Role of trigger receptor 2 expressed on myeloid cells in neuroinflammation－neglected multidimensional regulation of microglia

TREM2 Inhibits Tau Hyperphosphorylation and Neuronal Apoptosis via the PI3K/Akt/GSK-3β Signaling Pathway In vivo and In vitro

(2023) Xiaoqian Peng et al.   MOLECULAR NEUROBIOLOGY

Profiling TREM2 expression in amyotrophic lateral sclerosis

(2023) Ivonne Jericó et al.   BRAIN BEHAVIOR AND IMMUNITY

TREM2: A new player in the tumor microenvironment

(2023) Martina Molgora et al.   SEMINARS IN IMMUNOLOGY

Inflammasome activation under high cholesterol load triggers a protective microglial phenotype while promoting neuronal pyroptosis

(2023) Cristina de Dios et al.   Translational Neurodegeneration

TREM2, microglial and ischemic stroke

(2023) Hongxia Wang et al.   JOURNAL OF NEUROIMMUNOLOGY

Loss of TREM2 rescues hyperactivation of microglia, but not lysosomal deficits and neurotoxicity in models of progranulin deficiency

(2022) Anika Reifschneider et al.   EMBO JOURNAL

Positive feedback regulation of microglial glucose metabolism by histone H4 lysine 12 lactylation in Alzheimer’s disease

(2022) Rui-Yuan Pan et al.   Cell Metabolism

TREM2 in the pathogenesis of AD: a lipid metabolism regulator and potential metabolic therapeutic target

(2022) Rui-Yang Li et al.   Molecular Neurodegeneration

Novel potent liposome agonists of triggering receptor expressed on myeloid cells 2 phenocopy antibody treatment in cells

(2022) Christophe Boudesco et al.   GLIA

Microglial mTOR Activation Upregulates Trem2 and Enhances β-Amyloid Plaque Clearance in the 5XFAD Alzheimer's Disease Model

(2022) Qian Shi et al.   JOURNAL OF NEUROSCIENCE

LILRB2-mediated TREM2 signaling inhibition suppresses microglia functions

(2022) Peng Zhao et al.   Molecular Neurodegeneration

Cellular senescence in neuroinflammatory disease: new therapies for old cells?

(2022) Christopher Nelke et al.   TRENDS IN MOLECULAR MEDICINE

TREM2 Promotes Immune Evasion by Mycobacterium tuberculosis in Human Macrophages

(2022) Ankita Dabla et al.   mBio

Role of TREM2 in the Development of Neurodegenerative Diseases After Traumatic Brain Injury

(2022) Chunhao Zhang et al.   MOLECULAR NEUROBIOLOGY

TREM2 modulates neuroinflammation with elevated IRAK3 expression and plays a neuroprotective role after experimental SAH in rats

(2022) Cheng Cao et al.   NEUROBIOLOGY OF DISEASE

Microglia states and nomenclature: A field at its crossroads

(2022) Rosa C. Paolicelli et al.   NEURON

Activation of TREM2 attenuates neuroinflammation via PI3K/Akt signaling pathway to improve postoperative cognitive dysfunction in mice

(2022) Xue Han et al.   NEUROPHARMACOLOGY

A tetravalent TREM2 agonistic antibody reduced amyloid pathology in a mouse model of Alzheimer’s disease

(2022) Peng Zhao et al.   Science Translational Medicine

TREM2 improves neurological dysfunction and attenuates neuroinflammation, TLR signaling and neuronal apoptosis in the acute phase of intracerebral hemorrhage

(2022) Sidan Liu et al.   Frontiers in Aging Neuroscience

TREM2 activation alleviates neural damage via Akt/CREB/BDNF signalling after traumatic brain injury in mice

(2022) Jin Yan et al.   Journal of Neuroinflammation

MicroRNA‐3473b regulates the expression of TREM2/ULK1 and inhibits autophagy in inflammatory pathogenesis of Parkinson’s disease

(2021) Qiankun Lv et al.   JOURNAL OF NEUROCHEMISTRY

TREM2 alters the phagocytic, apoptotic and inflammatory response to Aβ42 in HMC3 cells

