaac Downs et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: Lessons learned from acetaminophen hepatotoxicity
- (2012) Hartmut Jaeschke et al. DRUG METABOLISM REVIEWS
- Acetaminophen protein adduct formation following low-dose acetaminophen exposure: comparison of immediate-release vs extended-release formulations
- (2012) Laura P. James et al. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
- Increased susceptibility of natural killer T-cell-deficient mice to acetaminophen-induced liver injury
- (2012) Brittany V. Martin-Murphy et al. HEPATOLOGY
- The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation
- (2012) Mitchell R. McGill et al. JOURNAL OF CLINICAL INVESTIGATION
- Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity
- (2012) Daniel J. Antoine et al. JOURNAL OF HEPATOLOGY
- Resistance to acetaminophen-induced hepatotoxicity in glutathione S-transferase Mu 1-null mice
- (2012) Shingo Arakawa et al. JOURNAL OF TOXICOLOGICAL SCIENCES
- Effect of Therapeutic Doses of Acetaminophen (up to 4 g/day) on Serum Alanine Aminotransferase Levels in Subjects Consuming Ethanol: Systematic Review and Meta-analysis of Randomized Controlled Trials
- (2012) Barry Rumack et al. PHARMACOTHERAPY
- Purinergic Receptor Antagonist A438079 Protects Against Acetaminophen-Induced Liver Injury by Inhibiting P450 Isoenzymes, Not by Inflammasome Activation
- (2012) Yuchao Xie et al. TOXICOLOGICAL SCIENCES
- Acetaminophen-induced liver injury in rats and mice: Comparison of protein adducts, mitochondrial dysfunction, and oxidative stress in the mechanism of toxicity
- (2012) Mitchell R. McGill et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
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- (2012) Sébastien Anthérieu et al. TOXICOLOGY IN VITRO
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- (2012) Hartmut Jaeschke et al. TOXICOLOGY LETTERS
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- (2011) Daniel S. Budnitz et al. AMERICAN JOURNAL OF PREVENTIVE MEDICINE
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- The role of the glutathione S-transferase genes GSTT1, GSTM1, and GSTP1 in acetaminophen-poisoned patients
- (2011) Anders Buchard et al. CLINICAL TOXICOLOGY
- UGT1A6 and UGT2B15 Polymorphisms and Acetaminophen Conjugation in Response to a Randomized, Controlled Diet of Select Fruits and Vegetables
- (2011) S. L. Navarro et al. DRUG METABOLISM AND DISPOSITION
- SIRT3-dependent deacetylation exacerbates acetaminophen hepatotoxicity
- (2011) Zhongping Lu et al. EMBO REPORTS
- Activation of liver X receptor increases acetaminophen clearance and prevents its toxicity in mice
- (2011) Simrat P.S. Saini et al. HEPATOLOGY
- c-Jun N-terminal Kinase (JNK)-dependent Acute Liver Injury from Acetaminophen or Tumor Necrosis Factor (TNF) Requires Mitochondrial Sab Protein Expression in Mice
- (2011) Sanda Win et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Current issues with acetaminophen hepatotoxicity—A clinically relevant model to test the efficacy of natural products
- (2011) Hartmut Jaeschke et al. LIFE SCIENCES
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- (2011) Hartmut Jaeschke et al. LIVER INTERNATIONAL
- Exacerbation of Acetaminophen Hepatotoxicity by the Anthelmentic Drug Fenbendazole
- (2011) Carol R. Gardner et al. TOXICOLOGICAL SCIENCES
- Apoptosis-Inducing Factor Modulates Mitochondrial Oxidant Stress in Acetaminophen Hepatotoxicity
- (2011) Mary Lynn Bajt et al. TOXICOLOGICAL SCIENCES
- The effects of paracetamol (acetaminophen) on hepatic tests in patients who chronically abuse alcohol - a randomized study
- (2010) R. C. Dart et al. ALIMENTARY PHARMACOLOGY & THERAPEUTICS
- Regulation of hepatic ABCC transporters by xenobiotics and in disease states
- (2010) Xinsheng Gu et al. DRUG METABOLISM REVIEWS
- Cyclophilin D deficiency protects against acetaminophen-induced oxidant stress and liver injury
- (2010) Anup Ramachandran et al. FREE RADICAL RESEARCH
- HepaRG cells: A human model to study mechanisms of acetaminophen hepatotoxicity
- (2010) Mitchell R. McGill et al. HEPATOLOGY
- Acetaminophen-Induced Hepatotoxicity in Mice Occurs with Inhibition of Activity and Nitration of Mitochondrial Manganese Superoxide Dismutase
- (2010) R. Agarwal et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
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- (2010) Florence Ying Lee et al. MOLECULAR ENDOCRINOLOGY
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- (2010) Hui-Min Yan et al. TOXICOLOGICAL SCIENCES
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- (2010) Chieko Saito et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Mitochondrial CYP2E1 is sufficient to mediate oxidative stress and cytotoxicity induced by ethanol and acetaminophen
- (2010) Laetitia Knockaert et al. TOXICOLOGY IN VITRO
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- (2009) L. P. James et al. DRUG METABOLISM AND DISPOSITION
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- (2009) J. Cheng et al. DRUG METABOLISM AND DISPOSITION
- Drug-metabolising enzymes are down-regulated by hypoxia in differentiated human hepatoma HepaRG cells: HIF-1α involvement in CYP3A4 repression
- (2009) Claire Legendre et al. EUROPEAN JOURNAL OF CANCER
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- (2009) Kenneth J. Simpson et al. LIVER TRANSPLANTATION
- Acute Liver Failure in a Metropolitan Area in Germany: a Retrospective Study (2002 – 2008)
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- (2008) Hayato Nakagawa et al. GASTROENTEROLOGY
- GlutathioneS-transferase m1 and t1 null genotypes increase susceptibility to idiosyncratic drug-induced liver injury
- (2008) M. Isabel Lucena et al. HEPATOLOGY
- Role of JNK Translocation to Mitochondria Leading to Inhibition of Mitochondria Bioenergetics in Acetaminophen-induced Liver Injury
- (2008) Naoko Hanawa et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Mitochondrial protein thiol modifications in acetaminophen hepatotoxicity: Effect on HMG-CoA synthase
- (2008) Kelly K. Andringa et al. TOXICOLOGY LETTERS
- Induction of Mrp3 and Mrp4 transporters during acetaminophen hepatotoxicity is dependent on Nrf2
- (2007) Lauren M. Aleksunes et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Genomics and proteomics analysis of cultured primary rat hepatocytes
- (2007) Juergen Beigel et al. TOXICOLOGY IN VITRO
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