The E3 ubiquitin ligase Peli1 regulates the metabolic actions of mTORC1 to suppress antitumor T cell responses

Navigating metabolic pathways to enhance antitumour immunity and immunotherapy

(2019) Xiaoyun Li et al.   Nature Reviews Clinical Oncology

Autophagy Regulation of Metabolism Is Required for CD8+ T Cell Anti-tumor Immunity

(2019) Lindsay DeVorkin et al.   Cell Reports

The deubiquitinase Otub1 controls the activation of CD8+ T cells and NK cells by regulating IL-15-mediated priming

(2019) Xiaofei Zhou et al.   NATURE IMMUNOLOGY

Antitumor T-cell Reconditioning: Improving Metabolic Fitness for Optimal Cancer Immunotherapy

(2018) Dayana B. Rivadeneira et al.   CLINICAL CANCER RESEARCH

Autophagy Sustains Pancreatic Cancer Growth through Both Cell-Autonomous and Nonautonomous Mechanisms

(2018) Annan Yang et al.   Cancer Discovery

Early TCR Signaling Induces Rapid Aerobic Glycolysis Enabling Distinct Acute T Cell Effector Functions

(2018) Ashley V. Menk et al.   Cell Reports

Recent Advances in Targeting CD8 T-Cell Immunity for More Effective Cancer Immunotherapy

(2018) Aurélie Durgeau et al.   Frontiers in Immunology

LC3-Associated Phagocytosis in Myeloid Cells Promotes Tumor Immune Tolerance

(2018) Larissa D. Cunha et al.   CELL

Autophagy maintains tumour growth through circulating arginine

(2018) Laura Poillet-Perez et al.   NATURE

Metabolic pathways in T cell activation and lineage differentiation

(2016) Luís Almeida et al.   SEMINARS IN IMMUNOLOGY

mTOR: a pharmacologic target for autophagy regulation

(2015) Young Chul Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Metabolic Regulation of T Lymphocytes

(2013) Nancie J. MacIver et al.   Annual Review of Immunology

Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis

(2013) Chih-Hao Chang et al.   CELL

Identification of a candidate therapeutic autophagy-inducing peptide

(2013) Sanae Shoji-Kawata et al.   NATURE

Fueling Immunity: Insights into Metabolism and Lymphocyte Function

(2013) E. L. Pearce et al.   SCIENCE

mTOR and metabolic pathways in T cell quiescence and functional activation

(2013) Kai Yang et al.   SEMINARS IN IMMUNOLOGY

Peli: a family of signal-responsive E3 ubiquitin ligases mediating TLR signaling and T-cell tolerance

(2012) Wei Jin et al.   Cellular & Molecular Immunology

Mammalian Target of Rapamycin Integrates Diverse Inputs To Guide the Outcome of Antigen Recognition in T Cells

(2012) A. T. Waickman et al.   JOURNAL OF IMMUNOLOGY

Aerobic Glycolysis: Meeting the Metabolic Requirements of Cell Proliferation

(2011) Sophia Y. Lunt et al.   Annual Review of Cell and Developmental Biology

Regulation of T-cell survival and mitochondrial homeostasis by TSC1

(2011) Thomas F. O'Brien et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The ubiquitin ligase Peli1 negatively regulates T cell activation and prevents autoimmunity

(2011) Mikyoung Chang et al.   NATURE IMMUNOLOGY

T Cell Activation

(2009) Jennifer E. Smith-Garvin et al.   Annual Review of Immunology

Peli1 facilitates TRIF-dependent Toll-like receptor signaling and proinflammatory cytokine production

(2009) Mikyoung Chang et al.   NATURE IMMUNOLOGY

The TSC1–TSC2 complex: a molecular switchboard controlling cell growth

(2008) Jingxiang Huang et al.   BIOCHEMICAL JOURNAL

The Pellino family: IRAK E3 ligases with emerging roles in innate immune signalling

(2008) Paul N. Moynagh   TRENDS IN IMMUNOLOGY