The flexible and iterative steps within the NHEJ pathway

Two distinct long-range synaptic complexes promote different aspects of end processing prior to repair of DNA breaks by non-homologous end joining

(2023) Christopher J. Buehl et al.   MOLECULAR CELL

Pol X DNA polymerases contribute to NHEJ flexibility

(2023) Michael R. Lieber   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Chromatin Landscape around DNA Double-Strand Breaks in Yeast and Its Influence on DNA Repair Pathway Choice

(2023) Chiara Frigerio et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The importance of DNAPKcs for blunt DNA end joining is magnified when XLF is weakened

(2022) Metztli Cisneros-Aguirre et al.   Nature Communications

Analysis of diverse double-strand break synapsis with Polλ reveals basis for unique substrate specificity in nonhomologous end-joining

(2022) Andrea M. Kaminski et al.   Nature Communications

Catalytically inactive DNA ligase IV promotes DNA repair in living cells

(2022) Noah J Goff et al.   NUCLEIC ACIDS RESEARCH

Double-strand break repair and mis-repair in 3D

(2022) Jennifer Zagelbaum et al.   DNA REPAIR

Dynamics of the Artemis and DNA-PKcs Complex in the Repair of Double-Strand Breaks

(2022) Go Watanabe et al.   JOURNAL OF MOLECULAR BIOLOGY

Polλ promotes microhomology-mediated end-joining

(2022) Gurushankar Chandramouly et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Multi-layered chromatin proteomics identifies cell vulnerabilities in DNA repair

(2022) Gianluca Sigismondo et al.   NUCLEIC ACIDS RESEARCH

53BP1: Keeping It under Control, Even at a Distance from DNA Damage

(2022) Emilie Rass et al.   Genes

SAP domain forms a flexible part of DNA aperture in Ku70/80

(2021) Aleš Hnízda et al.   FEBS Journal

Structural basis of long-range to short-range synaptic transition in NHEJ

(2021) Siyu Chen et al.   NATURE

Radiation-related genomic profile of papillary thyroid carcinoma after the Chernobyl accident

(2021) Lindsay M. Morton et al.   SCIENCE

Cryo-EM of NHEJ supercomplexes provides insights into DNA repair

(2021) Amanda K. Chaplin et al.   MOLECULAR CELL

Mechanism, cellular functions and cancer roles of polymerase-theta-mediated DNA end joining

(2021) Dale A. Ramsden et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

DNA End Resection: Mechanism and Control

(2021) Petr Cejka et al.   Annual Review of Genetics

Nonhomologous DNA end joining of nucleosomal substrates in a purified system

(2021) Christina A. Gerodimos et al.   DNA REPAIR

Autophosphorylation transforms DNA-PK from protecting to processing DNA ends

(2021) Lan Liu et al.   MOLECULAR CELL

Cutting antiparallel DNA strands in a single active site

(2020) Xuemin Chen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

How mouse RAG recombinase avoids DNA transposition

(2020) Xuemin Chen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Polymerase μ in non-homologous DNA end joining: importance of the order of arrival at a double-strand break in a purified system

(2020) Bailin Zhao et al.   NUCLEIC ACIDS RESEARCH

Preserving genome integrity in human cells via DNA double-strand break repair

(2020) Ryan B. Jensen et al.   MOLECULAR BIOLOGY OF THE CELL

DNA-PKcs chemical inhibition versus genetic mutation: Impact on the junctional repair steps of V(D)J recombination

(2020) Z. Anne Esguerra et al.   MOLECULAR IMMUNOLOGY

SHLD 2 promotes class switch recombination by preventing inactivating deletions within the Igh locus

(2020) Alexanda K Ling et al.   EMBO REPORTS

The role of the SWI/SNF chromatin remodelling complex in the response to DNA double strand breaks

(2020) Alison Harrod et al.   DNA REPAIR

The molecular basis and disease relevance of non-homologous DNA end joining

(2020) Bailin Zhao et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Dimers of DNA-PK create a stage for DNA double-strand break repair

(2020) Amanda K. Chaplin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Uncovering DNA-PKcs ancient phylogeny, unique sequence motifs and insights for human disease

(2020) James P. Lees-Miller et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Plugged into the Ku-DNA hub: The NHEJ network

(2019) Philippe Frit et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Shieldin – the protector of DNA ends

(2019) Dheva Setiaputra et al.   EMBO REPORTS

The essential elements for the noncovalent association of two DNA ends during NHEJ synapsis

(2019) Bailin Zhao et al.   Nature Communications

A Mechanism to Minimize Errors during Non-homologous End Joining

(2019) Benjamin M. Stinson et al.   MOLECULAR CELL

Cracking the DNA Code for V(D)J Recombination

(2018) Min-Sung Kim et al.   MOLECULAR CELL

Dissection of DNA double-strand-break repair using novel single-molecule forceps

(2018) Jing L. Wang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structures of DNA-bound human ligase IV catalytic core reveal insights into substrate binding and catalysis

(2018) Andrea M. Kaminski et al.   Nature Communications

Dissection of DNA double-strand-break repair using novel single-molecule forceps

(2018) Jing L. Wang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Comprehensive Mapping of Histone Modifications at DNA Double-Strand Breaks Deciphers Repair Pathway Chromatin Signatures

(2018) Thomas Clouaire et al.   MOLECULAR CELL

The shieldin complex mediates 53BP1-dependent DNA repair

(2018) Sylvie M. Noordermeer et al.   NATURE

A single XLF dimer bridges DNA ends during nonhomologous end joining

(2018) Thomas G. W. Graham et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

XLF and APLF bind Ku80 at two remote sites to ensure DNA repair by non-homologous end joining

(2018) Clement Nemoz et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Ribonucleotide incorporation enables repair of chromosome breaks by nonhomologous end joining

(2018) John M. Pryor et al.   SCIENCE

Effects of DNA end configuration on XRCC4-DNA ligase IV and its stimulation of Artemis activity

(2017) Christina A. Gerodimos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nonhomologous DNA end-joining for repair of DNA double-strand breaks

(2017) Nicholas R. Pannunzio et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DNA-PKcs structure suggests an allosteric mechanism modulating DNA double-strand break repair

(2017) Bancinyane L. Sibanda et al.   SCIENCE

Mutational phospho-mimicry reveals a regulatory role for the XRCC4 and XLF C-terminal tails in modulating DNA bridging during classical non-homologous end joining

(2017) Davide Normanno et al.   eLife

End-processing nucleases and phosphodiesterases: An elite supporting cast for the non-homologous end joining pathway of DNA double-strand break repair

(2016) Vijay Menon et al.   DNA REPAIR

Different DNA End Configurations Dictate Which NHEJ Components Are Most Important for Joining Efficiency

(2016) Howard H. Y. Chang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Two-Stage Synapsis of DNA Ends during Non-homologous End Joining

(2016) Thomas G.W. Graham et al.   MOLECULAR CELL

Sliding sleeves of XRCC4–XLF bridge DNA and connect fragments of broken DNA

(2016) Ineke Brouwer et al.   NATURE

Structure-Specific nuclease activities of Artemis and the Artemis: DNA-PKcs complex

(2016) Howard H.Y. Chang et al.   NUCLEIC ACIDS RESEARCH

PAXX Is an Accessory c-NHEJ Factor that Associates with Ku70 and Has Overlapping Functions with XLF

(2016) Satish K. Tadi et al.   Cell Reports

Nucleosome disassembly during human non-homologous end joining followed by concerted HIRA- and CAF-1-dependent reassembly

(2016) Xuan Li et al.   eLife

Unifying the DNA End-processing Roles of the Artemis Nuclease

(2015) Howard H. Y. Chang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal structure of the V(D)J recombinase RAG1–RAG2

(2015) Min-Sung Kim et al.   NATURE

Organization and dynamics of the nonhomologous end-joining machinery during DNA double-strand break repair

(2015) Dylan A. Reid et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Essential role for polymerase specialization in cellular nonhomologous end joining

(2015) John M. Pryor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neddylation Promotes Ubiquitylation and Release of Ku from DNA-Damage Sites

(2015) Jessica S. Brown et al.   Cell Reports

The spatial organization of non-homologous end joining: From bridging to end joining

