Mechanism, cellular functions and cancer roles of polymerase-theta-mediated DNA end joining
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Mechanism, cellular functions and cancer roles of polymerase-theta-mediated DNA end joining
Authors
Keywords
-
Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume -, Issue -, Pages -
Publisher
Springer Science and Business Media LLC
Online
2021-09-15
DOI
10.1038/s41580-021-00405-2
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Human DNA polymerase θ harbors DNA end-trimming activity critical for DNA repair
- (2021) Karl E. Zahn et al. MOLECULAR CELL
- Loss of TGFβ signaling increases alternative end-joining DNA repair that sensitizes to genotoxic therapies across cancer types
- (2021) Qi Liu et al. Science Translational Medicine
- Polθ promotes the repair of 5′-DNA-protein crosslinks by microhomology-mediated end-joining
- (2021) Gurushankar Chandramouly et al. Cell Reports
- Impact of chromatin context on Cas9-induced DNA double-strand break repair pathway balance
- (2021) Ruben Schep et al. MOLECULAR CELL
- Radiation-related genomic profile of papillary thyroid carcinoma after the Chernobyl accident
- (2021) Lindsay M. Morton et al. SCIENCE
- Recurrent deletions in clonal hematopoiesis are driven by microhomology-mediated end joining
- (2021) Tzah Feldman et al. Nature Communications
- Pathways and signatures of mutagenesis at targeted DNA nicks
- (2021) Yinbo Zhang et al. PLoS Genetics
- DNA polymerase theta suppresses mitotic crossing over
- (2021) Juan Carvajal-Garcia et al. PLoS Genetics
- Preservation of lagging strand integrity at sites of stalled replication by Pol α-primase and 9-1-1 complex
- (2021) Robin van Schendel et al. Science Advances
- Mapping yeast mitotic 5′ resection at base resolution reveals the sequence and positional dependence of nucleases in vivo
- (2021) Dominic Bazzano et al. NUCLEIC ACIDS RESEARCH
- Polθ inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance
- (2021) Diana Zatreanu et al. Nature Communications
- Reversion and non-reversion mechanisms of resistance to PARP inhibitor or platinum chemotherapy in BRCA1/2-mutant metastatic breast cancer
- (2020) Adrienne G. Waks et al. ANNALS OF ONCOLOGY
- Pan-cancer analysis of whole genomes
- (2020) NATURE
- The repertoire of mutational signatures in human cancer
- (2020) Ludmil B. Alexandrov et al. NATURE
- Patterns of somatic structural variation in human cancer genomes
- (2020) Yilong Li et al. NATURE
- Mechanistic basis for microhomology identification and genome scarring by polymerase theta
- (2020) Juan Carvajal-Garcia et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Homologous recombination DNA repair deficiency and PARP inhibition activity in primary triple negative breast cancer
- (2020) Neha Chopra et al. Nature Communications
- BRCA1-associated structural variations are a consequence of polymerase theta-mediated end-joining
- (2020) J. A. Kamp et al. Nature Communications
- Escape from nonsense-mediated decay associates with anti-tumor immunogenicity
- (2020) Kevin Litchfield et al. Nature Communications
- A meta-analysis of reversion mutations in BRCA genes identifies signatures of DNA end-joining repair mechanisms driving therapy resistance
- (2020) L. Tobalina et al. ANNALS OF ONCOLOGY
- The molecular basis and disease relevance of non-homologous DNA end joining
- (2020) Bailin Zhao et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Agrobacterium T‐DNA integration in somatic cells does not require the activity of DNA polymerase theta
- (2020) Ayako Nishizawa‐Yokoi et al. NEW PHYTOLOGIST
- POLQ suppresses interhomolog recombination and loss of heterozygosity at targeted DNA breaks
- (2020) Luther Davis et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Polymerase δ promotes chromosomal rearrangements and imprecise double-strand break repair
- (2020) Jacob V. Layer et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The shared frameshift mutation landscape of microsatellite-unstable cancers suggests immunoediting during tumor evolution
- (2020) Alexej Ballhausen et al. Nature Communications
- Repair of G1 induced DNA double-strand breaks in S-G2/M by alternative NHEJ
- (2020) Wei Yu et al. Nature Communications
- DNA Polymerase theta (POLQ) is important for repair of DNA double-strand breaks caused by fork collapse
- (2019) Zi Wang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets
- (2019) Kristen E. Mengwasser et al. MOLECULAR CELL
- Mitotic CDK Promotes Replisome Disassembly, Fork Breakage, and Complex DNA Rearrangements
- (2019) Lin Deng et al. MOLECULAR CELL
- Error-Prone Replication through UV Lesions by DNA Polymerase θ Protects against Skin Cancers
- (2019) Jung-Hoon Yoon et al. CELL
- Shieldin – the protector of DNA ends
- (2019) Dheva Setiaputra et al. EMBO REPORTS
- Precise therapeutic gene correction by a simple nuclease-induced double-stranded break
- (2019) Sukanya Iyer et al. NATURE
- The Gene Sculpt Suite: a set of tools for genome editing
- (2019) Carla M Mann et al. NUCLEIC ACIDS RESEARCH
- Microhomology Selection for Microhomology Mediated End Joining in Saccharomyces cerevisiae
- (2019) Kihoon Lee et al. Genes
- XRCC1 protein; Form and function
- (2019) Keith W. Caldecott DNA REPAIR
- DNA double-strand break repair-pathway choice in somatic mammalian cells
- (2019) Ralph Scully et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Massively parallel profiling and predictive modeling of the outcomes of CRISPR/Cas9-mediated double-strand break repair
- (2019) Wei Chen et al. NUCLEIC ACIDS RESEARCH
- Templated Insertions: A Smoking Gun for Polymerase Theta-Mediated End Joining
- (2019) Joost Schimmel et al. TRENDS IN GENETICS
- Distinct roles of RAD52 and POLQ in chromosomal break repair and replication stress response
- (2019) Andrew A. Kelso et al. PLoS Genetics
- Human papillomavirus 16 promotes microhomology-mediated end-joining
- (2019) Jonathan E. Leeman et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Adaptive mutability of colorectal cancers in response to targeted therapies
- (2019) Mariangela Russo et al. SCIENCE
- Genetic determinants of cellular addiction to DNA polymerase theta
- (2019) Wanjuan Feng et al. Nature Communications
- Molecular basis of microhomology-mediated end-joining by purified full-length Polθ
- (2019) Samuel J. Black et al. Nature Communications
- HMCES Functions in the Alternative End-Joining Pathway of the DNA DSB Repair during Class Switch Recombination in B Cells
- (2019) Vipul Shukla et al. MOLECULAR CELL
- Polymerase θ-helicase efficiently unwinds DNA and RNA-DNA hybrids
- (2018) Ahmet Y. Ozdemir et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Carboplatin in BRCA1/2-mutated and triple-negative breast cancer BRCAness subgroups: the TNT Trial
- (2018) Andrew Tutt et al. NATURE MEDICINE
- Template and primer requirements for DNA Pol θ-mediated end joining
- (2018) Peng He et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas
- (2018) Theo A. Knijnenburg et al. Cell Reports
- p53 orchestrates DNA replication restart homeostasis by suppressing mutagenic RAD52 and POLθ pathways
- (2018) Sunetra Roy et al. eLife
- Comprehensive Mapping of Histone Modifications at DNA Double-Strand Breaks Deciphers Repair Pathway Chromatin Signatures
- (2018) Thomas Clouaire et al. MOLECULAR CELL
- BRCA1 Mutation-Specific Responses to 53BP1 Loss-Induced Homologous Recombination and PARP Inhibitor Resistance
- (2018) Joseph Nacson et al. Cell Reports
- Robust activation of microhomology-mediated end joining for precision gene editing applications
- (2018) Hirotaka Ata et al. PLoS Genetics
- Survival analysis of carboplatin added to an anthracycline/taxane-based neoadjuvant chemotherapy and HRD score as predictor of response—final results from GeparSixto
- (2018) S Loibl et al. ANNALS OF ONCOLOGY
- Predictable and precise template-free CRISPR editing of pathogenic variants
- (2018) Max W. Shen et al. NATURE
- Predicting the mutations generated by repair of Cas9-induced double-strand breaks
- (2018) Felicity Allen et al. NATURE BIOTECHNOLOGY
- Insertion-and-deletion-derived tumour-specific neoantigens and the immunogenic phenotype: a pan-cancer analysis
- (2017) Samra Turajlic et al. LANCET ONCOLOGY
- HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signatures
- (2017) Helen Davies et al. NATURE MEDICINE
- The helicase domain of Polθ counteracts RPA to promote alt-NHEJ
- (2017) Pedro A Mateos-Gomez et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Secondary structure forming sequences drive SD-MMEJ repair of DNA double-strand breaks
- (2017) Varandt Y. Khodaverdian et al. NUCLEIC ACIDS RESEARCH
- Dual loss of human POLQ and LIG4 abolishes random integration
- (2017) Shinta Saito et al. Nature Communications
- Inactivation of Pol θ and C-NHEJ eliminates off-target integration of exogenous DNA
- (2017) Alex N. Zelensky et al. Nature Communications
- Pan-cancer analysis of bi-allelic alterations in homologous recombination DNA repair genes
- (2017) Nadeem Riaz et al. Nature Communications
- The helicase domain of Polθ counteracts RPA to promote alt-NHEJ
- (2017) Pedro A Mateos-Gomez et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- BRCA1 Directs the Repair Pathway to Homologous Recombination by Promoting 53BP1 Dephosphorylation
- (2017) Mayu Isono et al. Cell Reports
- Analysis of DNA polymerase ν function in meiotic recombination, immunoglobulin class-switching, and DNA damage tolerance
- (2017) Kei-ichi Takata et al. PLoS Genetics
- Drosophila DNA polymerase theta utilizes both helicase-like and polymerase domains during microhomology-mediated end joining and interstrand crosslink repair
- (2017) Kelly Beagan et al. PLoS Genetics
- Homologous Recombination Deficiency (HRD) Score Predicts Response to Platinum-Containing Neoadjuvant Chemotherapy in Patients with Triple-Negative Breast Cancer
- (2016) M. L. Telli et al. CLINICAL CANCER RESEARCH
- DNA polymerase θ (POLQ), double-strand break repair, and cancer
- (2016) Richard D. Wood et al. DNA REPAIR
- Noncanonical views of homology-directed DNA repair
- (2016) Priyanka Verma et al. GENES & DEVELOPMENT
- Essential Roles for Polymerase θ-Mediated End Joining in the Repair of Chromosome Breaks
- (2016) David W. Wyatt et al. MOLECULAR CELL
- DNA Repair Profiling Reveals Nonrandom Outcomes at Cas9-Mediated Breaks
- (2016) Megan van Overbeek et al. MOLECULAR CELL
- A role for human homologous recombination factors in suppressing microhomology-mediated end joining
- (2016) Sara Ahrabi et al. NUCLEIC ACIDS RESEARCH
- Redundant function of DNA ligase 1 and 3 in alternative end-joining during immunoglobulin class switch recombination
- (2016) Shahnaz Masani et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Polq-Mediated End Joining Is Essential for Surviving DNA Double-Strand Breaks during Early Zebrafish Development
- (2016) Summer B. Thyme et al. Cell Reports
- FANCD2 Maintains Fork Stability in BRCA1/2-Deficient Tumors and Promotes Alternative End-Joining DNA Repair
- (2016) Zeina Kais et al. Cell Reports
- Genomic Scars Generated by Polymerase Theta Reveal the Versatile Mechanism of Alternative End-Joining
- (2016) Robin van Schendel et al. PLoS Genetics
- Chromothripsis: A New Mechanism for Rapid Karyotype Evolution
- (2015) Mitchell L. Leibowitz et al. Annual Review of Genetics
- Replication stress activates DNA repair synthesis in mitosis
- (2015) Sheroy Minocherhomji et al. NATURE
- Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair
- (2015) Raphael Ceccaldi et al. NATURE
- Mammalian polymerase θ promotes alternative NHEJ and suppresses recombination
- (2015) Pedro A. Mateos-Gomez et al. NATURE
- Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism
- (2015) Zheng Hu et al. NATURE GENETICS
- Human DNA polymerase θ grasps the primer terminus to mediate DNA repair
- (2015) Karl E Zahn et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Mechanism of microhomology-mediated end-joining promoted by human DNA polymerase θ
- (2015) Tatiana Kent et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- DNA polymerases δ and λ cooperate in repairing double-strand breaks by microhomology-mediated end-joining inSaccharomyces cerevisiae
- (2015) Damon Meyer et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Essential role for polymerase specialization in cellular nonhomologous end joining
- (2015) John M. Pryor et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structure of the Helicase Domain of DNA Polymerase Theta Reveals a Possible Role in the Microhomology-Mediated End-Joining Pathway
- (2015) Joseph A. Newman et al. STRUCTURE
- Mutagenic consequences of a single G-quadruplex demonstrate mitotic inheritance of DNA replication fork barriers
- (2015) Bennie Lemmens et al. Nature Communications
- Polymerase Θ is a key driver of genome evolution and of CRISPR/Cas9-mediated mutagenesis
- (2015) Robin van Schendel et al. Nature Communications
- Human DNA polymerase θ grasps the primer terminus to mediate DNA repair
- (2015) Karl E Zahn et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Mechanism of microhomology-mediated end-joining promoted by human DNA polymerase θ
- (2015) Tatiana Kent et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- DNA Damage Response Factors from Diverse Pathways, Including DNA Crosslink Repair, Mediate Alternative End Joining
- (2015) Sean M. Howard et al. PLoS Genetics
- ATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signaling
- (2014) R. A. Deshpande et al. EMBO JOURNAL
- Polymerase theta-mediated end joining of replication-associated DNA breaks in C. elegans
- (2014) S. F. Roerink et al. GENOME RESEARCH
- RPA antagonizes microhomology-mediated repair of DNA double-strand breaks
- (2014) Sarah K Deng et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- A Polymerase Theta-dependent repair pathway suppresses extensive genomic instability at endogenous G4 DNA sites
- (2014) Wouter Koole et al. Nature Communications
- Escape from Telomere-Driven Crisis Is DNA Ligase III Dependent
- (2014) Rhiannon E. Jones et al. Cell Reports
- Mechanism of Suppression of Chromosomal Instability by DNA Polymerase POLQ
- (2014) Matthew J. Yousefzadeh et al. PLoS Genetics
- Diverse Mechanisms of Somatic Structural Variations in Human Cancer Genomes
- (2013) Lixing Yang et al. CELL
- Chromatin Remodeling at DNA Double-Strand Breaks
- (2013) Brendan D. Price et al. CELL
- Signatures of mutational processes in human cancer
- (2013) Ludmil B. Alexandrov et al. NATURE
- Double-strand break repair: 53BP1 comes into focus
- (2013) Stephanie Panier et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Microhomology-mediated End Joining and Homologous Recombination share the initial end resection step to repair DNA double-strand breaks in mammalian cells
- (2013) L. N. Truong et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Patterns of genomic loss of heterozygosity predict homologous recombination repair defects in epithelial ovarian cancer
- (2012) V Abkevich et al. BRITISH JOURNAL OF CANCER
- Ploidy and Large-Scale Genomic Instability Consistently Identify Basal-like Breast Carcinomas with BRCA1/2 Inactivation
- (2012) T. Popova et al. CANCER RESEARCH
- DNA polymerase POLQ and cellular defense against DNA damage
- (2012) Matthew J. Yousefzadeh et al. DNA REPAIR
- Robust chromosomal DNA repair via alternative end-joining in the absence of X-ray repair cross-complementing protein 1 (XRCC1)
- (2012) C. Boboila et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Telomeric Allelic Imbalance Indicates Defective DNA Repair and Sensitivity to DNA-Damaging Agents
- (2012) Nicolai J. Birkbak et al. Cancer Discovery
- Microhomology Directs Diverse DNA Break Repair Pathways and Chromosomal Translocations
- (2012) Diana D. Villarreal et al. PLoS Genetics
- Human Mre11/Human Rad50/Nbs1 and DNA Ligase IIIα/XRCC1 Protein Complexes Act Together in an Alternative Nonhomologous End Joining Pathway
- (2011) Julie Della-Maria et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Mismatch Repair Proteins MSH2, MLH1, and EXO1 Are Important for Class-Switch Recombination Events Occurring in B Cells That Lack Nonhomologous End Joining
- (2011) J. Eccleston et al. JOURNAL OF IMMUNOLOGY
- Functional Interplay of the Mre11 Nuclease and Ku in the Response to Replication-Associated DNA Damage
- (2011) S. S. Foster et al. MOLECULAR AND CELLULAR BIOLOGY
- Aberrant chromosome morphology in human cells defective for Holliday junction resolution
- (2011) Thomas Wechsler et al. NATURE
- Interhomolog recombination and loss of heterozygosity in wild-type and Bloom syndrome helicase (BLM)-deficient mammalian cells
- (2011) J. R. LaRocque et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- DNA Ligase III Promotes Alternative Nonhomologous End-Joining during Chromosomal Translocation Formation
- (2011) Deniz Simsek et al. PLoS Genetics
- A Small Interfering RNA Screen of Genes Involved in DNA Repair Identifies Tumor-Specific Radiosensitization by POLQ Knockdown
