Chromatin bridges: stochastic breakage or regulated resolution?

Antecedent chromatin organization determines cGAS recruitment to ruptured micronuclei

(2023) Kate M. MacDonald et al.   Nature Communications

ERα-associated translocations underlie oncogene amplifications in breast cancer

(2023) Jake June-Koo Lee et al.   NATURE

Mitotic clustering of pulverized chromosomes from micronuclei

(2023) Yu-Fen Lin et al.   NATURE

Epigenetic dysregulation from chromosomal transit in micronuclei

(2023) Albert S. Agustinus et al.   NATURE

Mitotic tethering enables inheritance of shattered micronuclear chromosomes

(2023) Prasad Trivedi et al.   NATURE

Biochemical and mechanistic analysis of the cleavage of branched DNA by human ANKLE1

(2023) Alasdair D J Freeman et al.   NUCLEIC ACIDS RESEARCH

Short-term molecular consequences of chromosome mis-segregation for genome stability

(2023) Lorenza Garribba et al.   Nature Communications

The abscission checkpoint senses chromatin bridges through Top2α recruitment to DNA knots

(2023) Eleni Petsalaki et al.   JOURNAL OF CELL BIOLOGY

NBS1-CtIP–mediated DNA end resection suppresses cGAS binding to micronuclei

(2022) Salim Abdisalaam et al.   NUCLEIC ACIDS RESEARCH

Breakage of cytoplasmic chromosomes by pathological DNA base excision repair

(2022) Shangming Tang et al.   NATURE

ER-directed TREX1 limits cGAS activation at micronuclei

(2021) Lisa Mohr et al.   MOLECULAR CELL

The Last Chance Saloon

(2021) Ye Hong et al.   Frontiers in Cell and Developmental Biology

Compromised nuclear envelope integrity drives TREX1-dependent DNA damage and tumor cell invasion

(2021) Guilherme Pedreira de Freitas Nader et al.   CELL

Regulation of mitotic chromosome architecture and resolution of ultrafine anaphase bridges by PICH

(2021) Primrose Chanboonyasitt et al.   CELL CYCLE

Chromatin bridges, not micronuclei, activate cGAS after drug-induced mitotic errors in human cells

(2021) Patrick J. Flynn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing

(2020) Isidro Cortés-Ciriano et al.   NATURE GENETICS

Molecular mechanisms and cellular functions of cGAS–STING signalling

(2020) Karl-Peter Hopfner et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanisms generating cancer genome complexity from a single cell division error

(2020) Neil T. Umbreit et al.   SCIENCE

Nuclear Membrane Rupture and Its Consequences

(2020) John Maciejowski et al.   Annual Review of Cell and Developmental Biology

APOBEC3-dependent kataegis and TREX1-driven chromothripsis during telomere crisis

(2020) John Maciejowski et al.   NATURE GENETICS

Anaphase Bridges: Not All Natural Fibers Are Healthy

(2020) Alice Finardi et al.   Genes

Structural basis for nucleosome-mediated inhibition of cGAS activity

(2020) Duanfang Cao et al.   CELL RESEARCH

Cancer‐associated mutations in the condensin II subunit CAPH2 cause genomic instability through telomere dysfunction and anaphase chromosome bridges

(2020) Emily Weyburne et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Human ANKLE1 Is a Nuclease Specific for Branched DNA

(2020) Junfang Song et al.   JOURNAL OF MOLECULAR BIOLOGY

The Molecular Basis of Tight Nuclear Tethering and Inactivation of cGAS

(2020) Baoyu Zhao et al.   NATURE

Structural basis for sequestration and autoinhibition of cGAS by chromatin

(2020) Sebastian Michalski et al.   NATURE

Structural basis for the inhibition of cGAS by nucleosomes

(2020) Tomoya Kujirai et al.   SCIENCE

Structural basis of nucleosome-dependent cGAS inhibition

(2020) Joshua A. Boyer et al.   SCIENCE

Chromothripsis drives the evolution of gene amplification in cancer

(2020) Ofer Shoshani et al.   NATURE

Chromosome segregation errors generate a diverse spectrum of simple and complex genomic rearrangements

(2019) Peter Ly et al.   NATURE GENETICS

The RIF1-PP1 Axis Controls Abscission Timing in Human Cells

(2019) Rahul Bhowmick et al.   CURRENT BIOLOGY

Chromosomal Instability in Tumor Initiation and Development

(2019) Duc-Hiep Bach et al.   CANCER RESEARCH

Rescue of DNA damage after constricted migration reveals a mechano-regulated threshold for cell cycle

(2019) Yuntao Xia et al.   JOURNAL OF CELL BIOLOGY

Condensin-Mediated Chromosome Folding and Internal Telomeres Drive Dicentric Severing by Cytokinesis

(2019) Thomas M. Guérin et al.   MOLECULAR CELL

Micronuclei-based model system reveals functional consequences of chromothripsis in human cells

(2019) Maja Kneissig et al.   eLife

Anaphase: a fortune-teller of genomic instability

(2018) Anna H Bizard et al.   CURRENT OPINION IN CELL BIOLOGY

LEM-3 is a midbody-tethered DNA nuclease that resolves chromatin bridges during late mitosis

(2018) Ye Hong et al.   Nature Communications

53BP1 can limit sister-chromatid rupture and rearrangements driven by a distinct ultrafine DNA bridging-breakage process

(2018) Ankana Tiwari et al.   Nature Communications

The conserved LEM-3/Ankle1 nuclease is involved in the combinatorial regulation of meiotic recombination repair and chromosome segregation in Caenorhabditis elegans

(2018) Ye Hong et al.   PLoS Genetics

The dark side of centromeres: types, causes and consequences of structural abnormalities implicating centromeric DNA

