Benzimidazole analogues as efficient arsenals in war against methicillin-resistance staphylococcus aureus (MRSA) and its SAR studies

A key review on oxadiazole analogs as potential methicillin-resistant Staphylococcus aureus (MRSA) activity: Structure-activity relationship studies

(2021) Santosh Kumar Verma et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Employing siRNA tool and its delivery platforms in suppressing cisplatin resistance: Approaching to a new era of cancer chemotherapy

(2021) Sepideh Mirzaei et al.   LIFE SCIENCES

A Novel Ruthenium Based Coordination Compound Against Pathogenic Bacteria

(2020) Vishma Pratap Sur et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Synthesis, antimicrobial properties, and theoretical analysis of benzimidazole-2-ylidene silver(I) complexes

(2020) Serpil Demir Düşünceli et al.   JOURNAL OF COORDINATION CHEMISTRY

Synthesis, molecular docking and ADME prediction of some new benzimidazole carboxamidines derivatives as antimicrobial agents

(2020) Meryem Erol et al.   MEDICINAL CHEMISTRY RESEARCH

ST09, A Novel Curcumin Derivative, Blocks Cell Migration by Inhibiting Matrix Metalloproteases in Breast Cancer Cells and Inhibits Tumor Progression in EAC Mouse Tumor Models

(2020) Snehal Nirgude et al.   MOLECULES

Catalyst free sequential one‐pot reaction for the synthesis of 3‐indole propanoates/propanoic acid/propanamides as antituberculosis agents

(2020) Narasimhamurthy Rajeev et al.   JOURNAL OF THE CHINESE CHEMICAL SOCIETY

Pyrazole-based analogs as potential antibacterial agents against methicillin-resistance staphylococcus aureus (MRSA) and its SAR elucidation

(2020) Rameshwari Verma et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The Anti-virulence Efficacy of 4-(1,3-Dimethyl-2,3-Dihydro-1H-Benzimidazol-2-yl)Phenol Against Methicillin-Resistant Staphylococcus aureus

(2019) Nagendran Tharmalingam et al.   Frontiers in Microbiology

Novel purine benzimidazoles as antimicrobial agents by regulating ROS generation and targeting clinically resistant Staphylococcus aureus DNA groove

(2018) Ya-Nan Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Novel aminopyrimidinyl benzimidazoles as potentially antimicrobial agents: Design, synthesis and biological evaluation

(2018) Han-Bo Liu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Biological Evaluation of Novel Thiazol-2yl-amine Derivatives as Potential Anticancer Agents

(2018) Chaithanya Somu et al.   LETTERS IN ORGANIC CHEMISTRY

A trisubstituted pyrazole derivative reduces DMBA-induced mammary tumor growth in rats by inhibiting estrogen receptor-α expression

(2018) Hanumappa Ananda et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Quorum-Sensing Systems as Targets for Antivirulence Therapy

(2018) Tom Defoirdt   TRENDS IN MICROBIOLOGY

Suppression of Staphylococcus aureus biofilm formation and virulence by a benzimidazole derivative, UM-C162

(2018) Cin Kong et al.   Scientific Reports

Autocyclized and Oxidized Forms of SCR7 Induce Cancer Cell Death by Inhibiting Nonhomologous DNA End joining in a Ligase IV Dependent Manner

(2018) Supriya V. Vartak et al.   FEBS Journal

Synthesis, anti-bacterial and anti-protozoal activities of amidinobenzimidazole derivatives and their interactions with DNA and RNA

(2018) Andrea Bistrović et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Antimicrobial and Antibiofilm Activity of Disubstituted Bis-benzimidazolium Salts

(2018) Jérémie Tessier et al.   ChemMedChem

Anticancer, antimicrobial and antioxidant potential of sterically tuned bis-N-heterocyclic salts

(2018) Noor ul Huda et al.   ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES

Design, synthesis and antimicrobial evaluation of novel benzimidazole-incorporated sulfonamide analogues

(2017) Hui-Zhen Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Disarming pathogens: benefits and challenges of antimicrobials that target bacterial virulence instead of growth and viability

(2017) Makrina Totsika   Future Medicinal Chemistry

Selective Inhibition of Escherichia coli RNA and DNA Topoisomerase I by Hoechst 33258 Derived Mono- and Bisbenzimidazoles

(2017) Nihar Ranjan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Triaryl Benzimidazoles as a New Class of Antibacterial Agents against Resistant Pathogenic Microorganisms

(2017) Pietro Picconi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Novel oxolane derivative DMTD mitigates high glucose-induced erythrocyte apoptosis by regulating oxidative stress

(2017) Swamy Jagadish et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Benzimidazole analogs as WTA biosynthesis inhibitors targeting methicillin resistant Staphylococcus aureus

(2016) Shu-Wei Yang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design, synthesis and biological evaluation of 5-fluorouracil-derived benzimidazoles as novel type of potential antimicrobial agents

(2016) Xue-Jie Fang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Diastereomeric bactericidal effect of Ru(phenanthroline)2 dipyridophenazine

(2016) Anna K. F. Mårtensson et al.   CHIRALITY

Design, synthesis and biological evaluation of berberine-benzimidazole hybrids as new type of potentially DNA-targeting antimicrobial agents

(2016) Ponmani Jeyakkumar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery of membrane active benzimidazole quinolones-based topoisomerase inhibitors as potential DNA-binding antimicrobial agents

(2016) Ling Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Platelet protective efficacy of 3,4,5 trisubstituted isoxazole analogue by inhibiting ROS-mediated apoptosis and platelet aggregation

(2016) Swamy Jagadish et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Induction of apoptosis and downregulation of ERα in DMBA-induced mammary gland tumors in Sprague–Dawley rats by synthetic 3,5-disubstituted isoxazole derivatives

(2016) Hanumappa Ananda et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Regioselective synthesis and biological studies of novel 1-aryl-3, 5-bis (het) aryl pyrazole derivatives as potential antiproliferative agents

(2016) Hanumappa Ananda et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Synthesis and Pharmacological Evaluation of Novel Pleuromutilin Derivatives with Substituted Benzimidazole Moieties

(2016) Xin Ai et al.   MOLECULES

Will 10 Million People Die a Year due to Antimicrobial Resistance by 2050?

(2016) Marlieke E. A. de Kraker et al.   PLOS MEDICINE

Benzimidazole-Based FabI Inhibitors: A Promising Novel Scaffold for Anti-staphylococcal Drug Development

(2016) Tina L. Mistry et al.   ACS Infectious Diseases

Calcium-chelating alizarin and other anthraquinones inhibit biofilm formation and the hemolytic activity of Staphylococcus aureus

(2016) Jin-Hyung Lee et al.   Scientific Reports

Structural and biological evaluation of a novel series of benzimidazole inhibitors of Francisella tularensis enoyl-ACP reductase (FabI)

(2015) Shahila Mehboob et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Antiproliferative and tumor inhibitory studies of 2,3 disubstituted 4-thiazolidinone derivatives

(2015) Kothanahally S. Sharath Kumar et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and characterization of novel oxazines and demonstration that they specifically target cyclooxygenase 2

(2015) V. Srinivas et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Targeting virulence not viability in the search for future antibacterials

(2015) Begoña Heras et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Design, Synthesis, and Antimicrobial Evaluation of Novel Quinolone Imidazoles and Interactions with MRSA DNA

(2015) Ling Zhang et al.   Chemical Biology & Drug Design

Ruthenium complexes as antimicrobial agents

(2015) Fangfei Li et al.   CHEMICAL SOCIETY REVIEWS

Synthesis and structure–activity relationship of amidine derivatives of 3,4-ethylenedioxythiophene as novel antibacterial agents

(2015) Ivana Stolić et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Strong Antibacterial Properties of Anion Transporters: A Result of Depolarization and Weakening of the Bacterial Membrane

(2015) Claude R. Elie et al.   JOURNAL OF MEDICINAL CHEMISTRY

Biological Activity and Molecular Structures of Bis(benzimidazole) and Trithiocyanurate Complexes

