XRCC4 and XLF form long helical protein filaments suitable for DNA end protection and alignment to facilitate DNA double strand break repair

The Response to and Repair of RAG-Mediated DNA Double-Strand Breaks

(2012) Beth A. Helmink et al.   Annual Review of Immunology

Non-homologous end-joining partners in a helical dance: structural studies of XLF–XRCC4 interactions

(2012) Qian Wu et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

CDK targeting of NBS1 promotes DNA-end resection, replication restart and homologous recombination

(2012) Jacob Falck et al.   EMBO REPORTS

Role of non-homologous end joining in V(D)J recombination

(2012) Shruti Malu et al.   IMMUNOLOGIC RESEARCH

Mechanism of Homology Recognition in DNA Recombination from Dual-Molecule Experiments

(2012) Iwijn De Vlaminck et al.   MOLECULAR CELL

XRCC4's interaction with XLF is required for coding (but not signal) end joining

(2012) S. Roy et al.   NUCLEIC ACIDS RESEARCH

A human XRCC4–XLF complex bridges DNA

(2012) Sara N. Andres et al.   NUCLEIC ACIDS RESEARCH

Overlapping functions between XLF repair protein and 53BP1 DNA damage response factor in end joining and lymphocyte development

(2012) X. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional redundancy between repair factor XLF and damage response mediator 53BP1 in V(D)J recombination and DNA repair

(2012) V. Oksenych et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystallization and preliminary X-ray diffraction analysis of the human XRCC4–XLF complex

(2011) Sara N. Andres et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Characterizing flexible and intrinsically unstructured biological macromolecules by SAS using the Porod-Debye law

(2011) Robert P. Rambo et al.   BIOPOLYMERS

Double-Strand Break Repair-Independent Role for BRCA2 in Blocking Stalled Replication Fork Degradation by MRE11

(2011) Katharina Schlacher et al.   CELL

Human Flap Endonuclease Structures, DNA Double-Base Flipping, and a Unified Understanding of the FEN1 Superfamily

(2011) Susan E. Tsutakawa et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

XPB and XPD helicases in TFIIH orchestrate DNA duplex opening and damage verification to coordinate repair with transcription and cell cycle via CAK kinase

(2011) Jill O. Fuss et al.   DNA REPAIR

Functional significance of the interaction with Ku in DNA double-strand break recognition of XLF

(2011) Ken-ichi Yano et al.   FEBS LETTERS

Polynucleotide Kinase and Aprataxin-like Forkhead-associated Protein (PALF) Acts as Both a Single-stranded DNA Endonuclease and a Single-Stranded DNA 3′ Exonuclease and Can Participate in DNA End Joining in a Biochemical System

(2011) Sicong Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ultrahigh Resolution and Full-length Pilin Structures with Insights for Filament Assembly, Pathogenic Functions, and Vaccine Potential

(2011) Sophia Hartung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

XRCC4 Protein Interactions with XRCC4-like Factor (XLF) Create an Extended Grooved Scaffold for DNA Ligation and Double Strand Break Repair

(2011) Michal Hammel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PARP-3 and APLF Function Together to Accelerate Nonhomologous End-Joining

(2011) Stuart L. Rulten et al.   MOLECULAR CELL

Choosing the right path: Does DNA-PK help make the decision?

(2011) Jessica A. Neal et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Structural characterization of filaments formed by human Xrcc4-Cernunnos/XLF complex involved in nonhomologous DNA end-joining

(2011) V. Ropars et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structures of SAS-6 Suggest Its Organization in Centrioles

(2011) M. van Breugel et al.   SCIENCE

Tidying up loose ends: the role of polynucleotide kinase/phosphatase in DNA strand break repair

(2011) Michael Weinfeld et al.   TRENDS IN BIOCHEMICAL SCIENCES

Unpairing and gating: sequence-independent substrate recognition by FEN superfamily nucleases

(2011) Jane A. Grasby et al.   TRENDS IN BIOCHEMICAL SCIENCES

The Mechanism of Double-Strand DNA Break Repair by the Nonhomologous DNA End-Joining Pathway

(2010) Michael R. Lieber   Annual Review of Biochemistry

Human DNA Ligase III Recognizes DNA Ends by Dynamic Switching between Two DNA-Bound States

(2010) Elizabeth Cotner-Gohara et al.   BIOCHEMISTRY

ATM regulates Mre11-dependent DNA end-degradation and microhomology-mediated end joining

(2010) Elias A. Rahal et al.   CELL CYCLE

Structural dynamics in DNA damage signaling and repair

(2010) J Jefferson P Perry et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Bridging the solution divide: comprehensive structural analyses of dynamic RNA, DNA, and protein assemblies by small-angle X-ray scattering

(2010) Robert P Rambo et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Mre11–Rad50–Nbs1 conformations and the control of sensing, signaling, and effector responses at DNA double-strand breaks

(2010) Gareth J. Williams et al.   DNA REPAIR

A structural model for regulation of NHEJ by DNA-PKcs autophosphorylation

(2010) Tracey A. Dobbs et al.   DNA REPAIR

Regulation of DNA strand exchange in homologous recombination

(2010) J. Thomas Holthausen et al.   DNA REPAIR

Yeast Nej1 Is a Key Participant in the Initial End Binding and Final Ligation Steps of Nonhomologous End Joining

(2010) Xi Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dual Modes of Interaction between XRCC4 and Polynucleotide Kinase/Phosphatase

(2010) Rajam S. Mani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Delineation of the Xrcc4-interacting Region in the Globular Head Domain of Cernunnos/XLF

(2010) Laurent Malivert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The DNA Damage Response: Making It Safe to Play with Knives

(2010) Alberto Ciccia et al.   MOLECULAR CELL

ATM damage response and XLF repair factor are functionally redundant in joining DNA breaks

(2010) Shan Zha et al.   NATURE

XLF Regulates Filament Architecture of the XRCC4·Ligase IV Complex

(2010) Michal Hammel et al.   STRUCTURE

Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining

(2009) Brandi L. Mahaney et al.   BIOCHEMICAL JOURNAL

Nbs1 Flexibly Tethers Ctp1 and Mre11-Rad50 to Coordinate DNA Double-Strand Break Processing and Repair

(2009) R. Scott Williams et al.   CELL

Electron microscopy of Xrcc4 and the DNA ligase IV–Xrcc4 DNA repair complex

(2009) María A. Recuero-Checa et al.   DNA REPAIR

Ku and DNA-dependent Protein Kinase Dynamic Conformations and Assembly Regulate DNA Binding and the Initial Non-homologous End Joining Complex

(2009) Michal Hammel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MRN complex function in the repair of chromosomal Rag-mediated DNA double-strand breaks

(2009) Beth A. Helmink et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Structural and Functional Interaction between the Human DNA Repair Proteins DNA Ligase IV and XRCC4

(2009) P.-Y. Wu et al.   MOLECULAR AND CELLULAR BIOLOGY

Flipping of alkylated DNA damage bridges base and nucleotide excision repair

(2009) Julie L. Tubbs et al.   NATURE

Robust, high-throughput solution structural analyses by small angle X-ray scattering (SAXS)

(2009) Greg L Hura et al.   NATURE METHODS

Requirement for XLF/Cernunnos in alignment-based gap filling by DNA polymerases λ and μ for nonhomologous end joining in human whole-cell extracts

(2009) Konstantin Akopiants et al.   NUCLEIC ACIDS RESEARCH

Three New Structures of Left-Handed RadA Helical Filaments: Structural Flexibility of N-Terminal Domain Is Critical for Recombinase Activity

(2009) Yu-Wei Chang et al.   PLoS One

Mechanism of Eukaryotic Homologous Recombination

(2008) Joseph San Filippo et al.   Annual Review of Biochemistry

Eukaryotic DNA Ligases: Structural and Functional Insights

(2008) Tom Ellenberger et al.   Annual Review of Biochemistry

XPD Helicase Structures and Activities: Insights into the Cancer and Aging Phenotypes from XPD Mutations

(2008) Li Fan et al.   CELL

Mre11 Dimers Coordinate DNA End Bridging and Nuclease Processing in Double-Strand-Break Repair

(2008) R. Scott Williams et al.   CELL

DNA-PK and ATM phosphorylation sites in XLF/Cernunnos are not required for repair of DNA double strand breaks

(2008) Y YU et al.   DNA REPAIR

Mechanistic flexibility as a conserved theme across 3 billion years of nonhomologous DNA end-joining

(2008) J. Gu et al.   GENES & DEVELOPMENT

The pathways and outcomes of mycobacterial NHEJ depend on the structure of the broken DNA ends

(2008) J. Aniukwu et al.   GENES & DEVELOPMENT

Molecular Mechanism of DNA Deadenylation by the Neurological Disease Protein Aprataxin

(2008) Ulrich Rass et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Defective DNA Ligation during Short-Patch Single-Strand Break Repair in Ataxia Oculomotor Apraxia 1

(2008) J. J. Reynolds et al.   MOLECULAR AND CELLULAR BIOLOGY

The C-Terminal Domain of Cernunnos/XLF Is Dispensable for DNA Repair In Vivo

(2008) L. Malivert et al.   MOLECULAR AND CELLULAR BIOLOGY

53BP1 facilitates long-range DNA end-joining during V(D)J recombination

(2008) Simone Difilippantonio et al.   NATURE

XLF-Cernunnos promotes DNA ligase IV–XRCC4 re-adenylation following ligation

(2008) Enriqueta Riballo et al.   NUCLEIC ACIDS RESEARCH