Effects of altered glycolysis levels on CD8+ T cell activation and function

Reduction of pro‐inflammatory effector functions through remodeling of fatty acid metabolism in CD8 + T‐cells from rheumatoid arthritis patients

(2023) Franziska V. Kraus et al.   Arthritis & Rheumatology

PHD2 Constrains Antitumor CD8+ T-cell Activity

(2023) Charlotte Bisilliat Donnet et al.   Cancer Immunology Research

Patients with Chronic Spinal Cord Injury and a Long Period of Evolution Exhibit an Altered Cytokine Production by CD4 and CD8 T Cell Populations

(2023) Sergio Haro Girón et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Clinical benefit from immunotherapy in patients with small cell lung cancer is associated with tumor capacity for antigen presentation

(2023) Charles M. Rudin et al.   Journal of Thoracic Oncology

The PI3K-Akt-mTOR pathway mediates renal pericyte-myofibroblast transition by enhancing glycolysis through HKII

(2023) Liangmei Chen et al.   Journal of Translational Medicine

The relationship between CD4+ T cell glycolysis and their functions

(2023) Siyi Liu et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Accumulation of branched-chain amino acids reprograms glucose metabolism in CD8+ T cells with enhanced effector function and anti-tumor response

(2023) Cheng-cheng Yao et al.   Cell Reports

Identification of fibrocyte cluster in tumors reveals the role in antitumor immunity by PD-L1 blockade

(2023) Atsushi Mitsuhashi et al.   Cell Reports

Mitochondrial fusion induced by transforming growth factor-β1 serves as a switch that governs the metabolic reprogramming during differentiation of regulatory T cells

(2023) Yulai Fang et al.   Redox Biology

PD-L1 checkpoint blockade promotes regulatory T cell activity that underlies therapy resistance

(2023) Mandy van Gulijk et al.   Science Immunology

Themis is indispensable for IL-2 and IL-15 signaling in T cells

(2022) Yongchao Liu et al.   Science Signaling

IL-6-induced FOXO1 activity determines the dynamics of metabolism in CD8 T cells cross-primed by liver sinusoidal endothelial cells

(2022) Michael Dudek et al.   Cell Reports

Chemical augmentation of mitochondrial electron transport chains tunes T cell activation threshold in tumors

(2022) Yosuke Dotsu et al.   Journal for ImmunoTherapy of Cancer

PMN-MDSCs accumulation induced by CXCL1 promotes CD8+ T cells exhaustion in gastric cancer

(2022) Xingyu Zhou et al.   CANCER LETTERS

Loss of Rnf31 and Vps4b sensitizes pancreatic cancer to T cell-mediated killing

(2022) Nina Frey et al.   Nature Communications

Taming metabolic competition via glycolysis inhibition for safe and potent tumor immunotherapy

(2022) Jun Lei et al.   BIOCHEMICAL PHARMACOLOGY

TCR activation directly stimulates PYGB-dependent glycogenolysis to fuel the early recall response in CD8+ memory T cells

(2022) Huafeng Zhang et al.   MOLECULAR CELL

Expression of NAC1 Restrains the Memory Formation of CD8+ T Cells during Viral Infection

(2022) Liqing Wang et al.   Viruses-Basel

Genetically Engineered Hematopoietic Stem Cells Deliver TGF‐ β Inhibitor to Enhance Bone Metastases Immunotherapy

(2022) Beilei Wang et al.   Advanced Science

Antiretroviral therapy duration and immunometabolic state determine efficacy of ex vivo dendritic cell-based treatment restoring functional HIV-specific CD8+ T cells in people living with HIV

(2022) Marta Calvet-Mirabent et al.   EBioMedicine

High tumor hexokinase-2 expression promotes a pro-tumorigenic immune microenvironment by modulating CD8+/regulatory T-cell infiltration

(2022) Sehui Kim et al.   BMC CANCER

The Critical Role of AMPKα1 in Regulating Autophagy and Mitochondrial Respiration in IL-15-Stimulated mTORC1Weak Signal-Induced T Cell Memory: An Interplay between Yin (AMPKα1) and Yang (mTORC1) Energy Sensors in T Cell Differentiation

(2022) Anjuman Ara et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

FOXP3 expression diversifies the metabolic capacity and enhances the efficacy of CD8 T cells in adoptive immunotherapy of melanoma

(2022) Enrique Conde et al.   MOLECULAR THERAPY

Oncometabolite d -2HG alters T cell metabolism to impair CD8 + T cell function

(2022) Giulia Notarangelo et al.   SCIENCE

Lactate increases stemness of CD8 + T cells to augment anti-tumor immunity

(2022) Qiang Feng et al.   Nature Communications

Tumorous expression of NAC1 restrains antitumor immunity through the LDHA-mediated immune evasion

(2022) Yijie Ren et al.   Journal for ImmunoTherapy of Cancer

Epinephrine facilitates the growth of T cell lymphoma by altering cell proliferation, apoptosis, and glucose metabolism

(2022) Rajan Kumar Tiwari et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Memory CD8 + T cells upregulate glycolysis and effector functions under limiting oxygen conditions

(2022) Ammarina Beumer‐Chuwonpad et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Bintrafusp Alfa, a Bifunctional Fusion Protein Targeting TGF-β and PD-L1, in Patients With Non-Small Cell Lung Cancer Resistant or Refractory to Immune Checkpoint Inhibitors

(2022) Fabrice Barlesi et al.   ONCOLOGIST

Gambogic Acid Induces Pyroptosis of Colorectal Cancer Cells through the GSDME-Dependent Pathway and Elicits an Antitumor Immune Response

(2022) Hanjie Xu et al.   Cancers

Enhanced immune memory through a constant Photothermal-Metabolism regulation for Cancer Prevention and Treatment

(2021) Lihua Luo et al.   BIOMATERIALS

Glucose metabolism characteristics and TLR8-mediated metabolic control of CD4+ Treg cells in ovarian cancer cells microenvironment

(2021) Rui Xu et al.   Cell Death & Disease

Tissue-specific immunity for a changing world

(2021) Stuart P. Weisberg et al.   CELL

Disrupted macrophage metabolic reprogramming in aged soleus muscle during early recovery following disuse atrophy

(2021) Dennis K. Fix et al.   AGING CELL

Inhibition of host Ogr1 enhances effector CD8+ T-cell function by modulating acidic microenvironment

(2021) Lin Cao et al.   CANCER GENE THERAPY

Costunolide ameliorates colitis via specific inhibition of HIF1α/glycolysis-mediated Th17 differentiation

(2021) Qi Lv et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

24-Norursodeoxycholic acid reshapes immunometabolism in CD8+ T cells and alleviates hepatic inflammation

(2021) Ci Zhu et al.   JOURNAL OF HEPATOLOGY

High Glucose Enhances Cytotoxic T Lymphocyte-Mediated Cytotoxicity

(2021) Jie Zhu et al.   Frontiers in Immunology

Brd4 Regulates the Homeostasis of CD8+ T-Lymphocytes and Their Proliferation in Response to Antigen Stimulation

(2021) Zhilin Peng et al.   Frontiers in Immunology

Elevated glycolysis imparts functional ability to CD8+ T cells in HIV infection

(2021) AKM Nur-ur Rahman et al.   Life Science Alliance

Glucocorticoid imprints a low glucose metabolism onto CD8 T cells and induces the persistent suppression of the immune response

(2021) Amane Konishi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Metabolic regulation by PD-1 signaling promotes long-lived quiescent CD8 T cell memory in mice

(2021) Vandana Kalia et al.   Science Translational Medicine

Hyperactive PI3Kδ predisposes naive T cells to activation via aerobic glycolysis programs

(2020) Yanjun Jia et al.   Cellular & Molecular Immunology

Glucose, glycolysis, and neurodegenerative diseases

(2020) Bor Luen Tang   JOURNAL OF CELLULAR PHYSIOLOGY

TCR Dependent Metabolic Programming Regulates Autocrine IL-4 Production Resulting in Self-Tuning of the CD8+ T Cell Activation Setpoint

(2020) Kali F. Crofts et al.   Frontiers in Immunology

Chromatin accessibility of CD8 T cell differentiation and metabolic regulation

(2020) Haiyang Lu et al.   CELL BIOLOGY AND TOXICOLOGY

Proinflammatory profile of autoimmune CD8 + T cells relies on increased LDHA activity and aerobic glycolysis

(2020) M. Margarida Souto‐Carneiro et al.   Arthritis & Rheumatology

T-cells produce acidic niches in lymph nodes to suppress their own effector functions

(2020) Hao Wu et al.   Nature Communications

Dysfunction of CD8 + PD-1 + T cells in type 2 diabetes caused by the impairment of metabolism-immune axis

(2020) Ichiro Nojima et al.   Scientific Reports

Critical Role of AdipoR1 in Regulating Th17 Cell Differentiation Through Modulation of HIF-1α-Dependent Glycolysis

(2020) Qian Zhang et al.   Frontiers in Immunology

The E3 ubiquitin ligase Peli1 regulates the metabolic actions of mTORC1 to suppress antitumor T cell responses

(2020) Chun‐Jung Ko et al.   EMBO JOURNAL

CD8 + T cells specific to apoptosis‐associated epitopes are expanded in patients with chronic HBV infection and fibrosis

(2020) Ilenia Pacella et al.   LIVER INTERNATIONAL

Combinatorial Approach to Improve Cancer Immunotherapy: Rational Drug Design Strategy to Simultaneously Hit Multiple Targets to Kill Tumor Cells and to Activate the Immune System

(2019) Shweta Joshi et al.   Journal of Oncology

CD4+T help promotes influenza virus-specific CD8+T cell memory by limiting metabolic dysfunction

(2019) Jolie G. Cullen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIF-1α regulates IL-1β and IL-17 in sarcoidosis

(2019) Jaya Talreja et al.   eLife

Autophagy metabolically suppresses CD8+ T cell antitumor immunity

(2019) Gillian Carleton et al.   Autophagy

Acylglycerol Kinase Maintains Metabolic State and Immune Responses of CD8+ T Cells

(2019) Zhilin Hu et al.   Cell Metabolism

Dynamic Metabolic State of Tissue Resident CD8 T Cells

(2019) Špela Konjar et al.   Frontiers in Immunology

PD-1 signaling affects cristae morphology and leads to mitochondrial dysfunction in human CD8+ T lymphocytes

(2019) Jesús Ogando et al.   Journal for ImmunoTherapy of Cancer

Toll-Like Receptor 7 Activation Enhances CD8+ T Cell Effector Functions by Promoting Cellular Glycolysis

(2019) Qian Li et al.   Frontiers in Immunology

STAT3 Activation-Induced Fatty Acid Oxidation in CD8+ T Effector Cells Is Critical for Obesity-Promoted Breast Tumor Growth

(2019) Chunyan Zhang et al.   Cell Metabolism

Cutting Edge: Elevated Glycolytic Metabolism Limits the Formation of Memory CD8+ T Cells in Early Life

(2019) Cybelle Tabilas et al.   JOURNAL OF IMMUNOLOGY

TLR2 Stimulation Increases Cellular Metabolism in CD8+ T Cells and Thereby Enhances CD8+ T Cell Activation, Function, and Antiviral Activity

(2019) Ejuan Zhang et al.   JOURNAL OF IMMUNOLOGY

Ketogenesis-generated β-hydroxybutyrate is an epigenetic regulator of CD8+ T-cell memory development

(2019) Huafeng Zhang et al.   NATURE CELL BIOLOGY

Compromised Metabolic Reprogramming Is an Early Indicator of CD8+ T Cell Dysfunction during Chronic Mycobacterium tuberculosis Infection

(2019) Shannon L. Russell et al.   Cell Reports

Mitochondria-Endoplasmic Reticulum Contact Sites Function as Immunometabolic Hubs that Orchestrate the Rapid Recall Response of Memory CD8 + T Cells

(2018) Glenn R. Bantug et al.   IMMUNITY

2B4 Mediates Inhibition of CD8+T Cell Responses via Attenuation of Glycolysis and Cell Division

(2018) Sonia J. Laurie et al.   JOURNAL OF IMMUNOLOGY

Metabolic Control of CD8 + T Cell Fate Decisions and Antitumor Immunity

(2018) Lianjun Zhang et al.   TRENDS IN MOLECULAR MEDICINE

Early TCR Signaling Induces Rapid Aerobic Glycolysis Enabling Distinct Acute T Cell Effector Functions

(2018) Ashley V. Menk et al.   Cell Reports

Immunotherapy with CAR-Modified T Cells: Toxicities and Overcoming Strategies

(2018) Shangjun Sun et al.   Journal of Immunology Research

Cord Blood CD8+ T Cells Have a Natural Propensity to Express IL-4 in a Fatty Acid Metabolism and Caspase Activation-Dependent Manner

(2018) Yuxia Zhang et al.   Frontiers in Immunology

Absence of Tumor Necrosis Factor Supports Alternative Activation of Macrophages in the Liver after Infection with Leishmania major

(2018) Shanshan Hu et al.   Frontiers in Immunology

β-Adrenergic signaling blocks murine CD8+ T-cell metabolic reprogramming during activation: a mechanism for immunosuppression by adrenergic stress

(2018) Guanxi Qiao et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

miR-143 Regulates Memory T Cell Differentiation by Reprogramming T Cell Metabolism

(2018) Tengfei Zhang et al.   JOURNAL OF IMMUNOLOGY

The tumor suppressor menin prevents effector CD8 T-cell dysfunction by targeting mTORC1-dependent metabolic activation

(2018) Junpei Suzuki et al.   Nature Communications

PPAR-induced fatty acid oxidation in T cells increases the number of tumor-reactive CD8+ T cells and facilitates anti-PD-1 therapy

(2018) Partha S. Chowdhury et al.   Cancer Immunology Research

Proteasome activity regulates CD8+ T lymphocyte metabolism and fate specification

(2017) Christella E. Widjaja et al.   JOURNAL OF CLINICAL INVESTIGATION

Glucose feeds the TCA cycle via circulating lactate

(2017) Sheng Hui et al.   NATURE

A Pck1-directed glycogen metabolic program regulates formation and maintenance of memory CD8+ T cells

(2017) Ruihua Ma et al.   NATURE CELL BIOLOGY

NFATc1 controls the cytotoxicity of CD8+ T cells

(2017) Stefan Klein-Hessling et al.   Nature Communications

Memory CD8 + T Cells Require Increased Concentrations of Acetate Induced by Stress for Optimal Function

(2016) Maria L. Balmer et al.   IMMUNITY

Targeting T Cell Co-receptors for Cancer Therapy

(2016) Margaret K. Callahan et al.   IMMUNITY

Phosphatidylinositol 3-Kinase p110δ Isoform Regulates CD8+T Cell Responses during Acute Viral and Intracellular Bacterial Infections

(2016) Donald T. Gracias et al.   JOURNAL OF IMMUNOLOGY

Emerging concepts of T cell metabolism as a target of immunotherapy

(2016) Chih-Hao Chang et al.   NATURE IMMUNOLOGY

Distinct Metabolic Requirements of Exhausted and Functional Virus-Specific CD8 T Cells in the Same Host

(2016) Anna Schurich et al.   Cell Reports

Metabolic plasticity of human T cells: Preserved cytokine production under glucose deprivation or mitochondrial restriction, but 2-deoxy-glucose affects effector functions

(2015) Kathrin Renner et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

T cell metabolism drives immunity

(2015) Michael D. Buck et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Targeting T cell metabolism for therapy

(2015) David O'Sullivan et al.   TRENDS IN IMMUNOLOGY

IRF4 and BATF are critical for CD8+ T-cell function following infection with LCMV

(2014) M Grusdat et al.   CELL DEATH AND DIFFERENTIATION

IRF4 at the crossroads of effector T-cell fate decision

(2014) Magdalena Huber et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

p38 signaling inhibits mTORC1-independent autophagy in senescent human CD8+ T cells

(2014) Sian M. Henson et al.   JOURNAL OF CLINICAL INVESTIGATION

Glucose Uptake Is Limiting in T Cell Activation and Requires CD28-Mediated Akt-Dependent and Independent Pathways

(2014) S. R. Jacobs et al.   JOURNAL OF IMMUNOLOGY

Metabolic Reprogramming towards Aerobic Glycolysis Correlates with Greater Proliferative Ability and Resistance to Metabolic Inhibition in CD8 versus CD4 T Cells

(2014) Yilin Cao et al.   PLoS One

Tsc1 promotes the differentiation of memory CD8+ T cells via orchestrating the transcriptional and metabolic programs

(2014) S. Shrestha et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The short and sweet of T-cell therapy

(2014) Madhusudhanan Sukumar et al.   OncoImmunology

Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function

(2013) Madhusudhanan Sukumar et al.   JOURNAL OF CLINICAL INVESTIGATION

The transcription factor IRF4 is essential for TCR affinity–mediated metabolic programming and clonal expansion of T cells

(2013) Kevin Man et al.   NATURE IMMUNOLOGY

Rapid effector function of memory CD8+ T cells requires an immediate-early glycolytic switch

(2013) Patrick M Gubser et al.   NATURE IMMUNOLOGY

Fueling Immunity: Insights into Metabolism and Lymphocyte Function

(2013) E. L. Pearce et al.   SCIENCE

PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+T cells

(2012) David K. Finlay et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Metabolic pathways in T cell fate and function

(2012) Valerie A. Gerriets et al.   TRENDS IN IMMUNOLOGY

Conditional IL-2 Gene Deletion: Consequences for T Cell Proliferation

(2012) Zoran Popmihajlov et al.   Frontiers in Immunology

Enhancing CD8 T-cell memory by modulating fatty acid metabolism

(2009) Erika L. Pearce et al.   NATURE

Glucose deprivation inhibits multiple key gene expression events and effector functions in CD8+ T cells

(2008) Candace M. Cham et al.   EUROPEAN JOURNAL OF IMMUNOLOGY