TLR2 Stimulation Increases Cellular Metabolism in CD8+ T Cells and Thereby Enhances CD8+ T Cell Activation, Function, and Antiviral Activity

TLR2 Stimulation Strengthens Intrahepatic Myeloid-Derived Cell-Mediated T Cell Tolerance through Inducing Kupffer Cell Expansion and IL-10 Production

(2018) Jia Liu et al.   JOURNAL OF IMMUNOLOGY

Differentially Expressed Intrahepatic Genes Contribute to Control of Hepatitis B Virus Replication in the Inactive Carrier Phase

(2018) Hongyan Liu et al.   JOURNAL OF INFECTIOUS DISEASES

Pre-Activation of Toll-Like Receptor 2 Enhances CD8+ T-Cell Responses and Accelerates Hepatitis B Virus Clearance in the Mouse Models

(2018) Yong Lin et al.   Frontiers in Immunology

Costimulation through TLR2 Drives Polyfunctional CD8+ T Cell Responses

(2018) Fiamma Salerno et al.   JOURNAL OF IMMUNOLOGY

Toll-like receptor 2 costimulation potentiates the antitumor efficacy of CAR T Cells

(2017) Y Lai et al.   LEUKEMIA

Targeting mitochondrial dysfunction can restore antiviral activity of exhausted HBV-specific CD8 T cells in chronic hepatitis B

(2017) Paola Fisicaro et al.   NATURE MEDICINE

TLR2 Expression in Peripheral CD4+ T Cells Promotes Th17 Response and Is Associated with Disease Aggravation of Hepatitis B Virus-Related Acute-On-Chronic Liver Failure

(2017) Chunli Xu et al.   Frontiers in Immunology

Resolution of TLR2-induced inflammation through manipulation of metabolic pathways in Rheumatoid Arthritis

(2017) Trudy McGarry et al.   Scientific Reports

Bioenergetic Insufficiencies Due to Metabolic Alterations Regulated by the Inhibitory Receptor PD-1 Are an Early Driver of CD8 + T Cell Exhaustion

(2016) Bertram Bengsch et al.   IMMUNITY

TLR-Mediated Innate Production of IFN-γ by CD8+T Cells Is Independent of Glycolysis

(2016) Fiamma Salerno et al.   JOURNAL OF IMMUNOLOGY

Molecular and Biochemical Aspects of the PD-1 Checkpoint Pathway

(2016) Vassiliki A. Boussiotis   NEW ENGLAND JOURNAL OF MEDICINE

Distinct Metabolic Requirements of Exhausted and Functional Virus-Specific CD8 T Cells in the Same Host

(2016) Anna Schurich et al.   Cell Reports

Chronic hepatitis B: A wave of new therapies on the horizon

(2015) Timothy M. Block et al.   ANTIVIRAL RESEARCH

Aberrant expression and dysfunction of TLR2 and its soluble form in chronic HBV infection and its regulation by antiviral therapy

(2015) Zuxiong Huang et al.   ANTIVIRAL RESEARCH

Metabolic regulation of hepatitis B immunopathology by myeloid-derived suppressor cells

(2015) Laura J Pallett et al.   NATURE MEDICINE

Woodchuck hepatitis virus core antigen-based DNA and protein vaccines induce qualitatively different immune responses that affect T cell recall responses and antiviral effects

(2015) Ejuan Zhang et al.   VIROLOGY

Contribution of Toll-like receptors to the control of hepatitis B virus infection by initiating antiviral innate responses and promoting specific adaptive immune responses

(2014) Zhiyong Ma et al.   Cellular & Molecular Immunology

The immune tolerant phase of chronic HBV infection: new perspectives on an old concept

(2014) Antonio Bertoletti et al.   Cellular & Molecular Immunology

Anti-HBV DNA vaccination does not prevent relapse after discontinuation of analogues in the treatment of chronic hepatitis B: a randomised trial—ANRS HB02 VAC-ADN

(2014) H Fontaine et al.   GUT

Restoration of HBV-specific CD8+ T cell function by PD-1 blockade in inactive carrier patients is linked to T cell differentiation

(2014) Bertram Bengsch et al.   JOURNAL OF HEPATOLOGY

Toll-like receptor (TLR)-mediated innate immune responses in the control of hepatitis B virus (HBV) infection

(2014) Ejuan Zhang et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

The transcription factor BATF operates as an essential differentiation checkpoint in early effector CD8+ T cells

