ER-directed TREX1 limits cGAS activation at micronuclei

BAF facilitates interphase nuclear membrane repair through recruitment of nuclear transmembrane proteins

(2020) Alexandra M. Young et al.   MOLECULAR BIOLOGY OF THE CELL

Mechanisms generating cancer genome complexity from a single cell division error

(2020) Neil T. Umbreit et al.   SCIENCE

Nuclear Membrane Rupture and Its Consequences

(2020) John Maciejowski et al.   Annual Review of Cell and Developmental Biology

Unrestrained ESCRT-III drives micronuclear catastrophe and chromosome fragmentation

(2020) Marina Vietri et al.   NATURE CELL BIOLOGY

APOBEC3-dependent kataegis and TREX1-driven chromothripsis during telomere crisis

(2020) John Maciejowski et al.   NATURE GENETICS

The N-Terminal Domain of cGAS Determines Preferential Association with Centromeric DNA and Innate Immune Activation in the Nucleus

(2019) Matteo Gentili et al.   Cell Reports

cGAS in action: Expanding roles in immunity and inflammation

(2019) Andrea Ablasser et al.   SCIENCE

Chromosome segregation errors generate a diverse spectrum of simple and complex genomic rearrangements

(2019) Peter Ly et al.   NATURE GENETICS

Characterizing Mutational Signatures in Human Cancer Cell Lines Reveals Episodic APOBEC Mutagenesis

(2019) Mia Petljak et al.   CELL

A bioactive mammalian disaccharide associated with autoimmunity activates STING-TBK1-dependent immune response

(2019) Charles S. Fermaintt et al.   Nature Communications

ESCRT-III is necessary for the integrity of the nuclear envelope in micronuclei but is aberrant at ruptured micronuclear envelopes generating damage

(2019) Jessica Willan et al.   Oncogenesis

The Cytoplasmic DNA Sensor cGAS Promotes Mitotic Cell Death

(2019) Christian Zierhut et al.   CELL

Repair of nuclear ruptures requires barrier-to-autointegration factor

(2019) Charles T. Halfmann et al.   JOURNAL OF CELL BIOLOGY

T Cells Produce IFN-α in the TREX1 D18N Model of Lupus-like Autoimmunity

(2019) Sean R. Simpson et al.   JOURNAL OF IMMUNOLOGY

Tight nuclear tethering of cGAS is essential for preventing autoreactivity

(2019) Hannah E Volkman et al.   eLife

Structure of the Human cGAS–DNA Complex Reveals Enhanced Control of Immune Surveillance

(2018) Wen Zhou et al.   CELL

Chromosomal instability drives metastasis through a cytosolic DNA response

(2018) Samuel F. Bakhoum et al.   NATURE

DNA-induced liquid phase condensation of cGAS activates innate immune signaling

(2018) Mingjian Du et al.   SCIENCE

Nuclear rupture at sites of high curvature compromises retention of DNA repair factors

(2018) Yuntao Xia et al.   JOURNAL OF CELL BIOLOGY

Nuclear envelope assembly defects link mitotic errors to chromothripsis

(2018) Shiwei Liu et al.   NATURE

The molecular origins and pathophysiological consequences of micronuclei: New insights into an age-old problem

(2018) Xihan Guo et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

The many ways tissue phagocytes respond to dying cells

(2017) J. Magarian Blander   IMMUNOLOGICAL REVIEWS

Immune Diseases Associated with TREX1 and STING Dysfunction

(2017) Nan Yan   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Molecular Responses of Human Retinal Cells to Infection with Dengue Virus

(2017) Jillian M. Carr et al.   MEDIATORS OF INFLAMMATION

cGAS surveillance of micronuclei links genome instability to innate immunity

(2017) Karen J. Mackenzie et al.   NATURE

Mitotic progression following DNA damage enables pattern recognition within micronuclei

(2017) Shane M. Harding et al.   NATURE

Cytoplasmic chromatin triggers inflammation in senescence and cancer

(2017) Zhixun Dou et al.   NATURE

Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence

(2017) Selene Glück et al.   NATURE CELL BIOLOGY

Live-cell measurements of kinase activity in single cells using translocation reporters

(2017) Takamasa Kudo et al.   Nature Protocols

cGAS is essential for cellular senescence

(2017) Hui Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

STIM1 promotes migration, phagosomal maturation and antigen cross-presentation in dendritic cells

(2017) Paula Nunes-Hasler et al.   Nature Communications

Mitotic Phosphorylation of TREX1 C Terminus Disrupts TREX1 Regulation of the Oligosaccharyltransferase Complex

(2017) Martin Kucej et al.   Cell Reports

Permanganate/S1 Nuclease Footprinting Reveals Non-B DNA Structures with Regulatory Potential across a Mammalian Genome

(2017) Fedor Kouzine et al.   Cell Systems

HELB Is a Feedback Inhibitor of DNA End Resection

(2016) Ján Tkáč et al.   MOLECULAR CELL

Selective Y centromere inactivation triggers chromosome shattering in micronuclei and repair by non-homologous end joining

(2016) Peter Ly et al.   NATURE CELL BIOLOGY

ESCRT III repairs nuclear envelope ruptures during cell migration to limit DNA damage and cell death

(2016) M. Raab et al.   SCIENCE

Nuclear envelope rupture and repair during cancer cell migration

(2016) C. M. Denais et al.   SCIENCE

RPA and Rad51 constitute a cell intrinsic mechanism to protect the cytosol from self DNA

(2016) Christine Wolf et al.   Nature Communications

Chromothripsis and Kataegis Induced by Telomere Crisis

(2015) John Maciejowski et al.   CELL

Cytosolic Nuclease TREX1 Regulates Oligosaccharyltransferase Activity Independent of Nuclease Activity to Suppress Immune Activation

(2015) Maroof Hasan et al.   IMMUNITY

Cutting Edge: cGAS Is Required for Lethal Autoimmune Disease in the Trex1-Deficient Mouse Model of Aicardi–Goutières Syndrome

(2015) Elizabeth E. Gray et al.   JOURNAL OF IMMUNOLOGY

Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression

(2015) Benjamin A. Diner et al.   MOLECULAR & CELLULAR PROTEOMICS

Chromothripsis from DNA damage in micronuclei

(2015) Cheng-Zhong Zhang et al.   NATURE

Exonuclease TREX1 degrades double-stranded DNA to prevent spontaneous lupus-like inflammatory disease

(2015) Jessica L. Grieves et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation

(2015) S. Liu et al.   SCIENCE

TREX1 Deficiency Triggers Cell-Autonomous Immunity in a cGAS-Dependent Manner

(2014) A. Ablasser et al.   JOURNAL OF IMMUNOLOGY

Signalling dynamics in the spindle checkpoint response

(2014) Nitobe London et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structure-Function Analysis of STING Activation by c[G(2′,5′)pA(3′,5′)p] and Targeting by Antiviral DMXAA

(2013) Pu Gao et al.   CELL

Catastrophic Nuclear Envelope Collapse in Cancer Cell Micronuclei

(2013) Emily M. Hatch et al.   CELL

cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING

(2013) Andrea Ablasser et al.   NATURE

Structural mechanism of cytosolic DNA sensing by cGAS

(2013) Filiz Civril et al.   NATURE

Structure of Human cGAS Reveals a Conserved Family of Second-Messenger Enzymes in Innate Immunity

(2013) Philip J. Kranzusch et al.   Cell Reports

The Innate Immune DNA Sensor cGAS Produces a Noncanonical Cyclic Dinucleotide that Activates Human STING

(2013) Elie J. Diner et al.   Cell Reports

DNA breaks and chromosome pulverization from errors in mitosis

(2012) Karen Crasta et al.   NATURE

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

(2012) L. Sun et al.   SCIENCE

Transient nuclear envelope rupturing during interphase in human cancer cells

(2012) Jesse D. Vargas et al.   Nucleus

Dominant Mutations of the TREX1 Exonuclease Gene in Lupus and Aicardi-Goutières Syndrome

(2011) Jason M. Fye et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Telomere Protection by TPP1/POT1 Requires Tethering to TIN2

(2011) Kaori K. Takai et al.   MOLECULAR CELL

Dissecting the role of MPS1 in chromosome biorientation and the spindle checkpoint through the small molecule inhibitor reversine

(2010) Stefano Santaguida et al.   JOURNAL OF CELL BIOLOGY

The DNA Damage Response: Making It Safe to Play with Knives

(2010) Alberto Ciccia et al.   MOLECULAR CELL

The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1

(2010) Nan Yan et al.   NATURE IMMUNOLOGY

STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

(2009) Hiroki Ishikawa et al.   NATURE

A Versatile Viral System for Expression and Depletion of Proteins in Mammalian Cells

(2009) Eric Campeau et al.   PLoS One

Trex1 Prevents Cell-Intrinsic Initiation of Autoimmunity

(2008) Daniel B. Stetson et al.   CELL

The TREX1 Double-stranded DNA Degradation Activity Is Defective in Dominant Mutations Associated with Autoimmune Disease

(2008) Duane A. Lehtinen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

(2008) Hiroki Ishikawa et al.   NATURE