(2021) Rumana Akhter et al.   MOLECULAR IMMUNOLOGY

Restoring metabolism of myeloid cells reverses cognitive decline in ageing

(2021) Paras S. Minhas et al.   NATURE

Expression and secretion of apoE isoforms in astrocytes and microglia during inflammation

(2021) Maria Fe Lanfranco et al.   GLIA

Alzheimer’s Disease Pathogenesis: Role of Autophagy and Mitophagy Focusing in Microglia

(2021) Mehdi Eshraghi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Normalization of cholesterol metabolism in spinal microglia alleviates neuropathic pain

(2021) Juliana M. Navia-Pelaez et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Early glycolytic reprogramming controls microglial inflammatory activation

(2021) Junjie Cheng et al.   Journal of Neuroinflammation

Autophagy deficiency modulates microglial lipid homeostasis and aggravates tau pathology and spreading

(2021) Yin Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epigenetic Modulation of Microglia Function and Phenotypes in Neurodegenerative Diseases

(2021) Li Wang et al.   NEURAL PLASTICITY

Precise gene delivery systems with detachable albumin shell remodeling dysfunctional microglia by TREM2 for treatment of Alzheimer's disease

(2021) Pengzhen Wang et al.   BIOMATERIALS

Epimedii Folium and Curculiginis Rhizoma ameliorate lipopolysaccharides-induced cognitive impairment by regulating the TREM2 signaling pathway

(2021) Kun Shi et al.   JOURNAL OF ETHNOPHARMACOLOGY

Dying by fire: noncanonical functions of autophagy proteins in neuroinflammation and neurodegeneration

(2021) BradleeL Heckmann et al.   Neural Regeneration Research

Triggering Receptor Expressed on Myeloid Cells 2 Protects Dopaminergic Neurons by Promoting Autophagy in the Inflammatory Pathogenesis of Parkinson’s Disease

(2021) Wei Huang et al.   Frontiers in Neuroscience

Maprotiline ameliorates isoflurane-induced microglial activation via regulating triggering receptor expressed in myeloid cells 2 (TREM2)

(2021) Rui Hu et al.   Bioengineered

TREM-2 is a sensor and activator of T cell response in SARS-CoV-2 infection

(2021) Yongjian Wu et al.   Science Advances

Sphingosine-1-phosphate, a novel TREM2 ligand, promotes microglial phagocytosis to protect against ischemic brain injury

(2021) Tengfei Xue et al.   Acta Pharmaceutica Sinica B

Peripheral innate immune and bacterial signals relate to clinical heterogeneity in Parkinson’s disease

(2020) Ruwani S. Wijeyekoon et al.   BRAIN BEHAVIOR AND IMMUNITY

TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge

(2020) Alicia A. Nugent et al.   NEURON

Enhancing protective microglial activities with a dual function TREM 2 antibody to the stalk region

(2020) Kai Schlepckow et al.   EMBO Molecular Medicine

TREM2 activation attenuates neuroinflammation and neuronal apoptosis via PI3K/Akt pathway after intracerebral hemorrhage in mice

(2020) Shengpan Chen et al.   Journal of Neuroinflammation

Triggering receptor expressed on myeloid Cells 2 activation downregulates toll‐like receptor 4 expression and ameliorates cognitive impairment in the Aβ 1‐42 ‐induced Alzheimer’s disease mouse model

(2020) Zhangjin Qin et al.   SYNAPSE

TREM2 activation on microglia promotes myelin debris clearance and remyelination in a model of multiple sclerosis

(2020) Francesca Cignarella et al.   ACTA NEUROPATHOLOGICA

The Physiology, Pathology, and Potential Therapeutic Applications of the TREM2 Signaling Pathway

(2020) Aleksandra Deczkowska et al.   CELL

Alzheimer’s-associated PLCγ2 is a signaling node required for both TREM2 function and the inflammatory response in human microglia

(2020) Benjamin J. Andreone et al.   NATURE NEUROSCIENCE

TREM2 ameliorates neuroinflammatory response and cognitive impairment via PI3K/AKT/FoxO3a signaling pathway in Alzheimer’s disease mice

(2020) Yaping Wang et al.   Aging-US

TREM2 overexpression rescues cognitive deficits in APP/PS1 transgenic mice by reducing neuroinflammation via the JAK/STAT/SOCS signaling pathway

(2020) John Bosco Ruganzu et al.   EXPERIMENTAL NEUROLOGY

Trem2 promotes anti-inflammatory responses in microglia and is suppressed under pro-inflammatory conditions

(2020) Wenfei Liu et al.   HUMAN MOLECULAR GENETICS

Resveratrol mediates mechanical allodynia through modulating inflammatory response via the TREM2-autophagy axis in SNI rat model

(2020) Yaping Wang et al.   Journal of Neuroinflammation

Therapeutic Trem2 activation ameliorates amyloid-beta deposition and improves cognition in the 5XFAD model of amyloid deposition

(2020) Brittani R. Price et al.   Journal of Neuroinflammation

Immunometabolism in the Brain: How Metabolism Shapes Microglial Function

(2020) Louis-Philippe Bernier et al.   TRENDS IN NEUROSCIENCES

TMEM59 interacts with TREM2 and modulates TREM2-dependent microglial activities

(2020) Zhaoji Liu et al.   Cell Death & Disease

Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer’s disease

(2020) Amanda McQuade et al.   Nature Communications

Targeting microglial autophagic degradation in NLRP3 inflammasome-mediated neurodegenerative diseases

(2020) An-Guo Wu et al.   AGEING RESEARCH REVIEWS

Up-Regulation of Trem2 Inhibits Hippocampal Neuronal Apoptosis and Alleviates Oxidative Stress in Epilepsy via the PI3K/Akt Pathway in Mice

(2019) Ai-Hua Liu et al.   Neuroscience Bulletin

Spatial and temporal heterogeneity of mouse and human microglia at single-cell resolution

(2019) Takahiro Masuda et al.   NATURE

TREM2 Attenuates Aβ1-42-Mediated Neuroinflammation in BV-2 Cells by Downregulating TLR Signaling

(2019) Huiping Long et al.   NEUROCHEMICAL RESEARCH

Efficacy and mechanism of cGAMP to suppress Alzheimer’s disease by elevating TREM2

(2019) Qiming Xu et al.   BRAIN BEHAVIOR AND IMMUNITY

LC3-Associated Endocytosis Facilitates β-Amyloid Clearance and Mitigates Neurodegeneration in Murine Alzheimer’s Disease

(2019) Bradlee L. Heckmann et al.   CELL

A Breakdown in Metabolic Reprogramming Causes Microglia Dysfunction in Alzheimer's Disease

(2019) Sung Hoon Baik et al.   Cell Metabolism

TREM2 Acts Downstream of CD33 in Modulating Microglial Pathology in Alzheimer’s Disease

(2019) Ana Griciuc et al.   NEURON

Aminophospholipids are signal-transducing TREM2 ligands on apoptotic cells

(2019) Keiro Shirotani et al.   Scientific Reports

Distinct Signaling Pathways Regulate TREM2 Phagocytic and NFκB Antagonistic Activities

(2019) Hailan Yao et al.   Frontiers in Cellular Neuroscience

Mitochondria-targeted TPP-MoS2 with dual enzyme activity provides efficient neuroprotection through M1/M2 microglial polarization in an Alzheimer's disease model

(2019) Chaoxiu Ren et al.   BIOMATERIALS

A locked immunometabolic switch underlies TREM2 R47H loss of function in human iPSC‐derived microglia

(2019) Thomas M. Piers et al.   FASEB JOURNAL

TREM2 modulates microglia phenotypes in the neuroinflammation of Parkinson's disease

(2018) Youwen Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Modulation of γ- and β-Secretases as Early Prevention Against Alzheimer’s Disease

(2018) Iryna Voytyuk et al.   BIOLOGICAL PSYCHIATRY

Disease-Associated Microglia: A Universal Immune Sensor of Neurodegeneration

(2018) Aleksandra Deczkowska et al.   CELL

TREM2 overexpression attenuates neuroinflammation and protects dopaminergic neurons in experimental models of Parkinson's disease

(2018) Manru Ren et al.   EXPERIMENTAL NEUROLOGY

High-Dimensional Single-Cell Mapping of Central Nervous System Immune Cells Reveals Distinct Myeloid Subsets in Health, Aging, and Disease

(2018) Dunja Mrdjen et al.   IMMUNITY

Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson’s disease

(2018) Seung Pil Yun et al.   NATURE MEDICINE

Diverse Brain Myeloid Expression Profiles Reveal Distinct Microglial Activation States and Aspects of Alzheimer’s Disease Not Evident in Mouse Models

(2018) Brad A. Friedman et al.   Cell Reports

Microglia TREM2 is required for electroacupuncture to attenuate neuroinflammation in focal cerebral ischemia/reperfusion rats

(2018) Hongbei Xu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Innate immune memory in the brain shapes neurological disease hallmarks

(2018) Ann-Christin Wendeln et al.   NATURE

Neuroinflammation in the central nervous system: Symphony of glial cells

(2018) Qiao‐qiao Yang et al.   GLIA

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

(2017) Susanne Krasemann et al.   IMMUNITY

TREM2-Ligand Interactions in Health and Disease

(2017) Daniel L. Kober et al.   JOURNAL OF MOLECULAR BIOLOGY

TREM2 Promotes Microglial Survival by Activating Wnt/β-Catenin Pathway

(2017) Honghua Zheng et al.   JOURNAL OF NEUROSCIENCE

Triggering Receptor Expressed on Myeloid Cells 2 Deficiency Alters Acute Macrophage Distribution and Improves Recovery after Traumatic Brain Injury

(2017) Maha Saber et al.   JOURNAL OF NEUROTRAUMA

TREM2 in Neurodegenerative Diseases

(2017) Taylor R. Jay et al.   Molecular Neurodegeneration

Immune hyperreactivity of Aβ plaque-associated microglia in Alzheimer's disease

(2017) Zhuoran Yin et al.   NEUROBIOLOGY OF AGING

Neocortical and hippocampal TREM2 protein levels during the progression of Alzheimer's disease

(2017) Sylvia E. Perez et al.   NEUROBIOLOGY OF AGING

TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy

(2017) Cheryl E. G. Leyns et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TREM2, Microglia, and Neurodegenerative Diseases

(2017) Felix L. Yeh et al.   TRENDS IN MOLECULAR MEDICINE

TREM2 protects against cerebral ischemia/reperfusion injury

(2017) Rong Wu et al.   Molecular Brain

Microglia in the TBI brain: The good, the bad, and the dysregulated

(2016) David J. Loane et al.   EXPERIMENTAL NEUROLOGY

Neuroprotective Effect of TREM-2 in Aging and Alzheimer’s Disease Model

(2016) Animesh Alexander Raha et al.   JOURNAL OF ALZHEIMERS DISEASE

Expression and processing analyses of wild type and p.R47H TREM2 variant in Alzheimer’s disease brains

(2016) Li Ma et al.   Molecular Neurodegeneration

Opposing roles of the triggering receptor expressed on myeloid cells 2 and triggering receptor expressed on myeloid cells-like transcript 2 in microglia activation

(2016) Honghua Zheng et al.   NEUROBIOLOGY OF AGING

TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia

(2016) Felix L. Yeh et al.   NEURON

TREM2 modifies microglial phenotype and provides neuroprotection in P301S tau transgenic mice

(2016) Teng Jiang et al.   NEUROPHARMACOLOGY

How neuroinflammation contributes to neurodegeneration

(2016) R. M. Ransohoff   SCIENCE

Untangling the brain’s neuroinflammatory and neurodegenerative transcriptional responses

(2016) Karpagam Srinivasan et al.   Nature Communications

microRNA-34a-Mediated Down-Regulation of the Microglial-Enriched Triggering Receptor and Phagocytosis-Sensor TREM2 in Age-Related Macular Degeneration

(2016) Surjyadipta Bhattacharjee et al.   PLoS One

TREM2 regulates microglial cell activation in response to demyelination in vivo

(2015) Claudia Cantoni et al.   ACTA NEUROPATHOLOGICA

The triggering receptor expressed on myeloid cells 2 (TREM2) is associated with enhanced inflammation, neuropathological lesions and increased risk for Alzheimer's dementia

(2015) Panos Roussos et al.   Alzheimers & Dementia

Modulation of inflammation by autophagy: Consequences for human disease

(2015) Romana T. Netea-Maier et al.   Autophagy

TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model

(2015) Yaming Wang et al.   CELL

TREM2 sustains microglial expansion during aging and response to demyelination

(2015) Pietro Luigi Poliani et al.   JOURNAL OF CLINICAL INVESTIGATION

TREM-2 promotes macrophage survival and lung disease after respiratory viral infection

(2015) Kangyun Wu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Nuclear Receptors License Phagocytosis by Trem2+ Myeloid Cells in Mouse Models of Alzheimer's Disease

(2015) J. C. Savage et al.   JOURNAL OF NEUROSCIENCE

Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) Deficiency Attenuates Phagocytic Activities of Microglia and Exacerbates Ischemic Damage in Experimental Stroke

(2015) M. Kawabori et al.   JOURNAL OF NEUROSCIENCE

Convergent Genetic and Expression Datasets Highlight TREM2 in Parkinson’s Disease Susceptibility

(2015) Guiyou Liu et al.   MOLECULAR NEUROBIOLOGY

CD33 modulates TREM2: convergence of Alzheimer loci

(2015) Gail Chan et al.   NATURE NEUROSCIENCE

Silencing of TREM2 exacerbates tau pathology, neurodegenerative changes, and spatial learning deficits in P301S tau transgenic mice

(2015) Teng Jiang et al.   NEUROBIOLOGY OF AGING

A Genome-wide Gene-Expression Analysis and Database in Transgenic Mice during Development of Amyloid or Tau Pathology

(2015) Mar Matarin et al.   Cell Reports

Deficient neuron-microglia signaling results in impaired functional brain connectivity and social behavior

(2014) Yang Zhan et al.   NATURE NEUROSCIENCE

Upregulation of TREM2 Ameliorates Neuropathology and Rescues Spatial Cognitive Impairment in a Transgenic Mouse Model of Alzheimer’s Disease

(2014) Teng Jiang et al.   NEUROPSYCHOPHARMACOLOGY

The Triggering Receptor Expressed on Myeloid Cells 2 Inhibits Complement Component 1q Effector Mechanisms and Exerts Detrimental Effects during Pneumococcal Pneumonia

(2014) Omar Sharif et al.   PLoS Pathogens

Empty liposomes induce antitumoral effects associated with macrophage responses distinct from those of the TLR1/2 agonist Pam3CSK4 (BLP)

(2013) Simone König et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

DJ-1 deficiency triggers microglia sensitivity to dopamine toward a pro-inflammatory phenotype that is attenuated by rasagiline

(2013) Dorit Trudler et al.   JOURNAL OF NEUROCHEMISTRY

Insights into TREM2 biology by network analysis of human brain gene expression data

(2013) Paola Forabosco et al.   NEUROBIOLOGY OF AGING

Missense variant in TREML2 protects against Alzheimer's disease

(2013) Bruno A. Benitez et al.   NEUROBIOLOGY OF AGING

Specific lipid recognition is a general feature of CD300 and TREM molecules

(2011) John P. Cannon et al.   IMMUNOGENETICS

A role for TREM2 ligands in the phagocytosis of apoptotic neuronal cells by microglia

(2009) Christine L. Hsieh et al.   JOURNAL OF NEUROCHEMISTRY

The surface-exposed chaperone, Hsp60, is an agonist of the microglial TREM2 receptor

(2009) Luisa Stefano et al.   JOURNAL OF NEUROCHEMISTRY

TREM2 is upregulated in amyloid plaque-associated microglia in aged APP23 transgenic mice

(2008) Stefanie Frank et al.   GLIA