(2018) V. Barra et al.   Nature Communications

cGAS surveillance of micronuclei links genome instability to innate immunity

(2017) Karen J. Mackenzie et al.   NATURE

Mitotic progression following DNA damage enables pattern recognition within micronuclei

(2017) Shane M. Harding et al.   NATURE

Cytoplasmic chromatin triggers inflammation in senescence and cancer

(2017) Zhixun Dou et al.   NATURE

Unresolved recombination intermediates lead to ultra-fine anaphase bridges, chromosome breaks and aberrations

(2017) Ying Wai Chan et al.   NATURE CELL BIOLOGY

Actomyosin drives cancer cell nuclear dysmorphia and threatens genome stability

(2017) Tohru Takaki et al.   Nature Communications

Mutations in genes encoding condensin complex proteins cause microcephaly through decatenation failure at mitosis

(2016) Carol-Anne Martin et al.   GENES & DEVELOPMENT

Selective Y centromere inactivation triggers chromosome shattering in micronuclei and repair by non-homologous end joining

(2016) Peter Ly et al.   NATURE CELL BIOLOGY

The Aurora-B-dependent NoCut checkpoint prevents damage of anaphase bridges after DNA replication stress

(2016) Nuno Amaral et al.   NATURE CELL BIOLOGY

Chromothripsis and Kataegis Induced by Telomere Crisis

(2015) John Maciejowski et al.   CELL

Cytokinesis breaks dicentric chromosomes preferentially at pericentromeric regions and telomere fusions

(2015) Virginia Lopez et al.   GENES & DEVELOPMENT

Cutting Edge: cGAS Is Required for Lethal Autoimmune Disease in the Trex1-Deficient Mouse Model of Aicardi–Goutières Syndrome

(2015) Elizabeth E. Gray et al.   JOURNAL OF IMMUNOLOGY

Chromothripsis from DNA damage in micronuclei

(2015) Cheng-Zhong Zhang et al.   NATURE

Exonuclease TREX1 degrades double-stranded DNA to prevent spontaneous lupus-like inflammatory disease

(2015) Jessica L. Grieves et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Checkpoints are blind to replication restart and recombination intermediates that result in gross chromosomal rearrangements

(2015) Saed Mohebi et al.   Nature Communications

PICH promotes sister chromatid disjunction and co-operates with topoisomerase II in mitosis

(2015) Christian F. Nielsen et al.   Nature Communications

C. eleganswhole-genome sequencing reveals mutational signatures related to carcinogens and DNA repair deficiency

(2014) Bettina Meier et al.   GENOME RESEARCH

Catastrophic Nuclear Envelope Collapse in Cancer Cell Micronuclei

(2013) Emily M. Hatch et al.   CELL

Cyclic GMP-AMP Synthase Is an Innate Immune Sensor of HIV and Other Retroviruses

(2013) D. Gao et al.   SCIENCE

Chromothripsis and Focal Copy Number Alterations Determine Poor Outcome in Malignant Melanoma

(2012) D. Hirsch et al.   CANCER RESEARCH

Enzymatic Removal of Ribonucleotides from DNA Is Essential for Mammalian Genome Integrity and Development

(2012) Martin A.M. Reijns et al.   CELL

Genome Sequencing of Pediatric Medulloblastoma Links Catastrophic DNA Rearrangements with TP53 Mutations

(2012) Tobias Rausch et al.   CELL

The endonuclease Ankle1 requires its LEM and GIY-YIG motifs for DNA cleavage in vivo

(2012) Andreas Brachner et al.   JOURNAL OF CELL SCIENCE

Recombination-restarted replication makes inverted chromosome fusions at inverted repeats

(2012) Ken’Ichi Mizuno et al.   NATURE

Sequencing of neuroblastoma identifies chromothripsis and defects in neuritogenesis genes

(2012) Jan J. Molenaar et al.   NATURE

The BLM helicase contributes to telomere maintenance through processing of late-replicating intermediate structures

(2012) Colleen Barefield et al.   NUCLEIC ACIDS RESEARCH

LEM-3 – A LEM Domain Containing Nuclease Involved in the DNA Damage Response in C. elegans

(2012) Christina M. Dittrich et al.   PLoS One

ESCRT-III Governs the Aurora B-Mediated Abscission Checkpoint Through CHMP4C

(2012) J. G. Carlton et al.   SCIENCE

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

(2012) L. Sun et al.   SCIENCE

Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer Development

(2011) Philip J. Stephens et al.   CELL

Chromosome Segregation Errors as a Cause of DNA Damage and Structural Chromosome Aberrations

(2011) A. Janssen et al.   SCIENCE

Interactions Between Nuclei and the Cytoskeleton Are Mediated by SUN-KASH Nuclear-Envelope Bridges

(2010) Daniel A. Starr et al.   Annual Review of Cell and Developmental Biology

Micropatterning as a tool to decipher cell morphogenesis and functions

(2010) M. Thery   JOURNAL OF CELL SCIENCE

Aurora B-Mediated Abscission Checkpoint Protects against Tetraploidization

(2009) Patrick Steigemann et al.   CELL

Nearby inverted repeats fuse to generate acentric and dicentric palindromic chromosomes by a replication template exchange mechanism

(2009) K. Mizuno et al.   GENES & DEVELOPMENT

Replication stress induces sister-chromatid bridging at fragile site loci in mitosis

(2009) Kok Lung Chan et al.   NATURE CELL BIOLOGY

Trex1 Prevents Cell-Intrinsic Initiation of Autoimmunity

(2008) Daniel B. Stetson et al.   CELL

The TREX1 Double-stranded DNA Degradation Activity Is Defective in Dominant Mutations Associated with Autoimmune Disease

(2008) Duane A. Lehtinen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY