Compromised nuclear envelope integrity drives TREX1-dependent DNA damage and tumor cell invasion

ER-directed TREX1 limits cGAS activation at micronuclei

(2021) Lisa Mohr et al.   MOLECULAR CELL

Nuclear fragility, blaming the blebs

(2021) Nishit Srivastava et al.   CURRENT OPINION IN CELL BIOLOGY

The cGAS/STING/TBK1/IRF3 innate immunity pathway maintains chromosomal stability through regulation of p21 levels

(2020) Abdul Basit et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

CHMPions of repair: Emerging perspectives on sensing and repairing the nuclear envelope barrier

(2020) C. Patrick Lusk et al.   CURRENT OPINION IN CELL BIOLOGY

Nuclear Deformation Causes DNA Damage by Increasing Replication Stress

(2020) Pragya Shah et al.   CURRENT BIOLOGY

The N-Terminal Domain of cGAS Determines Preferential Association with Centromeric DNA and Innate Immune Activation in the Nucleus

(2019) Matteo Gentili et al.   Cell Reports

Phosphorylation of proliferating cell nuclear antigen promotes cancer progression by activating the ATM/AKT/GSK3β/Snail signaling pathway

(2019) Bo Peng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanosensing by the Lamina Protects against Nuclear Rupture, DNA Damage, and Cell-Cycle Arrest

(2019) Sangkyun Cho et al.   DEVELOPMENTAL CELL

Interleukin 6-triggered ataxia-telangiectasia mutated kinase activation facilitates epithelial-to-mesenchymal transition in lung cancer by upregulating vimentin expression

(2019) Yi Na Jiang et al.   EXPERIMENTAL CELL RESEARCH

Unjamming overcomes kinetic and proliferation arrest in terminally differentiated cells and promotes collective motility of carcinoma

(2019) Andrea Palamidessi et al.   NATURE MATERIALS

Opposing Functions of Interferon Coordinate Adaptive and Innate Immune Responses to Cancer Immune Checkpoint Blockade

(2019) Joseph L. Benci et al.   CELL

Cellular Senescence: Defining a Path Forward

(2019) Vassilis Gorgoulis et al.   CELL

Mutant lamins cause nuclear envelope rupture and DNA damage in skeletal muscle cells

(2019) Ashley J. Earle et al.   NATURE MATERIALS

Nuclear envelope rupture: little holes, big openings

(2018) Emily M .Hatch   CURRENT OPINION IN CELL BIOLOGY

Microinvasive Carcinoma versus Ductal Carcinoma In Situ: A Comparison of Clinicopathological Features and Clinical Outcomes

(2018) Milim Kim et al.   Journal of Breast Cancer

Downregulation of cytoplasmic DNases is implicated in cytoplasmic DNA accumulation and SASP in senescent cells

(2018) Akiko Takahashi et al.   Nature Communications

LINC complex-Lis1 interplay controls MT1-MMP matrix digest-on-demand response for confined tumor cell migration

(2018) Elvira Infante et al.   Nature Communications

Divergent Matrix-Remodeling Strategies Distinguish Developmental from Neoplastic Mammary Epithelial Cell Invasion Programs

(2018) Tamar Y. Feinberg et al.   DEVELOPMENTAL CELL

Coronin 1C promotes triple-negative breast cancer invasiveness through regulation of MT1-MMP traffic and invadopodia function

(2018) Alessia Castagnino et al.   ONCOGENE

Nuclear cGAS suppresses DNA repair and promotes tumorigenesis

(2018) Haipeng Liu et al.   NATURE

A prosurvival DNA damage-induced cytoplasmic interferon response is mediated by end resection factors and is limited by Trex1

(2017) Erkin Erdal et al.   GENES & DEVELOPMENT

Mitotic progression following DNA damage enables pattern recognition within micronuclei

(2017) Shane M. Harding et al.   NATURE

Myofibril contraction and crosslinking drive nuclear movement to the periphery of skeletal muscle

(2017) William Roman et al.   NATURE CELL BIOLOGY

Chemical screening identifies ATM as a target for alleviating senescence

(2017) Hyun Tae Kang et al.   Nature Chemical Biology

Endocytic reawakening of motility in jammed epithelia

(2017) Chiara Malinverno et al.   NATURE MATERIALS

Bursting the Bubble – Nuclear Envelope Rupture as a Path to Genomic Instability?

(2017) Pragya Shah et al.   TRENDS IN CELL BIOLOGY

DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity

(2017) Claire Vanpouille-Box et al.   Nature Communications

Nuclear envelope rupture is induced by actin-based nucleus confinement

(2016) Emily M. Hatch et al.   JOURNAL OF CELL BIOLOGY

ESCRT III repairs nuclear envelope ruptures during cell migration to limit DNA damage and cell death

(2016) M. Raab et al.   SCIENCE

Nuclear envelope rupture and repair during cancer cell migration

(2016) C. M. Denais et al.   SCIENCE

Chromothripsis and Kataegis Induced by Telomere Crisis

(2015) John Maciejowski et al.   CELL

Confinement and Low Adhesion Induce Fast Amoeboid Migration of Slow Mesenchymal Cells

(2015) Yan-Jun Liu et al.   CELL

Establishment of NE asymmetry—targeting of membrane proteins to the inner nuclear membrane

(2015) Rosemarie Ungricht et al.   CURRENT OPINION IN CELL BIOLOGY

p63/MT1-MMP axis is required for in situ to invasive transition in basal-like breast cancer

(2015) C Lodillinsky et al.   ONCOGENE

The Capsids of HIV-1 and HIV-2 Determine Immune Detection of the Viral cDNA by the Innate Sensor cGAS in Dendritic Cells

(2013) Xavier Lahaye et al.   IMMUNITY

Fine control of nuclear confinement identifies a threshold deformation leading to lamina rupture and induction of specific genes

(2012) Maël Le Berre et al.   Integrative Biology

Activation of the ATM-Snail pathway promotes breast cancer metastasis

(2012) Mianen Sun et al.   Journal of Molecular Cell Biology

Transient nuclear envelope rupturing during interphase in human cancer cells

(2012) Jesse D. Vargas et al.   Nucleus

Repetitive disruptions of the nuclear envelope invoke temporary loss of cellular compartmentalization in laminopathies

(2011) Winnok H. De Vos et al.   HUMAN MOLECULAR GENETICS

The nucleoplasmic reticulum: form and function

(2011) Ashraf Malhas et al.   TRENDS IN CELL BIOLOGY

Collective cell migration in morphogenesis, regeneration and cancer

(2009) Peter Friedl et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Trex1 Prevents Cell-Intrinsic Initiation of Autoimmunity

(2008) Daniel B. Stetson et al.   CELL

The TREX1 Double-stranded DNA Degradation Activity Is Defective in Dominant Mutations Associated with Autoimmune Disease

(2008) Duane A. Lehtinen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY