Pyrazole-based analogs as potential antibacterial agents against methicillin-resistance staphylococcus aureus (MRSA) and its SAR elucidation

Indole-based derivatives as potential antibacterial activity against methicillin-resistance Staphylococcus aureus (MRSA)

(2020) Hua-Li Qin et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and evaluation of dihydrotriazine derivatives-bearing 5-aryloxypyrazole moieties as antibacterial agents

(2020) Tian-Yi Zhang et al.   MOLECULAR DIVERSITY

Discovery of novel multi-substituted benzo-indole pyrazole schiff base derivatives with antibacterial activity targeting DNA gyrase

(2020) Hao Liu et al.   BIOORGANIC CHEMISTRY

Design and synthesis of 4-[4-formyl-3-(2-naphthyl)pyrazol-1-yl]benzoic acid derivatives as potent growth inhibitors of drug-resistant Staphylococcus aureus

(2020) Rawan Alnufaie et al.   JOURNAL OF ANTIBIOTICS

Synthesis and Antimicrobial Studies of Coumarin-Substituted Pyrazole Derivatives as Potent Anti-Staphylococcus aureus Agents

(2020) Rawan Alnufaie et al.   MOLECULES

Ultrasound-assisted synthesis and antibacterial activity of novel 1,3,4-thiadiazole-1H-pyrazol-4-yl-thiazolidin-4-one derivatives

(2020) Nagaraju Kerru et al.   MONATSHEFTE FUR CHEMIE

Characterization of Five Novel Anti-MRSA Compounds Identified Using a Whole-Animal Caenorhabditis elegans/Galleria mellonella Sequential-Screening Approach

(2020) Rajamohammed Khader et al.   Antibiotics-Basel

Novel bis(pyrazole-benzofuran) hybrids possessing piperazine linker: Synthesis of potent bacterial biofilm and MurB inhibitors

(2020) Ahmed E.M. Mekky et al.   BIOORGANIC CHEMISTRY

Antibacterial activities with the structure-activity relationship of coumarin derivatives

(2020) Hua-Li Qin et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of novel dihydrotriazine derivatives bearing 1,3-diaryl pyrazole moieties as potential antibacterial agents

(2019) Tian-Yi Zhang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis of Hydrazone Derivatives of 4-[4-Formyl-3-(2-oxochromen-3-yl)pyrazol-1-yl]benzoic acid as Potent Growth Inhibitors of Antibiotic-resistant Staphylococcus aureus and Acinetobacter baumannii

(2019) Jedidiah Whitt et al.   MOLECULES

Synthetic approaches and pharmaceutical applications of chloro-containing molecules for drug discovery: A critical review

(2019) Wan-Yin Fang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of pyrazolo[3,4-b]azepines and their antioxidant and antibacterial studies

(2019) Pablo E. Romo et al.   MONATSHEFTE FUR CHEMIE

From Phenylthiazoles to Phenylpyrazoles: Broadening the Antibacterial Spectrum toward Carbapenem-Resistant Bacteria

(2019) Ali Hammad et al.   JOURNAL OF MEDICINAL CHEMISTRY

Antibacterial Evaluation, In Silico Characters and Molecular Docking of Schiff Bases Derived from 5-aminopyrazoles

(2019) Ashraf Hassan et al.   MOLECULES

Synthesis and Antimicrobial Studies of 4-[3-(3-Fluorophenyl)-4-formyl-1H-pyrazol-1-yl]benzoic Acid and 4-[3-(4-Fluorophenyl)-4-formyl-1H-pyrazol-1-yl]benzoic Acid as Potent Growth Inhibitors of Drug-Resistant Bacteria

(2019) Jedidiah Whitt et al.   ACS Omega

New library of pyrazole–imidazo[1,2‐α]pyridine molecular conjugates: Synthesis, antibacterial activity and molecular docking studies

(2019) Oluwakemi Ebenezer et al.   Chemical Biology & Drug Design

Vancomycin resistant Staphylococcus aureus infections: A review of case updating and clinical features

(2019) Yanguang Cong et al.   Journal of Advanced Research

Synthesis and antimicrobial studies of hydrazone derivatives of 4-[3-(2,4-difluorophenyl)-4-formyl-1 H -pyrazol-1-yl]benzoic acid and 4-[3-(3,4-difluorophenyl)-4-formyl-1 H -pyrazol-1-yl]benzoic acid

(2018) A.A. Zakeyah et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and Biological Evaluation of Novel Thiazol-2yl-amine Derivatives as Potential Anticancer Agents

(2018) Chaithanya Somu et al.   LETTERS IN ORGANIC CHEMISTRY

Vision for medicine: Staphylococcus aureus biofilm war and unlocking key's for anti-biofilm drug development

(2018) H.M. Manukumar et al.   MICROBIAL PATHOGENESIS

A trisubstituted pyrazole derivative reduces DMBA-induced mammary tumor growth in rats by inhibiting estrogen receptor-α expression

(2018) Hanumappa Ananda et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Promising bactericidal approach of dihydrazone analogues against bio-film forming Gram-negative bacteria and molecular mechanistic studies

(2018) K. P. Rakesh et al.   RSC Advances

Propyl-5-hydroxy-3-methyl-1-phenyl-1H-pyrazole-4-carbodithioate (HMPC): a new bacteriostatic agent against methicillin—resistant Staphylococcus aureus

(2018) Tatiana Johnston et al.   Scientific Reports

Aryl fluorosulfate analogues as potent antimicrobial agents: SAR, cytotoxicity and docking studies

(2018) Lekkala Ravindar et al.   BIOORGANIC CHEMISTRY

Multi-targeted dihydrazones as potent biotherapeutics

(2018) Chen Li et al.   BIOORGANIC CHEMISTRY

Autocyclized and Oxidized Forms of SCR7 Induce Cancer Cell Death by Inhibiting Nonhomologous DNA End joining in a Ligase IV Dependent Manner

(2018) Supriya V. Vartak et al.   FEBS Journal

Structure-activity relationships of pyrazole-4-carbodithioates as antibacterials against methicillin–resistant Staphylococcus aureus

(2018) Hiwa Majed et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of novel arylethenesulfonyl fluorides as potential candidates against methicillin-resistant of Staphylococcus aureus (MRSA) for overcoming multidrug resistance of bacterial infections

(2018) Gao-Feng Zha et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Pharmaceutical and medicinal significance of sulfur (SVI)-Containing motifs for drug discovery: A critical review

(2018) Chuang Zhao et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Combating a Master Manipulator: Staphylococcus aureus Immunomodulatory Molecules as Targets for Combinatorial Drug Discovery

(2018) Kadalipura P. Rakesh et al.   ACS Combinatorial Science

Pyrazole derived ultra-short antimicrobial peptidomimetics with potent anti-biofilm activity

(2017) Mija Ahn et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Novel oxolane derivative DMTD mitigates high glucose-induced erythrocyte apoptosis by regulating oxidative stress

(2017) Swamy Jagadish et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Benzisoxazole: a privileged scaffold for medicinal chemistry

(2017) K. P. Rakesh et al.   MedChemComm

Development of Novel Amphiphilic Pyrazole-g -PolyGlycidyl methacrylate-Based Polymers with Potential Antimicrobial Activity

(2016) Mohamed Samir Mohy Eldin et al.   ADVANCES IN POLYMER TECHNOLOGY

Discovery and Characterization of a Class of Pyrazole Inhibitors of Bacterial Undecaprenyl Pyrophosphate Synthase

(2016) Nestor Concha et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis, and biological evaluation of novel fluorinated pyrazole encompassing pyridyl 1,3,4-oxadiazole motifs

(2016) Nisheeth C. Desai et al.   MEDICINAL CHEMISTRY RESEARCH

Synthesis and antiproliferative studies of curcumin pyrazole derivatives

(2016) Honnalagere Ramesh Puneeth et al.   MEDICINAL CHEMISTRY RESEARCH

Synthesis and antimicrobial studies of azomethine and N-arylamine derivatives of 4-(4-formyl-3-phenyl-1H-pyrazol-1-yl)benzoic acid as potent anti-methicillin-resistant Staphylococcus aureus agents

