Journal
ACS COMBINATORIAL SCIENCE
Volume 20, Issue 12, Pages 681-693Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acscombsci.8b00088
Keywords
Staphylococcus aureus; combinatorial chemistry; precision antimicrobial therapeutics; pathogen defense; virulence factors
Funding
- National Natural Science Foundation of China [21772150]
- Wuhan Applied Fundamental Research Program of Wuhan Science and Technology Bureau [2017060201010216]
- Wuhan University of Technology
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Staphylococcus aureus is a bacterial pathogen that can cause significant disease burden and mortality by counteracting host defenses through producing virulence factors to survive the immune responses evoked by infection. This emerging drug-resistant pathogen has led to a decline in the efficacy of traditional antimicrobial therapy. To combat these threats, precision antimicrobial therapeutics have been created to target key virulence determinants of specific pathogens. Here we review the benefits of, progresses in, and roadblocks to the development of precision antimicrobial therapeutics using combinatorial chemistry.
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