(2014) Makoto Kurachi et al.   NATURE IMMUNOLOGY

Enhancing Virus-Specific Immunity In Vivo by Combining Therapeutic Vaccination and PD-L1 Blockade in Chronic Hepadnaviral Infection

(2014) Jia Liu et al.   PLoS Pathogens

Metabolic Regulation of T Lymphocytes

(2013) Nancie J. MacIver et al.   Annual Review of Immunology

Interferon Regulatory Factor 4 Sustains CD8+ T Cell Expansion and Effector Differentiation

(2013) Shuyu Yao et al.   IMMUNITY

Results of a phase III clinical trial with an HBsAg-HBIG immunogenic complex therapeutic vaccine for chronic hepatitis B patients: Experiences and findings

(2013) Dao-Zhen Xu et al.   JOURNAL OF HEPATOLOGY

TLR1/2 Ligand-Stimulated Mouse Liver Endothelial Cells Secrete IL-12 and Trigger CD8+ T Cell Immunity In Vitro

(2013) J. Liu et al.   JOURNAL OF IMMUNOLOGY

Hepatitis B Virus Surface Antigen Selectively Inhibits TLR2 Ligand-Induced IL-12 Production in Monocytes/Macrophages by Interfering with JNK Activation

(2013) S. Wang et al.   JOURNAL OF IMMUNOLOGY

Novel Woodchuck Hepatitis Virus (WHV) Transgene Mouse Models Show Sex-Dependent WHV Replicative Activity and Development of Spontaneous Immune Responses to WHV Proteins

(2013) Z. Meng et al.   JOURNAL OF VIROLOGY

The transcription factor IRF4 is essential for TCR affinity–mediated metabolic programming and clonal expansion of T cells

(2013) Kevin Man et al.   NATURE IMMUNOLOGY

The Third Signal Cytokine IL-12 Rescues the Anti-Viral Function of Exhausted HBV-Specific CD8 T Cells

(2013) Anna Schurich et al.   PLoS Pathogens

Combination of DNA Prime – Adenovirus Boost Immunization with Entecavir Elicits Sustained Control of Chronic Hepatitis B in the Woodchuck Model

(2013) Anna D. Kosinska et al.   PLoS Pathogens

Role of Toll-like receptor 2 in the immune response against hepadnaviral infection

(2012) Xiaoyong Zhang et al.   JOURNAL OF HEPATOLOGY

DNA Prime-Adenovirus Boost Immunization Induces a Vigorous and Multifunctional T-Cell Response against Hepadnaviral Proteins in the Mouse and Woodchuck Model

(2012) A. D. Kosinska et al.   JOURNAL OF VIROLOGY

Metabolic checkpoints in activated T cells

(2012) Ruoning Wang et al.   NATURE IMMUNOLOGY

Innate and adaptive immune responses in chronic hepatitis B virus infections: towards restoration of immune control of viral infection

(2011) Antonio Bertoletti et al.   GUT

Transient depletion of regulatory T cells in transgenic mice reactivates virus-specific CD8+ T cells and reduces chronic retroviral set points

(2011) K. K. Dietze et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

When Toll-like receptor and T-cell receptor signals collide: a mechanism for enhanced CD8 T-cell effector function

(2010) D. Geng et al.   BLOOD

Amplifying TLR-MyD88 Signals within Tumor-Specific T Cells Enhances Antitumor Activity to Suboptimal Levels of Weakly Immunogenic Tumor Antigens

(2010) D. Geng et al.   CANCER RESEARCH

The contribution of direct TLR signaling to T cell responses

(2009) Adeeb H. Rahman et al.   IMMUNOLOGIC RESEARCH

Toll-like receptor-induced innate immune responses in non-parenchymal liver cells are cell type-specific

(2009) Jun Wu et al.   IMMUNOLOGY

TLR2 Engagement on CD8 T Cells Enables Generation of Functional Memory Cells in Response to a Suboptimal TCR Signal

(2009) B. C. Mercier et al.   JOURNAL OF IMMUNOLOGY

Immune effectors required for hepatitis B virus clearance

(2009) P. L. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expression profiles and function of Toll-like receptors 2 and 4 in peripheral blood mononuclear cells of chronic hepatitis B patients

(2008) Zhiao Chen et al.   CLINICAL IMMUNOLOGY