Genetically Engineered Hematopoietic Stem Cells Deliver TGF‐ β Inhibitor to Enhance Bone Metastases Immunotherapy

Intratumoral heterogeneity in cancer progression and response to immunotherapy

(2021) Ilio Vitale et al.   NATURE MEDICINE

Immunosuppressive Nanoparticles for Management of Immune-Related Adverse Events in Liver

(2021) Shufang Shen et al.   ACS Nano

The bone microenvironment invigorates metastatic seeds for further dissemination

(2021) Weijie Zhang et al.   CELL

Acetylation of KLF5 maintains EMT and tumorigenicity to cause chemoresistant bone metastasis in prostate cancer

(2021) Baotong Zhang et al.   Nature Communications

Breast cancer–secreted factors perturb murine bone growth in regions prone to metastasis

(2021) Aaron E. Chiou et al.   Science Advances

From Design to Clinic: Engineered Nanobiomaterials for Immune Normalization Therapy of Cancer

(2021) Madiha Saeed et al.   ADVANCED MATERIALS

Mesenchymal Stem Cell‐Derived Extracellular Vesicles with High PD‐L1 Expression for Autoimmune Diseases Treatment

(2021) Fang Xu et al.   ADVANCED MATERIALS

Genetically engineered and enucleated human mesenchymal stromal cells for the targeted delivery of therapeutics to diseased tissue

(2021) Huawei Wang et al.   Nature Biomedical Engineering

The Role of TGF-β in Bone Metastases

(2021) Trupti Trivedi et al.   Biomolecules

PD-1 blockade inhibits osteoclast formation and murine bone cancer pain

(2020) Kaiyuan Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

Bintrafusp Alfa, a Bifunctional Fusion Protein Targeting TGF-β and PD-L1, in Second-Line Treatment of Patients With NSCLC: Results From an Expansion Cohort of a Phase 1 Trial

(2020) Luis Paz-Ares et al.   Journal of Thoracic Oncology

Role of the bone microenvironment in bone metastasis of malignant tumors - therapeutic implications

(2020) Xiaoting Ma et al.   CELLULAR ONCOLOGY

TGF-β suppresses type 2 immunity to cancer

(2020) Ming Liu et al.   NATURE

Cancer immunotherapy via targeted TGF-β signalling blockade in TH cells

(2020) Shun Li et al.   NATURE

An implantable blood clot–based immune niche for enhanced cancer vaccination

(2020) Qin Fan et al.   Science Advances

Cryo-shocked cancer cells for targeted drug delivery and vaccination

(2020) Tianyuan Ci et al.   Science Advances

Tumor mutational load predicts survival after immunotherapy across multiple cancer types

(2019) Robert M. Samstein et al.   NATURE GENETICS

Initial results from a phase II study of nivolumab (NIVO) plus ipilimumab (IPI) for the treatment of metastatic castration-resistant prostate cancer (mCRPC; CheckMate 650).

(2019) Padmanee Sharma et al.   JOURNAL OF CLINICAL ONCOLOGY

Differences in Tumor Microenvironment Dictate T Helper Lineage Polarization and Response to Immune Checkpoint Therapy

(2019) Shiping Jiao et al.   CELL

Combination of Microwave Ablation and Percutaneous Osteoplasty for Treatment of Painful Extraspinal Bone Metastasis

(2019) Yuan-Yuan Qiu et al.   JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY

Phase I Trial of M7824 (MSB0011359C), a Bifunctional Fusion Protein Targeting PD-L1 and TGFβ, in Advanced Solid Tumors

(2018) Julius Strauss et al.   CLINICAL CANCER RESEARCH

Combination Cancer Therapy with Immune Checkpoint Blockade: Mechanisms and Strategies

(2018) Shetal A. Patel et al.   IMMUNITY

Immune checkpoint blockade therapy for cancer: An overview of FDA-approved immune checkpoint inhibitors

(2018) Kristian M. Hargadon et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Next generation of immune checkpoint therapy in cancer: new developments and challenges

(2018) Julian A. Marin-Acevedo et al.   Journal of Hematology & Oncology

Understanding the tumor immune microenvironment (TIME) for effective therapy

(2018) Mikhail Binnewies et al.   NATURE MEDICINE

Enhanced preclinical antitumor activity of M7824, a bifunctional fusion protein simultaneously targeting PD-L1 and TGF-β

(2018) Yan Lan et al.   Science Translational Medicine

Targeting the TGFβ pathway with galunisertib, a TGFβRI small molecule inhibitor, promotes anti-tumor immunity leading to durable, complete responses, as monotherapy and in combination with checkpoint blockade

(2018) Rikke B. Holmgaard et al.   Journal for ImmunoTherapy of Cancer

Cell-based drug delivery systems for biomedical applications

(2018) Teng Li et al.   Nano Research

TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells

(2018) Sanjeev Mariathasan et al.   NATURE

Randomized, Double-Blind, Phase III Trial of Ipilimumab Versus Placebo in Asymptomatic or Minimally Symptomatic Patients With Metastatic Chemotherapy-Naive Castration-Resistant Prostate Cancer

(2017) Tomasz M. Beer et al.   JOURNAL OF CLINICAL ONCOLOGY

TGF-β Family Signaling in Tumor Suppression and Cancer Progression

(2017) Joan Seoane et al.   Cold Spring Harbor Perspectives in Biology

Halofuginone Inhibits the Establishment and Progression of Melanoma Bone Metastases

(2012) P. Juarez et al.   CANCER RESEARCH

Clinical usefulness of bone markers in prostate cancer with bone metastasis

(2012) Naoto Kamiya et al.   INTERNATIONAL JOURNAL OF UROLOGY

Enhanced antitumor efficacy of folate-linked liposomal doxorubicin with TGF-β type I receptor inhibitor

(2010) Yukimi Taniguchi et al.   CANCER SCIENCE

The Bone Marrow Microenvironment as a Tumor Sanctuary and Contributor to Drug Resistance

(2008) M. B. Meads et al.   CLINICAL CANCER RESEARCH