- (2010) Geoff S. Higgins et al. CANCER RESEARCH
- 53BP1 Inhibits Homologous Recombination in Brca1-Deficient Cells by Blocking Resection of DNA Breaks
- (2010) Samuel F. Bunting et al. CELL
- ATM regulates Mre11-dependent DNA end-degradation and microhomology-mediated end joining
- (2010) Elias A. Rahal et al. CELL CYCLE
- 53BP1 regulates DNA resection and the choice between classical and alternative end joining during class switch recombination
- (2010) Anne Bothmer et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Lesion Bypass Activity of DNA Polymerase θ (POLQ) Is an Intrinsic Property of the Pol Domain and Depends on Unique Sequence Inserts
- (2010) Matthew Hogg et al. JOURNAL OF MOLECULAR BIOLOGY
- 53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers
- (2010) Peter Bouwman et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- CtIP promotes microhomology-mediated alternative end joining during class-switch recombination
- (2010) Mieun Lee-Theilen et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- An essential role for CtIP in chromosomal translocation formation through an alternative end-joining pathway
- (2010) Yu Zhang et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- The alternative end-joining pathway for repair of DNA double-strand breaks requires PARP1 but is not dependent upon microhomologies
- (2010) Wael Y. Mansour et al. NUCLEIC ACIDS RESEARCH
- Synthesis-dependent microhomology-mediated end joining accounts for multiple types of repair junctions
- (2010) Amy Marie Yu et al. NUCLEIC ACIDS RESEARCH
- DNA polymerase up-regulation is associated with poor survival in breast cancer, perturbs DNA replication, and promotes genetic instability
- (2010) F. Lemee et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Dual Roles for DNA Polymerase Theta in Alternative End-Joining Repair of Double-Strand Breaks in Drosophila
- (2010) Sze Ham Chan et al. PLoS Genetics
- Distinct kinetics of human DNA ligases I, IIIα, IIIβ, and IV reveal direct DNA sensing ability and differential physiological functions in DNA repair
- (2009) Xi Chen et al. DNA REPAIR
- Roles for NBS1 in Alternative Nonhomologous End-Joining of V(D)J Recombination Intermediates
- (2009) Ludovic Deriano et al. MOLECULAR CELL
- CtIP-BRCA1 modulates the choice of DNA double-strand-break repair pathway throughout the cell cycle
- (2009) Maximina H. Yun et al. NATURE
- The DNA replication FoSTeS/MMBIR mechanism can generate genomic, genic and exonic complex rearrangements in humans
- (2009) Feng Zhang et al. NATURE GENETICS
- Role of mammalian Mre11 in classical and alternative nonhomologous end joining
- (2009) Anyong Xie et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Mitotic Recombination: Why? When? How? Where?
- (2009) Matthew C. LaFave et al. PLoS Genetics
- Mre11 Dimers Coordinate DNA End Bridging and Nuclease Processing in Double-Strand-Break Repair
- (2008) R. Scott Williams et al. CELL
- Sgs1 Helicase and Two Nucleases Dna2 and Exo1 Resect DNA Double-Strand Break Ends
- (2008) Zhu Zhu et al. CELL
- Caenorhabditis elegans POLQ-1 and HEL-308 function in two distinct DNA interstrand cross-link repair pathways
- (2008) Diego M. Muzzini et al. DNA REPAIR
- Reevaluation of the role of DNA polymerase θ in somatic hypermutation of immunoglobulin genes
- (2008) Stella A. Martomo et al. DNA REPAIR
- Altered kinetics of nonhomologous end joining and class switch recombination in ligase IV–deficient B cells
- (2008) Li Han et al. JOURNAL OF EXPERIMENTAL MEDICINE
- ERCC1-XPF Endonuclease Facilitates DNA Double-Strand Break Repair
- (2008) A. Ahmad et al. MOLECULAR AND CELLULAR BIOLOGY
- Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing
- (2008) Eleni P. Mimitou et al. NATURE
- Low-fidelity DNA synthesis by human DNA polymerase theta
- (2008) M. E. Arana et al. NUCLEIC ACIDS RESEARCH
- Alternative-NHEJ Is a Mechanistically Distinct Pathway of Mammalian Chromosome Break Repair
- (2008) Nicole Bennardo et al. PLoS Genetics
- DNA polymerase θ (POLQ) can extend from mismatches and from bases opposite a (6-4) photoproduct
- (2007) Mineaki Seki et al. DNA REPAIR
Become a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get StartedAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started