(2015) Pavel Kopel et al.   MOLECULES

Synthesis and Evaluation of Selected Benzimidazole Derivatives as Potential Antimicrobial Agents

(2015) Fatmah Alasmary et al.   MOLECULES

Novel benzimidazole derived naphthalimide triazoles: synthesis, antimicrobial activity and interactions with calf thymus DNA

(2015) Yun-Lei Luo et al.   Science China-Chemistry

A novel benzimidazole derivative binds to the DNA minor groove and induces apoptosis in leukemic cells

(2015) Mahesh Hegde et al.   RSC Advances

ZrO2-β-cyclodextrin catalyzed synthesis of 2,4,5-trisubstituted imidazoles and 1,2-disubstituted benzimidazoles under solvent free conditions and evaluation of their antibacterial study

(2015) Yarabhally R. Girish et al.   RSC Advances

Potent Antifungal and Antistaphylococcal 2-Anilinobenzimidazoles

(2015) Hakan Göker et al.   ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES

Synthesis and antiproliferative effect of novel 4-thiazolidinone-, pyridine- and piperazine-based conjugates on human leukemic cells

(2014) Kothanahally S. Sharath Kumar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, antibacterial and antitubercular activities of benzimidazole bearing substituted 2-pyridone motifs

(2014) N.C. Desai et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and potent antistaphylococcal activity of some new 2-[4-(3,4-dimethoxyphenoxy)phenyl]-1,N-disubstituted-1H-benzimidazole-5-carboxamidines

(2014) M. Orhan Püsküllü et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

A Catalyst-free Green Protocol for the Synthesis of Pyranopyrazoles Using Room Temperature Ionic Liquid Choline Chloride-urea

(2014) Toreshettahally R. Swaroop et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

ZnO: An Ecofriendly, Green Nano-catalyst for the Synthesis of Pyrazole Derivatives under Aqueous Media

(2014) Yarabally R. Girish et al.   JOURNAL OF THE CHINESE CHEMICAL SOCIETY

Design, synthesis, and biological evaluation of novel benzimidazole derivatives and their interaction with calf thymus DNA and synergistic effects with clinical drugs

(2014) HuiZhen Zhang et al.   Science China-Chemistry

A unique one-pot reaction via CC cleavage from aminomethylene benzimidazoles to access benzimidazolones with wide potentiality

(2014) Hui-Zhen Zhang et al.   TETRAHEDRON LETTERS

Synthesis and antimicrobial activity of novel 2-[4-(1$H$-benzimidazol-1-yl)phenyl]-1$H$-benzimidazoles

(2014) Mehmet ALP et al.   TURKISH JOURNAL OF CHEMISTRY

Easy access for the synthesis of 2-aryl 2,3-dihydroquinazolin-4(1H)-ones using gem-dibromomethylarenes as synthetic aldehyde equivalent

(2014) Kereyagalahally H. Narasimhamurthy et al.   RSC Advances

ZrO2-supported Cu(ii)–β-cyclodextrin complex: construction of 2,4,5-trisubstituted-1,2,3-triazoles via azide–chalcone oxidative cycloaddition and post-triazole alkylation

(2014) Yarabally R. Girish et al.   RSC Advances

RNA-Seq-based transcriptome analysis of methicillin-resistant Staphylococcus aureus biofilm inhibition by ursolic acid and resveratrol

(2014) Nan Qin et al.   Scientific Reports

Chronic wounds and the medical biofilm paradigm

(2014) R.D. Wolcott et al.   Journal of Wound Care

Synthetic Utility of Propylphosphonic Anhydride–DMSO Media: An Efficient One-pot Three-component Synthesis of 2-Arylquinolines

(2013) Kereyagalahally H. Narasimhamurthy et al.   CHEMISTRY LETTERS

Synthesis, Characterization, and Antimicrobial Activity of Silver(I) and Copper(II) Complexes of Phosphate Derivatives of Pyridine And Benzimidazole

(2013) Urszula Kalinowska-Lis et al.   ChemMedChem

Design, synthesis and antimicrobial evaluation of novel benzimidazole type of Fluconazole analogues and their synergistic effects with Chloromycin, Norfloxacin and Fluconazole

