The pharmacological effects of Berberine and its therapeutic potential in different diseases: Role of the phosphatidylinositol 3‐kinase/AKT signaling pathway
Published 2023 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
The pharmacological effects of Berberine and its therapeutic potential in different diseases: Role of the phosphatidylinositol 3‐kinase/AKT signaling pathway
Authors
Keywords
-
Journal
PHYTOTHERAPY RESEARCH
Volume -, Issue -, Pages -
Publisher
Wiley
Online
2023-11-04
DOI
10.1002/ptr.8040
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Berberine regulates mesangial cell proliferation and cell cycle to attenuate diabetic nephropathy through the PI3K/Akt/AS160/GLUT1 signalling pathway
- (2022) Wei‐Jian Ni et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Metformin in Alzheimer’s disease: An overview of potential mechanisms, preclinical and clinical findings
- (2022) Mohammad Rafi Khezri et al. BIOCHEMICAL PHARMACOLOGY
- The PI3K/AKT signaling pathway in cancer: Molecular mechanisms and possible therapeutic interventions
- (2022) Mohammad Rafi Khezri et al. EXPERIMENTAL AND MOLECULAR PATHOLOGY
- Interplay between PI3K/AKT pathway and heart disorders
- (2022) Soudeh Ghafouri-Fard et al. MOLECULAR BIOLOGY REPORTS
- Berberine attenuates sepsis‑induced cardiac dysfunction by upregulating the Akt/eNOS pathway in mice
- (2022) Hong Zhang et al. Experimental and Therapeutic Medicine
- SARS-CoV-2 infects cells following viral entry via clathrin-mediated endocytosis
- (2021) Armin Bayati et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Berberine-induced TFEB deacetylation by SIRT1 promotes autophagy in peritoneal macrophages
- (2021) Yinghong Zheng et al. Aging-US
- Oxyberberine, an absorbed metabolite of berberine, possess superior hypoglycemic effect via regulating the PI3K/Akt and Nrf2 signaling pathways
- (2021) Yaoxing Dou et al. BIOMEDICINE & PHARMACOTHERAPY
- Curcumin and cardiovascular diseases: Focus on cellular targets and cascades
- (2021) Ali Mohammad Pourbagher-Shahri et al. BIOMEDICINE & PHARMACOTHERAPY
- Anticancer potential of metformin: focusing on gastrointestinal cancers
- (2021) Mohammad rafi Khezri et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Azithromycin: Immunomodulatory and Antiviral Properties for SARS-CoV-2 Infection
- (2021) Mohammad Rafi Khezri et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Berberine Inhibits Dengue Virus through Dual Mechanisms
- (2021) Thippayawan Ratanakomol et al. MOLECULES
- Efficacy and safety of berberine in preventing recurrence of colorectal adenomas: A systematic review and meta-analysis
- (2021) ShuangShuang Fang et al. JOURNAL OF ETHNOPHARMACOLOGY
- Atheroprotective Effects and Molecular Mechanism of Berberine
- (2021) Lu Xing et al. Frontiers in Molecular Biosciences
- Berberine Reverses Doxorubicin Resistance by Inhibiting Autophagy Through the PTEN/Akt/mTOR Signaling Pathway in Breast Cancer
- (2020) Ye Wang et al. OncoTargets and Therapy
- Role of PI3K/AKT pathway in cancer: the framework of malignant behavior
- (2020) Ningni Jiang et al. MOLECULAR BIOLOGY REPORTS
- Targeting apoptosis in cancer therapy
- (2020) Benedito A. Carneiro et al. Nature Reviews Clinical Oncology
- The epigallocatechin gallate derivative Y6 inhibits human hepatocellular carcinoma by inhibiting angiogenesis in MAPK/ERK1/2 and PI3K/AKT/ HIF-1α/VEGF dependent pathways
- (2020) Zhi-Hong Liao et al. JOURNAL OF ETHNOPHARMACOLOGY
- Berberine Improves Inflammatory Responses of Diabetes Mellitus in Zucker Diabetic Fatty Rats and Insulin-Resistant HepG2 Cells through the PPM1B Pathway
- (2020) Yang Sheng Wu et al. Journal of Immunology Research
- Berberine promotes peri‐implant osteogenesis in diabetic rats by ROS ‐mediated IRS ‐1 pathway
- (2020) Jingjing Shao et al. BIOFACTORS
- Dual down‐regulation of EGFR and ErbB2 by berberine contributes to suppression of migration and invasion of human ovarian cancer cells
- (2020) Tzu‐Chao Chuang et al. ENVIRONMENTAL TOXICOLOGY
- Berberine Improves Chemo-Sensitivity to Cisplatin by Enhancing Cell Apoptosis and Repressing PI3K/AKT/mTOR Signaling Pathway in Gastric Cancer
- (2020) Yingying Kou et al. Frontiers in Pharmacology
- Effects of Metformin on the Gut Microbiota in Obesity and Type 2 Diabetes Mellitus
- (2020) Qi Zhang et al. Diabetes Metabolic Syndrome and Obesity-Targets and Therapy
- Berberine and barberry (Berberis vulgaris ): A clinical review
- (2019) Mohsen Imenshahidi et al. PHYTOTHERAPY RESEARCH
- Berberine as a potential autophagy modulator
- (2019) Reza Mohammadinejad et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Heart Disease and Stroke Statistics—2019 Update: A Report From the American Heart Association
- (2019) Emelia J. Benjamin et al. CIRCULATION
- Type 2 diabetes: a multifaceted disease
- (2019) Ewan R. Pearson DIABETOLOGIA
- Akt Signaling in Macrophage Polarization, Survival, and Atherosclerosis
- (2019) MacRae F. Linton et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Vascular smooth muscle cells in atherosclerosis
- (2019) Gemma L. Basatemur et al. Nature Reviews Cardiology
- Targeting Early Atherosclerosis: A Focus on Oxidative Stress and Inflammation
- (2019) Patricia Marchio et al. Oxidative Medicine and Cellular Longevity
- Oxidative stress in the aging substantia nigra and the etiology of Parkinson's disease
- (2019) Benjamin G. Trist et al. AGING CELL
- Berberine chloride ameliorated PI3K/Akt‐p/SIRT‐1/PTEN signaling pathway in insulin resistance syndrome induced in rats
- (2019) Marwa El‐Zeftawy et al. JOURNAL OF FOOD BIOCHEMISTRY
- Coronary microvascular obstruction: the new frontier in cardioprotection
- (2019) Gerd Heusch BASIC RESEARCH IN CARDIOLOGY
- Therapeutic and biological activities of berberine: The involvement of Nrf2 signaling pathway
- (2019) Milad Ashrafizadeh et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- A view on drug resistance in cancer
- (2019) Neil Vasan et al. NATURE
- Berberine mitigates cognitive decline in an Alzheimer’s Disease Mouse Model by targeting both tau hyperphosphorylation and autophagic clearance
- (2019) Ying Chen et al. BIOMEDICINE & PHARMACOTHERAPY
- Berberine alleviates rotenone-induced cytotoxicity by antioxidation and activation of PI3K/Akt signaling pathway in SH-SY5Y cells
- (2019) Han Deng et al. NEUROREPORT
- Berberine decreases insulin resistance in a PCOS rats by improving GLUT4: Dual regulation of the PI3K/AKT and MAPK pathways
- (2019) Ning Zhang et al. REGULATORY TOXICOLOGY AND PHARMACOLOGY
- Nano strategies for berberine delivery, a natural alkaloid of Berberis
- (2018) Elaheh Mirhadi et al. BIOMEDICINE & PHARMACOTHERAPY
- Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018
- (2018) Lorenzo Galluzzi et al. CELL DEATH AND DIFFERENTIATION
- Berberine attenuates podocytes injury caused by exosomes derived from high glucose-induced mesangial cells through TGFβ1-PI3K/AKT pathway
- (2018) Ying-Ying Wang et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Protective role of melatonin in cardiac ischemia-reperfusion injury: From pathogenesis to targeted therapy
- (2018) Hao Zhou et al. JOURNAL OF PINEAL RESEARCH
- Berberine Ameliorates MCAO Induced Cerebral Ischemia/Reperfusion Injury via Activation of the BDNF–TrkB–PI3K/Akt Signaling Pathway
- (2018) Jun Yang et al. NEUROCHEMICAL RESEARCH
- Berberine: Pathways to protect neurons
- (2018) Xiaorui Lin et al. PHYTOTHERAPY RESEARCH
- Gut Microbiota-Regulated Pharmacokinetics of Berberine and Active Metabolites in Beagle Dogs After Oral Administration
- (2018) Ru Feng et al. Frontiers in Pharmacology
- ER–Mitochondria Microdomains in Cardiac Ischemia–Reperfusion Injury: A Fresh Perspective
- (2018) Hao Zhou et al. Frontiers in Physiology
- The PI3K/AKT pathway in obesity and type 2 diabetes
- (2018) Xingjun Huang et al. International Journal of Biological Sciences
- Treatment of Alzheimer's Disease with the GSK-3 Inhibitor Tideglusib: A Pilot Study
- (2018) Teodoro del Ser et al. JOURNAL OF ALZHEIMERS DISEASE
- Berberine Alleviates Tau Hyperphosphorylation and Axonopathy-Associated with Diabetic Encephalopathy via Restoring PI3K/Akt/GSK3β Pathway
- (2018) Shanshan Wang et al. JOURNAL OF ALZHEIMERS DISEASE
- Application of nanodiagnostics and nanotherapy to CNS diseases
- (2018) Weiyuan Zhang et al. Nanomedicine
- Atheroprotective effects and molecular targets of bioactive compounds from traditional Chinese medicine
- (2018) Lei Qiao et al. PHARMACOLOGICAL RESEARCH
- Efficacy and safety of berberine for dyslipidaemias: a systematic review and meta-analysis of randomized clinical trials
- (2018) Jianqing Ju et al. PHYTOMEDICINE
- Global, Regional, and National Burden of Cardiovascular Diseases for 10 Causes, 1990 to 2015
- (2017) Gregory A. Roth et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Atheroprotective Effects and Molecular Targets of Tanshinones Derived From Herbal Medicine Danshen
- (2017) Jian Fang et al. MEDICINAL RESEARCH REVIEWS
- Novel role of the nutraceutical bioactive compound berberine in lectin-like OxLDL receptor 1-mediated endothelial dysfunction in comparison to lovastatin
- (2017) C. Caliceti et al. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
- Berberine-sonodynamic therapy induces autophagy and lipid unloading in macrophage
- (2017) Jiayuan Y Kou et al. Cell Death & Disease
- Berberine Restricts Coxsackievirus B Type 3 Replication via Inhibition of c-Jun N-Terminal Kinase (JNK) and p38 MAPK Activation In Vitro
- (2017) Qian Dai et al. MEDICAL SCIENCE MONITOR
- Berberine Ameliorates Diabetes-Associated Cognitive Decline through Modulation of Aberrant Inflammation Response and Insulin Signaling Pathway in DM Rats
- (2017) Qingjie Chen et al. Frontiers in Pharmacology
- Berberine protects against 6-OHDA-induced neurotoxicity in PC12 cells and zebrafish through hormetic mechanisms involving PI3K/AKT/Bcl-2 and Nrf2/HO-1 pathways
- (2017) Chao Zhang et al. Redox Biology
- Gastrointestinal cancer cells treatment with bevacizumab activates a VEGF autoregulatory mechanism involving telomerase catalytic subunit hTERT via PI3K-AKT, HIF-1α and VEGF receptors
- (2017) Nadine Mahfouz et al. PLoS One
- Berberine Preconditioning Protects Neurons Against Ischemia via Sphingosine-1-Phosphate and Hypoxia-Inducible Factor-1α
- (2016) Qichun Zhang et al. AMERICAN JOURNAL OF CHINESE MEDICINE
