Cancer‐associated mutations in the condensin II subunit CAPH2 cause genomic instability through telomere dysfunction and anaphase chromosome bridges

Mechanisms generating cancer genome complexity from a single cell division error

(2020) Neil T. Umbreit et al.   SCIENCE

Tumor suppressor MCPH1 regulates gene expression profiles related to malignant conversion and chromosomal assembly

(2019) Anna Tervasmäki et al.   INTERNATIONAL JOURNAL OF CANCER

Condensin II subunit NCAPH2 associates with shelterin protein TRF1 and is required for telomere stability

(2019) Heather A. Wallace et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The emerging links between chromosomal instability (CIN), metastasis, inflammation and tumour immunity

(2019) Andréa E. Tijhuis et al.   Molecular Cytogenetics

Diminished Condensin Gene Expression Drives Chromosome Instability That May Contribute to Colorectal Cancer Pathogenesis

(2019) Allison K. Baergen et al.   Cancers

A pathway for mitotic chromosome formation

(2018) Johan H. Gibcus et al.   SCIENCE

MukB ATPases are regulated independently by the N- and C-terminal domains of MukF kleisin

(2018) Katarzyna Zawadzka et al.   eLife

Shelterin-Mediated Telomere Protection

(2018) Titia de Lange   Annual Review of Genetics

PARP2 controls double-strand break repair pathway choice by limiting 53BP1 accumulation at DNA damage sites and promoting end-resection

(2017) Alexis Fouquin et al.   NUCLEIC ACIDS RESEARCH

Structural and functional analysis of the human POT1-TPP1 telomeric complex

(2017) Cory Rice et al.   Nature Communications

BRCA1 Directs the Repair Pathway to Homologous Recombination by Promoting 53BP1 Dephosphorylation

(2017) Mayu Isono et al.   Cell Reports

Chromosomal Instability as a Driver of Tumor Heterogeneity and Evolution

(2017) Samuel F. Bakhoum et al.   Cold Spring Harbor Perspectives in Medicine

Plk1 phosphorylation of CAP-H2 triggers chromosome condensation by condensin II at the early phase of mitosis

(2017) Yuya Kagami et al.   Scientific Reports

Oligomerization and ATP stimulate condensin-mediated DNA compaction

(2017) Ross A. Keenholtz et al.   Scientific Reports

Condensin-Based Chromosome Organization from Bacteria to Vertebrates

(2016) Tatsuya Hirano   CELL

Mutations in genes encoding condensin complex proteins cause microcephaly through decatenation failure at mitosis

(2016) Carol-Anne Martin et al.   GENES & DEVELOPMENT

Condensin II mutation causes T-cell lymphoma through tissue-specific genome instability

(2016) Jessica Woodward et al.   GENES & DEVELOPMENT

NCAPG2 promotes tumour proliferation by regulating G2/M phase and associates with poor prognosis in lung adenocarcinoma

(2016) Ping Zhan et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Human BRCA1–BARD1 ubiquitin ligase activity counteracts chromatin barriers to DNA resection

(2016) Ruth M Densham et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Human BRCA1–BARD1 ubiquitin ligase activity counteracts chromatin barriers to DNA resection

(2016) Ruth M Densham et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

SMC4, which is essentially involved in lung development, is associated with lung adenocarcinoma progression

(2016) Chengli Zhang et al.   Scientific Reports

Chromothripsis from DNA damage in micronuclei

(2015) Cheng-Zhong Zhang et al.   NATURE

Involvement of ATM in homologous recombination after end resection and RAD51 nucleofilament formation

(2015) A. Bakr et al.   NUCLEIC ACIDS RESEARCH

ATM and ATR as therapeutic targets in cancer

(2015) Anika Maria Weber et al.   PHARMACOLOGY & THERAPEUTICS

Condensin targets and reduces unwound DNA structures associated with transcription in mitotic chromosome condensation

(2015) Takashi Sutani et al.   Nature Communications

Cell cycle-dependent inhibition of 53BP1 signaling by BRCA1

(2015) Lin Feng et al.   Cell Discovery

Inactivation of SMC2 shows a synergistic lethal response inMYCN-amplified neuroblastoma cells

(2014) Yuko Murakami-Tonami et al.   CELL CYCLE

A novel miR-219-SMC4-JAK2/Stat3 regulatory pathway in human hepatocellular carcinoma

(2014) Bo Zhou et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Pan-cancer network analysis identifies combinations of rare somatic mutations across pathways and protein complexes

(2014) Mark D M Leiserson et al.   NATURE GENETICS

Association of condensin with chromosomes depends on DNA binding by its HEAT-repeat subunits

(2014) Ilaria Piazza et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Haploinsufficiency of an RB-E2F1-Condensin II Complex Leads to Aberrant Replication and Aneuploidy

(2014) C. H. Coschi et al.   Cancer Discovery

Condensins are Required for Maintenance of Nuclear Architecture

(2014) Carolyn George et al.   Cells

Catastrophic Nuclear Envelope Collapse in Cancer Cell Micronuclei

(2013) Emily M. Hatch et al.   CELL

Chromothripsis and beyond: rapid genome evolution from complex chromosomal rearrangements

(2013) C.-Z. Zhang et al.   GENES & DEVELOPMENT

NUP214-ABL1-mediated cell proliferation in T-cell acute lymphoblastic leukemia is dependent on the LCK kinase and various interacting proteins

(2013) K. De Keersmaecker et al.   HAEMATOLOGICA

Replication stress links structural and numerical cancer chromosomal instability

(2013) Rebecca A. Burrell et al.   NATURE

The causes and consequences of genetic heterogeneity in cancer evolution

(2013) Rebecca A. Burrell et al.   NATURE

An asymmetric SMC–kleisin bridge in prokaryotic condensin

(2013) Frank Bürmann et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Primary Microcephaly Gene MCPH1 Shows Signatures of Tumor Suppressors and Is Regulated by miR-27a in Oral Squamous Cell Carcinoma

(2013) Thejaswini Venkatesh et al.   PLoS One

53BP1: pro choice in DNA repair

(2013) Michal Zimmermann et al.   TRENDS IN CELL BIOLOGY

DNA Damage Sensing by the ATM and ATR Kinases

(2013) A. Marechal et al.   Cold Spring Harbor Perspectives in Biology

Multiple Structural Maintenance of Chromosome Complexes at Transcriptional Regulatory Elements

(2013) Jill M. Dowen et al.   Stem Cell Reports

Using DNA as a Fiducial Marker To Study SMC Complex Interactions with the Atomic Force Microscope

(2012) M.E. Fuentes-Perez et al.   BIOPHYSICAL JOURNAL

Human telomere disease due to disruption of the CCAAT box of the TERC promoter

(2012) A. M. Aalbers et al.   BLOOD

RTEL1 Dismantles T Loops and Counteracts Telomeric G4-DNA to Maintain Telomere Integrity

(2012) Jean-Baptiste Vannier et al.   CELL

Human SMC2 Protein, a Core Subunit of Human Condensin Complex, Is a Novel Transcriptional Target of the WNT Signaling Pathway and a New Therapeutic Target

(2012) Verónica Dávalos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Contrasting roles of condensin I and condensin II in mitotic chromosome formation

(2012) L. C. Green et al.   JOURNAL OF CELL SCIENCE

DNA breaks and chromosome pulverization from errors in mitosis

(2012) Karen Crasta et al.   NATURE

Overexpression of the structural maintenance of chromosome 4 protein is associated with tumor de-differentiation, advanced stage and vascular invasion of primary liver cancer

(2012) BO ZHOU et al.   ONCOLOGY REPORTS

Condensin II Promotes the Formation of Chromosome Territories by Inducing Axial Compaction of Polyploid Interphase Chromosomes

(2012) Christopher R. Bauer et al.   PLoS Genetics

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Condensin dysfunction in human cells induces nonrandom chromosomal breaks in anaphase, with distinct patterns for both unique and repeated genomic regions

(2011) Alexander Samoshkin et al.   CHROMOSOMA

MCPH1 regulates chromosome condensation and shaping as a composite modulator of condensin II

(2011) Daisuke Yamashita et al.   JOURNAL OF CELL BIOLOGY

Telomere Protection by TPP1/POT1 Requires Tethering to TIN2

(2011) Kaori K. Takai et al.   MOLECULAR CELL

High Cleavage Efficiency of a 2A Peptide Derived from Porcine Teschovirus-1 in Human Cell Lines, Zebrafish and Mice

(2011) Jin Hee Kim et al.   PLoS One

Chromosome Segregation Errors as a Cause of DNA Damage and Structural Chromosome Aberrations

(2011) A. Janssen et al.   SCIENCE

Loss of pRB causes centromere dysfunction and chromosomal instability

(2010) A. L. Manning et al.   GENES & DEVELOPMENT

DNA damage signaling in response to double-strand breaks during mitosis

(2010) Simona Giunta et al.   JOURNAL OF CELL BIOLOGY

Molecular mechanisms of micronucleus, nucleoplasmic bridge and nuclear bud formation in mammalian and human cells

(2010) M. Fenech et al.   MUTAGENESIS

Structural Studies of a Bacterial Condensin Complex Reveal ATP-Dependent Disruption of Intersubunit Interactions

(2009) Jae-Sung Woo et al.   CELL

Mammalian Telomeres Resemble Fragile Sites and Require TRF1 for Efficient Replication

(2009) Agnel Sfeir et al.   CELL

Spontaneous occurrence of telomeric DNA damage response in the absence of chromosome fusions

(2009) Anthony J Cesare et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

RBF1 promotes chromatin condensation through a conserved interaction with the Condensin II protein dCAP-D3

(2008) M. S. Longworth et al.   GENES & DEVELOPMENT

Examining the link between chromosomal instability and aneuploidy in human cells

(2008) Sarah L. Thompson et al.   JOURNAL OF CELL BIOLOGY

MukB acts as a macromolecular clamp in DNA condensation

(2008) Yuanbo Cui et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

PROMALS3D: a tool for multiple protein sequence and structure alignments

(2008) Jimin Pei et al.   NUCLEIC ACIDS RESEARCH

Condensin II Resolves Chromosomal Associations to Enable Anaphase I Segregation in Drosophila Male Meiosis

(2008) Tom A. Hartl et al.   PLoS Genetics