(2013) Hui-Zhen Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Staphylococcus aureus virulence factors in evasion from innate immune defenses in human and animal diseases

(2013) Alfonso Zecconi et al.   IMMUNOLOGY LETTERS

Antibacterial activity of head-to-head bis-benzimidazoles

(2013) Joao B. Moreira et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Symmetric Bis-benzimidazoles Are Potent Anti-Staphylococcal Agents with Dual Inhibitory Mechanisms against DNA Gyrase

(2012) Aaron G. Dale et al.   BIOCHEMISTRY

Optimization and structure–activity relationships of a series of potent inhibitors of methicillin-resistant Staphylococcus aureus (MRSA) pyruvate kinase as novel antimicrobial agents

(2012) Nag S. Kumar et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and Potent In vitro Activity of Novel 1H-Benzimidazoles as Anti-MRSA Agents

(2012) Hacer Karataş et al.   Chemical Biology & Drug Design

Synthesis, characterization, and antimicrobial activity of silver carbene complexes derived from 4,5,6,7-tetrachlorobenzimidazole against antibiotic resistant bacteria

(2012) Brian D. Wright et al.   DALTON TRANSACTIONS

Synthesis and biological evaluation of novel benzimidazole derivatives and their binding behavior with bovine serum albumin

(2012) Shao-Lin Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Benzimidazolium-based synthetic chloride and calcium transporters in bacterial membranes

(2012) Claude-Rosny Elie et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Novel Inhibitors of Staphylococcus aureus Virulence Gene Expression and Biofilm Formation

(2012) Yibao Ma et al.   PLoS One

An Easy Access to 4,5-Disubstituted Thiazoles via Base-Induced Click Reaction of Active Methylene Isocyanides with Methyl Dithiocarboxylates

(2012) Marilinganadoddi Sadashiva et al.   SYNTHESIS-STUTTGART

T3P®-DMSO mediated one pot cascade protocol for the synthesis of 4-thiazolidinones from alcohols

(2012) Kothanahally S. Sharath Kumar et al.   TETRAHEDRON LETTERS

Identification of a Novel Benzimidazole That Inhibits Bacterial Biofilm Formation in a Broad-Spectrum Manner

(2011) Karthik Sambanthamoorthy et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

One-step syntheses of nitrofuranyl benzimidazoles that are active against multidrug-resistant bacteria

(2011) Garrett C Moraski et al.   JOURNAL OF ANTIBIOTICS

In Vitro Synergistic Action of Certain Combinations of Gentamicin and Essential Oils

(2010) A. Rosato et al.   CURRENT MEDICINAL CHEMISTRY

Design and Synthesis of Anti-MRSA Benzimidazolylbenzene-sulfonamides. QSAR Studies for Prediction of Antibacterial Activity

(2010) Marco Martín González-Chávez et al.   MOLECULES

Oral multispecies biofilm development and the key role of cell–cell distance

(2010) Paul E. Kolenbrander et al.   NATURE REVIEWS MICROBIOLOGY

Optimization of the central linker of dicationic bis-benzimidazole anti-MRSA and anti-VRE agents

(2009) Laixing Hu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A theobromine derived silver N-heterocyclic carbene: synthesis, characterization, and antimicrobial efficacy studies on cystic fibrosis relevant pathogens

(2009) Matthew J. Panzner et al.   DALTON TRANSACTIONS

Antimalarial pharmacodynamics of chalcone derivatives in combination with artemisinin against Plasmodium falciparum in vitro

(2009) Amit Bhattacharya et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Antibiotics for Emerging Pathogens

(2009) M. A. Fischbach et al.   SCIENCE

Pseudomonas aeruginosa hypoxic or anaerobic biofilm infections within cystic fibrosis airways

(2009) Daniel J. Hassett et al.   TRENDS IN MICROBIOLOGY

Synthesis, Stability, and Antimicrobial Studies of Electronically Tuned Silver AcetateN-Heterocyclic Carbenes

(2008) Khadijah M. Hindi et al.   JOURNAL OF MEDICINAL CHEMISTRY