The dark side of centromeres: types, causes and consequences of structural abnormalities implicating centromeric DNA

Simple and Complex Centromeric Satellites inDrosophilaSibling Species

(2018) Paul B. Talbert et al.   GENETICS

Simple and Complex Centromeric Satellites inDrosophilaSibling Species

(2018) Paul B. Talbert et al.   GENETICS

Essential role for centromeric factors following p53 loss and oncogenic transformation

(2017) Dan Filipescu et al.   GENES & DEVELOPMENT

Integrity of the human centromere DNA repeats is protected by CENP-A, CENP-C, and CENP-T

(2017) Simona Giunta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A mitosis-specific and R loop–driven ATR pathway promotes faithful chromosome segregation

(2017) Lilian Kabeche et al.   SCIENCE

Mislocalization of centromeric histone H3 variant CENP-A contributes to chromosomal instability (CIN) in human cells

(2017) Roshan L. Shrestha et al.   Oncotarget

Elevated expression of the centromere protein-A(CENP-A)-encoding gene as a prognostic and predictive biomarker in human cancers

(2016) Xia Sun et al.   INTERNATIONAL JOURNAL OF CANCER

Centromeric DNA replication reconstitution reveals DNA loops and ATR checkpoint suppression

(2016) Antoine Aze et al.   NATURE CELL BIOLOGY

Mechanisms underlying structural variant formation in genomic disorders

(2016) Claudia M. B. Carvalho et al.   NATURE REVIEWS GENETICS

Repression of harmful meiotic recombination in centromeric regions

(2016) Mridula Nambiar et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

CENP-A Is Dispensable for Mitotic Centromere Function after Initial Centromere/Kinetochore Assembly

(2016) Sebastian Hoffmann et al.   Cell Reports

CENP-A Ubiquitylation Is Inherited through Dimerization between Cell Divisions

(2016) Yohei Niikura et al.   Cell Reports

Chromothripsis and Kataegis Induced by Telomere Crisis

(2015) John Maciejowski et al.   CELL

Linking replication stress with heterochromatin formation

(2015) Ivaylo Nikolov et al.   CHROMOSOMA

Rif1 Is Required for Resolution of Ultrafine DNA Bridges in Anaphase to Ensure Genomic Stability

(2015) Rutger C.C. Hengeveld et al.   DEVELOPMENTAL CELL

DNA Sequence-Specific Binding of CENP-B Enhances the Fidelity of Human Centromere Function

(2015) Daniele Fachinetti et al.   DEVELOPMENTAL CELL

Cytokinesis breaks dicentric chromosomes preferentially at pericentromeric regions and telomere fusions

(2015) Virginia Lopez et al.   GENES & DEVELOPMENT

The molecular basis for centromere identity and function

(2015) Kara L. McKinley et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mutations in CDCA7 and HELLS cause immunodeficiency–centromeric instability–facial anomalies syndrome

(2015) Peter E. Thijssen et al.   Nature Communications

TOPBP1 recruits TOP2A to ultra-fine anaphase bridges to aid in their resolution

(2015) Ronan Broderick et al.   Nature Communications

Chromosome 17 copy number changes in male breast cancer

(2015) Miangela M. Lacle et al.   CELLULAR ONCOLOGY

The structure of an endogenous Drosophila centromere reveals the prevalence of tandemly repeated sequences able to form i-motifs

(2015) Miguel Garavís et al.   Scientific Reports

Genomic instability in complicated and uncomplicated Egyptian schistosomiasis haematobium patients

(2015) Amany A Abd El-Aal et al.   Molecular Cytogenetics

Re-replication of a Centromere Induces Chromosomal Instability and Aneuploidy

(2015) Stacey L. Hanlon et al.   PLoS Genetics

Atypical centromeres in plants—what they can tell us

(2015) Maria Cuacos et al.   Frontiers in Plant Science

The Architecture and Evolution of Cancer Neochromosomes

(2014) Dale W. Garsed et al.   CANCER CELL

The Robertsonian phenomenon in the house mouse: mutation, meiosis and speciation

(2014) Silvia Garagna et al.   CHROMOSOMA

Centromere Strength Provides the Cell Biological Basis for Meiotic Drive and Karyotype Evolution in Mice

(2014) Lukáš Chmátal et al.   CURRENT BIOLOGY

Ectopic Centromere Nucleation by CENP-A in Fission Yeast

(2014) Marlyn Gonzalez et al.   GENETICS

Centromere reference models for human chromosomes X and Y satellite arrays

(2014) K. H. Miga et al.   GENOME RESEARCH

Decoding complex patterns of genomic rearrangement in hepatocellular carcinoma

(2014) Julio Fernandez-Banet et al.   GENOMICS

Kinetochore genes are coordinately up-regulated in human tumors as part of a FoxM1-related cell division program

(2014) Prathapan Thiru et al.   MOLECULAR BIOLOGY OF THE CELL

The histone chaperone HJURP is a new independent prognostic marker for luminal A breast carcinoma

(2014) Rocío Montes de Oca et al.   Molecular Oncology

Constitutional and somatic rearrangement of chromosome 21 in acute lymphoblastic leukaemia

(2014) Yilong Li et al.   NATURE

Mosaic loss of chromosome Y in peripheral blood is associated with shorter survival and higher risk of cancer

(2014) Lars A Forsberg et al.   NATURE GENETICS

Replication of alpha-satellite DNA arrays in endogenous human centromeric regions and in human artificial chromosome

(2014) Indri Erliandri et al.   NUCLEIC ACIDS RESEARCH

Expression and prognostic relevance of centromere protein A in primary osteosarcoma

(2014) Xiao-Min Gu et al.   PATHOLOGY RESEARCH AND PRACTICE

Smoking is associated with mosaic loss of chromosome Y

(2014) J. P. Dumanski et al.   SCIENCE

Escape from Telomere-Driven Crisis Is DNA Ligase III Dependent

(2014) Rhiannon E. Jones et al.   Cell Reports

Rad51–Rad52 Mediated Maintenance of Centromeric Chromatin in Candida albicans

(2014) Sreyoshi Mitra et al.   PLoS Genetics

Induced dicentric chromosome formation promotes genomic rearrangements and tumorigenesis

(2013) Karen E. Gascoigne et al.   CHROMOSOME RESEARCH

Three wise centromere functions: see no error, hear no break, speak no delay

(2013) Tomoyuki U Tanaka et al.   EMBO REPORTS

Heterogeneous clinical presentation in ICF syndrome: correlation with underlying gene defects

(2013) Corry MR Weemaes et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Higher-order unfolding of satellite heterochromatin is a consistent and early event in cell senescence

(2013) Eric C. Swanson et al.   JOURNAL OF CELL BIOLOGY

HJURP Regulates Cellular Senescence in Human Fibroblasts and Endothelial Cells Via a p53-Dependent Pathway

(2013) J.-I. Heo et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

 H2A-Binding Protein Brc1 Affects Centromere Function in Fission Yeast

(2013) S. Y. Lee et al.   MOLECULAR AND CELLULAR BIOLOGY

Replication stress links structural and numerical cancer chromosomal instability

(2013) Rebecca A. Burrell et al.   NATURE

A two-step mechanism for epigenetic specification of centromere identity and function

(2013) Daniele Fachinetti et al.   NATURE CELL BIOLOGY

Nucleotide-resolution DNA double-strand break mapping by next-generation sequencing

(2013) Nicola Crosetto et al.   NATURE METHODS

Prognostic Significance of EDN/RB, HJURP, p60/CAF-1 and PDLI4, Four New Markers in High-Grade Gliomas

(2013) Marie de Tayrac et al.   PLoS One

Replication Fork Stability Is Essential for the Maintenance of Centromere Integrity in the Absence of Heterochromatin

(2013) Pao-Chen Li et al.   Cell Reports

DNA Topoisomerase III Localizes to Centromeres and Affects Centromeric CENP-A Levels in Fission Yeast

(2013) Ulrika Norman-Axelsson et al.   PLoS Genetics

Neocentromeres and epigenetically inherited features of centromeres

(2012) Laura S. Burrack et al.   CHROMOSOME RESEARCH

Dicentric chromosomes: unique models to study centromere function and inactivation

(2012) Kaitlin M. Stimpson et al.   CHROMOSOME RESEARCH

Expression and prognostic significance of centromere protein A in human lung adenocarcinoma

(2012) Qing Wu et al.   LUNG CANCER

Two novel unbalanced whole arm translocations are frequently detected in cervical squamous cell carcinoma

(2012) Claudia Backsch et al.   Cancer Genetics

Localization of centromeric breaks in head and neck squamous cell carcinoma

(2012) Jorge García Martínez et al.   Cancer Genetics

Neocentric X-chromosome in a girl with Turner-like syndrome

(2012) Morteza Hemmat et al.   Molecular Cytogenetics

Factors That Promote H3 Chromatin Integrity during Transcription Prevent Promiscuous Deposition of CENP-ACnp1 in Fission Yeast

(2012) Eun Shik Choi et al.   PLoS Genetics

Centromere fission, not telomere erosion, triggers chromosomal instability in human carcinomas

(2011) C. Martinez-A et al.   CARCINOGENESIS

Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer Development

(2011) Philip J. Stephens et al.   CELL

Interstitial Deletion of Proximal 8q Including Part of the Centromere from Unbalanced Segregation of a Paternal Deletion/Marker Karyotype with Neocentromere Formation at 8p22

(2011) R.D. Burnside et al.   CYTOGENETIC AND GENOME RESEARCH

Cdk Activity Couples Epigenetic Centromere Inheritance to Cell Cycle Progression

(2011) Mariana C.C. Silva et al.   DEVELOPMENTAL CELL

PICH and BLM limit histone association with anaphase centromeric DNA threads and promote their resolution

(2011) Yuwen Ke et al.   EMBO JOURNAL

Centromere repositioning in mammals

(2011) M Rocchi et al.   HEREDITY

FoSTeS, MMBIR and NAHR at the human proximal Xp region and the mechanisms of human Xq isochromosome formation

(2011) George Koumbaris et al.   HUMAN MOLECULAR GENETICS

Heterochromatin boundaries are hotspots for de novo kinetochore formation

(2011) Agata M. Olszak et al.   NATURE CELL BIOLOGY

Chromosome Segregation Errors as a Cause of DNA Damage and Structural Chromosome Aberrations

(2011) A. Janssen et al.   SCIENCE

A case of angioimmunoblastic T-cell non-Hodgkin lymphoma with a neocentric inv dup(1)

(2010) Eric Blom et al.   CANCER GENETICS AND CYTOGENETICS

A patient with Edwards syndrome caused by a rare pseudodicentric chromosome 18 of paternal origin

(2010) Claus Højbjerg Gravholt et al.   CLINICAL GENETICS

First Case of a Neocentromere Formation in an Otherwise Normal Chromosome 7

(2010) T. Liehr et al.   CYTOGENETIC AND GENOME RESEARCH

Loss of pRB causes centromere dysfunction and chromosomal instability

(2010) A. L. Manning et al.   GENES & DEVELOPMENT

Chickens possess centromeres with both extended tandem repeats and short non-tandem-repetitive sequences

(2010) W.-H. Shang et al.   GENOME RESEARCH

Large inverted repeats within Xp11.2 are present at the breakpoints of isodicentric X chromosomes in Turner syndrome

(2010) S. A. Scott et al.   HUMAN MOLECULAR GENETICS

Human Topoisomerase IIIα Is a Single-stranded DNA Decatenase That Is Stimulated by BLM and RMI1

(2010) Jay Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epigenetic centromere specification directs aurora B accumulation but is insufficient to efficiently correct mitotic errors

(2010) Emily A. Bassett et al.   JOURNAL OF CELL BIOLOGY

Centromere DNA decatenation depends on cohesin removal and is required for mammalian cell division

(2010) L. H.-C. Wang et al.   JOURNAL OF CELL SCIENCE

CENP-A Reduction Induces a p53-Dependent Cellular Senescence Response To Protect Cells from Executing Defective Mitoses

(2010) K. Maehara et al.   MOLECULAR AND CELLULAR BIOLOGY

Replication Termination at Eukaryotic Chromosomes Is Mediated by Top2 and Occurs at Genomic Loci Containing Pausing Elements

(2010) Daniele Fachinetti et al.   MOLECULAR CELL

CENP-B preserves genome integrity at replication forks paused by retrotransposon LTR

(2010) Mikel Zaratiegui et al.   NATURE

Centromere-localized breaks indicate the generation of DNA damage by the mitotic spindle

(2010) A. A. Guerrero et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A role for recombination in centromere function

(2010) Ramsay J. McFarlane et al.   TRENDS IN GENETICS

A paucity of heterochromatin at functional human neocentromeres

(2010) Alicia Alonso et al.   Epigenetics & Chromatin

Widespread Gene Conversion in Centromere Cores

(2010) Jinghua Shi et al.   PLOS BIOLOGY

Telomere Disruption Results in Non-Random Formation of De Novo Dicentric Chromosomes Involving Acrocentric Human Chromosomes