(2014) Takashi Ochi et al.   DNA REPAIR

Cooperative Assembly of a Protein-DNA Filament for Nonhomologous End Joining

(2013) Chun J. Tsai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A noncatalytic function of the ligation complex during nonhomologous end joining

(2013) Jessica Cottarel et al.   JOURNAL OF CELL BIOLOGY

Nucleosome dynamics regulates DNA processing

(2013) Nicholas L Adkins et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

RPA Accumulation during Class Switch Recombination Represents 5′–3′ DNA-End Resection during the S–G2/M Phase of the Cell Cycle

(2013) Arito Yamane et al.   Cell Reports

Saccharomyces cerevisiae DNA Ligase IV Supports Imprecise End Joining Independently of Its Catalytic Activity

(2013) Kishore K. Chiruvella et al.   PLoS Genetics

Non-homologous end-joining partners in a helical dance: structural studies of XLF–XRCC4 interactions

(2012) Qian Wu et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

XRCC4 and XLF form long helical protein filaments suitable for DNA end protection and alignment to facilitate DNA double strand break repair

(2012) Brandi L. Mahaney et al.   Biochemistry and Cell Biology

Ribonucleotides and manganese ions improve non-homologous end joining by human Polµ

(2012) Maria Jose Martin et al.   NUCLEIC ACIDS RESEARCH

A human XRCC4–XLF complex bridges DNA

(2012) Sara N. Andres et al.   NUCLEIC ACIDS RESEARCH

Nonimmunoglobulin target loci of activation-induced cytidine deaminase (AID) share unique features with immunoglobulin genes

(2012) L. Kato et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Destroying the ring: Freeing DNA from Ku with ubiquitin

(2011) Lisa Postow   FEBS LETTERS

Polynucleotide Kinase and Aprataxin-like Forkhead-associated Protein (PALF) Acts as Both a Single-stranded DNA Endonuclease and a Single-Stranded DNA 3′ Exonuclease and Can Participate in DNA End Joining in a Biochemical System

(2011) Sicong Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

XRCC4 Protein Interactions with XRCC4-like Factor (XLF) Create an Extended Grooved Scaffold for DNA Ligation and Double Strand Break Repair

(2011) Michal Hammel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural characterization of filaments formed by human Xrcc4-Cernunnos/XLF complex involved in nonhomologous DNA end-joining

(2011) V. Ropars et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Mechanism of Double-Strand DNA Break Repair by the Nonhomologous DNA End-Joining Pathway

(2010) Michael R. Lieber   Annual Review of Biochemistry

XLF Regulates Filament Architecture of the XRCC4·Ligase IV Complex

(2010) Michal Hammel et al.   STRUCTURE

Structural and Functional Interaction between the Human DNA Repair Proteins DNA Ligase IV and XRCC4

(2009) P.-Y. Wu et al.   MOLECULAR AND CELLULAR BIOLOGY

Mechanistic flexibility as a conserved theme across 3 billion years of nonhomologous DNA end-joining

(2008) J. Gu et al.   GENES & DEVELOPMENT

Analysis of Histones inXenopus laevis

(2008) David Shechter et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Biochemically Defined System for Coding Joint Formation in V(D)J Recombination

(2008) Haihui Lu et al.   MOLECULAR CELL

FACT-Mediated Exchange of Histone Variant H2AX Regulated by Phosphorylation of H2AX and ADP-Ribosylation of Spt16

(2008) Kyu Heo et al.   MOLECULAR CELL

Distinct effects of DNA-PKcs and Artemis inactivation on signal joint formation in vivo

(2008) Cédric Touvrey et al.   MOLECULAR IMMUNOLOGY

Coordinate 5′ and 3′ endonucleolytic trimming of terminally blocked blunt DNA double-strand break ends by Artemis nuclease and DNA-dependent protein kinase

(2008) Steven M. Yannone et al.   NUCLEIC ACIDS RESEARCH

Evidence for an inositol hexakisphosphate-dependent role for Ku in mammalian nonhomologous end joining that is independent of its role in the DNA-dependent protein kinase

(2008) Joyce C.Y. Cheung et al.   NUCLEIC ACIDS RESEARCH

Evidence that base stacking potential in annealed 3′ overhangs determines polymerase utilization in yeast nonhomologous end joining

(2007) James M. Daley et al.   DNA REPAIR