Short-term molecular consequences of chromosome mis-segregation for genome stability

Hallmarks of Cancer: New Dimensions

(2022) Douglas Hanahan   Cancer Discovery

The Dynamic Instability of the Aneuploid Genome

(2022) Lorenza Garribba et al.   Frontiers in Cell and Developmental Biology

Genetic instability from a single S phase after whole-genome duplication

(2022) Simon Gemble et al.   NATURE

Purification of mammalian telomeric DNA for single-molecule analysis

(2022) Giulia Mazzucco et al.   Nature Protocols

Human DDK rescues stalled forks and counteracts checkpoint inhibition at unfired origins to complete DNA replication

(2021) Mathew J.K. Jones et al.   MOLECULAR CELL

Aneuploidy renders cancer cells vulnerable to mitotic checkpoint inhibition

(2021) Yael Cohen-Sharir et al.   NATURE

Twelve years of SAMtools and BCFtools

(2021) Petr Danecek et al.   GigaScience

Gene copy-number changes and chromosomal instability induced by aneuploidy confer resistance to chemotherapy

(2021) Marica Rosaria Ippolito et al.   DEVELOPMENTAL CELL

Chromosomal instability accelerates the evolution of resistance to anti-cancer therapies

(2021) Devon A. Lukow et al.   DEVELOPMENTAL CELL

Aneuploid senescent cells activate NF‐κB to promote their immune clearance by NK cells

(2021) Ruoxi W Wang et al.   EMBO REPORTS

Transient genomic instability drives tumorigenesis through accelerated clonal evolution

(2021) Ofer Shoshani et al.   GENES & DEVELOPMENT

Clonal selection of stable aneuploidies in progenitor cells drives high-prevalence tumorigenesis

(2021) Marianna Trakala et al.   GENES & DEVELOPMENT

Replication Stress Induces ATR/CHK1-Dependent Nonrandom Segregation of Damaged Chromosomes

(2020) Meichun Xing et al.   MOLECULAR CELL

Folate stress induces SLX1- and RAD51-dependent mitotic DNA synthesis at the fragile X locus in human cells

(2020) Lorenza Garribba et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Telomere damage induces internal loops that generate telomeric circles

(2020) Giulia Mazzucco et al.   Nature Communications

Aneuploidy increases resistance to chemotherapeutics by antagonizing cell division

(2020) John Michael Replogle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Next-generation characterization of the Cancer Cell Line Encyclopedia

(2019) Mahmoud Ghandi et al.   NATURE

Molecular mechanism and potential target indication of TAK-931, a novel CDC7-selective inhibitor

(2019) Kenichi Iwai et al.   Science Advances

Context is everything: aneuploidy in cancer

(2019) Uri Ben-David et al.   NATURE REVIEWS GENETICS

Mild replication stress causes chromosome mis-segregation via premature centriole disengagement

(2019) Therese Wilhelm et al.   Nature Communications

Heterochromatin protein 1α interacts with parallel RNA and DNA G-quadruplexes

(2019) Ruby J Roach et al.   NUCLEIC ACIDS RESEARCH

FoxM1 repression during human aging leads to mitotic decline and aneuploidy-driven full senescence

(2018) Joana Catarina Macedo et al.   Nature Communications

State-of-the-art strategies for targeting the DNA damage response in cancer

(2018) Patrick G. Pilié et al.   Nature Reviews Clinical Oncology

Replication fork slowing and stalling are distinct, checkpoint-independent consequences of replicating damaged DNA

(2017) Divya Ramalingam Iyer et al.   PLoS Genetics

Genomic Instability in Human Pluripotent Stem Cells Arises from Replicative Stress and Chromosome Condensation Defects