- Berberine activates Nrf2 nuclear translocation and inhibits apoptosis induced by high glucose in renal tubular epithelial cells through a phosphatidylinositol 3-kinase/Akt-dependent mechanism
- (2016) Xiuli Zhang et al. APOPTOSIS
- Berberine improves mesenteric artery insulin sensitivity through up-regulating insulin receptor-mediated signalling in diabetic rats
- (2016) Feng-Hao Geng et al. BRITISH JOURNAL OF PHARMACOLOGY
- Macrophage Phenotype and Function in Different Stages of Atherosclerosis
- (2016) Ira Tabas et al. CIRCULATION RESEARCH
- Role of gut microbiota in atherosclerosis
- (2016) Annika Lindskog Jonsson et al. Nature Reviews Cardiology
- Berberine attenuates myocardial ischemia reperfusion injury by suppressing the activation of PI3K/AKT signaling
- (2016) ZHU QIN-WEI et al. Experimental and Therapeutic Medicine
- C-reactive protein can upregulate VEGF expression to promote ADSC-induced angiogenesis by activating HIF-1α via CD64/PI3k/Akt and MAPK/ERK signaling pathways
- (2016) JiaYuan Chen et al. Stem Cell Research & Therapy
- Protective effect of berberine against myocardial ischemia reperfusion injury: role of Notch1/Hes1-PTEN/Akt signaling
- (2015) Liming Yu et al. APOPTOSIS
- Crosstalk Between MAPK/ERK and PI3K/AKT Signal Pathways During Brain Ischemia/Reperfusion
- (2015) Jing Zhou et al. ASN Neuro
- The influence of dysfunctional signaling and lipid homeostasis in mediating the inflammatory responses during atherosclerosis
- (2015) Melanie L. Buckley et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Current knowledge and pharmacological profile of berberine: An update
- (2015) Anil Kumar et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Berberine inhibits Chlamydia pneumoniae infection-induced vascular smooth muscle cell migration through downregulating MMP3 and MMP9 via PI3K
- (2015) Lu Ma et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Meta-analysis of the effect and safety of berberine in the treatment of type 2 diabetes mellitus, hyperlipemia and hypertension
- (2015) Jiarong Lan et al. JOURNAL OF ETHNOPHARMACOLOGY
- Growth-suppressive effect of berberine on endometrial carcinoma cells: Role of mitochondrial and PI3K/Akt pathway
- (2015) Han-Peng Kuo et al. Journal of Functional Foods
- PI3K/AKT signaling pathway and cancer: an updated review
- (2014) Miriam Martini et al. ANNALS OF MEDICINE
- Berberine reduces ischemia/reperfusion-induced myocardial apoptosis via activating AMPK and PI3K–Akt signaling in diabetic rats
- (2014) Keke Chen et al. APOPTOSIS
- PI3K/Akt-mediated regulation of p53 in cancer
- (2014) Aswin G. Abraham et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Entry of a Novel Marine DNA Virus, Singapore Grouper Iridovirus, into Host Cells Occurs via Clathrin-Mediated Endocytosis and Macropinocytosis in a pH-Dependent Manner
- (2014) S. Wang et al. JOURNAL OF VIROLOGY
- Inflammasomes in the CNS
- (2014) John G. Walsh et al. NATURE REVIEWS NEUROSCIENCE
- Berberine hydrochloride IL-8 dependently inhibits invasion and IL-8-independently promotes cell apoptosis in MDA-MB-231 cells
- (2014) XIANG LI et al. ONCOLOGY REPORTS
- Inhibitory Effects of Isoquinoline Alkaloid Berberine on Ischemia-Induced Apoptosis via Activation of Phosphoinositide 3-Kinase/Protein Kinase B Signaling Pathway
- (2014) Mia Kim et al. International Neurourology Journal
- Targeting PI3K/Akt/mTOR Signaling in Cancer
- (2014) Camillo Porta et al. Frontiers in Oncology
- Berberine Suppresses TPA-Induced Fibronectin Expression through the Inhibition of VEGF Secretion in Breast Cancer Cells
- (2013) Sangmin Kim et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- Berberine Targets AP-2/hTERT, NF-κB/COX-2, HIF-1α/VEGF and Cytochrome-c/Caspase Signaling to Suppress Human Cancer Cell Growth
- (2013) Lingyi Fu et al. PLoS One
- Berberine, a natural antidiabetes drug, attenuates glucose neurotoxicity and promotes Nrf2-related neurite outgrowth
- (2013) Ya-Yun Hsu et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Inflammation in Atherosclerosis
- (2012) Peter Libby ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Berberine suppresses amyloid-beta-induced inflammatory response in microglia by inhibiting nuclear factor-kappaB and mitogen-activated protein kinase signalling pathways
- (2012) Liyun Jia et al. JOURNAL OF PHARMACY AND PHARMACOLOGY
- Berberine ameliorates β-amyloid pathology, gliosis, and cognitive impairment in an Alzheimer's disease transgenic mouse model
- (2012) Siva Sundara Kumar Durairajan et al. NEUROBIOLOGY OF AGING
- FoxO1, the transcriptional chief of staff of energy metabolism
- (2011) Stavroula Kousteni BONE
- PI3K p55γ promoter activity enhancement is involved in the anti-apoptotic effect of berberine against cerebral ischemia–reperfusion
- (2011) Jun Hu et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Inhibition of H1N1 influenza A virus growth and induction of inflammatory mediators by the isoquinoline alkaloid berberine and extracts of goldenseal (Hydrastis canadensis)
- (2011) Chad E. Cecil et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Growth Suppression of HER2-Overexpressing Breast Cancer Cells by Berberine via Modulation of the HER2/PI3K/Akt Signaling Pathway
- (2011) Han-Peng Kuo et al. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
- Ebola Virus Enters Host Cells by Macropinocytosis and Clathrin-Mediated Endocytosis
- (2011) Paulina Aleksandrowicz et al. JOURNAL OF INFECTIOUS DISEASES
- Berberine modulates AP-1 activity to suppress HPV transcription and downstream signaling to induce growth arrest and apoptosis in cervical cancer cells
- (2011) Sutapa Mahata et al. Molecular Cancer
- Berberine-induced Haemolysis Revisited: Safety of Rhizoma coptidis and Cortex phellodendri in Chronic Haematological Diseases
- (2011) Yeh-ching Linn et al. PHYTOTHERAPY RESEARCH
- Cytokines, macrophage lipid metabolism and foam cells: Implications for cardiovascular disease therapy
- (2011) James E. McLaren et al. PROGRESS IN LIPID RESEARCH
- Natural compounds from traditional medicinal herbs in the treatment of cerebral ischemia/reperfusion injury
- (2010) Peng-fei Wu et al. ACTA PHARMACOLOGICA SINICA
- PTEN regulates angiogenesis and VEGF expression through phosphatase-dependent and -independent mechanisms in HepG2 cells
- (2010) Tao Tian et al. CARCINOGENESIS
- Growth factors protect intestinal stem cells from radiation-induced apoptosis by suppressing PUMA through the PI3K/AKT/p53 axis
- (2009) W Qiu et al. ONCOGENE
- Rapid Activation of Akt2 Is Sufficient to Stimulate GLUT4 Translocation in 3T3-L1 Adipocytes
- (2008) Yvonne Ng et al. Cell Metabolism
- PI3K/Akt: getting it right matters
- (2008) T F Franke ONCOGENE
- Alzheimer's disease-type neuronal tau hyperphosphorylation induced by Aβ oligomers
- (2007) Fernanda G. De Felice et al. NEUROBIOLOGY OF AGING
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreDiscover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversation