LILRB2-mediated TREM2 signaling inhibition suppresses microglia functions

Trem2 restrains the enhancement of tau accumulation and neurodegeneration by β-amyloid pathology

(2021) Seung-Hye Lee et al.   NEURON

Systematic phenotyping and characterization of the 5xFAD mouse model of Alzheimer’s disease

(2021) Stefania Forner et al.   Scientific Data

The clinical promise of biomarkers of synapse damage or loss in Alzheimer’s disease

(2020) Martí Colom-Cadena et al.   Alzheimers Research & Therapy

Enhancing protective microglial activities with a dual function TREM 2 antibody to the stalk region

(2020) Kai Schlepckow et al.   EMBO Molecular Medicine

Anti-human TREM2 induces microglia proliferation and reduces pathology in an Alzheimer’s disease model

(2020) Shoutang Wang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Impact of TREM2R47H variant on tau pathology–induced gliosis and neurodegeneration

(2020) Maud Gratuze et al.   JOURNAL OF CLINICAL INVESTIGATION

Multi-omic comparison of Alzheimer’s variants in human ESC–derived microglia reveals convergence at APOE

(2020) Tongfei Liu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

An epoxide hydrolase inhibitor reduces neuroinflammation in a mouse model of Alzheimer’s disease

(2020) Anamitra Ghosh et al.   Science Translational Medicine

Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer’s disease model

(2019) Li Zhong et al.   Nature Communications

Systematic and standardized comparison of reported Amyloid-β receptors for sufficiency, affinity, and Alzheimer’s disease relevance

(2019) Levi M. Smith et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Apolipoprotein E associated with reconstituted high‐density lipoprotein‐like particles is protected from aggregation

(2019) Ellen Hubin et al.   FEBS LETTERS

TREM2 Acts Downstream of CD33 in Modulating Microglial Pathology in Alzheimer’s Disease

(2019) Ana Griciuc et al.   NEURON

Aminophospholipids are signal-transducing TREM2 ligands on apoptotic cells

(2019) Keiro Shirotani et al.   Scientific Reports

Microglia in Alzheimer Disease: Well-Known Targets and New Opportunities

(2019) Anne-Laure Hemonnot et al.   Frontiers in Aging Neuroscience

Alzheimer Disease: An Update on Pathobiology and Treatment Strategies

(2019) Justin M. Long et al.   CELL

Partial Leptin Reduction as an Insulin Sensitization and Weight Loss Strategy

(2019) Shangang Zhao et al.   Cell Metabolism

Human iPSC-derived microglia assume a primary microglia-like state after transplantation into the neonatal mouse brain

(2019) Devon S. Svoboda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anti-Amyloid-β Monoclonal Antibodies for Alzheimer’s Disease: Pitfalls and Promise

(2018) Christopher H. van Dyck   BIOLOGICAL PSYCHIATRY

Disease-Associated Microglia: A Universal Immune Sensor of Neurodegeneration

(2018) Aleksandra Deczkowska et al.   CELL

Amyloid-beta modulates microglial responses by binding to the triggering receptor expressed on myeloid cells 2 (TREM2)

(2018) Li Zhong et al.   Molecular Neurodegeneration

TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function

(2018) Yingjun Zhao et al.   NEURON

Inhibiting amyloid-ß cytotoxicity through its interaction with the cell surface receptor LilrB2 by structure-based design

(2018) Qin Cao et al.   Nature Chemistry

TREM2 — a key player in microglial biology and Alzheimer disease

(2018) Tyler K. Ulland et al.   Nature Reviews Neurology

Blocking immunoinhibitory receptor LILRB2 reprograms tumor-associated myeloid cells and promotes antitumor immunity

(2018) Hui-Ming Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

New insights into the role of TREM2 in Alzheimer’s disease

(2018) Maud Gratuze et al.   Molecular Neurodegeneration

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

(2017) Susanne Krasemann et al.   IMMUNITY

TREM2 deficiency exacerbates tau pathology through dysregulated kinase signaling in a mouse model of tauopathy

(2017) Shane M. Bemiller et al.   Molecular Neurodegeneration

Differentiation of human and murine induced pluripotent stem cells to microglia-like cells

(2017) Hetal Pandya et al.   NATURE NEUROSCIENCE

iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases

(2017) Edsel M. Abud et al.   NEURON

TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy

(2017) Cheryl E. G. Leyns et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphatidylserine is a global immunosuppressive signal in efferocytosis, infectious disease and cancer

(2016) R B Birge et al.   CELL DEATH AND DIFFERENTIATION

TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques

(2016) Yaming Wang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia

(2016) Felix L. Yeh et al.   NEURON

The Role of Amyloid-β Oligomers in Toxicity, Propagation, and Immunotherapy

(2016) Urmi Sengupta et al.   EBioMedicine

TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model

(2015) Yaming Wang et al.   CELL

Of ITIMs, ITAMs, and ITAMis: revisiting immunoglobulin Fc receptor signaling

(2015) Andrew Getahun et al.   IMMUNOLOGICAL REVIEWS

Amyloid-β Receptors: The Good, the Bad, and the Prion Protein

(2015) Heledd H. Jarosz-Griffiths et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TREM2 deficiency eliminates TREM2+inflammatory macrophages and ameliorates pathology in Alzheimer’s disease mouse models

(2015) Taylor R. Jay et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A review on Alzheimer's disease pathophysiology and its management: an update

(2015) Anil Kumar et al.   Pharmacological Reports

Microglial internalization and degradation of pathological tau is enhanced by an anti-tau monoclonal antibody

(2015) Wenjie Luo et al.   Scientific Reports

A motif in LILRB2 critical for Angptl2 binding and activation

(2014) M. Deng et al.   BLOOD

Deciphering key features in protein structures with the new ENDscript server

(2014) Xavier Robert et al.   NUCLEIC ACIDS RESEARCH

TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis

(2014) G. Kleinberger et al.   Science Translational Medicine

p85α recruitment by the CD300f phosphatidylserine receptor mediates apoptotic cell clearance required for autoimmunity suppression

(2014) Linjie Tian et al.   Nature Communications

The role of Fc gamma receptors in the activity of immunomodulatory antibodies for cancer

(2014) Ross Stewart et al.   Journal for ImmunoTherapy of Cancer

Membrane-Anchored A  Accelerates Amyloid Formation and Exacerbates Amyloid-Associated Toxicity in Mice

(2013) A. Nagarathinam et al.   JOURNAL OF NEUROSCIENCE

Alzheimer’s Disease Risk Gene CD33 Inhibits Microglial Uptake of Amyloid Beta

(2013) Ana Griciuc et al.   NEURON

Human LilrB2 Is a  -Amyloid Receptor and Its Murine Homolog PirB Regulates Synaptic Plasticity in an Alzheimer's Model

(2013) T. Kim et al.   SCIENCE

Cytochalasin D acts as an inhibitor of the actin–cofilin interaction

(2012) Kazuyasu Shoji et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Binding of β-Amyloid (1–42) Peptide to Negatively Charged Phospholipid Membranes in the Liquid-Ordered State: Modeling and Experimental Studies

(2012) Hasna Ahyayauch et al.   BIOPHYSICAL JOURNAL

Human CD300a binds to phosphatidylethanolamine and phosphatidylserine, and modulates the phagocytosis of dead cells

(2012) V. R. Simhadri et al.   BLOOD

A comparative review of cell culture systems for the study of microglial biology in Alzheimer’s disease

(2012) Branden Stansley et al.   Journal of Neuroinflammation

HER3 intracellular domains play a crucial role in HER3/HER2 dimerization and activation of downstream signaling pathways

(2012) Byung-Kwon Choi et al.   Protein & Cell

ERBB3 (HER3) is a key sensor in the regulation of ERBB-mediated signaling in both low and high ERBB2 (HER2) expressing cancer cells

(2012) Byung-Kwon Choi et al.   Cancer Medicine

Phosphatidylserine-containing liposomes suppress inflammatory bone loss by ameliorating the cytokine imbalance provoked by infiltrated macrophages

(2011) Hong Mei Ma et al.   LABORATORY INVESTIGATION

Phosphatidylserine targeting for diagnosis and treatment of human diseases

(2010) Kristof Schutters et al.   APOPTOSIS

Tau in Alzheimer Disease and Related Tauopathies

(2010) K. Iqbal et al.   Current Alzheimer Research

Lysophosphatidylcholine modulates fibril formation of amyloid beta peptide

(2010) Abdullah Md. Sheikh et al.   FEBS Journal

Formic acid is essential for immunohistochemical detection of aggregated intraneuronal Aβ peptides in mouse models of Alzheimer's disease

(2009) Ditte Z. Christensen et al.   BRAIN RESEARCH

A role for TREM2 ligands in the phagocytosis of apoptotic neuronal cells by microglia

(2009) Christine L. Hsieh et al.   JOURNAL OF NEUROCHEMISTRY

Beta-Amyloid Deposition and the Aging Brain

(2009) Karen M. Rodrigue et al.   NEUROPSYCHOLOGY REVIEW

Hyperphosphorylation of Microtubule-Associated Protein Tau: A Promising Therapeutic Target for Alzheimer Disease

(2008) C.-X. Gong et al.   CURRENT MEDICINAL CHEMISTRY

Neuroinflammation and microglia: considerations and approaches for neurotoxicity assessment

(2008) Gaylia Jean Harry et al.   Expert Opinion on Drug Metabolism & Toxicology