Interaction of RIPK1 and A20 modulates MAPK signaling in murine acetaminophen toxicity

A20 and Cell Death-driven Inflammation

(2020) Dario Priem et al.   TRENDS IN IMMUNOLOGY

RIPK1 ubiquitination: Evidence, correlations and the undefined

(2020) Daniel S. Simpson et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Emerging and established modes of cell death during acetaminophen-induced liver injury

(2019) Hartmut Jaeschke et al.   ARCHIVES OF TOXICOLOGY

New insights into the role and mechanism of c-Jun-N-terminal kinase signaling in the pathobiology of liver diseases

(2018) Sanda Win et al.   HEPATOLOGY

The Receptor Interacting Protein Kinases in the Liver

(2018) Lily Dara   SEMINARS IN LIVER DISEASE

Drug-Induced Liver Injury: Cascade of Events Leading to Cell Death, Apoptosis or Necrosis

(2017) Andrea Iorga et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Acetaminophen (APAP) hepatotoxicity—Isn’t it time for APAP to go away?

(2017) William M. Lee   JOURNAL OF HEPATOLOGY

The deubiquitinating enzyme TNFAIP3 mediates inactivation of hepatic ASK1 and ameliorates nonalcoholic steatohepatitis

(2017) Peng Zhang et al.   NATURE MEDICINE

The role of MAP2 kinases and p38 kinase in acute murine liver injury models

(2017) Jun Zhang et al.   Cell Death & Disease

A20/TNFAIP3 Discriminates Tumor Necrosis Factor (TNF)-Induced NF-κB from JNK Pathway Activation in Hepatocytes

(2017) Federico Pinna et al.   Frontiers in Physiology

The pseudokinase MLKL mediates programmed hepatocellular necrosis independently of RIPK3 during hepatitis

(2016) Claudia Günther et al.   JOURNAL OF CLINICAL INVESTIGATION

Knockdown of RIPK1 Markedly Exacerbates Murine Immune-Mediated Liver Injury through Massive Apoptosis of Hepatocytes, Independent of Necroptosis and Inhibition of NF-κB

(2016) Jo Suda et al.   JOURNAL OF IMMUNOLOGY

A20 prevents chronic liver inflammation and cancer by protecting hepatocytes from death

(2016) L Catrysse et al.   Cell Death & Disease

Receptor interacting protein kinase 1 mediates murine acetaminophen toxicity independent of the necrosome and not through necroptosis

(2015) Lily Dara et al.   HEPATOLOGY

A20 Restricts Ubiquitination of Pro-Interleukin-1β Protein Complexes and Suppresses NLRP3 Inflammasome Activity

(2015) Bao H. Duong et al.   IMMUNITY

The diverse role of RIP kinases in necroptosis and inflammation

(2015) John Silke et al.   NATURE IMMUNOLOGY

RIPK1 and RIPK3: critical regulators of inflammation and cell death

(2015) Kim Newton   TRENDS IN CELL BIOLOGY

Divergent effects of RIP1 or RIP3 blockade in murine models of acute liver injury

(2015) M Deutsch et al.   Cell Death & Disease

Role of receptor interacting protein (RIP)1 on apoptosis-inducing factor-mediated necroptosis during acetaminophen-evoked acute liver failure in mice

(2014) Ye-Fa Zhang et al.   TOXICOLOGY LETTERS

Necrostatin-1 protects against reactive oxygen species (ROS)-induced hepatotoxicity in acetaminophen-induced acute liver failure

(2014) Kenji Takemoto et al.   FEBS Open Bio

Receptor interacting protein kinase 3 is a critical early mediator of acetaminophen-induced hepatocyte necrosis in mice

(2013) Anup Ramachandran et al.   HEPATOLOGY

The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism

(2013) James M. Murphy et al.   IMMUNITY

A20 in inflammation and autoimmunity

(2013) Leen Catrysse et al.   TRENDS IN IMMUNOLOGY

Identification of the NF-κB inhibitor A20 as a key regulator for human adipogenesis

(2013) A Dorronsoro et al.   Cell Death & Disease

ARC is a novel therapeutic approach against acetaminophen-induced hepatocellular necrosis

(2012) Junfeng An et al.   JOURNAL OF HEPATOLOGY

Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models

(2012) N Takahashi et al.   Cell Death & Disease

c-Jun N-terminal Kinase (JNK)-dependent Acute Liver Injury from Acetaminophen or Tumor Necrosis Factor (TNF) Requires Mitochondrial Sab Protein Expression in Mice

(2011) Sanda Win et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel anti-apoptotic mechanism of A20 through targeting ASK1 to suppress TNF-induced JNK activation

(2010) M Won et al.   CELL DEATH AND DIFFERENTIATION

O-Glycosylation Regulates Ubiquitination and Degradation of the Anti-Inflammatory Protein A20 to Accelerate Atherosclerosis in Diabetic ApoE-Null Mice

(2010) Gautam V. Shrikhande et al.   PLoS One

Deletion of Apoptosis Signal-Regulating Kinase 1 Attenuates Acetaminophen-Induced Liver Injury by Inhibiting c-Jun N-Terminal Kinase Activation

(2008) Hayato Nakagawa et al.   GASTROENTEROLOGY

Role of JNK Translocation to Mitochondria Leading to Inhibition of Mitochondria Bioenergetics in Acetaminophen-induced Liver Injury

(2008) Naoko Hanawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY