Antibacterial drug discovery in the resistance era

Novel Approaches Are Needed to Develop Tomorrow’s Antibacterial Therapies

(2015) Brad Spellberg et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Unconventional screening approaches for antibiotic discovery

(2015) Maya A. Farha et al.   Annals of the New York Academy of Sciences

Unraveling the Physiological Complexities of Antibiotic Lethality

(2015) Daniel J. Dwyer et al.   Annual Review of Pharmacology and Toxicology

Bioinformatics of antimicrobial resistance in the age of molecular epidemiology

(2015) Andrew G McArthur et al.   CURRENT OPINION IN MICROBIOLOGY

Mining the microbial dark matter

(2015) Corie Lok   NATURE

A new antibiotic kills pathogens without detectable resistance

(2015) Losee L. Ling et al.   NATURE

ESKAPEing the labyrinth of antibacterial discovery

(2015) Ruben Tommasi et al.   NATURE REVIEWS DRUG DISCOVERY

Essential genome ofPseudomonas aeruginosain cystic fibrosis sputum

(2015) Keith H. Turner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antagonism screen for inhibitors of bacterial cell wall biogenesis uncovers an inhibitor of undecaprenyl diphosphate synthase

(2015) Maya A. Farha et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Beta-Lactam Antibiotics Induce a Lethal Malfunctioning of the Bacterial Cell Wall Synthesis Machinery

(2014) Hongbaek Cho et al.   CELL

The antibiotic resistome: what's new?

(2014) Julie Ann Perry et al.   CURRENT OPINION IN MICROBIOLOGY

The soil resistome: a critical review on antibiotic resistance origins, ecology and dissemination potential in telluric bacteria

(2014) Joseph Nesme et al.   ENVIRONMENTAL MICROBIOLOGY

Privileged Structures: Efficient Chemical “Navigators” toward Unexplored Biologically Relevant Chemical Spaces

(2014) Jonghoon Kim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Bacterial phylogeny structures soil resistomes across habitats

(2014) Kevin J. Forsberg et al.   NATURE

An environmental bacterial taxon with a large and distinct metabolic repertoire

(2014) Micheal C. Wilson et al.   NATURE

Aspergillomarasmine A overcomes metallo-β-lactamase antibiotic resistance

(2014) Andrew M. King et al.   NATURE

Antibiotics induce redox-related physiological alterations as part of their lethality

(2014) D. J. Dwyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Specialized Transduction Designed for Precise High-Throughput Unmarked Deletions in Mycobacterium tuberculosis

(2014) P. Jain et al.   mBio

Identification of Anti-virulence Compounds That Disrupt Quorum-Sensing Regulated Acute and Persistent Pathogenicity

(2014) Melissa Starkey et al.   PLoS Pathogens

Is the GAIN Act a turning point in new antibiotic discovery?

(2013) Eric D. Brown   CANADIAN JOURNAL OF MICROBIOLOGY

Discovery of Wall Teichoic Acid Inhibitors as Potential Anti-MRSA β-Lactam Combination Agents

(2013) Hao Wang et al.   CHEMISTRY & BIOLOGY

The Scourge of Antibiotic Resistance: The Important Role of the Environment

(2013) R. L. Finley et al.   CLINICAL INFECTIOUS DISEASES

Design, diversity-oriented synthesis and structure activity relationship studies of quinolinyl heterocycles as antimycobacterial agents

(2013) Venkatesham Rachakonda et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Intrinsic antibiotic resistance: Mechanisms, origins, challenges and solutions

(2013) Georgina Cox et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Potentiating antibacterial activity by predictably enhancing endogenous microbial ROS production

(2013) Mark P Brynildsen et al.   NATURE BIOTECHNOLOGY

Metabolic suppression identifies new antibacterial inhibitors under nutrient limitation

(2013) Soumaya Zlitni et al.   Nature Chemical Biology

Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis

(2013) Kevin Pethe et al.   NATURE MEDICINE

Transposon insertion sequencing: a new tool for systems-level analysis of microorganisms

(2013) Tim van Opijnen et al.   NATURE REVIEWS MICROBIOLOGY

Ribosome-targeting antibiotics and mechanisms of bacterial resistance

(2013) Daniel N. Wilson   NATURE REVIEWS MICROBIOLOGY

A structural basis for streptomycin-induced misreading of the genetic code

(2013) Hasan Demirci et al.   Nature Communications

A Forward Chemical Screen Identifies Antibiotic Adjuvants in Escherichia coli

(2012) Patricia L. Taylor et al.   ACS Chemical Biology

Inhibition of WTA Synthesis Blocks the Cooperative Action of PBPs and Sensitizes MRSA to β-Lactams

(2012) Maya A. Farha et al.   ACS Chemical Biology

Recover the lost art of drug discovery

(2012) Kim Lewis   NATURE

Antibiotic Resistance Is Prevalent in an Isolated Cave Microbiome

(2012) Kirandeep Bhullar et al.   PLoS One

Non-Traditional Antibacterial Screening Approaches for the Identification of Novel Inhibitors of the Glyoxylate Shunt in Gram-Negative Pathogens

(2012) Kelly C. Fahnoe et al.   PLoS One

The Shared Antibiotic Resistome of Soil Bacteria and Human Pathogens

(2012) K. J. Forsberg et al.   SCIENCE

Challenges of Antibacterial Discovery

(2011) L. L. Silver   CLINICAL MICROBIOLOGY REVIEWS

Antibiotic resistance is ancient

(2011) Vanessa M. D’Costa et al.   NATURE

Combinations of antibiotics and nonantibiotic drugs enhance antimicrobial efficacy

(2011) Linda Ejim et al.   Nature Chemical Biology

Impact of high-throughput screening in biomedical research

(2011) Ricardo Macarron et al.   NATURE REVIEWS DRUG DISCOVERY

Genetic Interaction Maps in Escherichia coli Reveal Functional Crosstalk among Cell Envelope Biogenesis Pathways

(2011) Mohan Babu et al.   PLoS Genetics

Antibiotic Sensitivity Profiles Determined with an Escherichia coli Gene Knockout Collection: Generating an Antibiotic Bar Code

(2010) A. Liu et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Phenotypic Landscape of a Bacterial Cell

(2010) Robert J. Nichols et al.   CELL

Daptomycin: From the Mountain to the Clinic, with Essential Help from Francis Tally, MD

(2010) Barry I. Eisenstein et al.   CLINICAL INFECTIOUS DISEASES

Origins and Evolution of Antibiotic Resistance

(2010) J. Davies et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Structural basis for effectiveness of siderophore-conjugated monocarbams against clinically relevant strains of Pseudomonas aeruginosa

(2010) S. Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Genetic Landscape of a Cell

(2010) M. Costanzo et al.   SCIENCE

Discovery of a Small Molecule that Blocks Wall Teichoic Acid Biosynthesis inStaphylococcus aureus

(2009) Jonathan G. Swoboda et al.   ACS Chemical Biology

The discovery of antibacterial agents using diversity-oriented synthesis

(2009) Warren R. J. D. Galloway et al.   CHEMICAL COMMUNICATIONS

Probing Teichoic Acid Genetics with Bioactive Molecules Reveals New Interactions among Diverse Processes in Bacterial Cell Wall Biogenesis

(2009) Michael A. D'Elia et al.   CHEMISTRY & BIOLOGY

Chemical genomics in Escherichia coli identifies an inhibitor of bacterial lipoprotein targeting

(2009) Ranjana Pathania et al.   Nature Chemical Biology

Network visualization and analysis of gene expression data using BioLayout Express3D

(2009) Athanasios Theocharidis et al.   Nature Protocols

Antibiotics for Emerging Pathogens

(2009) M. A. Fischbach et al.   SCIENCE

Are essential genes really essential?

(2009) Michael A. D’Elia et al.   TRENDS IN MICROBIOLOGY

OPT-80, a macrocyclic antimicrobial agent for the treatment ofClostridium difficileinfections: a review

(2008) Michael Gerber et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Physicochemical Properties of Antibacterial Compounds: Implications for Drug Discovery

(2008) Rosemarie O’Shea et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Neglected Intrinsic Resistome of Bacterial Pathogens

(2008) Alicia Fajardo et al.   PLoS One