The PI3K-Akt-mTOR pathway mediates renal pericyte-myofibroblast transition by enhancing glycolysis through HKII

Silencing of YAP attenuates pericyte‐myofibroblast transition and subretinal fibrosis in experimental model of choroidal neovascularization

(2022) Ya‐hui Xu et al.   CELL BIOLOGY INTERNATIONAL

Transition of acute kidney injury to chronic kidney disease: role of metabolic reprogramming

(2022) Zijing Zhu et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

IGFBP5 promotes diabetic kidney disease progression by enhancing PFKFB3-mediated endothelial glycolysis

(2022) Chengcheng Song et al.   Cell Death & Disease

Tubular epithelial cell-derived extracellular vesicles induce macrophage glycolysis by stabilizing HIF-1α in diabetic kidney disease

(2022) Yijie Jia et al.   MOLECULAR MEDICINE

Compromised glycolysis contributes to foot process fusion of podocytes in diabetic kidney disease: Role of ornithine catabolism

(2022) Qiang Luo et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

SOX9 is required for kidney fibrosis and activates NAV3 to drive renal myofibroblast function

(2021) Sayyid Raza et al.   Science Signaling

Activated mesangial cells induce glomerular endothelial cells proliferation in rat anti‐Thy‐1 nephritis through VEGFA/VEGFR2 and Angpt2/Tie2 pathway

(2021) Yinghua Zhao et al.   CELL PROLIFERATION

PI3K-Akt-mTOR/PFKFB3 pathway mediated lung fibroblast aerobic glycolysis and collagen synthesis in lipopolysaccharide-induced pulmonary fibrosis

(2020) Xiaoting Hu et al.   LABORATORY INVESTIGATION

Metabolic Coordination of Pericyte Phenotypes: Therapeutic Implications

(2020) Emmanuel Nwadozi et al.   Frontiers in Cell and Developmental Biology

TGF-β in renal fibrosis: triumphs and challenges

(2020) Yue-Yu Gu et al.   Future Medicinal Chemistry

Role of pyruvate kinase M2-mediated metabolic reprogramming during podocyte differentiation

(2020) Qi Yuan et al.   Cell Death & Disease

Endothelial-to-mesenchymal transition compromises vascular integrity to induce Myc-mediated metabolic reprogramming in kidney fibrosis

(2020) Sara Lovisa et al.   Science Signaling

Primary Human Fibroblasts in Culture Switch to a Myofibroblast-Like Phenotype Independently of TGF Beta

(2019) Ulrike Baranyi et al.   Cells

Sirtuin 3, Endothelial Metabolic Reprogramming, and Heart Failure With Preserved Ejection Fraction

(2019) Heng Zeng et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Metabolic reprogramming for cancer cells and their microenvironment: Beyond the Warburg Effect

(2018) Linchong Sun et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Pericyte implantation in the brain enhances cerebral blood flow and reduces amyloid-β pathology in amyloid model mice

(2018) Masaya Tachibana et al.   EXPERIMENTAL NEUROLOGY

Mitochondrial bioenergetics, redox state, dynamics and turnover alterations in renal mass reduction models of chronic kidney diseases and their possible implications in the progression of this illness

(2018) Omar Emiliano Aparicio-Trejo et al.   PHARMACOLOGICAL RESEARCH

Metabolic regulation of transcription through compartmentalized NAD+biosynthesis

(2018) Keun Woo Ryu et al.   SCIENCE

Metabolite regulates differentiation

(2018) Sophie Trefely et al.   SCIENCE

Complement Activation During Ischemia/Reperfusion Injury Induces Pericyte-to-Myofibroblast Transdifferentiation Regulating Peritubular Capillary Lumen Reduction Through pERK Signaling

(2018) Giuseppe Castellano et al.   Frontiers in Immunology

Glycolytic Switch Is Required for Transdifferentiation to Endothelial Lineage

(2018) Li Lai et al.   CIRCULATION

ROS induces epithelial‑mesenchymal transition via the TGF‑β1/PI3K/Akt/mTOR pathway in diabetic nephropathy

(2018) Qian Lu et al.   Experimental and Therapeutic Medicine

Involvement of PUMA in pericyte migration induced by methamphetamine

(2017) Yanhong Zhang et al.   EXPERIMENTAL CELL RESEARCH

Occludin regulates glucose uptake and ATP production in pericytes by influencing AMP-activated protein kinase activity

(2017) Victor Castro et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

FGF-dependent metabolic control of vascular development

(2017) Pengchun Yu et al.   NATURE

What can target kidney fibrosis?

(2017) Irina A Leaf et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

VSIG4 inhibits proinflammatory macrophage activation by reprogramming mitochondrial pyruvate metabolism

(2017) Jialin Li et al.   Nature Communications

Polo-like kinase 1 coordinates biosynthesis during cell cycle progression by directly activating pentose phosphate pathway

(2017) Xiaoyu Ma et al.   Nature Communications

Novel Mechanism of the Pericyte-Myofibroblast Transition in Renal Interstitial Fibrosis: Core Fucosylation Regulation

(2017) Nan Wang et al.   Scientific Reports

Inhibition of the Glycolytic Activator PFKFB3 in Endothelium Induces Tumor Vessel Normalization, Impairs Metastasis, and Improves Chemotherapy

(2016) Anna Rita Cantelmo et al.   CANCER CELL

Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming

(2016) Michael D. Buck et al.   CELL

Metabolic reprogramming during neuronal differentiation

(2016) M Agostini et al.   CELL DEATH AND DIFFERENTIATION

Proliferation, survival and metabolism: the role of PI3K/AKT/mTOR signalling in pluripotency and cell fate determination

(2016) Jason S. L. Yu et al.   DEVELOPMENT

Transforming growth factor beta 1, a cytokine with regenerative functions

(2016) Wale Sulaiman et al.   Neural Regeneration Research

Inhibition of Aerobic Glycolysis Attenuates Disease Progression in Polycystic Kidney Disease

(2016) Meliana Riwanto et al.   PLoS One

Metabolic Reprogramming Is Required for Myofibroblast Contractility and Differentiation

(2015) Karen Bernard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Origin of myofibroblasts and cellular events triggering fibrosis

(2015) Matthias Mack et al.   KIDNEY INTERNATIONAL

Cell line dependence of metabolite leakage in metabolome analyses of adherent normal and cancer cell lines

(2015) Rahul Vijay Kapoore et al.   Metabolomics

Fatty acid carbon is essential for dNTP synthesis in endothelial cells

(2015) Sandra Schoors et al.   NATURE

Diverse origins of the myofibroblast—implications for kidney fibrosis

(2015) Lucas L. Falke et al.   Nature Reviews Nephrology

TGF-β/Smad signaling in renal fibrosis

(2015) Xiao-Ming Meng et al.   Frontiers in Physiology

Translational Profiles of Medullary Myofibroblasts during Kidney Fibrosis

(2014) I. Grgic et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Plk1 Phosphorylation of PTEN Causes a Tumor-Promoting Metabolic State

(2014) Z. Li et al.   MOLECULAR AND CELLULAR BIOLOGY

Kidney Pericytes: Roles in Regeneration and Fibrosis

(2014) Rafael Kramann et al.   SEMINARS IN NEPHROLOGY

Cellular Mechanisms of Tissue Fibrosis. 3. Novel mechanisms of kidney fibrosis

(2013) Gabriela Campanholle et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Role of PFKFB3-Driven Glycolysis in Vessel Sprouting

(2013) Katrien De Bock et al.   CELL

Leptin Attenuates Cerebral Ischemia Injury through the Promotion of Energy Metabolism via the PI3K/Akt Pathway

(2013) Jinying Zhang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

LRP-6 is a coreceptor for multiple fibrogenic signaling pathways in pericytes and myofibroblasts that are inhibited by DKK-1

(2013) Shuyu Ren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transforming Growth Factor β-1 Stimulates Profibrotic Epithelial Signaling to Activate Pericyte-Myofibroblast Transition in Obstructive Kidney Fibrosis

(2012) Ching-Fang Wu et al.   AMERICAN JOURNAL OF PATHOLOGY

Lactic Acid Is Elevated in Idiopathic Pulmonary Fibrosis and Induces Myofibroblast Differentiation via pH-Dependent Activation of Transforming Growth Factor-β

(2012) Robert Matthew Kottmann et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Diverse Roles of TGF-β/Smads in Renal Fibrosis and Inflammation

(2012) Hui Yao Lan   International Journal of Biological Sciences

Pericyte TIMP3 and ADAMTS1 Modulate Vascular Stability after Kidney Injury

(2012) C. Schrimpf et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

TGF-β/Smad Signaling in Kidney Disease

(2012) Hui Y. Lan et al.   SEMINARS IN NEPHROLOGY

Targeting Endothelium-Pericyte Cross Talk by Inhibiting VEGF Receptor Signaling Attenuates Kidney Microvascular Rarefaction and Fibrosis

(2011) Shuei-Liong Lin et al.   AMERICAN JOURNAL OF PATHOLOGY

Pericytes: Developmental, Physiological, and Pathological Perspectives, Problems, and Promises

(2011) Annika Armulik et al.   DEVELOPMENTAL CELL

Platelet-derived growth factor receptor signaling activates pericyte–myofibroblast transition in obstructive and post-ischemic kidney fibrosis

(2011) Yi-Ting Chen et al.   KIDNEY INTERNATIONAL

Origin of new cells in the adult kidney: results from genetic labeling techniques

(2010) Jeremy S. Duffield et al.   KIDNEY INTERNATIONAL

Fate Tracing Reveals the Pericyte and Not Epithelial Origin of Myofibroblasts in Kidney Fibrosis

(2009) Benjamin D. Humphreys et al.   AMERICAN JOURNAL OF PATHOLOGY

Pericytes and Perivascular Fibroblasts Are the Primary Source of Collagen-Producing Cells in Obstructive Fibrosis of the Kidney

(2008) Shuei-Liong Lin et al.   AMERICAN JOURNAL OF PATHOLOGY