Triazole derivatives as potential antifungal agents: A structure-activity relationship (SAR) studies

Discovery of novel triazoles containing benzyloxy phenyl isoxazole side chain with potent and broad-spectrum antifungal activity

(2023) Xiaochen Chi et al.   BIOORGANIC CHEMISTRY

Novel antifungal triazoles with alkynyl-methoxyl side chains: Design, synthesis, and biological activity evaluation

(2023) Fei Xie et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Pyrazole and pyrazoline derivatives as antimalarial agents: A key review

(2022) Lekkala Ravindar et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

A key review on oxadiazole analogs as potential methicillin-resistant Staphylococcus aureus (MRSA) activity: Structure-activity relationship studies

(2021) Santosh Kumar Verma et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Benzimidazole analogues as efficient arsenals in war against methicillin-resistance staphylococcus aureus (MRSA) and its SAR studies

(2021) Gao-Feng Zha et al.   BIOORGANIC CHEMISTRY

Design, synthesis and structure-activity relationship of economically triazole sulfonamide aryl derivatives with high fungicidal activity

(2020) Jian Lin et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Synthesis of 1, 2, 4-triazole benzoyl arylamine derivatives and their high antifungal activities

(2020) Yi-Nan Cheng et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Structure based approach for twin-enzyme targeted benzimidazolyl-1,2,4-triazole molecular hybrids as antifungal agents

(2020) Radha Ahuja et al.   Arabian Journal of Chemistry

Pyrazole-based analogs as potential antibacterial agents against methicillin-resistance staphylococcus aureus (MRSA) and its SAR elucidation

(2020) Rameshwari Verma et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis, and antifungal activity of carboxamide derivatives possessing 1,2,3-triazole as potential succinate dehydrogenase inhibitors

(2019) Wei Yan et al.   PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY

Synthesis and antimicrobial activity of novel 1,2,3-triazole-conjugates of quinazolin-4-ones

(2019) Iwona E. Głowacka et al.   ARCHIV DER PHARMAZIE

Radical scavenging and anti-inflammatory activities of (hetero)arylethenesulfonyl fluorides: Synthesis and structure-activity relationship (SAR) and QSAR studies

(2019) Ying Jiang et al.   BIOORGANIC CHEMISTRY

Chalcone derivatives and their antibacterial activities: Current development

(2019) Man Xu et al.   BIOORGANIC CHEMISTRY

Design, synthesis, and structure-activity relationship studies of novel tetrazole antifungal agents with potent activity, broad antifungal spectrum and high selectivity

(2018) Anran Qian et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design, synthesis, biological activities and DFT calculation of novel 1,2,4-triazole Schiff base derivatives

(2018) Ru-Yi Jin et al.   BIOORGANIC CHEMISTRY

Amino acids/peptides conjugated heterocycles: A tool for the recent development of novel therapeutic agents

(2018) Meng Wang et al.   BIOORGANIC CHEMISTRY

Molecular docking, design, synthesis and antifungal activity study of novel triazole derivatives

(2018) Junqi Wu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, crystal structure and antimicrobial potential of some fluorinated chalcone-1,2,3-triazole conjugates

(2018) Pinki Yadav et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Role of BP*C@AgNPs in Bap-dependent multicellular behavior of clinically important methicillin-resistant Staphylococcus aureus (MRSA) biofilm adherence: A key virulence study

(2018) Zhang Xu et al.   MICROBIAL PATHOGENESIS

Effect of Low Charge and High Hydrophobicity on Antimicrobial Activity of the Quinazolinone-Peptide Conjugates

(2018) Kadallipura Puttaswamy Rakesh et al.   RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY

Promising bactericidal approach of dihydrazone analogues against bio-film forming Gram-negative bacteria and molecular mechanistic studies

(2018) K. P. Rakesh et al.   RSC Advances

1,2,3-Triazole fused with pyridine/pyrimidine as new template for antimicrobial agents: Regioselective synthesis and identification of potent N-heteroarenes

(2018) Nagaraju Marepu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Aryl fluorosulfate analogues as potent antimicrobial agents: SAR, cytotoxicity and docking studies

(2018) Lekkala Ravindar et al.   BIOORGANIC CHEMISTRY

Multi-targeted dihydrazones as potent biotherapeutics

(2018) Chen Li et al.   BIOORGANIC CHEMISTRY

Discovery of novel arylethenesulfonyl fluorides as potential candidates against methicillin-resistant of Staphylococcus aureus (MRSA) for overcoming multidrug resistance of bacterial infections

(2018) Gao-Feng Zha et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Combating a Master Manipulator: Staphylococcus aureus Immunomodulatory Molecules as Targets for Combinatorial Drug Discovery

(2018) Kadalipura P. Rakesh et al.   ACS Combinatorial Science

Design, synthesis, and in vitro antifungal evaluation of novel triazole derivatives bearing alkynyl side chains

(2018) Tingjunhong Ni et al.   Journal of Saudi Chemical Society

Convenient synthesis, antimalarial and antimicrobial potential of thioethereal 1,4-disubstituted 1,2,3-triazoles with ester functionality

(2017) C. P. Kaushik et al.   MEDICINAL CHEMISTRY RESEARCH

Antibiotic tolerance facilitates the evolution of resistance

(2017) Irit Levin-Reisman et al.   SCIENCE

Design, synthesis and biological evaluation of amino organophosphorus imidazoles as a new type of potential antimicrobial agents

(2017) Wei-Wei Gao et al.   Science China-Chemistry

Synthesis and molecular docking studies of xanthone attached amino acids as potential antimicrobial and anti-inflammatory agents

(2017) Xing Chen et al.   MedChemComm

Synthesis and antifungal activity of novel oxazolidin-2-one-linked 1,2,3-triazole derivatives

(2017) Alejandra Ramírez-Villalva et al.   MedChemComm

Discovery of potential antifungal triazoles: design, synthesis, biological evaluation, and preliminary antifungal mechanism exploration

(2017) Yuan Zhang et al.   MedChemComm

Design, synthesis and biological evaluation of novel Schiff base-bridged tetrahydroprotoberberine triazoles as a new type of potential antimicrobial agents

(2017) Jun-Rong Duan et al.   MedChemComm

Recent Developments on 1,2,4-Triazole Nucleus in Anticancer Compounds: A Review

(2016) Ramandeep Kaur et al.   Anti-Cancer Agents in Medicinal Chemistry

Design, synthesis and biological evaluation of 5-fluorouracil-derived benzimidazoles as novel type of potential antimicrobial agents

(2016) Xue-Jie Fang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Multi-targeting exploration of new 2-aminothiazolyl quinolones: Synthesis, antimicrobial evaluation, interaction with DNA, combination with topoisomerase IV and penetrability into cells

(2016) Yu Cheng et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Quinazolinone azolyl ethanols: potential lead antimicrobial agents with dual action modes targeting methicillin-resistantStaphylococcus aureusDNA

(2016) Xin-Mei Peng et al.   Future Medicinal Chemistry

New Progress in Azole Compounds as Antimicrobial Agents

(2016) Hui-Zhen Zhang et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Antibacterial drug discovery in the resistance era

(2016) Eric D. Brown et al.   NATURE

Foretelling toxicity: FDA researchers work to predict risk of liver injury from drugs

(2016) Cassandra Willyard   NATURE MEDICINE

Design, synthesis, characterization of some new 1,2,3-triazolyl chalcone derivatives as potential anti-microbial, anti-oxidant and anti-cancer agents via a Claisen–Schmidt reaction approach

(2016) Manjunatha Bhat et al.   RSC Advances

Re-engineering of PIP3-antagonist triazole PITENIN's chemical scaffold: development of novel antifungal leads

(2016) Sravani Pulya et al.   RSC Advances

Synthesis and biological evaluation of fluconazole analogs with triazole-modified scaffold as potent antifungal agents

(2015) Seyedeh Mahdieh Hashemi et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and antifungal activity of 5-iodo-1,4-disubstituted-1,2,3-triazole derivatives as pyruvate dehydrogenase complex E1 inhibitors

(2015) Jun-Bo He et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Click reaction based synthesis, antimicrobial, and cytotoxic activities of new 1,2,3-triazoles

(2015) Mohamed Ramadan El Sayed Aly et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Schiff’s bases of quinazolinone derivatives: Synthesis and SAR studies of a novel series of potential anti-inflammatory and antioxidants

(2015) K.P. Rakesh et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Azole antifungals: 35 years of invasive fungal infection management

(2015) David Allen et al.   Expert Review of Anti-Infective Therapy

Click chemistry inspired synthesis of piperazine-triazole derivatives and evaluation of their antimicrobial activities

(2015) Poonam Khedar et al.   MEDICINAL CHEMISTRY RESEARCH

Synthesis and antimicrobial potential of nitrofuran–triazole congeners

(2015) Ahmed Kamal et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis and antifungal activity of 1,2,3-triazole phenylhydrazone derivatives

(2015) Zhi-Cheng Dai et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Discovery of highly potent triazoleantifungal agents with piperidine-oxadiazole side chains

(2015) Xiaomeng He et al.   MedChemComm

Design, synthesis and antifungal activity of novel triazole derivatives containing substituted 1,2,3-triazole-piperdine side chains

(2014) Zhigan Jiang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The synthesis and activities of novel mononuclear or dinuclear cyclen complexes bearing azole pendants as antibacterial and antifungal agents

(2014) Shuo Li et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, antifungal activities and molecular docking studies of novel 2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl dithiocarbamates

(2014) Yan Zou et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis, and Structure–Activity Relationship Studies of Novel Fused Heterocycles-Linked Triazoles with Good Activity and Water Solubility

(2014) Xufeng Cao et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and evaluation of novel azoles as potent antifungal agents

(2013) Liangjing Li et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

1,2,3-Triazole-derived naphthalimides as a novel type of potential antimicrobial agents: Synthesis, antimicrobial activity, interaction with calf thymus DNA and human serum albumin

(2013) Jing-Song Lv et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis, antifungal and antibacterial activity for novel amide derivatives containing a triazole moiety

(2013) Ruping Tang et al.   Chemistry Central Journal

Current Developments in the Syntheses of 1,2,4-Triazole Compounds

(2013) Hui-Zhen Zhang et al.   CURRENT ORGANIC CHEMISTRY

Recent Developments in Azole Compounds as Antibacterial and Antifungal Agents

(2013) Xin-Mei Peng et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Design, synthesis and antimicrobial evaluation of novel benzimidazole type of Fluconazole analogues and their synergistic effects with Chloromycin, Norfloxacin and Fluconazole

(2013) Hui-Zhen Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Comprehensive Review in Current Developments of Imidazole-Based Medicinal Chemistry

(2013) Ling Zhang et al.   MEDICINAL RESEARCH REVIEWS

Synthesis and antifungal activity of the novel triazole compounds

(2013) Shichong Yu et al.   MedChemComm

Molecular docking, design, synthesis and antifungal activity study of novel triazole derivatives containing the 1,2,3-triazole group

(2013) Shichong Yu et al.   RSC Advances

Chemical and microbial semi-synthesis of tetrahydroprotoberberines as inhibitors on tissue factor procoagulant activity

(2012) Hai-Xia Ge et al.   BIOORGANIC & MEDICINAL CHEMISTRY

New triazole derivatives as antifungal agents: Synthesis via click reaction, in vitro evaluation and molecular docking studies

(2012) Yan Zou et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Recent Researches in Triazole Compounds as Medicinal Drugs

(2012) C. -H. Zhou et al.   CURRENT MEDICINAL CHEMISTRY

Synthesis of novel sulfonamide-1,2,4-triazoles, 1,3,4-thiadiazoles and 1,3,4-oxadiazoles, as potential antibacterial and antifungal agents. Biological evaluation and conformational analysis studies

(2011) P. Zoumpoulakis et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Structure-Based Design, Synthesis, and Antifungal Activity of New Triazole Derivatives

(2011) Chunquan Sheng et al.   Chemical Biology & Drug Design

New azoles with antifungal activity: Design, synthesis, and molecular docking

(2010) Xiaoyun Chai et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Azole antimicrobial pharmacophore-based tetrazoles: Synthesis and biological evaluation as potential antimicrobial and anticonvulsant agents

(2009) Sherif A.F. Rostom et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design of new antifungal agents: synthesis and evaluation of 1-[(1H-indol-5-ylmethyl)amino]-2-phenyl-3-(1H-1,2,4-triazol-1-yl)propan-2-ols

(2009) Rémi Guillon et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and antimicrobial activity evaluation of new 1,2,4-triazoles and 1,3,4-thiadiazoles bearing imidazo[2,1-b]thiazole moiety

(2009) Nuray Ulusoy Güzeldemirci et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and SAR studies of biaryloxy-substituted triazoles as antifungal agents

(2008) Ping Liu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and antifungal activity of 1,2,3-triazole containing fluconazole analogues

(2008) Nilkanth G. Aher et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and biological evaluation of bile acid dimers linked with 1,2,3-triazole and bis-β-lactam

(2008) Namdev S. Vatmurge et al.   ORGANIC & BIOMOLECULAR CHEMISTRY