(2010) Kaitlin M. Stimpson et al.   PLoS Genetics

Epigenetically-Inherited Centromere and Neocentromere DNA Replicates Earliest in S-Phase

(2010) Amnon Koren et al.   PLoS Genetics

Rad3ATR Decorates Critical Chromosomal Domains with γH2A to Protect Genome Integrity during S-Phase in Fission Yeast

(2010) Sophie Rozenzhak et al.   PLoS Genetics

A case of childhood acute myeloid leukemia AML (M5) with a neocentric chromosome neo(1)(qter→q23∼24::q23∼24→q43→neo→q43→qter) and tetrasomy of chromosomes 8 and 21

(2009) Amanda Faria de Figueiredo et al.   CANCER GENETICS AND CYTOGENETICS

HJURP Is a Cell-Cycle-Dependent Maintenance and Deposition Factor of CENP-A at Centromeres

(2009) Elaine M. Dunleavy et al.   CELL

Centromere-Specific Assembly of CENP-A Nucleosomes Is Mediated by HJURP

(2009) Daniel R. Foltz et al.   CELL

Centromeric α-Satellite DNA Break in Reciprocal Translocations

(2009) J.-C. Wang et al.   CYTOGENETIC AND GENOME RESEARCH

Failed gene conversion leads to extensive end processing and chromosomal rearrangements in fission yeast

(2009) Helen Tinline-Purvis et al.   EMBO JOURNAL

The life and miracles of kinetochores

(2009) Stefano Santaguida et al.   EMBO JOURNAL

Smc5/6 maintains stalled replication forks in a recombination-competent conformation

(2009) Anja Irmisch et al.   EMBO JOURNAL

Inverted duplications on acentric markers: mechanism of formation

(2009) Andrea E. Murmann et al.   HUMAN MOLECULAR GENETICS

U-type exchange is the most frequent mechanism for inverted duplication with terminal deletion rearrangements

(2009) L R Rowe et al.   JOURNAL OF MEDICAL GENETICS

CENPA overexpression promotes genome instability in pRb-depleted human cells

(2009) Angela Amato et al.   Molecular Cancer

Stabilization of Dicentric Translocations through Secondary Rearrangements Mediated by Multiple Mechanisms in S. cerevisiae

(2009) Vincent Pennaneach et al.   PLoS One

Double-strand DNA breaks recruit the centromeric histone CENP-A

(2009) S. G. Zeitlin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neocentromeres Form Efficiently at Multiple Possible Loci in Candida albicans

(2009) Carrie Ketel et al.   PLoS Genetics

LINE Retrotransposon RNA Is an Essential Structural and Functional Epigenetic Component of a Core Neocentromeric Chromatin

(2009) Anderly C. Chueh et al.   PLoS Genetics

Neocentromeres: New Insights into Centromere Structure, Disease Development, and Karyotype Evolution

(2008) Owen J. Marshall et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Genetic counseling in Robertsonian translocations der(13;14): Frequencies of reproductive outcomes and infertility in 101 pedigrees

(2008) Hartmut Engels et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

High-resolution array CGH clarifies events occurring on 8p in carcinogenesis

(2008) Susanna L Cooke et al.   BMC CANCER

Variability of origin for the neocentromeric sequences in analphoid supernumerary marker chromosomes of well-differentiated liposarcomas

(2008) Antoine Italiano et al.   CANCER LETTERS

First prenatally detected small supernumerary neocentromeric derivative chromosome 13 resulting in a non-mosaic partial tetrasomy 13q

(2008) A. Mascarenhas et al.   CYTOGENETIC AND GENOME RESEARCH

Rad51 suppresses gross chromosomal rearrangement at centromere in Schizosaccharomyces pombe

(2008) Ken-ichi Nakamura et al.   EMBO JOURNAL

Altered Dosage and Mislocalization of Histone H3 and Cse4p Lead to Chromosome Loss in Saccharomyces cerevisiae

(2008) W.-C. Au et al.   GENETICS

Centromere mitotic recombination in mammalian cells

(2008) Isabel Jaco et al.   JOURNAL OF CELL BIOLOGY

Hairpin structures formed by alpha satellite DNA of human centromeres are cleaved by human topoisomerase II 

(2008) A. T. Jonstrup et al.   NUCLEIC ACIDS RESEARCH

Heterochromatin Integrity Affects Chromosome Reorganization After Centromere Dysfunction

(2008) K. Ishii et al.   SCIENCE