(2016) Noa Lamm et al.   Cell Stem Cell

RAD52 Facilitates Mitotic DNA Synthesis Following Replication Stress

(2016) Rahul Bhowmick et al.   MOLECULAR CELL

The presence of extra chromosomes leads to genomic instability

(2016) Verena Passerini et al.   Nature Communications

Aneuploidy-induced cellular stresses limit autophagic degradation

(2015) Stefano Santaguida et al.   GENES & DEVELOPMENT

An efficient and scalable analysis framework for variant extraction and refinement from population-scale DNA sequence data

(2015) Goo Jun et al.   GENOME RESEARCH

Mitotic entry in the presence of DNA damage is a widespread property of aneuploidy in yeast

(2015) Heidi M. Blank et al.   MOLECULAR BIOLOGY OF THE CELL

Replication stress activates DNA repair synthesis in mitosis

(2015) Sheroy Minocherhomji et al.   NATURE

Chromothripsis from DNA damage in micronuclei

(2015) Cheng-Zhong Zhang et al.   NATURE

DNA replication origin activation in space and time

(2015) Michalis Fragkos et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Short- and long-term effects of chromosome mis-segregation and aneuploidy

(2015) Stefano Santaguida et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Replication fork reversal in eukaryotes: from dead end to dynamic response

(2015) Kai J. Neelsen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Aneuploidy generates proteotoxic stress and DNA damage concurrently with p53-mediated post-mitotic apoptosis in SAC-impaired cells

(2015) Akihiro Ohashi et al.   Nature Communications

featureCounts: an efficient general purpose program for assigning sequence reads to genomic features

(2013) Y. Liao et al.   BIOINFORMATICS

Cumulative Haploinsufficiency and Triplosensitivity Drive Aneuploidy Patterns and Shape the Cancer Genome

(2013) Teresa Davoli et al.   CELL

How unfinished business from S-phase affects mitosis and beyond

(2013) Hocine W Mankouri et al.   EMBO JOURNAL

Replication stress links structural and numerical cancer chromosomal instability

(2013) Rebecca A. Burrell et al.   NATURE

Causes and consequences of replication stress

(2013) Michelle K. Zeman et al.   NATURE CELL BIOLOGY

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Discovery of XL413, a potent and selective CDC7 inhibitor

(2012) Elena S. Koltun et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A Subpopulation of Adult Skeletal Muscle Stem Cells Retains All Template DNA Strands after Cell Division

(2012) Pierre Rocheteau et al.   CELL

Global analysis of genome, transcriptome and proteome reveals the response to aneuploidy in human cells

(2012) Silvia Stingele et al.   Molecular Systems Biology

Fast gapped-read alignment with Bowtie 2

(2012) Ben Langmead et al.   NATURE METHODS

Eukaryotic Origin-Dependent DNA Replication In Vitro Reveals Sequential Action of DDK and S-CDK Kinases

(2011) Ryan C. Heller et al.   CELL

Optimization of calyculin A-induced premature chromosome condensation assay for chromosome aberration studies

(2011) Tomisato Miura et al.   CYTOMETRY PART A

Aneuploidy Drives Genomic Instability in Yeast

(2011) J. M. Sheltzer et al.   SCIENCE

How do Cdc7 and cyclin-dependent kinases trigger the initiation of chromosome replication in eukaryotic cells?

(2010) K. Labib   GENES & DEVELOPMENT

Dissecting the role of MPS1 in chromosome biorientation and the spindle checkpoint through the small molecule inhibitor reversine

(2010) Stefano Santaguida et al.   JOURNAL OF CELL BIOLOGY

Sustained Mps1 activity is required in mitosis to recruit O-Mad2 to the Mad1–C-Mad2 core complex

(2010) Laura Hewitt et al.   JOURNAL OF CELL BIOLOGY

Replication stress induces sister-chromatid bridging at fragile site loci in mitosis

(2009) Kok Lung Chan et al.   NATURE CELL BIOLOGY

Visualizing Spatiotemporal Dynamics of Multicellular Cell-Cycle Progression

(2008) Asako Sakaue-Sawano et al.   CELL