Activation of human endogenous retroviruses and its physiological consequences

The Immunological Conundrum of Endogenous Retroelements

(2023) George Kassiotis   Annual Review of Immunology

Resurrection of endogenous retroviruses during aging reinforces senescence

(2023) Xiaoqian Liu et al.   CELL

Endogenous Reverse Transcriptase Inhibition Attenuates TLR5-Mediated Inflammation

(2023) Nicholas Dopkins et al.   mBio

Epigenetically controlled tumor antigens derived from splice junctions between exons and transposable elements

(2023) Marianne Burbage et al.   Science Immunology

Noncanonical splicing junctions between exons and transposable elements represent a source of immunogenic recurrent neo-antigens in patients with lung cancer

(2023) Antonela Merlotti et al.   Science Immunology

Association of Human Endogenous Retrovirus-W (HERV-W) Copies with Pemphigus Vulgaris

(2023) Abbas Karimi et al.   CURRENT MOLECULAR MEDICINE

Antibodies against endogenous retroviruses promote lung cancer immunotherapy

(2023) Kevin W. Ng et al.   NATURE

Pan-cancer analysis identifies tumor-specific antigens derived from transposable elements

(2023) Nakul M. Shah et al.   NATURE GENETICS

Pathogenesis of autoimmune disease

(2023) David S. Pisetsky   Nature Reviews Nephrology

Interplay between endogenous and exogenous human retroviruses

(2023) Eleni Kyriakou et al.   TRENDS IN MICROBIOLOGY

Endogenous retroviruses and TDP-43 proteinopathy form a sustaining feedback driving intercellular spread of Drosophila neurodegeneration

(2023) Yung-Heng Chang et al.   Nature Communications

Nuclear lamina erosion-induced resurrection of endogenous retroviruses underlies neuronal aging

(2023) Hui Zhang et al.   Cell Reports

Expression of L1 retrotransposons in granulocytes from patients with active systemic lupus erythematosus

(2023) Kennedy C. Ukadike et al.   Mobile DNA

Molecular architecture and conservation of an immature human endogenous retrovirus

(2023) Anna-Sophia Krebs et al.   Nature Communications

Locus specific endogenous retroviral expression associated with Alzheimer’s disease

(2023) Tyson Dawson et al.   Frontiers in Aging Neuroscience

Human reproduction is regulated by retrotransposons derived from ancient Hominidae-specific viral infections

(2022) Xinyu Xiang et al.   Nature Communications

Identification of shared tumor epitopes from endogenous retroviruses inducing high-avidity cytotoxic T cells for cancer immunotherapy

(2022) Paola Bonaventura et al.   Science Advances

Chromatin modifier HUSH co-operates with RNA decay factor NEXT to restrict transposable element expression

(2022) William Garland et al.   MOLECULAR CELL

Roles of transposable elements in the regulation of mammalian transcription

(2022) Raquel Fueyo et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Species-specific KRAB-ZFPs function as repressors of retroviruses by targeting PBS regions

(2022) Bo Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The complete sequence of a human genome

(2022) Sergey Nurk et al.   SCIENCE

Reverse Transcriptase Inhibition Disrupts Repeat Element Life Cycle in Colorectal Cancer

(2022) Mihir Rajurkar et al.   Cancer Discovery

Recent Bioinformatic Progress to Identify Epigenetic Changes Associated to Transposable Elements

(2022) Emmanuelle Lerat   Frontiers in Genetics

Interferons reshape the 3D conformation and accessibility of macrophage chromatin

(2022) Ekaterini Platanitis et al.   iScience

HERVs characterize normal and leukemia stem cells and represent a source of shared epitopes for cancer immunotherapy

(2022) Vincent Alcazer et al.   AMERICAN JOURNAL OF HEMATOLOGY

Antibody response to HML‐2 may be protective in Amyotrophic Lateral Sclerosis

(2022) Marta Garcia‐Montojo et al.   ANNALS OF NEUROLOGY

Human Endogenous Retrovirus K Envelope in Spinal Fluid of Amyotrophic Lateral Sclerosis Is Toxic

(2022) Joseph P. Steiner et al.   ANNALS OF NEUROLOGY

Dark genome, bright ideas: Recent approaches to harness transposable elements in immunotherapies

(2022) Ashley Reid Cahn et al.   CANCER CELL

A field guide to endogenous retrovirus regulatory networks

(2022) Nicholas Dopkins et al.   MOLECULAR CELL

Evolution and antiviral activity of a human protein of retroviral origin

(2022) John A. Frank et al.   SCIENCE

How human endogenous retroviruses interact with the microbiota in health and disease

(2022) Nicholas Dopkins et al.   TRENDS IN MICROBIOLOGY

Widespread expression of the ancient HERV-K (HML-2) provirus group in normal human tissues

(2022) Aidan Burn et al.   PLOS BIOLOGY

SoloTE for improved analysis of transposable elements in single-cell RNA-Seq data using locus-specific expression

(2022) Rocío Rodríguez-Quiroz et al.   Communications Biology

m6A RNA methylation regulates the fate of endogenous retroviruses

(2021) Tomasz Chelmicki et al.   NATURE

CAR T cells in solid tumors: challenges and opportunities

(2021) Faroogh Marofi et al.   Stem Cell Research & Therapy

Activation of endogenous retroviruses during brain development causes an inflammatory response

(2021) Marie E Jönsson et al.   EMBO JOURNAL

Identifying transposable element expression dynamics and heterogeneity during development at the single-cell level with a processing pipeline scTE

(2021) Jiangping He et al.   Nature Communications

Locus-specific characterization of human endogenous retrovirus expression in prostate, breast, and colon cancers

(2021) Margaret C. Steiner et al.   CANCER RESEARCH

Activation of HERV-K(HML-2) disrupts cortical patterning and neuronal differentiation by increasing NTRK3

(2021) Vidya Padmanabhan Nair et al.   Cell Stem Cell

The struggle of a good friend getting old: cellular senescence in viral responses and therapy

(2021) Jaskaren Kohli et al.   EMBO REPORTS

Atypical acute myeloid leukemia-specific transcripts generate shared and immunogenic MHC class-I-associated epitopes

(2021) Grégory Ehx et al.   IMMUNITY

Endogenous retroviruses promote homeostatic and inflammatory responses to the microbiota

(2021) Djalma S. Lima-Junior et al.   CELL

Efficacy and safety of temelimab in multiple sclerosis: Results of a randomized phase 2b and extension study

(2021) Hans-Peter Hartung et al.   Multiple Sclerosis Journal

Locus-specific expression of transposable elements in single cells with CELLO-seq

(2021) Rebecca V. Berrens et al.   NATURE BIOTECHNOLOGY

Pathogenic tau accelerates aging-associated activation of transposable elements in the mouse central nervous system

(2021) Paulino Ramirez et al.   PROGRESS IN NEUROBIOLOGY

Morc3 silences endogenous retroviruses by enabling Daxx-mediated histone H3.3 incorporation

(2021) Sophia Groh et al.   Nature Communications

Measuring and interpreting transposable element expression

(2020) Sophie Lanciano et al.   NATURE REVIEWS GENETICS

Multifaceted deregulation of gene expression and protein synthesis with age

(2020) Aleksandra S. Anisimova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transposable Elements: A Common Feature of Neurodevelopmental and Neurodegenerative Disorders

(2020) Marie E. Jönsson et al.   TRENDS IN GENETICS

Human endogenous retroviral protein triggers deficit in glutamate synapse maturation and behaviors associated with psychosis

(2020) E. M. Johansson et al.   Science Advances

Gut microbiota in human metabolic health and disease

(2020) Yong Fan et al.   NATURE REVIEWS MICROBIOLOGY

Structural Mimicry Drives HIV-1 Rev-Mediated HERV-K Expression

(2020) Ina P. O'Carroll et al.   JOURNAL OF MOLECULAR BIOLOGY

SQuIRE reveals locus-specific regulation of interspersed repeat expression

(2019) Wan R Yang et al.   NUCLEIC ACIDS RESEARCH

Transactivation of human endogenous retroviruses by tumor viruses and their functions in virus-associated malignancies

(2019) Jungang Chen et al.   Oncogenesis

Quantitative analysis of human endogenous retrovirus-K transcripts in postmortem premotor cortex fails to confirm elevated expression of HERV-K RNA in amyotrophic lateral sclerosis

(2019) Jeremy A. Garson et al.   Acta Neuropathologica Communications

The Lupus Susceptibility Locus Sgp3 Encodes the Suppressor of Endogenous Retrovirus Expression SNERV

(2019) Rebecca S. Treger et al.   IMMUNITY

Hominoid-Specific Transposable Elements and KZFPs Facilitate Human Embryonic Genome Activation and Control Transcription in Naive Human ESCs

(2019) Julien Pontis et al.   Cell Stem Cell

Technical considerations in detection of HERV-K in amyotrophic lateral sclerosis: selection of controls and the perils of qPCR

(2019) Marta Garcia-Montojo et al.   Acta Neuropathologica Communications

Telescope: Characterization of the retrotranscriptome by accurate estimation of transposable element expression

(2019) Matthew L. Bendall et al.   PLoS Computational Biology

Postmortem Cortex Samples Identify Distinct Molecular Subtypes of ALS: Retrotransposon Activation, Oxidative Stress, and Activated Glia

(2019) Oliver H. Tam et al.   Cell Reports

LTR-retrotransposon transcriptome modulation in response to endotoxin-induced stress in PBMCs

(2018) Marine Mommert et al.   BMC GENOMICS

Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells

(2018) Tahsin Stefan Barakat et al.   Cell Stem Cell

Pathogenic tau-induced piRNA depletion promotes neuronal death through transposable element dysregulation in neurodegenerative tauopathies

(2018) Wenyan Sun et al.   NATURE NEUROSCIENCE

Transactivation of human endogenous retrovirus K (HERV-K) by KSHV promotes Kaposi’s sarcoma development

(2018) Lu Dai et al.   ONCOGENE

Human Endogenous Retroviruses in Neurological Diseases

(2018) Patrick Küry et al.   TRENDS IN MOLECULAR MEDICINE

Tau Activates Transposable Elements in Alzheimer’s Disease

(2018) Caiwei Guo et al.   Cell Reports

Transcriptional profiling of HERV-K(HML-2) in amyotrophic lateral sclerosis and potential implications for expression of HML-2 proteins

(2018) Jens Mayer et al.   Molecular Neurodegeneration

Converging pathways in neurodegeneration, from genetics to mechanisms

(2018) Li Gan et al.   NATURE NEUROSCIENCE

Evaluating intrinsic and non-intrinsic cancer risk factors

(2018) Song Wu et al.   Nature Communications

LTRs activated by Epstein-Barr virus–induced transformation of B cells alter the transcriptome

(2018) Amy Leung et al.   GENOME RESEARCH

Endogenous retroviral signatures predict immunotherapy response in clear cell renal cell carcinoma

(2018) Christof C. Smith et al.   JOURNAL OF CLINICAL INVESTIGATION

Reverse-Transcriptase Inhibitors in the Aicardi–Goutières Syndrome

(2018) Gillian I. Rice et al.   NEW ENGLAND JOURNAL OF MEDICINE

ERVmap analysis reveals genome-wide transcription of human endogenous retroviruses

(2018) Maria Tokuyama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Classification and characterization of human endogenous retroviruses; mosaic forms are common

(2016) Laura Vargiu et al.   Retrovirology

Regulatory evolution of innate immunity through co-option of endogenous retroviruses

(2016) E. B. Chuong et al.   SCIENCE

Endogenous retroviral promoter exaptation in human cancer

(2016) Artem Babaian et al.   Mobile DNA

Identification of a new subclass of ALK-negative ALCL expressing aberrant levels of ERBB4 transcripts

(2015) I. Scarfo et al.   BLOOD

Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses

(2015) Katherine B. Chiappinelli et al.   CELL

New bioinformatic tool for quick identification of functionally relevant endogenous retroviral inserts in human genome

(2015) Andrew Garazha et al.   CELL CYCLE

Dynamic Transcription of Distinct Classes of Endogenous Retroviral Elements Marks Specific Populations of Early Human Embryonic Cells

(2015) Jonathan Göke et al.   Cell Stem Cell

Intrinsic retroviral reactivation in human preimplantation embryos and pluripotent cells

(2015) Edward J. Grow et al.   NATURE

Alternative transcription initiation leads to expression of a novel ALK isoform in cancer

(2015) Thomas Wiesner et al.   NATURE

The Dfam database of repetitive DNA families

(2015) Robert Hubley et al.   NUCLEIC ACIDS RESEARCH

Onco-exaptation of an endogenous retroviral LTR drives IRF5 expression in Hodgkin lymphoma

(2015) A Babaian et al.   ONCOGENE

Human endogenous retrovirus-K contributes to motor neuron disease

(2015) Wenxue Li et al.   Science Translational Medicine

Repbase Update, a database of repetitive elements in eukaryotic genomes

(2015) Weidong Bao et al.   Mobile DNA

Chimeric antigen receptor T cells targeting HERV-K inhibit breast cancer and its metastasis through downregulation of Ras

(2015) Fuling Zhou et al.   OncoImmunology

A comprehensive analysis of piRNAs from adult human testis and their relationship with genes and mobile elements

(2014) Hongseok Ha et al.   BMC GENOMICS

Interplay of TRIM28 and DNA methylation in controlling human endogenous retroelements

(2014) Priscilla Turelli et al.   GENOME RESEARCH

The retrovirus HERVH is a long noncoding RNA required for human embryonic stem cell identity

(2014) Xinyi Lu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Distinct isoform of FABP7 revealed by screening for retroelement-activated genes in diffuse large B-cell lymphoma

(2014) F. E. Lock et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microarray analysis reveals global modulation of endogenous retroelement transcription by microbes

(2014) George R Young et al.   Retrovirology

The role of replicates for error mitigation in next-generation sequencing

(2013) Kimberly Robasky et al.   NATURE REVIEWS GENETICS

Immunotherapeutic Potential of Anti-Human Endogenous Retrovirus-K Envelope Protein Antibodies in Targeting Breast Tumors

(2012) Feng Wang-Johanning et al.   JNCI-Journal of the National Cancer Institute

Expression of Human Endogenous Retrovirus Type K (HML-2) Is Activated by the Tat Protein of HIV-1

(2012) M. J. Gonzalez-Hernandez et al.   JOURNAL OF VIROLOGY

Intrinsic antiviral immunity

(2012) Nan Yan et al.   NATURE IMMUNOLOGY

Repetitive DNA and next-generation sequencing: computational challenges and solutions

(2011) Todd J. Treangen et al.   NATURE REVIEWS GENETICS

Viral subversion of the host protein synthesis machinery

(2011) Derek Walsh et al.   NATURE REVIEWS MICROBIOLOGY

An autoimmune disease prevented by anti-retroviral drugs

(2011) Gabriele B Beck-Engeser et al.   Retrovirology

Activation of LTRs from Different Human Endogenous Retrovirus (HERV) Families by the HTLV-1 Tax Protein and T-Cell Activators

(2011) Chirine Toufaily et al.   Viruses-Basel

Identification of active loci of a human endogenous retrovirus in neurons of patients with amyotrophic lateral sclerosis

(2010) Renée Douville et al.   ANNALS OF NEUROLOGY

Transposable elements have rewired the core regulatory network of human embryonic stem cells

(2010) Galih Kunarso et al.   NATURE GENETICS

Derepression of an endogenous long terminal repeat activates the CSF1R proto-oncogene in human lymphoma

(2010) Björn Lamprecht et al.   NATURE MEDICINE

Syncytin-A knockout mice demonstrate the critical role in placentation of a fusogenic, endogenous retrovirus-derived, envelope gene

(2009) A. Dupressoir et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of Retroviruses on Host Genome Function

(2008) Patric Jern et al.   Annual Review of Genetics