IL-6-induced FOXO1 activity determines the dynamics of metabolism in CD8 T cells cross-primed by liver sinusoidal endothelial cells

NASH limits anti-tumour surveillance in immunotherapy-treated HCC

(2021) Dominik Pfister et al.   NATURE

Auto-aggressive CXCR6+ CD8 T cells cause liver immune pathology in NASH

(2021) Michael Dudek et al.   NATURE

Control of endothelial quiescence by FOXO-regulated metabolites

(2021) Jorge Andrade et al.   NATURE CELL BIOLOGY

Single-cell RNA sequencing reveals the heterogeneity of liver-resident immune cells in human

(2020) Juanjuan Zhao et al.   Cell Discovery

TOX transcriptionally and epigenetically programs CD8+ T cell exhaustion

(2019) Omar Khan et al.   NATURE

Dynamics and genomic landscape of CD8+ T cells undergoing hepatic priming

(2019) Alexandre P. Bénéchet et al.   NATURE

Maintenance of CD4 T cell fitness through regulation of Foxo1

(2018) Ryan H. Newton et al.   NATURE IMMUNOLOGY

Metabolic Reprogramming and Longevity of Tissue-Resident Memory T Cells

(2018) Youdong Pan et al.   Frontiers in Immunology

Survival of tissue-resident memory T cells requires exogenous lipid uptake and metabolism

(2017) Youdong Pan et al.   NATURE

Harnessing the properties of dendritic cells in the pursuit of immunological tolerance

(2017) Christopher Horton et al.   Biomedical Journal

Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming

(2016) Michael D. Buck et al.   CELL

Liver-Resident Memory CD8 + T Cells Form a Front-Line Defense against Malaria Liver-Stage Infection

(2016) Daniel Fernandez-Ruiz et al.   IMMUNITY

FOXO1 couples metabolic activity and growth state in the vascular endothelium

(2016) Kerstin Wilhelm et al.   NATURE

Aerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism

(2016) M. Peng et al.   SCIENCE

Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression

(2015) Chih-Hao Chang et al.   CELL

Single cell tuning of Myc expression by antigen receptor signal strength and interleukin-2 in T lymphocytes

(2015) G. C. Preston et al.   EMBO JOURNAL

Immunometabolism governs dendritic cell and macrophage function

(2015) Luke A.J. O’Neill et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Nanoparticle-based autoantigen delivery to Treg-inducing liver sinusoidal endothelial cells enables control of autoimmunity in mice

(2015) Antonella Carambia et al.   JOURNAL OF HEPATOLOGY

Metabolic regulation of hepatitis B immunopathology by myeloid-derived suppressor cells

(2015) Laura J Pallett et al.   NATURE MEDICINE

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation

(2015) Nikolaos Patsoukis et al.   Nature Communications

Metabolic Regulation of Immune Responses

(2014) Kirthana Ganeshan et al.   Annual Review of Immunology

The return of metabolism: biochemistry and physiology of the pentose phosphate pathway

(2014) Anna Stincone et al.   BIOLOGICAL REVIEWS

Immune tolerance in liver disease

(2014) Ian N. Crispe   HEPATOLOGY

Inflammatory T Cell Responses Rely on Amino Acid Transporter ASCT2 Facilitation of Glutamine Uptake and mTORC1 Kinase Activation

(2014) Mako Nakaya et al.   IMMUNITY

TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKɛ supports the anabolic demands of dendritic cell activation

(2014) Bart Everts et al.   NATURE IMMUNOLOGY

mTOR- and HIF-1 -mediated aerobic glycolysis as metabolic basis for trained immunity

(2014) S.-C. Cheng et al.   SCIENCE

The Liver May Act as a Firewall Mediating Mutualism Between the Host and Its Gut Commensal Microbiota

(2014) M. L. Balmer et al.   Science Translational Medicine

IL-6 trans-Signaling-Dependent Rapid Development of Cytotoxic CD8+ T Cell Function

(2014) Jan P. Böttcher et al.   Cell Reports

Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis

(2013) Chih-Hao Chang et al.   CELL

Differentiation of CD8 memory T cells depends on Foxo1

(2013) Rodrigo Hess Michelini et al.   JOURNAL OF EXPERIMENTAL MEDICINE

FoxO1 Controls Effector-to-Memory Transition and Maintenance of Functional CD8 T Cell Memory

(2013) M. M. Tejera et al.   JOURNAL OF IMMUNOLOGY

Metabolism of inflammation limited by AMPK and pseudo-starvation

(2013) Luke A. J. O'Neill et al.   NATURE

Fueling Immunity: Insights into Metabolism and Lymphocyte Function

(2013) E. L. Pearce et al.   SCIENCE

Liver-Primed Memory T Cells Generated under Noninflammatory Conditions Provide Anti-infectious Immunity

(2013) Jan P. Böttcher et al.   Cell Reports

The Third Signal Cytokine IL-12 Rescues the Anti-Viral Function of Exhausted HBV-Specific CD8 T Cells

(2013) Anna Schurich et al.   PLoS Pathogens

The scavenger endothelial cell: a new player in homeostasis and immunity

(2012) Karen Kristine Sørensen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

STAT3 Protein Interacts with Class O Forkhead Transcription Factors in the Cytoplasm and Regulates Nuclear/Cytoplasmic Localization of FoxO1 and FoxO3a Proteins in CD4+T Cells

(2012) Hyun-Mee Oh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation

(2011) Ruoning Wang et al.   IMMUNITY

An Interleukin-21- Interleukin-10-STAT3 Pathway Is Critical for Functional Maturation of Memory CD8+ T Cells

(2011) Weiguo Cui et al.   IMMUNITY

Mitochondrial Respiratory Capacity Is a Critical Regulator of CD8+ T Cell Memory Development

(2011) Gerritje J.W. van der Windt et al.   IMMUNITY

Discovery of Novel Forkhead Box O1 Inhibitors for Treating Type 2 Diabetes: Improvement of Fasting Glycemia in Diabetic db/db Mice

(2010) T. Nagashima et al.   MOLECULAR PHARMACOLOGY

Distinct kinetics and dynamics of cross-presentation in liver sinusoidal endothelial cells compared to dendritic cells

(2009) Anna Schurich et al.   HEPATOLOGY

Enhancing CD8 T-cell memory by modulating fatty acid metabolism

(2009) Erika L. Pearce et al.   NATURE

mTOR regulates memory CD8 T-cell differentiation

(2009) Koichi Araki et al.   NATURE