(2016) Jamarcus Brider et al.   MEDICINAL CHEMISTRY RESEARCH

Platelet protective efficacy of 3,4,5 trisubstituted isoxazole analogue by inhibiting ROS-mediated apoptosis and platelet aggregation

(2016) Swamy Jagadish et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Regioselective synthesis and biological studies of novel 1-aryl-3, 5-bis (het) aryl pyrazole derivatives as potential antiproliferative agents

(2016) Hanumappa Ananda et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Discovery of Pyrazolopyridones as a Novel Class of Gyrase B Inhibitors Using Structure Guided Design

(2016) Jason B. Cross et al.   ACS Medicinal Chemistry Letters

Synthesis and biological evaluation of 1,3-diaryl pyrazole derivatives as potential antibacterial and anti-inflammatory agents

(2015) Ya-Ru Li et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis, biological activity evaluation and molecular docking studies of novel coumarin substituted thiazolyl-3-aryl-pyrazole-4-carbaldehydes

(2015) Krishnaiah Vaarla et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Antiproliferative and tumor inhibitory studies of 2,3 disubstituted 4-thiazolidinone derivatives

(2015) Kothanahally S. Sharath Kumar et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and characterization of novel oxazines and demonstration that they specifically target cyclooxygenase 2

(2015) V. Srinivas et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The synthesis and antibacterial activity of pyrazole-fused tricyclic diterpene derivatives

(2015) Li-Gang Yu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery of a Teraryl Oxazolidinone Compound (S)-N-((3-(3-Fluoro-4-(4-(pyridin-2-yl)-1H-pyrazol-1-yl)phenyl)-2-oxooxazolidin-5-yl)methyl)acetamide Phosphate as a Novel Antimicrobial Agent with Enhanced Safety Profile and Efficacies

(2015) Tao Yang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Microwave-assisted synthesis of novel pyrazole and pyrazolo[3,4-d]pyridazine derivatives incorporating diaryl sulfone moiety as potential antimicrobial agents

(2015) Mohamed F. Mady et al.   RESEARCH ON CHEMICAL INTERMEDIATES

A novel benzimidazole derivative binds to the DNA minor groove and induces apoptosis in leukemic cells

(2015) Mahesh Hegde et al.   RSC Advances

ZrO2-β-cyclodextrin catalyzed synthesis of 2,4,5-trisubstituted imidazoles and 1,2-disubstituted benzimidazoles under solvent free conditions and evaluation of their antibacterial study

(2015) Yarabhally R. Girish et al.   RSC Advances

Synthesis and Antibacterial and Cytotoxic Activities of NewN-3 Substituted Thiazolidine-2,4-dione Derivatives Bearing the Pyrazole Moiety

(2014) Nisheeth C. Desai et al.   ARCHIV DER PHARMAZIE

A 12-year survey of methicillin-resistant Staphylococcus aureus infections in Greece: ST80-IV epidemic?

(2014) E. Drougka et al.   CLINICAL MICROBIOLOGY AND INFECTION

Synthesis, structure–activity relationships, and in vitro antibacterial and antifungal activity evaluations of novel pyrazole carboxylic and dicarboxylic acid derivatives

(2014) Samet Mert et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and antiproliferative effect of novel 4-thiazolidinone-, pyridine- and piperazine-based conjugates on human leukemic cells

(2014) Kothanahally S. Sharath Kumar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery and characterization of a novel class of pyrazolopyrimidinedione tRNA synthesis inhibitors

(2014) Justin I Montgomery et al.   JOURNAL OF ANTIBIOTICS

A Catalyst-free Green Protocol for the Synthesis of Pyranopyrazoles Using Room Temperature Ionic Liquid Choline Chloride-urea

(2014) Toreshettahally R. Swaroop et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

ZnO: An Ecofriendly, Green Nano-catalyst for the Synthesis of Pyrazole Derivatives under Aqueous Media

(2014) Yarabally R. Girish et al.   JOURNAL OF THE CHINESE CHEMICAL SOCIETY

Synthesis of new fluorescent pyrazolo[4,3-a]acridine derivatives having strong antibacterial activities

(2014) Leila Rezaei Daghigh et al.   JOURNAL OF CHEMICAL RESEARCH

Synthesis of pyrazole encompassing 2-pyridone derivatives as antibacterial agents

(2013) Nisheeth C. Desai et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Pyrazole containing natural products: Synthetic preview and biological significance

(2013) Vinod Kumar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Prospects for new antibiotics: a molecule-centered perspective

(2013) Christopher T Walsh et al.   JOURNAL OF ANTIBIOTICS

Natural Products Containing a Nitrogen–Nitrogen Bond

(2013) Lachlan M. Blair et al.   JOURNAL OF NATURAL PRODUCTS

Antinociceptive, anti-inflammatory and antipyretic effects of 1.5-diphenyl-1H-Pyrazole-3-carbohydrazide, a new heterocyclic pyrazole derivative

(2013) David do Carmo Malvar et al.   LIFE SCIENCES

Development of novel antibacterial agents against methicillin-resistant Staphylococcus aureus

(2012) Hao-Chieh Chiu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and biological evaluation of 5-aryloxypyrazole derivatives bearing a rhodanine-3-aromatic acid as potential antimicrobial agents

(2012) Chang-Ji Zheng et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and antibacterial activity of novel 1,3-diphenyl-1H-pyrazoles functionalized with phenylalanine-derived rhodanines

(2012) Chang-Ji Zheng et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and antibacterial evaluation of rhodanine-based 5-aryloxy pyrazoles against selected methicillin resistant and quinolone-resistant Staphylococcus aureus (MRSA and QRSA)

(2012) Ming-Xia Song et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and biological evaluation of novel pyrazole derivatives as antibacterial agents

(2012) Fariba Daemi et al.   JOURNAL OF CHEMICAL RESEARCH

The Synthesis and Antimicrobial Activity of Heterocyclic Derivatives of Totarol

(2012) Michelle B. Kim et al.   ACS Medicinal Chemistry Letters

Synthesis and In-vitro Antibacterial Activity of 7-(3-Aminopyrrolo[3,4-c]pyrazol-5(2H,4H,6H)-yl)-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic Acid Derivatives

(2011) Xin Guo et al.   ARCHIV DER PHARMAZIE

Synthesis and Antimicrobial Evaluation of Some New Cyclooctanones and Cyclooctane-Based Heterocycles

(2011) Korany A. Ali et al.   ARCHIV DER PHARMAZIE

Thermal solvent-free synthesis of novel pyrazolyl chalcones and pyrazolines as potential antimicrobial agents

(2011) Zeba N. Siddiqui et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and in vitro antimicrobial activities of new (cyano-NNO-azoxy)pyrazole derivatives

(2011) Donatella Boschi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and biological evaluation of novel pyrazole derivatives with anticancer activity

(2011) Alessandro Balbi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of novel 1,3-diaryl pyrazole derivatives bearing rhodanine-3-fatty acid moieties as potential antibacterial agents

(2011) Li-Li Xu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

N’-[(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)methylene] 2/4-substituted hydrazides: Synthesis and anticonvulsant activity

(2010) Darpan Kaushik et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Waves of resistance: Staphylococcus aureus in the antibiotic era

(2009) Henry F. Chambers et al.   NATURE REVIEWS MICROBIOLOGY

Synthesis and in silico biological activity evaluation of new N-substituted pyrazolo-oxazin-2-one systems

(2008) Nora Benaamane et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Epidemiology of Methicillin‐ResistantStaphylococcus aureus

(2008) Helen W. Boucher et al.   CLINICAL INFECTIOUS DISEASES

An antibacterial pyrazole derivative from Burkholderia glumae, a bacterial pathogen of rice

(2008) Robin E. Mitchell et al.   PHYTOCHEMISTRY

New Celecoxib Derivatives as Anti-Inflammatory Agents

(2007) György Szabó et al.   JOURNAL OF MEDICINAL CHEMISTRY