TREM2 Promotes Immune Evasion by Mycobacterium tuberculosis in Human Macrophages

Protein Kinase R Restricts the Intracellular Survival of Mycobacterium tuberculosis by Promoting Selective Autophagy

(2021) Robin Smyth et al.   Frontiers in Microbiology

Host‐directed therapy to combat mycobacterial infections*

(2021) Gül Kilinç et al.   IMMUNOLOGICAL REVIEWS

TREM2 Dictates Antibacterial Defense and Viability of Bone Marrow-derived Macrophages During Bacterial Infection

(2021) ShiYue Yang et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

TREM2 is a receptor for non-glycosylated mycolic acids of mycobacteria that limits anti-mycobacterial macrophage activation

(2021) Ei’ichi Iizasa et al.   Nature Communications

Type I interferon decreases macrophage energy metabolism during mycobacterial infection

(2021) Gregory S. Olson et al.   Cell Reports

Mycobacterium tuberculosis Exploits Focal Adhesion Kinase to Induce Necrotic Cell Death and Inhibit Reactive Oxygen Species Production

(2021) Afrakoma Afriyie-Asante et al.   Frontiers in Immunology

Plasma membrane damage causes NLRP3 activation and pyroptosis during Mycobacterium tuberculosis infection

(2020) Kai S. Beckwith et al.   Nature Communications

TREM2 suppresses the proinflammatory response to facilitate PRRSV infection via PI3K/NF-κB signaling

(2020) Zhenbang Zhu et al.   PLoS Pathogens

Anti-human TREM2 induces microglia proliferation and reduces pathology in an Alzheimer’s disease model

(2020) Shoutang Wang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Priming Is Dispensable for NLRP3 Inflammasome Activation in Human Monocytes In Vitro

(2020) Anna Gritsenko et al.   Frontiers in Immunology

Triggering Receptor Expressed on Myeloid Cell 2 R47H Exacerbates Immune Response in Alzheimer’s Disease Brain

(2020) Olena Korvatska et al.   Frontiers in Immunology

Efficacy and mechanism of cGAMP to suppress Alzheimer’s disease by elevating TREM2

(2019) Qiming Xu et al.   BRAIN BEHAVIOR AND IMMUNITY

Comprehensive Characterization of the Attenuated Double Auxotroph Mycobacterium tuberculosisΔleuDΔpanCD as an Alternative to H37Rv

(2019) Jomien M. Mouton et al.   Frontiers in Microbiology

Distinct Signaling Pathways Regulate TREM2 Phagocytic and NFκB Antagonistic Activities

(2019) Hailan Yao et al.   Frontiers in Cellular Neuroscience

Comparison of human monocyte derived macrophages and THP1-like macrophages as in vitro models for M. tuberculosis infection

(2019) Abhilasha Madhvi et al.   COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES

Necroptosis in development and diseases

(2018) Bing Shan et al.   GENES & DEVELOPMENT

Mycobacterium tuberculosis and lipids: Insights into molecular mechanisms from persistence to virulence

(2018) Ciamak Ghazaei   Journal of Research in Medical Sciences

Mycobacterium tuberculosis–induced IFN-β production requires cytosolic DNA and RNA sensing pathways

(2018) Yong Cheng et al.   JOURNAL OF EXPERIMENTAL MEDICINE

New insights into the role of TREM2 in Alzheimer’s disease

(2018) Maud Gratuze et al.   Molecular Neurodegeneration

TREM2 Promotes Microglial Survival by Activating Wnt/β-Catenin Pathway

(2017) Honghua Zheng et al.   JOURNAL OF NEUROSCIENCE

Mycobacterium tuberculosis exploits the PPM1A signaling pathway to block host macrophage apoptosis

(2017) Kaitlyn Schaaf et al.   Scientific Reports

N-acetyl-cysteine exhibits potent anti-mycobacterial activity in addition to its known anti-oxidative functions

(2016) Eduardo P. Amaral et al.   BMC MICROBIOLOGY

The Roles of Type I Interferon in Bacterial Infection

(2016) Gayle M. Boxx et al.   Cell Host & Microbe

Novel Attributions of TREMs in Immunity

(2016)   CURRENT ISSUES IN MOLECULAR BIOLOGY

TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques

(2016) Yaming Wang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Importance of First Impressions: Early Events in Mycobacterium tuberculosis Infection Influence Outcome

(2016) Anthony M. Cadena et al.   mBio

Protein phosphatase, Mg2+/Mn2+-dependent 1A controls the innate antiviral and antibacterial response of macrophages during HIV-1 and Mycobacterium tuberculosis infection

(2016) Jim Sun et al.   Oncotarget

Discovery of GSK2795039, a Novel Small Molecule NADPH Oxidase 2 Inhibitor

(2015) Kazufumi Hirano et al.   ANTIOXIDANTS & REDOX SIGNALING

TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model

(2015) Yaming Wang et al.   CELL

The Cytosolic Sensor cGAS Detects Mycobacterium tuberculosis DNA to Induce Type I Interferons and Activate Autophagy

(2015) Robert O. Watson et al.   Cell Host & Microbe

Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) Deficiency Attenuates Phagocytic Activities of Microglia and Exacerbates Ischemic Damage in Experimental Stroke

(2015) M. Kawabori et al.   JOURNAL OF NEUROSCIENCE

Interaction of Pattern Recognition Receptors with Mycobacterium Tuberculosis

(2014) Esmaeil Mortaz et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Interleukin-10 Promotes Mycobacterium tuberculosis Disease Progression in CBA/J Mice

(2014) G. L. Beamer et al.   JOURNAL OF IMMUNOLOGY

TREM-2 Promotes Macrophage-Mediated Eradication ofPseudomonas aeruginosavia a PI3K/Akt Pathway

(2014) M. Zhu et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

The Triggering Receptor Expressed on Myeloid Cells 2 Inhibits Complement Component 1q Effector Mechanisms and Exerts Detrimental Effects during Pneumococcal Pneumonia

(2014) Omar Sharif et al.   PLoS Pathogens

Triggering Receptor Expressed on Myeloid Cells-2 Protects against Polymicrobial Sepsis by Enhancing Bacterial Clearance

(2013) QiXing Chen et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Receptor-mediated recognition of mycobacterial pathogens

(2013) Kate E. Killick et al.   CELLULAR MICROBIOLOGY

Endocytosis ofMycobacterium tuberculosisHeat Shock Protein 60 Is Required to Induce Interleukin-10 Production in Macrophages

(2013) Nazia Parveen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Silencing of triggering receptor expressed on myeloid cells-2 enhances the inflammatory responses of alveolar macrophages to lipopolysaccharide

(2013) XIAOLING GAO et al.   Molecular Medicine Reports

Mycobacteria manipulate macrophage recruitment through coordinated use of membrane lipids

(2013) C. J. Cambier et al.   NATURE

Shikonin Kills Glioma Cells through Necroptosis Mediated by RIP-1

(2013) Chuanjiang Huang et al.   PLoS One

Dichloro-dihydro-fluorescein diacetate (DCFH-DA) assay: A quantitative method for oxidative stress assessment of nanoparticle-treated cells

(2013) A. Aranda et al.   TOXICOLOGY IN VITRO

Mycobacterium tuberculosis Nucleoside Diphosphate Kinase Inactivates Small GTPases Leading to Evasion of Innate Immunity

(2013) Jim Sun et al.   PLoS Pathogens

Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

(2012) Liming Sun et al.   CELL

Vitamin D Is Required for IFN- -Mediated Antimicrobial Activity of Human Macrophages

(2011) M. Fabri et al.   Science Translational Medicine

Molecular Mechanism of NLRP3 Inflammasome Activation

(2010) Chengcheng Jin et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Mycobacterium tuberculosis Activates Human Macrophage Peroxisome Proliferator-Activated Receptor   Linking Mannose Receptor Recognition to Regulation of Immune Responses

(2010) M. V. S. Rajaram et al.   JOURNAL OF IMMUNOLOGY

Optimisation of Bioluminescent Reporters for Use with Mycobacteria

(2010) Nuria Andreu et al.   PLoS One

The Type I NADH Dehydrogenase of Mycobacterium tuberculosis Counters Phagosomal NOX2 Activity to Inhibit TNF-α-Mediated Host Cell Apoptosis

(2010) Jessica L. Miller et al.   PLoS Pathogens

Mycobacterium tuberculosis Eis Regulates Autophagy, Inflammation, and Cell Death through Redox-dependent Signaling

(2010) Dong-Min Shin et al.   PLoS Pathogens

The MIQE Guidelines: Minimum Information for Publication of Quantitative Real-Time PCR Experiments

(2009) S. A. Bustin et al.   CLINICAL CHEMISTRY

TREM-2 (triggering receptor expressed on myeloid cells 2) is a phagocytic receptor for bacteria

(2009) Elsa-Noah N'Diaye et al.   JOURNAL OF CELL BIOLOGY

Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle

(2009) Eri Ishikawa et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The surface-exposed chaperone, Hsp60, is an agonist of the microglial TREM2 receptor

(2009) Luisa Stefano et al.   JOURNAL OF NEUROCHEMISTRY

MARCO, TLR2, and CD14 Are Required for Macrophage Cytokine Responses to Mycobacterial Trehalose Dimycolate and Mycobacterium tuberculosis

(2009) Dawn M. E. Bowdish et al.   PLoS Pathogens

Mycobacterium tuberculosis Prevents Inflammasome Activation

(2008) Sharon S. Master et al.   Cell Host & Microbe

From expression to signaling: Roles of TREM-1 and TREM-2 in innate immunity and bacterial infection

(2008) Omar Sharif et al.   IMMUNOBIOLOGY

The Innate Immune Response to Salmonella enterica Serovar Typhimurium by Macrophages Is Dependent on TREM2-DAP12

(2008) J. F. Charles et al.   INFECTION AND IMMUNITY