A key review on oxadiazole analogs as potential methicillin-resistant Staphylococcus aureus (MRSA) activity: Structure-activity relationship studies

Synthetic Polymeric Antibacterial Hydrogel for Methicillin-Resistant Staphylococcus aureus-Infected Wound Healing: Nanoantimicrobial Self-Assembly, Drug- and Cytokine-Free Strategy

(2020) Wenshuai Liu et al.   ACS Nano

ST09, A Novel Curcumin Derivative, Blocks Cell Migration by Inhibiting Matrix Metalloproteases in Breast Cancer Cells and Inhibits Tumor Progression in EAC Mouse Tumor Models

(2020) Snehal Nirgude et al.   MOLECULES

Antibacterial activities with the structure-activity relationship of coumarin derivatives

(2020) Hua-Li Qin et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Anti-tuberculosis activity and its structure-activity relationship (SAR) studies of oxadiazole derivatives: A key review

(2020) Santosh Kumar Verma et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Catalyst free sequential one‐pot reaction for the synthesis of 3‐indole propanoates/propanoic acid/propanamides as antituberculosis agents

(2020) Narasimhamurthy Rajeev et al.   JOURNAL OF THE CHINESE CHEMICAL SOCIETY

Pyrazole-based analogs as potential antibacterial agents against methicillin-resistance staphylococcus aureus (MRSA) and its SAR elucidation

(2020) Rameshwari Verma et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Methicillin-resistant Staphylococcus aureus: an overview of basic and clinical research

(2019) Nicholas A. Turner et al.   NATURE REVIEWS MICROBIOLOGY

A Small-Molecule Inhibitor of trans-Translation Synergistically Interacts with Cathelicidin Antimicrobial Peptides To Impair Survival of Staphylococcus aureus

(2019) Yueyang Huang et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Antibacterial Small Molecules That Potently Inhibit Staphylococcus aureus Lipoteichoic Acid Biosynthesis

(2019) George A. Naclerio et al.   ChemMedChem

Synthesis, Structure Elucidation and Antimicrobial Properties of New Bis-1,3,4-Oxadiazole Derivatives

(2019) Taoufik Rohand et al.   PHARMACEUTICAL CHEMISTRY JOURNAL

Discovery of 1,3,4-oxadiazol-2-one-containing benzamide derivatives targeting FtsZ as highly potent agents of killing a variety of MDR bacteria strains

(2019) Fangchao Bi et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthetic approaches and pharmaceutical applications of chloro-containing molecules for drug discovery: A critical review

(2019) Wan-Yin Fang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design and synthesis of new norfloxacin-1,3,4-oxadiazole hybrids as antibacterial agents against methicillin-resistant Staphylococcus aureus (MRSA)

(2019) Yong Guo et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Synthesis and antibacterial evaluation of a novel library of 2-(thiazol-5-yl)-1,3,4-oxadiazole derivatives against methicillin-resistant Staphylococcus aureus (MRSA)

(2019) Mohamed H. Hannoun et al.   BIOORGANIC CHEMISTRY

Structure–Activity Relationship for the Oxadiazole Class of Antibacterials

(2019) Marc A. Boudreau et al.   ACS Medicinal Chemistry Letters

Activities of oxadiazole antibacterials against Staphylococcus aureus and other Gram-positive bacteria

(2018) Sara Ceballos et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Biphenylthiazole antibiotics with an oxadiazole linker: An approach to improve physicochemical properties and oral bioavailability

(2018) Mohamed Hagras et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

N -(1,3,4-oxadiazol-2-yl)benzamide analogs, bacteriostatic agents against methicillin- and vancomycin-resistant bacteria

(2018) Clement Opoku-Temeng et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Antimicrobial activity of 1,3,4-oxadiazole derivatives against planktonic cells and biofilm of Staphylococcus aureus

(2018) Zhaojun Zheng et al.   Future Medicinal Chemistry

Synthesis and Biological Evaluation of Novel Thiazol-2yl-amine Derivatives as Potential Anticancer Agents

(2018) Chaithanya Somu et al.   LETTERS IN ORGANIC CHEMISTRY

Role of BP*C@AgNPs in Bap-dependent multicellular behavior of clinically important methicillin-resistant Staphylococcus aureus (MRSA) biofilm adherence: A key virulence study

(2018) Zhang Xu et al.   MICROBIAL PATHOGENESIS

A trisubstituted pyrazole derivative reduces DMBA-induced mammary tumor growth in rats by inhibiting estrogen receptor-α expression

(2018) Hanumappa Ananda et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Promising bactericidal approach of dihydrazone analogues against bio-film forming Gram-negative bacteria and molecular mechanistic studies

(2018) K. P. Rakesh et al.   RSC Advances

Methicillin-resistant Staphylococcus aureus

(2018) Andie S. Lee et al.   Nature Reviews Disease Primers

Aryl fluorosulfate analogues as potent antimicrobial agents: SAR, cytotoxicity and docking studies

(2018) Lekkala Ravindar et al.   BIOORGANIC CHEMISTRY

Multi-targeted dihydrazones as potent biotherapeutics

(2018) Chen Li et al.   BIOORGANIC CHEMISTRY

Autocyclized and Oxidized Forms of SCR7 Induce Cancer Cell Death by Inhibiting Nonhomologous DNA End joining in a Ligase IV Dependent Manner

(2018) Supriya V. Vartak et al.   FEBS Journal

Novel 5H-[1,2,4]oxadiazolo[4,5-a]pyrimidin-5-one derivatives as antibacterial and anticancer agents: Synthesis and biological evaluation

(2018) Xiaoyu Liu et al.   TETRAHEDRON LETTERS

Discovery of novel arylethenesulfonyl fluorides as potential candidates against methicillin-resistant of Staphylococcus aureus (MRSA) for overcoming multidrug resistance of bacterial infections

(2018) Gao-Feng Zha et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Pharmaceutical and medicinal significance of sulfur (SVI)-Containing motifs for drug discovery: A critical review

(2018) Chuang Zhao et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Bioactive amide and α-aminophosphonate inhibitors for methicillin-resistant Staphylococcus aureus (MRSA)

(2018) Nader M. Boshta et al.   MONATSHEFTE FUR CHEMIE

Combating a Master Manipulator: Staphylococcus aureus Immunomodulatory Molecules as Targets for Combinatorial Drug Discovery

(2018) Kadalipura P. Rakesh et al.   ACS Combinatorial Science

Investigating the Antibacterial Activity of Biphenylthiazoles against Methicillin- and Vancomycin-Resistant Staphylococcus aureus (MRSA and VRSA)

(2017) Mohamed Hagras et al.   JOURNAL OF MEDICINAL CHEMISTRY

Novel oxolane derivative DMTD mitigates high glucose-induced erythrocyte apoptosis by regulating oxidative stress

(2017) Swamy Jagadish et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Synthesis and molecular docking studies of xanthone attached amino acids as potential antimicrobial and anti-inflammatory agents

(2017) Xing Chen et al.   MedChemComm

Novel T-C@AgNPs mediated biocidal mechanism against biofilm associated methicillin-resistant Staphylococcus aureus (Bap-MRSA) 090, cytotoxicity and its molecular docking studies

(2017) H. M. Manukumar et al.   MedChemComm

A facile one-pot synthesis of novel 2,5-disubstituted-1,3,4-oxadiazoles under conventional and microwave conditions and evaluation of their in vitro antimicrobial activities

(2017) Nida N. Farshori et al.   Arabian Journal of Chemistry

In VitroandIn VivoSynergy of the Oxadiazole Class of Antibacterials with β-Lactams

(2016) Jeshina Janardhanan et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Design and synthesis of novel HDAC8 inhibitory 2,5-disubstituted-1,3,4-oxadiazoles containing glycine and alanine hybrids with anti cancer activity

(2016) Vijaya Rao Pidugu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The oxadiazole antibacterials

(2016) Jeshina Janardhanan et al.   CURRENT OPINION IN MICROBIOLOGY

Second-Generation Phenylthiazole Antibiotics with Enhanced Pharmacokinetic Properties

(2016) Mohammed A. Seleem et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis, and biological evaluation of novel fluorinated pyrazole encompassing pyridyl 1,3,4-oxadiazole motifs

(2016) Nisheeth C. Desai et al.   MEDICINAL CHEMISTRY RESEARCH

Synthesis and antiproliferative studies of curcumin pyrazole derivatives

(2016) Honnalagere Ramesh Puneeth et al.   MEDICINAL CHEMISTRY RESEARCH

Platelet protective efficacy of 3,4,5 trisubstituted isoxazole analogue by inhibiting ROS-mediated apoptosis and platelet aggregation

(2016) Swamy Jagadish et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Induction of apoptosis and downregulation of ERα in DMBA-induced mammary gland tumors in Sprague–Dawley rats by synthetic 3,5-disubstituted isoxazole derivatives

(2016) Hanumappa Ananda et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Regioselective synthesis and biological studies of novel 1-aryl-3, 5-bis (het) aryl pyrazole derivatives as potential antiproliferative agents

(2016) Hanumappa Ananda et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Identification of Bacillus anthracis PurE inhibitors with antimicrobial activity

(2015) Anna Kim et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Antiproliferative and tumor inhibitory studies of 2,3 disubstituted 4-thiazolidinone derivatives

(2015) Kothanahally S. Sharath Kumar et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and characterization of novel oxazines and demonstration that they specifically target cyclooxygenase 2

(2015) V. Srinivas et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Exploration of the structure–activity relationship of 1,2,4-oxadiazole antibiotics

(2015) Derong Ding et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Novel synthetic organic compounds inspired from antifeedant marine alkaloids as potent bacterial biofilm inhibitors

(2015) Rajesh A. Rane et al.   BIOORGANIC CHEMISTRY

Transition Metal Free Chemoselective Reduction ofα,β-Unsaturated Ketones to Saturated Ketones Using Tosyl Hydrazide as a Hydrogen Donor

(2015) Yarabally R Girish et al.   CHINESE JOURNAL OF CHEMISTRY

Powerful Antibacterial Activity of Phenyl-Thiolatobismuth(III) Complexes Derived from Oxadiazolethiones

(2015) Ahmad Luqman et al.   EUROPEAN JOURNAL OF INORGANIC CHEMISTRY

Structure–Activity Relationship for the Oxadiazole Class of Antibiotics

(2015) Edward Spink et al.   JOURNAL OF MEDICINAL CHEMISTRY

A novel benzimidazole derivative binds to the DNA minor groove and induces apoptosis in leukemic cells

(2015) Mahesh Hegde et al.   RSC Advances

ZrO2-β-cyclodextrin catalyzed synthesis of 2,4,5-trisubstituted imidazoles and 1,2-disubstituted benzimidazoles under solvent free conditions and evaluation of their antibacterial study

(2015) Yarabhally R. Girish et al.   RSC Advances

New potent antibacterials against Gram-positive multiresistant pathogens: Effects of side chain modification and chirality in linezolid-like 1,2,4-oxadiazoles

(2014) Cosimo G. Fortuna et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Update on the antibiotic resistance crisis

(2014) Gian Maria Rossolini et al.   CURRENT OPINION IN PHARMACOLOGY

Synthesis and antiproliferative effect of novel 4-thiazolidinone-, pyridine- and piperazine-based conjugates on human leukemic cells

(2014) Kothanahally S. Sharath Kumar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and evaluation of the antimicrobial activities of 3-((5-phenyl-1,3,4-oxadiazol-2-yl)methyl)-2-thioxothiazolidin-4-one derivatives

(2014) Jia-Chun Liu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A Catalyst-free Green Protocol for the Synthesis of Pyranopyrazoles Using Room Temperature Ionic Liquid Choline Chloride-urea

(2014) Toreshettahally R. Swaroop et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

Discovery and Characterization of Potent Thiazoles versus Methicillin- and Vancomycin-Resistant Staphylococcus aureus

(2014) Haroon Mohammad et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of a New Class of Non-β-lactam Inhibitors of Penicillin-Binding Proteins with Gram-Positive Antibacterial Activity

(2014) Peter I. O’Daniel et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

ZnO: An Ecofriendly, Green Nano-catalyst for the Synthesis of Pyrazole Derivatives under Aqueous Media

(2014) Yarabally R. Girish et al.   JOURNAL OF THE CHINESE CHEMICAL SOCIETY

Synthesis and evaluation of in vitro antimicrobial activity of novel 2-[2-(aroyl)aroyloxy]methyl-1,3,4-oxadiazoles

(2014) V. Girish et al.   RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY

Easy access for the synthesis of 2-aryl 2,3-dihydroquinazolin-4(1H)-ones using gem-dibromomethylarenes as synthetic aldehyde equivalent

(2014) Kereyagalahally H. Narasimhamurthy et al.   RSC Advances

ZrO2-supported Cu(ii)–β-cyclodextrin complex: construction of 2,4,5-trisubstituted-1,2,3-triazoles via azide–chalcone oxidative cycloaddition and post-triazole alkylation

(2014) Yarabally R. Girish et al.   RSC Advances

Synthesis, biological evaluation, and molecular docking studies of novel 1,3,4-oxadiazole derivatives possessing benzotriazole moiety as FAK inhibitors with anticancer activity

(2013) Shuai Zhang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthetic Utility of Propylphosphonic Anhydride–DMSO Media: An Efficient One-pot Three-component Synthesis of 2-Arylquinolines

(2013) Kereyagalahally H. Narasimhamurthy et al.   CHEMISTRY LETTERS

Synthesis and evaluation of novel 4-nitropyrrole-based 1,3,4-oxadiazole derivatives as antimicrobial and anti-tubercular agents

(2013) Rajesh A. Rane et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

New linezolid-like 1,2,4-oxadiazoles active against Gram-positive multiresistant pathogens

(2013) Cosimo G. Fortuna et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of novel 1-[5-(4-methoxy-phenyl)-[1,3,4]oxadiazol-2-yl]-piperazine derivatives and evaluation of their in vivo anticonvulsant activity

(2013) Kikkeri P. Harish et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

How allosteric control of Staphylococcus aureus penicillin binding protein 2a enables methicillin resistance and physiological function

(2013) L. H. Otero et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel limonene and citral based 2,5-disubstituted-1,3,4-oxadiazoles: A natural product coupled approach to semicarbazones for antiepileptic activity

(2012) Harish Rajak et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and preliminary antibacterial evaluation of Linezolid-like 1,2,4-oxadiazole derivatives

(2012) Antonio Palumbo Piccionello et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Syntheses and anti-allergic activity of 2-((bis(trimethylsilyl)methylthio/methylsulfonyl)methyl)-5-aryl-1,3,4-oxadiazoles

(2012) Dinneswara Reddy Guda et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

An Easy Access to 4,5-Disubstituted Thiazoles via Base-Induced Click Reaction of Active Methylene Isocyanides with Methyl Dithiocarboxylates

(2012) Marilinganadoddi Sadashiva et al.   SYNTHESIS-STUTTGART

T3P®-DMSO mediated one pot cascade protocol for the synthesis of 4-thiazolidinones from alcohols

(2012) Kothanahally S. Sharath Kumar et al.   TETRAHEDRON LETTERS

Treponema denticolaPurE Is a Bacterial AIR Carboxylase

(2011) Sylvain Tranchimand et al.   BIOCHEMISTRY

The structure–antituberculosis activity relationships study in a series of 5-aryl-2-thio-1,3,4-oxadiazole derivatives

(2011) Fliur Macaev et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Discovery of novel antitubercular 1,5-dimethyl-2-phenyl-4-([5-(arylamino)-1,3,4-oxadiazol-2-yl]methylamino)-1,2-dihydro-3H-pyrazol-3-one analogues

(2011) Mohamed Jawed Ahsan et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Linezolid pharmacokinetics and pharmacodynamics in clinical treatment

(2011) M. S. Dryden   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Synthesis and in vitro antibacterial assessment of novel chromones featuring 1,2,4-oxadiazole

(2011) Santosh D. Diwakar et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

Synthesis, Characterization, and Antimicrobial Evaluation of Oxadiazole Congeners

(2011) Bassem Sadek et al.   MOLECULES

Nitropyrrolins A−E, Cytotoxic Farnesyl-α-nitropyrroles from a Marine-Derived Bacterium within the Actinomycete FamilyStreptomycetaceae

(2010) Hak Cheol Kwon et al.   JOURNAL OF NATURAL PRODUCTS

Heronapyrroles A−C: Farnesylated 2-Nitropyrroles from an Australian Marine-DerivedStreptomycessp.

(2010) Ritesh Raju et al.   ORGANIC LETTERS

Structural biology of the purine biosynthetic pathway

(2008) Y. Zhang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES