Therapeutic and biological activities of berberine: The involvement of Nrf2 signaling pathway

Redox regulation by NRF2 in aging and disease

(2019) Cody J. Schmidlin et al.   FREE RADICAL BIOLOGY AND MEDICINE

Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases

(2019) Antonio Cuadrado et al.   NATURE REVIEWS DRUG DISCOVERY

Berberine and barberry (Berberis vulgaris ): A clinical review

(2019) Mohsen Imenshahidi et al.   PHYTOTHERAPY RESEARCH

Shedding light on gene therapy: carbon dots for the minimally invasive image-guided delivery of plasmids and noncoding RNAs

(2019) Reza Mohammadinejad et al.   Journal of Advanced Research

Critical Role of Nrf2 in Experimental Ischemic Stroke

(2019) Lei Liu et al.   Frontiers in Pharmacology

Nrf2/ARE Pathway Modulation by Dietary Energy Regulation in Neurological Disorders

(2019) Andrea Rodrigues Vasconcelos et al.   Frontiers in Pharmacology

The oncoprotein HBXIP competitively binds KEAP1 to activate NRF2 and enhance breast cancer cell growth and metastasis

(2019) Xiao-Lei Zhou et al.   ONCOGENE

Drug delivery systems for resveratrol, a non-flavonoid polyphenol: Emerging evidence in last decades

(2019) Zahra Ahmadi et al.   JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY

Berberine as a potential autophagy modulator

(2019) Reza Mohammadinejad et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Does Bach1 & c-Myc dependent redox dysregulation of Nrf2 & adaptive homeostasis decrease cancer risk in ageing?

(2019) Kelvin J.A. Davies et al.   FREE RADICAL BIOLOGY AND MEDICINE

Autophagy, anoikis, ferroptosis, necroptosis, and endoplasmic reticulum stress: Potential applications in melanoma therapy

(2019) Milad Ashrafizadeh et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Regulation of Cell Signaling Pathways by Berberine in Different Cancers: Searching for Missing Pieces of an Incomplete Jig-Saw Puzzle for an Effective Cancer Therapy

(2019) Ammad Ahmad Farooqi et al.   Cancers

Melatonin as a potential modulator of Nrf2

(2019) Zahra Ahmadi et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Nano strategies for berberine delivery, a natural alkaloid of Berberis

(2018) Elaheh Mirhadi et al.   BIOMEDICINE & PHARMACOTHERAPY

Neuroprotective effect of clavulanic acid on trimethyltin (TMT)-induced cytotoxicity in PC12 cells

(2018) Samaneh Silakhori et al.   DRUG AND CHEMICAL TOXICOLOGY

Berberine Upregulates P-Glycoprotein in Human Caco-2 Cells and in an Experimental Model of Colitis in the Rat via Activation of Nrf2-Dependent Mechanisms

(2018) Wanghui Jing et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Adenosine monophosphate-activated protein kinase modulation by berberine attenuates mitochondrial deficits and redox imbalance in experimental diabetic neuropathy

(2018) Veera Ganesh Yerra et al.   NEUROPHARMACOLOGY

The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis

(2018) Masayuki Yamamoto et al.   PHYSIOLOGICAL REVIEWS

Berberine: Pathways to protect neurons

(2018) Xiaorui Lin et al.   PHYTOTHERAPY RESEARCH

Berberine nanoparticles with enhanced in vitro bioavailability: characterization and antimicrobial activity

(2018) Muhammad Umar Khayam Sahibzada et al.   Drug Design Development and Therapy

Gut Microbiota-Regulated Pharmacokinetics of Berberine and Active Metabolites in Beagle Dogs After Oral Administration

(2018) Ru Feng et al.   Frontiers in Pharmacology

Astaxanthin: A mechanistic review on its biological activities and health benefits

(2018) Sajad Fakhri et al.   PHARMACOLOGICAL RESEARCH

The Pathogenesis of Diabetes Mellitus by Oxidative Stress and Inflammation: Its Inhibition by Berberine

(2018) Xueling Ma et al.   Frontiers in Pharmacology

Berberine: Botanical Occurrence, Traditional Uses, Extraction Methods, and Relevance in Cardiovascular, Metabolic, Hepatic, and Renal Disorders

(2018) Maria A. Neag et al.   Frontiers in Pharmacology

The impact of Keap1/Nrf2, P38MAPK/NF-κB and Bax/Bcl2/caspase-3 signaling pathways in the protective effects of berberine against methotrexate-induced nephrotoxicity

(2018) Emad H.M. Hassanein et al.   BIOMEDICINE & PHARMACOTHERAPY

The Role of Berberine in the Prevention of HIF-1α Activation to Alleviate Adipose Tissue Fibrosis in High-Fat-Diet-Induced Obese Mice

(2018) Meilin Hu et al.   Evidence-based Complementary and Alternative Medicine

NRF2 Is One of the Players Involved in Bone Marrow Mediated Drug Resistance in Multiple Myeloma

(2018) Chia-Hung Yen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Study of nuclear factor‐2 erythroid related factor‐2 activator, berberine, in paclitaxel induced peripheral neuropathy pain model in rats

(2018) Jagjit Singh et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Berberine ameliorates lipopolysaccharide-induced acute lung injury via the PERK-mediated Nrf2/HO-1 signaling axis

(2018) Yuan Liang et al.   PHYTOTHERAPY RESEARCH

Involvement of Nrf2 in myocardial ischemia and reperfusion injury

(2018) Yiming Shen et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Berberine, an isoquinoline alkaloid suppresses TXNIP mediated NLRP3 inflammasome activation in MSU crystal stimulated RAW 264.7 macrophages through the upregulation of Nrf2 transcription factor and alleviates MSU crystal induced inflammation in rats

(2017) Palani Dinesh et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Berberine binds RXRα to suppress β-catenin signaling in colon cancer cells

(2017) H Ruan et al.   ONCOGENE

Berberine ameliorates fatty acid-induced oxidative stress in human hepatoma cells

(2017) Yixuan Sun et al.   Scientific Reports

Berberine protects against 6-OHDA-induced neurotoxicity in PC12 cells and zebrafish through hormetic mechanisms involving PI3K/AKT/Bcl-2 and Nrf2/HO-1 pathways

(2017) Chao Zhang et al.   Redox Biology

Berberine activates Nrf2 nuclear translocation and inhibits apoptosis induced by high glucose in renal tubular epithelial cells through a phosphatidylinositol 3-kinase/Akt-dependent mechanism

(2016) Xiuli Zhang et al.   APOPTOSIS

Berberine reverses lapatinib resistance of HER2-positive breast cancer cells by increasing the level of ROS

(2016) Ruohan Zhang et al.   CANCER BIOLOGY & THERAPY

Berberine Hydrochloride Protects C2C12 Myoblast Cells Against Oxidative Stress-Induced Damage via Induction of Nrf-2-Mediated HO-1 Expression

(2016) Yung Hyun Choi   DRUG DEVELOPMENT RESEARCH

A Homeostatic Shift Facilitates Endoplasmic Reticulum Proteostasis through Transcriptional Integration of Proteostatic Stress Response Pathways

(2016) Liam Baird et al.   MOLECULAR AND CELLULAR BIOLOGY

Effect of crocin on aged rat kidney through inhibition of oxidative stress and proinflammatory state

(2016) Saeed Samarghandian et al.   PHYTOTHERAPY RESEARCH

NRF2 promotes breast cancer cell proliferation and metastasis by increasing RhoA/ROCK pathway signal transduction

(2016) Chao Zhang et al.   Oncotarget

Berberine ameliorates nonalcoholic fatty liver disease by a global modulation of hepatic mRNA and lncRNA expression profiles

(2015) Xinlu Yuan et al.   Journal of Translational Medicine

Potential drugs which activate nuclear factor E2-related factor 2 signaling to prevent diabetic cardiovascular complications: A focus on fumaric acid esters

(2015) Shanshan Zhou et al.   LIFE SCIENCES

The Nrf2 regulatory network provides an interface between redox and intermediary metabolism

(2014) John D. Hayes et al.   TRENDS IN BIOCHEMICAL SCIENCES

The Crosstalk Between Nrf2 and AMPK Signal Pathways Is Important for the Anti-Inflammatory Effect of Berberine in LPS-Stimulated Macrophages and Endotoxin-Shocked Mice

(2013) Chunfen Mo et al.   ANTIOXIDANTS & REDOX SIGNALING

Inhibitory effects of berberine on lipopolysaccharide-induced inducible nitric oxide synthase and the high-mobility group box 1 release in macrophages

(2013) Danbi Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Berberine and S allyl cysteine mediated amelioration of DEN+CCl4 induced hepatocarcinoma

(2013) Dipanwita Sengupta et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Berberine protects 6-hydroxydopamine-induced human dopaminergic neuronal cell death through the induction of heme oxygenase-1

(2013) Jinbum Bae et al.   MOLECULES AND CELLS

Berberine, a natural antidiabetes drug, attenuates glucose neurotoxicity and promotes Nrf2-related neurite outgrowth

(2013) Ya-Yun Hsu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Berberine attenuates bleomycin induced pulmonary toxicity and fibrosis via suppressing NF-κB dependant TGF-β activation: A biphasic experimental study

(2013) Palanivel Chitra et al.   TOXICOLOGY LETTERS

Berberine activates Nrf2 nuclear translocation and protects against oxidative damage via a phosphatidylinositol 3-kinase/Akt-dependent mechanism in NSC34 motor neuron-like cells

(2012) Ya-Yun Hsu et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

NFE2L3 (NRF3): the Cinderella of the Cap‘n’Collar transcription factors

(2011) Grégory Chevillard et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Berberine induces heme oxygenase-1 up-regulation through phosphatidylinositol 3-kinase/AKT and NF-E2-related factor-2 signaling pathway in astrocytes

(2011) Jia-Hong Chen et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Proteasomal Degradation Is Transcriptionally Controlled by TCF11 via an ERAD-Dependent Feedback Loop

(2010) Janos Steffen et al.   MOLECULAR CELL

NRF2, cancer and calorie restriction

(2010) A Martín-Montalvo et al.   ONCOGENE

On the mechanism of antidepressant-like action of berberine chloride

(2008) Shrinivas K. Kulkarni et al.   EUROPEAN JOURNAL OF PHARMACOLOGY